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1. 发明申请

US20210017309A1 ZWITTERIONIC POLYMER, METHOD FOR PRODUCING SAME AND PROTEIN STABILIZER CONTAINING ZWITTERIONIC POLYMER 有权
公开(公告)号：US20210017309A1
公开(公告)日：2021-01-21
申请号：US16955375
申请日：2018-12-26
申请人： NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITY , NOF CORPORATION
发明人： Hideharu MORI , Ryutaro IMAMURA
IPC分类号： C08F20/58 , C08F8/02 , C07C321/18
摘要： Provided is a zwitterionic polymer that has a zwitterion that includes an effect of improving the stability of proteins. This zwitterionic polymer is a polymeric protein stabilizer that exhibits a protein stabilizing effect even at a small addition amount of addition, and at the same time has an antioxidant capability. Also provided is a method for producing this zwitterionic polymer. This problem is solved by a zwitterionic polymer containing a repeating unit represented by formula (1) and having a number-average molecular weight of 1,000 to 1,000,000. On formula (1), R1 and R2 are each independently selected from a hydrogen atom; linear, branched or cyclic alkyl groups having 1 to 6 carbons; aromatic groups having 6 to 20 carbons; or alkylene groups having 1 to 6 carbons and formed by linking R1 to R2. R3 represents a hydrogen atom or a methyl group).

2. 发明授权

US10759748B2 Compounds as L-cystine crystallization inhibitors and uses thereof 有权
公开(公告)号：US10759748B2
公开(公告)日：2020-09-01
申请号：US15926657
申请日：2018-03-20
申请人： NEW YORK UNIVERSITY
发明人： Michael D. Ward , Zina Zhu
IPC分类号： C07C321/20 , A61K31/195 , A61K31/225 , A61K31/095 , A61K31/132 , C07C229/22 , C07C321/14 , C07C321/18
摘要： A method of preventing or inhibiting L-cystine crystallization is disclosed, using the compounds of formula I: R1a—[O]v-(-A-L-)m-A-[O]v—R1b I wherein A, L, R1a, R1b, m, and v are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.

3. 发明授权

US10314802B2 Isoprenyl compounds and methods thereof 有权
公开(公告)号：US10314802B2
公开(公告)日：2019-06-11
申请号：US15665922
申请日：2017-08-01
申请人： Signum Biosciences, Inc.
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： A61K31/197 , A61K9/00 , C07C323/59 , C07C335/08 , C07C243/34 , C07C321/18 , C07D209/18 , C07D209/48 , C07D217/26 , C07D295/145 , C07D307/54 , C07D333/24 , C07D207/16 , C07D243/34
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

4. 发明申请

US20130143967A1 Organosulfur compounds for the prevention and treatment of neurodegenerative diseases 有权
标题翻译：有机硫化合物用于预防和治疗神经退行性疾病
公开(公告)号：US20130143967A1
公开(公告)日：2013-06-06
申请号：US13373878
申请日：2011-12-05
申请人： David M. Ott
发明人： David M. Ott
IPC分类号： A61K31/198 , A61P25/00 , A61P25/16 , C07C321/18 , A61P25/28
CPC分类号： A61K31/198
摘要： S-allylmercapto-N-acetylcysteine and related compounds are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compounds include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.
摘要翻译：公开了S-烯丙基巯基-N-乙酰半胱氨酸和相关化合物，其可以被施用以提供保护免于形成醛 - 蛋白质加合物，蛋白质羰基化，蛋白质聚集和所产生的神经炎症。适用于使用这些化合物治疗的各种神经变性疾病包括阿尔茨海默氏病，老年性痴呆，帕金森病，多发性硬化，路易体病，周围神经病，脊髓损伤，中风和脑缺血。

5. 发明授权

US08455565B2 Disulfide monomers comprising ethylenically unsaturated groups suitable for dental compositions 有权
标题翻译：包含适用于牙齿组合物的烯属不饱和基团的二硫化物单体
公开(公告)号：US08455565B2
公开(公告)日：2013-06-04
申请号：US13110900
申请日：2011-05-18
申请人： Ahmed S. Abuelyaman , Joel D. Oxman , Yizhong Wang , Christopher N. Bowman , Hee Young Park , Christopher J. Kloxin
发明人： Ahmed S. Abuelyaman , Joel D. Oxman , Yizhong Wang , Christopher N. Bowman , Hee Young Park , Christopher J. Kloxin
IPC分类号： A61K6/00 , A61K6/08 , A61K6/083 , C08F28/04 , C07C321/18
CPC分类号： C07C323/12 , A61K6/083 , C08L33/06
摘要： Dental compositions and disulfide monomers are described. The disulfide monomer comprise a disulfide backbone group wherein each of the sulfur atoms are bonded to an ethylenically unsaturated group via a divalent linking group and the linking group comprises at least one heteroatom; and at least one other monomer ethylenically unsaturated monomer.
摘要翻译：描述了牙科组合物和二硫化物单体。二硫化物单体包含二硫主链基团，其中每个硫原子通过二价连接基团与烯属不饱和基团键合，并且连接基团包含至少一个杂原子; 和至少一种其它单体烯属不饱和单体。

