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1. 发明申请

US20120050720A1 SYSTEM FOR DIAGNOSING PATHOLOGICAL CHANGE OF LIPID IN BLOOD VESSELS USING NON-LINEAR OPTICAL MICROSCOPY 审中-公开
标题翻译：使用非线性光学显微镜诊断血液中脂质的病理变化的系统
公开(公告)号：US20120050720A1
公开(公告)日：2012-03-01
申请号：US13320014
申请日：2009-05-11
申请人： Se Hwa Kim , Jae Yong Lee , Eun Seong Lee , Dae Won Moon
发明人： Se Hwa Kim , Jae Yong Lee , Eun Seong Lee , Dae Won Moon
IPC分类号： G01J3/44
CPC分类号： G02B21/002 , G01J3/0248 , G01J3/10 , G01J3/44 , G01N21/65 , G01N2021/653 , G02B21/0088 , G02B21/16
摘要： Disclosed is a system for diagnosing the pathological change in lipids in blood vessels using coherent anti-strokes raman microscopy which can image lipids abnormally deposited on the deep intima of blood vessels and analyze the components of the imaged lipids, without labeling or destroying blood vessels, to diagnose minute pathological changes in the blood vessels, whereby the stage of progression of lipid-related diseases can be determined.
摘要翻译：公开了一种用于使用相干抗冲击拉曼显微镜诊断血管中脂质的病理变化的系统，其可以将血液中的脂质异常沉积在血管的深内膜上并分析成像的脂质的成分，而不标记或破坏血管，诊断血管的微小病理变化，由此可以确定与脂质相关的疾病进展的阶段。

2. 发明授权

US08064053B2 3-color multiplex CARS spectrometer 有权
标题翻译： 3色多重CARS光谱仪
公开(公告)号：US08064053B2
公开(公告)日：2011-11-22
申请号：US12318373
申请日：2008-12-29
申请人： Jae Yong Lee , Eun Seong Lee , Dae Won Moon
发明人： Jae Yong Lee , Eun Seong Lee , Dae Won Moon
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/0227 , G01J3/0237 , G01J3/4412
摘要： The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion.
摘要翻译：本发明涉及一种三色多重CARS光谱仪。在三色多重CARS光谱仪中，通过将由宽带激光光源产生的短波长泵浦光束与由稳定的激光产生的长波长斯托克斯光束组合，实现了样品的多分子振动的拉曼共振源和另一个具有窄线宽的短波长激光束然后被单独引入以用作与激光驱动样本相互作用的探测光束，从而产生其波长分量可以被解析的CARS光谱信号。因此，三色多路CARS光谱仪解决了传统的双色多重CARS光谱的问题，其中对于高分辨率分辨率需要的CARS信号的波长分解在宽带泵浦光引起CARS频谱失真是不可能的。

3. 发明授权

US08203708B2 Spectrally encoded coherent ant-stokes raman scattering endoscope 有权
标题翻译：光谱编码相干蚂蚁散射内镜
公开(公告)号：US08203708B2
公开(公告)日：2012-06-19
申请号：US12441684
申请日：2008-11-27
申请人： Eun Seong Lee , Jae Yong Lee , Dae Won Moon
发明人： Eun Seong Lee , Jae Yong Lee , Dae Won Moon
IPC分类号： G01J3/44
CPC分类号： A61B5/6852 , A61B5/0066 , G01N21/65 , G01N2021/653
摘要： Disclosed is a spectrally encoded coherent anti-Stokes Raman scattering (CARS) endoscope that is capable of spatially encoding spectral dispersions of two light sources having frequency difference as much as a Raman shift and overlapping two laser beams on a position where a sample to be measured is placed, thereby acquiring a spatial distribution of CARS signals.
摘要翻译：公开了一种频谱编码的相干反斯托克斯拉曼散射（CARS）内窥镜，其能够空间编码具有与拉曼位移一样多的频率差异的两个光源的光谱色散，并且在待测样品的位置上重叠两个激光束被放置，从而获得CARS信号的空间分布。

