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1. 发明授权

US5988857A Automatic processing system 失效
标题翻译：自动处理系统
公开(公告)号：US5988857A
公开(公告)日：1999-11-23
申请号：US916667
申请日：1997-08-22
申请人： Satoshi Ozawa , Kootaroo Yamashita , Yuji Miyahara , Toshiyuki Ikeda
发明人： Satoshi Ozawa , Kootaroo Yamashita , Yuji Miyahara , Toshiyuki Ikeda
IPC分类号： G01N35/00 , G01N35/02 , G06F19/00 , G06G7/66
CPC分类号： G01N35/00732 , G01N35/0092 , G01N35/0095 , G01N35/02 , G01N2035/00782 , G01N2035/00881 , G01N2035/0093
摘要： An automatic processing system and method which has high flexibility, extendibility and failure resistance. An automatic processing system and method that provides for the decentralized control of processings of plural samples. The invention combines a plurality of processing instruments and makes use of sample containers for each sample. Each sample container includes an information processing mechanism, a memory mechanism and a communication mechanism. The sample container has stored therein an abstract processing procedure, and determines, based on information concerning the processing instruments obtained from the processing instruments and the abstract processing procedure, a processing procedure for processing the sample. Thereafter, the processing instruments process the sample based on the processing procedure determined by the sample container. The processing procedure of each sample container can allow for performing priority, and cooperative and concerted operations among the processing instruments and the sample containers.
摘要翻译：具有高灵活性，可扩展性和抗破坏性的自动处理系统和方法。一种自动处理系统和方法，其提供对多个样品的处理的分散控制。本发明组合了多个处理设备并且使用每个样品的样品容器。每个样本容器包括信息处理机构，存储机构和通信机制。样本容器在其中存储抽象处理过程，并且基于从处理工具获得的处理设备和抽象处理过程的信息确定处理样本的处理过程。此后，处理工具基于由样品容器确定的处理过程处理样品。每个样品容器的处理程序可以在处理设备和样品容器之间执行优先级和协作一致的操作。

2. 发明授权

US5413685A Ion-selective electrode 失效
标题翻译：离子选择电极
公开(公告)号：US5413685A
公开(公告)日：1995-05-09
申请号：US128236
申请日：1993-09-29
申请人： Satoshi Ozawa , Yuji Miyahara , Mamoru Taki , Koutarou Yamashita , Yoshio Watanabe
发明人： Satoshi Ozawa , Yuji Miyahara , Mamoru Taki , Koutarou Yamashita , Yoshio Watanabe
IPC分类号： G01N27/333
CPC分类号： G01N27/333
摘要： An ion-selective electrode comprises an ion-sensing membrane, an internal electrode adhered to the ion-sensing membrane, and a lead connected to said internal electrode. The internal electrode used comprises a plurality of metallic wires arranged into a grating or a mesh. The wires comprises a metal core and a surface layer of a salt of the metal. The metal of the core is silver and the salt of the metal is a silver halide selected from the group consisting of silver bromide, silver chloride and silver iodide. At least a part of the internal electrode is buried inside the ion-sensing membrane. Various components, the ion-sensing membrane, the internal electrode, the lead, an external terminal, are disposed in a flow-through cell having a flow path formed therein, through which path a sample solution is passed, to constitute the ion-selective electrode. In the flow-through cell is disposed a means of maintaining the humidity to feed water vapor therefrom to the ion-sensing membrane. This structure, even when the ion-sensing membrane has a complicated configuration such as concave or convex surface, enables the establishment of good adhering conditions between the internal electrode and the ion-sensing membrane while retaining the complicated configuration of the ion-sensing membrane without reducing the effective contact areas of the ion-sensing membrane and the internal electrode.
摘要翻译：离子选择性电极包括离子感测膜，粘附到离子感测膜的内部电极和连接到所述内部电极的引线。使用的内部电极包括布置成光栅或网格的多根金属线。电线包括金属芯和金属盐的表面层。芯的金属是银，金属的盐是选自溴化银，氯化银和碘化银的卤化银。内部电极的至少一部分被埋在离子感测膜的内部。各种成分，离子感测膜，内部电极，引线，外部端子配置在具有形成在其中的流路的流通池中，通过该流路通过样品溶液以构成离子选择性电极。在流通池中设置有保持湿度以将水蒸汽从其中供给到离子感测膜的手段。这种结构即使当离子感测膜具有诸如凹凸表面的复杂构造时，也能够在保持离子感测膜的复杂结构而在内部电极和离子感测膜之间建立良好的粘附条件而没有减少离子感测膜和内部电极的有效接触面积。