6. 发明申请

US20050176815A1 Anti-inflammatory nitro-and thia-fatty acids 审中-公开
标题翻译：抗炎性硝基和硫脂肪酸
公开(公告)号：US20050176815A1
公开(公告)日：2005-08-11
申请号：US11072195
申请日：2005-03-04
申请人： Antonio Ferrante , Christopher Easton , Ling Xia
发明人： Antonio Ferrante , Christopher Easton , Ling Xia
IPC分类号： A61K8/30 , A61K8/36 , A61K8/40 , A61K8/46 , A61K31/04 , A61K31/10 , A61K31/19 , A61K31/20 , A61K31/202 , A61K31/21 , A61K31/335 , A61P1/04 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P31/00 , A61P33/06 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/06 , A61P43/00 , C07C17/16 , C07C45/30 , C07C205/02 , C07C205/03 , C07C205/14 , C07C205/15 , C07C205/50 , C07C205/51 , C07C317/44 , C07C321/14 , C07C321/18 , C07C323/52 , C07C409/40 , A61K31/336 , C07C23/04
CPC分类号： C07C409/40 , A61K31/19 , A61K31/20 , A61K31/202 , A61K31/21 , A61K31/335 , A61K45/06 , C07C17/16 , C07C45/30 , C07C205/02 , C07C205/03 , C07C205/14 , C07C205/15 , C07C205/50 , C07C205/51 , C07C317/44 , C07C323/52 , Y02A50/411 , C07C19/075 , C07C21/14 , C07C47/02 , C07C47/21 , A61K2300/00
摘要： The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A′ is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B′ is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.
摘要翻译：本发明涉及以下通式的化合物：其中A是14-26个碳原子的饱和或不饱和烃链，B是（CH 2 CH 2））其中n为0〜2的整数，m为0〜2的整数，n为0〜2的整数。或通式（I），其中A'是9-26个碳原子的饱和或不饱和烃链，X是氧或不存在，B'是（CH 2 CH 2）其中，j为1〜3的整数，k为0或1的化合物（COOH）k < 及其衍生物，其中烃链包括一个或多于一个选自羟基，氢过氧基，环氧基和过氧基的取代基。这些化合物具有生物活性，例如作为抗感染或抗炎剂。

7. 发明授权

US5807899A Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents 失效
标题翻译：三苯乙烯，其制备方法，含有这些三苯乙烯的药物制剂以及其用于生产药剂的用途
公开(公告)号：US5807899A
公开(公告)日：1998-09-15
申请号：US675906
申请日：1996-07-05
申请人： Rolf Bohlmann , Joseph Heindl , Hermann Kunzer , Yukishige Nishino , Karsten Parczyk , Martin Schneider
发明人： Rolf Bohlmann , Joseph Heindl , Hermann Kunzer , Yukishige Nishino , Karsten Parczyk , Martin Schneider
IPC分类号： C07C317/18 , C07C317/28 , C07C323/12 , C07C323/25 , C07C323/60 , C07D213/32 , C07D213/34 , A61K31/10 , C07C317/12 , C07C321/18 , C07C321/20
CPC分类号： C07C323/25 , C07C317/18 , C07C317/28 , C07C323/12 , C07C323/60 , C07D213/32 , C07D213/34
摘要： This invention describes the new triphenylethylenes of general formula I ##STR1## in which n means an integer from 1 to 10, R' means a sulfur-containing organic radical, R" means a hydrogen atom, an iodine atom or a hydroxy groups, E means a hydrogen atom, G means a hydrogen atom or E and G together mean a methylene bridge. The new compounds have strong antiestrogenic properties and are suitable for the production of pharmaceutical agents, for example for treating breast cancer.
摘要翻译：本发明描述了通式I（I）的新的三苯乙烯，其中n表示1至10的整数，R'表示含硫有机基团，R“表示氢原子，碘原子或羟基，E表示氢原子，G表示氢原子或E和G一起表示亚甲基桥。新化合物具有强的抗雌激素特性，适用于制药，例如用于治疗乳腺癌。