4. 发明申请

US20100020318A1 3-Color multiplex cars spectrometer 有权
标题翻译： 3色多路车光谱仪
公开(公告)号：US20100020318A1
公开(公告)日：2010-01-28
申请号：US12318373
申请日：2008-12-29
申请人： Jae Yong Lee , Eun Seong Lee , Dae Won Moon
发明人： Jae Yong Lee , Eun Seong Lee , Dae Won Moon
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/0227 , G01J3/0237 , G01J3/4412
摘要： The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion.
摘要翻译：本发明涉及一种三色多重CARS光谱仪。在三色多重CARS光谱仪中，通过将由宽带激光光源产生的短波长泵浦光束与由稳定的激光产生的长波长斯托克斯光束组合，实现了样品的多分子振动的拉曼共振源和另一个具有窄线宽的短波长激光束然后被单独引入以用作与激光驱动样本相互作用的探测光束，从而产生其波长分量可以被解析的CARS光谱信号。因此，三色多路CARS光谱仪解决了传统的双色多重CARS光谱的问题，其中对于高分辨率分辨率需要的CARS信号的波长分解在宽带泵浦光引起CARS频谱失真是不可能的。

5. 发明申请

US20100174145A1 SPECTRALLY ENCODED COHERENT ANTI-STOKES RAMAN SCATTERING ENDOSCOPE 有权
标题翻译：光谱编码相干反射拉曼散射内窥镜
公开(公告)号：US20100174145A1
公开(公告)日：2010-07-08
申请号：US12441684
申请日：2008-11-27
申请人： Eun Seong Lee , Jae Yong Lee , Dae Won Moon
发明人： Eun Seong Lee , Jae Yong Lee , Dae Won Moon
IPC分类号： A61B1/06 , G01J3/44
CPC分类号： A61B5/6852 , A61B5/0066 , G01N21/65 , G01N2021/653
摘要： Disclosed is a spectrally encoded coherent anti-Stokes Raman scattering (CARS) endoscope that is capable of spatially encoding spectral dispersions of two light sources having frequency difference as much as a Raman shift and overlapping two laser beams on a position where a sample to be measured is placed, thereby acquiring a spatial distribution of CARS signals.
摘要翻译：公开了一种频谱编码的相干反斯托克斯拉曼散射（CARS）内窥镜，其能够空间编码具有与拉曼位移一样多的频率差异的两个光源的光谱色散，并且在待测样品的位置上重叠两个激光束被放置，从而获得CARS信号的空间分布。

6. 发明授权

US08450684B2 Quantification method of functional groups of organic layer 有权
标题翻译：有机层官能团的定量方法
公开(公告)号：US08450684B2
公开(公告)日：2013-05-28
申请号：US13063616
申请日：2009-09-24
申请人： Tae Geol Lee , Dae Won Moon , Hyegeun Min
发明人： Tae Geol Lee , Dae Won Moon , Hyegeun Min
IPC分类号： G01N23/203
CPC分类号： G01N23/2255
摘要： A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layer by means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c).
摘要翻译：有机薄层中的官能团的定量方法包括：a）通过MEIS光谱测量具有包括在参考有机薄层中的官能团的分析参考材料的每单位面积的绝对量; b）进行与a）相同的参考有机薄层的光谱测定，从而获得参考有机薄层中的官能团的峰值强度; c）进行与b）相同的光谱测定，对于具有相同官能团的待分析有机薄层，从而测量具有未知量的官能团的峰强度; 和d）比较a）中测定的官能团的峰强度相对于分析参考物质的绝对量，从而确定在c）中测量的具有未知量的官能团的每单位面积的绝对量。

7. 发明申请

US20110152119A1 Quantification Method of Biochemical Substances Using Ion Scattering Spectroscopy and Specific-Binding Efficiency Quantification Method of Biochemical Substances Using Ion Scattering Spectroscopy 审中-公开
标题翻译：使用离子散射光谱法和生物化学物质的特异性结合效率定量方法的生物化学物质的定量方法
公开(公告)号：US20110152119A1
公开(公告)日：2011-06-23
申请号：US13059445
申请日：2009-08-21
申请人： Tae Geol Lee , Dae Won Moon , Hye geun Min
发明人： Tae Geol Lee , Dae Won Moon , Hye geun Min
IPC分类号： C40B30/04
CPC分类号： G01N33/54353
摘要： A method for direct quantification of the areal density (number per surface area of a substrate) of an analyte including a biochemical substance bound on the surface of a substrate and for direct quantification of the binding efficiency of biochemical substances is disclosed. Specifically, the areal density of an analyte including a biochemical substance bound on the surface of a substrate, and the binding efficiency between a first biochemical substance fixed on the substrate surface and a second biochemical substance is measured by ion scattering spectroscopy (ISS).
摘要翻译：公开了用于直接定量包含结合在基材表面上的生物化学物质的分析物的面密度（基底的每个表面积的数量）和用于直接定量生化物质的结合效率的方法。具体地，通过离子散射光谱法（ISS）测量包含结合在基材表面上的生物化学物质的分析物的面密度和固定在基材表面上的第一生物化学物质与第二生化物质之间的结合效率。