3. 发明授权

US5505836A Solid-state ion sensor 失效
标题翻译：固态离子传感器
公开(公告)号：US5505836A
公开(公告)日：1996-04-09
申请号：US219259
申请日：1994-03-29
申请人： Yuji Miyahara , Satoshi Ozawa , Koutarou Yamashita , Yoshio Watanabe
发明人： Yuji Miyahara , Satoshi Ozawa , Koutarou Yamashita , Yoshio Watanabe
IPC分类号： G01N27/414 , G01N27/333 , G01N27/403
CPC分类号： G01N27/3335 , G01N27/403
摘要： The solid-state ion sensor of the present invention comprises an inner electrode comprising a metal and a water-insoluble salt of the metal which covers at least a part of the surface of the metal, an ion-selective membrane selectively responsive to the ion species to be determined, and an intermediate layer comprising a hydrophilic polymeric membrane provided between the inner electrode and the ion-selective membrane. The inner electrode comprises a metal and a halogenide of the metal which covers at least a part of the surface of the metal. In the hydrophilic polymeric membrane is dispersed a hydrophilic electrolyte having halogen ions same as or different from those constituting the halogenide with the weight ratio of the electrolyte and the polymer [(electrolyte) wt. %/(polymer) wt. %] being at least 1/100. A polymeric ion-conductor can be used as the hydrophilic polymeric membrane.
摘要翻译：本发明的固体离子传感器包括内部电极，其包含覆盖金属表面的至少一部分的金属和金属的水不溶性盐，选择性地响应离子种类的离子选择膜以及包含设置在内部电极和离子选择性膜之间的亲水性聚合物膜的中间层。内部电极包括覆盖金属表面的至少一部分的金属的金属和卤化物。在亲水性聚合物膜中分散有具有与构成卤化物的卤素离子相同或不同的卤素离子的亲水电解质，其电解质和聚合物的重量比[（电解质）wt。％/（聚合物）wt。％]至少为1/100。聚合物离子导体可用作亲水性聚合物膜。

4. 发明授权

US5690893A Analyzer having sensor with memory device 失效
标题翻译：分析仪具有带存储器件的传感器
公开(公告)号：US5690893A
公开(公告)日：1997-11-25
申请号：US461160
申请日：1995-06-05
申请人： Satoshi Ozawa , Takafumi Kikuchi , Yoshiki Murakami , Masaaki Nakai , Koutarou Yamashita , Toshiko Fujii , Yuji Miyahara , Yoshio Watanabe
发明人： Satoshi Ozawa , Takafumi Kikuchi , Yoshiki Murakami , Masaaki Nakai , Koutarou Yamashita , Toshiko Fujii , Yuji Miyahara , Yoshio Watanabe
IPC分类号： G01N35/00 , G01N27/333
CPC分类号： G01N35/00732 , G01N2035/00683 , G01N2035/00782 , G01N35/00663 , Y10T436/11 , Y10T436/115831 , Y10T436/2575
摘要： An analyzer includes an exchangeable and consumable element such as a sensor, column or reagent the characteristic of which specifies an analyzing condition. The element is provided with a non-volatile semiconductor memory which holds an analyzing condition adapted for the element as data. When the element is mounted on an analyzer body, a controller of the analyzer reads the analyzing condition from the memory to update an analyzing condition inherently provided in the analyzer body. The result of analysis and/or operational history information of use of the element may be written into the memory with which the element is provided.
摘要翻译：分析仪包括可交换和可消耗元件，例如传感器，色谱柱或试剂，其特性指定分析条件。该元件设置有非易失性半导体存储器，其将适合该元件的分析条件保持为数据。当元件安装在分析器本体上时，分析器的控制器从存储器读取分析条件，以更新分析器主体中固有地提供的分析条件。可以将元素的使用的分析和/或操作历史信息的结果写入到提供元件的存储器中。