8. 发明授权

US5324858A New sulfured compounds 失效
标题翻译：新型硫化物
公开(公告)号：US5324858A
公开(公告)日：1994-06-28
申请号：US940890
申请日：1992-10-28
申请人： Ourida Aberkane , Maurice Born , Jean Luc Mielzoszynski , Daniel Paquer , Guy Barc
发明人： Ourida Aberkane , Maurice Born , Jean Luc Mielzoszynski , Daniel Paquer , Guy Barc
IPC分类号： C07C321/14 , C07C321/18 , C10M135/22
CPC分类号： C07C321/14 , C07C321/18 , C10M135/22 , C10M2219/082 , C10M2221/043
摘要： New sulfurized compounds, their preparation and their use are described. They correspond to the general formula: {[R--S.sub.X --(CH.sub.2).sub.n --].sub.z CH.sub.3-z --(CH.sub.2).sub.P --}.sub.2 S.sub.y, in which R represents a monovalent hydrocarbon radical with 1 to 30 carbon atoms, optionally functionalized; x is a number equal to or greater than 1; z is an integer equal to 1 or 2; when z=1, n is an integer from 0 to 3 and p is an integer from 0 to 3, with n+p being an integer from 0 to 3; when z=2, n is an integer from 1 to 3 and p is an integer from 0 to 3; and y is a number equal to or greater than 1, at last one of the numbers x and y being strictly greater than 1. These sulfurized compounds can be used as extreme-pressure and anti-wear additives in lubricating oils, in particular oils for gear systems and oil for working metals.
摘要翻译： PCT No.PCT / FR91 / 01026 Sec。 371日期：1992年10月28日 102（e）日期1992年10月28日PCT 1991年12月17日PCT PCT。公开号WO92 / 12126 日期：1992年7月23日。新的硫化化合物，它们的制备及其用途被描述。它们对应于以下通式：{[R-SX-（CH2）n-] zCH3-z-（CH2）P-} 2Sy，其中R表示具有1至30个碳原子的一价烃基，任选地官能化; x是等于或大于1的数字; z是等于1或2的整数; 当z = 1时，n为0〜3的整数，p为0〜3的整数，n + p为0〜3的整数。当z = 2时，n为1〜3的整数，p为0〜3的整数。并且y为等于或大于1的数，最后一个数字x和y严格大于1.这些硫化化合物可用作润滑油中的极压和抗磨添加剂，特别是用于齿轮系统和工作金属油。

9. 发明授权

US3717681A Alkenyl trisulfides 失效
标题翻译：亚苄基三聚体
公开(公告)号：US3717681A
公开(公告)日：1973-02-20
申请号：US3717681D
申请日：1971-05-26
申请人： INT FLAVORS & FRAGRANCES INC
发明人： BRODNITZ M
IPC分类号： A23L23/10 , A23L27/20 , C07C321/18 , C07C149/12
CPC分类号： C07C321/18 , A23L23/10 , A23L27/2022 , C07C321/00
摘要： Novel compounds have been discovered which impart cooked onion flavor and aroma to foods treated therewith. Said novel compounds are alkyl 1-alkenyl disulfides having the formula: WHEREIN R'' is hydrogen or alkyl and R and R1 are alkyl. Representative compounds are methyl propenyl disulfide, propyl propenyl disulfide, and ethyl propenyl disulfide. Compositions containing said compounds preferably at levels of from 0.01 to 20 percent by weight are also disclosed. Additionally, said compositions may contain other disulfides and trisulfides including novel alkenyl trisulfides having the formula: WHEREIN R7 and R8 are alkyl groups and R6 and R9 are hydrogen or alkyl.
摘要翻译：已经发现新的化合物，其赋予经过处理的食品烹制的洋葱风味和香气。所述新化合物是具有下式的烷基1-烯基二硫化物：

10. 发明授权

US3703504A Process for producing sulfurized olefins 失效
标题翻译：生产硫化油的方法
公开(公告)号：US3703504A
公开(公告)日：1972-11-21
申请号：US3703504D
申请日：1970-01-12
申请人： MOBIL OIL CORP
发明人： HORODYSKY ANDREW G
IPC分类号： C07B45/06 , C07B31/00 , C07C67/00 , C07C309/80 , C07C313/00 , C07C319/14 , C07C321/18 , C08G75/00 , C10M135/04 , C07C161/00
CPC分类号： C07C319/14 , C08G75/00 , C10M135/04 , C10M2219/022 , C10N2250/10 , C07C321/14
摘要： OLEFINS (E.G., ISOBUTYLENE) ARE REACTED WITH SULFUR MONOCHLORIDE IN THE PRESENCE OF A CATALYTIC AMOUNT OF METHANOL TO FORM A SULFOCHLORINATED INTERMEDIATE PRODUCT WHICH IS THEN REACTED IN THE PRESENCE OF A RELATIVELY LARGE AMOUNT OF ISOPROPANOL WITH AN AQUEOUS SOLUTION OF SODIUM MONOSULFIDE DERIVED FROM SPENT CASUTIC SODA LIQUORS OF PETROLEUM REFINERY ORIGIN IN PRODUCING A NONCORROSIVE SULFURIZED ORGANIC PRODUCT OF UNUSUALLY HIGH SULFUR CONTENT. THE SULFURIZING AND DECHLORINATING REACTANT FOR THE SECOND STAGE OF THE PROCESS IS PREPARED FROM THE SPENT EFFLUENTS (SULFURIZED AQUEOUS SODIUM HYDROXIDE SOLUTIONS) FROM VARIOUS HYDROCARBON PURIFICATION OPERATIONS BY PRELIMINARY TREATMENT WITH HYDROGEN SULFIDE FOR SEPARATION OF ORGANIC COMPONENTS TO SODIUM HYDROSULFIDE FOLLOWED BY THE ADDICOMPOUNDS TO SODIUM HYDROSULFIDE FOLLOWED BY THE ADDITION OF SODIUM HYDROXIDE TO THE HYDROSULFIDE SOLUTION TO PRODUCE THE SODIUM MONOSULFIDE REACTANT.

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