8. 发明申请

US20110133081A1 Spectrophotometer Using Medium Energy Ion 有权
标题翻译：分光光度计使用中等能量离子
公开(公告)号：US20110133081A1
公开(公告)日：2011-06-09
申请号：US13056427
申请日：2009-07-28
申请人： Dae Won Moon , Ju Hwang Kim , Yeon Jin Yi , Kyu-Sang Yu , Wan Sup Kim
发明人： Dae Won Moon , Ju Hwang Kim , Yeon Jin Yi , Kyu-Sang Yu , Wan Sup Kim
IPC分类号： G01N23/225
CPC分类号： G21K1/02 , G21K1/08 , G21K5/04 , G21K5/10
摘要： Provided is a spectrophotometer using medium energy ion. The spectrophotometer using medium energy ion is configured to include: an ion source 10 generating ions; a collimator 20 collimating the ions as a parallel beam; an accelerator 30 accelerating the parallel beam; an ion beam pulse generator 40 pulsing the accelerated ion beam; a focusing objective 50 focusing the pulsed ion beam on a specimen 1; a detector 60 detecting a spectroscopic signal of scattered ion from a specimen 1; and a data analyzer 70 analyzing and processing the spectroscopic signal detected by the detector 60.
摘要翻译：提供了使用中等能量离子的分光光度计。使用中等能量离子的分光光度计被配置为包括：产生离子的离子源10; 准直器20将离子准直为平行光束; 加速平行光束的加速器30; 离子束脉冲发生器40脉冲加速的离子束; 将脉冲离子束聚焦在样本1上的聚焦目标50; 检测器60，检测来自样本1的散射离子的光谱信号; 以及分析和处理由检测器60检测的分光信号的数据分析器70。

9. 发明授权

US08283117B2 Disease diagnosis method, marker screening method and marker using TOF-SIMS 有权
标题翻译：疾病诊断方法，标记筛选方法和使用TOF-SIMS的标记
公开(公告)号：US08283117B2
公开(公告)日：2012-10-09
申请号：US12994263
申请日：2008-06-25
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： A61K38/21
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体地，本发明提供了使用以飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量（m / z）峰的图案，标记物，标记筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

10. 发明授权

US07838257B2 Evaluation method of organic or bio-conjugation on nanoparticles using imaging of time-of-flight secondary ion mass spectrometry 有权
标题翻译：使用飞行时间二次离子质谱的成像技术对纳米粒子进行有机或生物共轭的评估方法
公开(公告)号：US07838257B2
公开(公告)日：2010-11-23
申请号：US12149223
申请日：2008-04-29
申请人： Tea Geol Lee , Hyegeun Min , Dae Won Moon
发明人： Tea Geol Lee , Hyegeun Min , Dae Won Moon
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54346 , G01N33/54353 , H01J49/0004 , Y10T436/143333 , Y10T436/24
摘要： A method of evaluating conjugation between materials using imaging of time-of-flight secondary ion mass spectrometry (TOF-SIMS) according to the present invention is carried out by following the steps, a) forming a spontaneous pattern on a substrate with a mixture containing nanoparticles and a conjugation material selected from organic, bio or inorganic material, b) obtaining an ion detection pattern from the conjugation material and nanoparticles, respectively, depending on their position on the substrate by using time-of-flight secondary ion mass spectrometry, and c) determining whether the conjugation is formed between the conjugation material and nanoparticles by comparing the ion detection pattern of the conjugation material with the ion detection pattern of the nanoparticles.
摘要翻译：使用根据本发明的飞行时间二次离子质谱（TOF-SIMS）成像的材料之间的共轭的方法通过以下步骤进行：a）在基底上形成自发图案，其中含有纳米颗粒和选自有机，生物或无机材料的共轭材料，b）通过使用飞行时间二次离子质谱法分别根据它们在基底上的位置从共轭材料和纳米颗粒获得离子检测图案，以及 c）通过将共轭材料的离子检测图案与纳米颗粒的离子检测图案进行比较来确定共轭材料和纳米颗粒之间是否形成共轭。

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