5. 发明授权

US5472590A Ion sensor 失效
标题翻译：离子传感器
公开(公告)号：US5472590A
公开(公告)日：1995-12-05
申请号：US354643
申请日：1994-12-13
申请人： Koutarou Yamashita , Mamoru Taki , Yuji Miyahara , Toshiko Fujii , Satoshi Ozawa , Yoshio Watanabe
发明人： Koutarou Yamashita , Mamoru Taki , Yuji Miyahara , Toshiko Fujii , Satoshi Ozawa , Yoshio Watanabe
IPC分类号： G01N27/333 , G01N27/414 , G01N27/26
CPC分类号： G01N27/414 , G01N27/3335
摘要： An ion sensor having an ion selectivity, which comprises an internal electrode of metal/metal salt, composed of an electroconductive layer of at least one metal and a layer of an insoluble salt of the metal in contact with the electroconductive layer, an ion selective membrane whose supporting membrane is composed of a hydrophobic polymer, and an intermediate layer capable of keeping water molecules, provided between the internal solid electrode and the ion selective membrane, where the organic compound having a water-keeping property is polymethylene glycol, polyethylene glycol or polypropylene glycol, each having a molecular weight of 200 to 600, and the inorganic compound having a water-keeping property is calcium chloride, gold chloride, magnesium perchlorate, magnesium fluoride or vanadium chloride dioxide, is suitable for analysis of specific ion species in a biological fluid with practically prolonged maintenance of properties of electrode.
摘要翻译：一种具有离子选择性的离子传感器，其包括金属/金属盐的内部电极，其由至少一种金属的导电层和与导电层接触的金属的不溶性盐层，离子选择性膜其内部固体电极与离子选择性膜之间具有疏水性聚合物和能够保持水分子的中间层，其中具有保水性的有机化合物为聚亚甲基二醇，聚乙二醇或聚丙烯乙二醇，分子量为200〜600，具有保水性的无机化合物为氯化钙，氯化金，高氯酸镁，氟化镁或二氯化钒，适用于分析生物中的特定离子种类流体与电极性能几乎延长。

6. 发明申请

US20120283403A1 Phenylboronic Acid Monomer and Phenylboronic Acid Polymer 审中-公开
标题翻译：苯硼酸单体和苯硼酸聚合物
公开(公告)号：US20120283403A1
公开(公告)日：2012-11-08
申请号：US13520710
申请日：2010-12-27
申请人： Akira Matsumoto , Takehiko Ishii , Kazunori Kataoka , Yuji Miyahara
发明人： Akira Matsumoto , Takehiko Ishii , Kazunori Kataoka , Yuji Miyahara
IPC分类号： C07F5/02 , C08F230/06 , C08F30/06
CPC分类号： C07F5/025 , C08F220/56
摘要： Disclosed are a phenylboronic acid monomer and a phenylboronic acid polymer, each of which can have a pKa value suitable for the use under physiological environments and can be used for various applications. The pheanylboronic acid monomer has a structure represented by formula (13) and therefore has high hydrophilicity, can have a satisfactorily low pKa value when the phenyl ring is fluorinated, and can have a polymerizable unsaturated bond. The phenylboronic acid monomer has high hydrophilicity at a pKa value of 7.4 or less which is a physiological level, and can be polymerized with a wide variety of monomers to produce polymers suitable for the intended purposes.
摘要翻译：公开了苯基硼酸单体和苯基硼酸聚合物，其各自可以具有适合在生理环境下使用的pKa值，并可用于各种应用。苯基苯基硼酸单体具有式（13）所示的结构，因此具有高亲水性，当苯基环被氟化时，可以具有令人满意的低pKa值，并且可以具有可聚合的不饱和键。苯基硼酸单体在pKa值为7.4或更低的生物水平下具有高亲水性，并且可以与各种单体聚合以产生适合于预期目的的聚合物。

7. 发明申请

US20120283119A1 POTENTIOMETRIC DNA MICROARRAY, PROCESS FOR PRODUCING THE SAME AND METHOD OF ANALYZING NUCLEIC ACID 审中-公开
标题翻译：潜在的DNA微阵列，其生产方法和分析核酸的方法
公开(公告)号：US20120283119A1
公开(公告)日：2012-11-08
申请号：US13493534
申请日：2012-06-11
申请人： Yuji Miyahara , Kenji Yasuda , Kumiko Hattori
发明人： Yuji Miyahara , Kenji Yasuda , Kumiko Hattori
IPC分类号： C40B30/04
CPC分类号： B01J19/0046 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01L3/5085 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , G01N27/4145 , C12Q2565/501 , C12Q2565/607
摘要： A DNA microarray system whereby measurement can be performed at a low running cost, a low price and yet a high accuracy. A nucleic acid probe (3) is immobilized on the surface of a gate insulator of an electric field effect transistor and then hybridized with a target gene on the surface of the gate insulator. A change in the surface electric charge density thus arising is detected by using the electric effect.
摘要翻译：一种DNA微阵列系统，其可以以低运行成本，低价格和高精度进行测量。将核酸探针（3）固定在电场效应晶体管的栅极绝缘体的表面上，然后与栅极绝缘体的表面上的目标基因杂交。通过使用电效应来检测由此产生的表面电荷密度的变化。

8. 发明授权

US07888013B2 Method of analyzing DNA sequence using field-effect device, and base sequence analyzer 有权
标题翻译：使用场效应分析DNA序列的方法和碱基序列分析仪
公开(公告)号：US07888013B2
公开(公告)日：2011-02-15
申请号：US11574353
申请日：2005-08-26
申请人： Yuji Miyahara , Toshiya Sakata
发明人： Yuji Miyahara , Toshiya Sakata
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： B01L7/00 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , G01N27/4145
摘要： Since conventional DNA sequence analyzing technologies are based on the fundamental principle of fluorescent detection, expensive, complex optical systems and laser sources have been necessary.A field-effect device for gene detection of the present invention analyzes a base sequence by immobilizing a single-strand nucleic acid probe at a gate portion, inducing hybridization at the gate portion to form a double-stranded DNA, inducing elongation reaction by adding a DNA polymerase and one of the substrates, and measuring the electrical characteristic of the field-effect device caused by elongation reaction.Since the elongation reaction of one base induced at the gate portion can be directly converted to an electrical signal, expensive lasers or complex optical systems are not needed. Thus, a small gene polymorphism detection system that can conduct measurement at high precision can be provided.
摘要翻译：由于常规DNA序列分析技术是基于荧光检测的基本原理，因此必须使用昂贵的复杂光学系统和激光源。本发明的用于基因检测的场效应装置通过在门部固定单链核酸探针来分析碱基序列，在门部诱导杂交以形成双链DNA，通过加入 DNA聚合酶和其中一种底物，并测量由伸长反应引起的场效应装置的电特性。由于在栅极部分引起的一个基极的伸长反应可以直接转换成电信号，所以不需要昂贵的激光器或复杂的光学系统。因此，可以提供可以高精度地进行测量的小型基因多态性检测系统。

9. 发明申请

US20100197001A1 GENE DETECTION FIELD-EFFECT DEVICE AND METHOD OF ANALYZING GENE POLYMORPHISM THEREWITH 审中-公开
标题翻译：基因检测场效应装置及其分析基因多态性的方法
公开(公告)号：US20100197001A1
公开(公告)日：2010-08-05
申请号：US12696342
申请日：2010-01-29
申请人： Yuji Miyahara , Toshiya Sakata
发明人： Yuji Miyahara , Toshiya Sakata
IPC分类号： C12M1/00
CPC分类号： C12Q1/6825 , C12Q2600/156 , G01N27/4145 , C12Q2565/607 , C12Q2565/537
摘要： A gene detection field-effect device provided with an insulation film (2), a semiconductor substrate (3), and a reference electrode (4), includes: (a) the insulation film (2) including a nucleic acid probe (5) immobilized on one of the surfaces thereof and is in contact with a sample solution (6) containing at least one type of a target gene (601) for detection and analysis; (b) the semiconductor substrate (3) being installed so as to abut against the other surface of the insulation film (2); and (c) the reference electrode (4) being provided in the sample solution (6).
摘要翻译：设置有绝缘膜（2），半导体基板（3）和参考电极（4）的基因检测场效应元件包括：（a）包含核酸探针（5）的绝缘膜（2）固定在其一个表面上并与含有至少一种类型的目标基因（601）的样品溶液（6）接触以进行检测和分析; （b）半导体衬底（3）被安装成抵靠绝缘膜（2）的另一个表面; 和（c）参考电极（4）设置在样品溶液（6）中。

10. 发明授权

US07695907B2 Gene detection field-effect device and method of analyzing gene polymorphism therewith 有权
标题翻译：基因检测场效应仪及其分析基因多态性的方法
公开(公告)号：US07695907B2
公开(公告)日：2010-04-13
申请号：US10587941
申请日：2005-02-03
申请人： Yuji Miyahara , Toshiya Sakata
发明人： Yuji Miyahara , Toshiya Sakata
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q2600/156 , G01N27/4145 , C12Q2565/607 , C12Q2565/537
摘要： A gene detection field-effect device provided with an insulation film (2), a semiconductor substrate (3), and a reference electrode (4), includes: (a) the insulation film (2) including a nucleic acid probe (5) immobilized on one of the surfaces thereof and is in contact with a sample solution (6) containing at least one type of a target gene (601) for detection and analysis; (b) the semiconductor substrate (3) being installed so as to abut against the other surface of the insulation film (2); and (c) the reference electrode (4) being provided in the sample solution (6).
摘要翻译：设置有绝缘膜（2），半导体基板（3）和参考电极（4）的基因检测场效应元件包括：（a）包含核酸探针（5）的绝缘膜（2）固定在其一个表面上并与含有至少一种类型的目标基因（601）的样品溶液（6）接触以进行检测和分析; （b）半导体衬底（3）被安装成抵靠绝缘膜（2）的另一个表面; 和（c）参考电极（4）设置在样品溶液（6）中。

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