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1. 发明授权

US5413685A Ion-selective electrode 失效
标题翻译：离子选择电极
公开(公告)号：US5413685A
公开(公告)日：1995-05-09
申请号：US128236
申请日：1993-09-29
申请人： Satoshi Ozawa , Yuji Miyahara , Mamoru Taki , Koutarou Yamashita , Yoshio Watanabe
发明人： Satoshi Ozawa , Yuji Miyahara , Mamoru Taki , Koutarou Yamashita , Yoshio Watanabe
IPC分类号： G01N27/333
CPC分类号： G01N27/333
摘要： An ion-selective electrode comprises an ion-sensing membrane, an internal electrode adhered to the ion-sensing membrane, and a lead connected to said internal electrode. The internal electrode used comprises a plurality of metallic wires arranged into a grating or a mesh. The wires comprises a metal core and a surface layer of a salt of the metal. The metal of the core is silver and the salt of the metal is a silver halide selected from the group consisting of silver bromide, silver chloride and silver iodide. At least a part of the internal electrode is buried inside the ion-sensing membrane. Various components, the ion-sensing membrane, the internal electrode, the lead, an external terminal, are disposed in a flow-through cell having a flow path formed therein, through which path a sample solution is passed, to constitute the ion-selective electrode. In the flow-through cell is disposed a means of maintaining the humidity to feed water vapor therefrom to the ion-sensing membrane. This structure, even when the ion-sensing membrane has a complicated configuration such as concave or convex surface, enables the establishment of good adhering conditions between the internal electrode and the ion-sensing membrane while retaining the complicated configuration of the ion-sensing membrane without reducing the effective contact areas of the ion-sensing membrane and the internal electrode.
摘要翻译：离子选择性电极包括离子感测膜，粘附到离子感测膜的内部电极和连接到所述内部电极的引线。使用的内部电极包括布置成光栅或网格的多根金属线。电线包括金属芯和金属盐的表面层。芯的金属是银，金属的盐是选自溴化银，氯化银和碘化银的卤化银。内部电极的至少一部分被埋在离子感测膜的内部。各种成分，离子感测膜，内部电极，引线，外部端子配置在具有形成在其中的流路的流通池中，通过该流路通过样品溶液以构成离子选择性电极。在流通池中设置有保持湿度以将水蒸汽从其中供给到离子感测膜的手段。这种结构即使当离子感测膜具有诸如凹凸表面的复杂构造时，也能够在保持离子感测膜的复杂结构而在内部电极和离子感测膜之间建立良好的粘附条件而没有减少离子感测膜和内部电极的有效接触面积。

2. 发明授权

US5690893A Analyzer having sensor with memory device 失效
标题翻译：分析仪具有带存储器件的传感器
公开(公告)号：US5690893A
公开(公告)日：1997-11-25
申请号：US461160
申请日：1995-06-05
申请人： Satoshi Ozawa , Takafumi Kikuchi , Yoshiki Murakami , Masaaki Nakai , Koutarou Yamashita , Toshiko Fujii , Yuji Miyahara , Yoshio Watanabe
发明人： Satoshi Ozawa , Takafumi Kikuchi , Yoshiki Murakami , Masaaki Nakai , Koutarou Yamashita , Toshiko Fujii , Yuji Miyahara , Yoshio Watanabe
IPC分类号： G01N35/00 , G01N27/333
CPC分类号： G01N35/00732 , G01N2035/00683 , G01N2035/00782 , G01N35/00663 , Y10T436/11 , Y10T436/115831 , Y10T436/2575
摘要： An analyzer includes an exchangeable and consumable element such as a sensor, column or reagent the characteristic of which specifies an analyzing condition. The element is provided with a non-volatile semiconductor memory which holds an analyzing condition adapted for the element as data. When the element is mounted on an analyzer body, a controller of the analyzer reads the analyzing condition from the memory to update an analyzing condition inherently provided in the analyzer body. The result of analysis and/or operational history information of use of the element may be written into the memory with which the element is provided.
摘要翻译：分析仪包括可交换和可消耗元件，例如传感器，色谱柱或试剂，其特性指定分析条件。该元件设置有非易失性半导体存储器，其将适合该元件的分析条件保持为数据。当元件安装在分析器本体上时，分析器的控制器从存储器读取分析条件，以更新分析器主体中固有地提供的分析条件。可以将元素的使用的分析和/或操作历史信息的结果写入到提供元件的存储器中。

3. 发明授权

US5472590A Ion sensor 失效
标题翻译：离子传感器
公开(公告)号：US5472590A
公开(公告)日：1995-12-05
申请号：US354643
申请日：1994-12-13
申请人： Koutarou Yamashita , Mamoru Taki , Yuji Miyahara , Toshiko Fujii , Satoshi Ozawa , Yoshio Watanabe
发明人： Koutarou Yamashita , Mamoru Taki , Yuji Miyahara , Toshiko Fujii , Satoshi Ozawa , Yoshio Watanabe
IPC分类号： G01N27/333 , G01N27/414 , G01N27/26
CPC分类号： G01N27/414 , G01N27/3335
摘要： An ion sensor having an ion selectivity, which comprises an internal electrode of metal/metal salt, composed of an electroconductive layer of at least one metal and a layer of an insoluble salt of the metal in contact with the electroconductive layer, an ion selective membrane whose supporting membrane is composed of a hydrophobic polymer, and an intermediate layer capable of keeping water molecules, provided between the internal solid electrode and the ion selective membrane, where the organic compound having a water-keeping property is polymethylene glycol, polyethylene glycol or polypropylene glycol, each having a molecular weight of 200 to 600, and the inorganic compound having a water-keeping property is calcium chloride, gold chloride, magnesium perchlorate, magnesium fluoride or vanadium chloride dioxide, is suitable for analysis of specific ion species in a biological fluid with practically prolonged maintenance of properties of electrode.
摘要翻译：一种具有离子选择性的离子传感器，其包括金属/金属盐的内部电极，其由至少一种金属的导电层和与导电层接触的金属的不溶性盐层，离子选择性膜其内部固体电极与离子选择性膜之间具有疏水性聚合物和能够保持水分子的中间层，其中具有保水性的有机化合物为聚亚甲基二醇，聚乙二醇或聚丙烯乙二醇，分子量为200〜600，具有保水性的无机化合物为氯化钙，氯化金，高氯酸镁，氟化镁或二氯化钒，适用于分析生物中的特定离子种类流体与电极性能几乎延长。

4. 发明授权

US5505836A Solid-state ion sensor 失效
标题翻译：固态离子传感器
公开(公告)号：US5505836A
公开(公告)日：1996-04-09
申请号：US219259
申请日：1994-03-29
申请人： Yuji Miyahara , Satoshi Ozawa , Koutarou Yamashita , Yoshio Watanabe
发明人： Yuji Miyahara , Satoshi Ozawa , Koutarou Yamashita , Yoshio Watanabe
IPC分类号： G01N27/414 , G01N27/333 , G01N27/403
CPC分类号： G01N27/3335 , G01N27/403
摘要： The solid-state ion sensor of the present invention comprises an inner electrode comprising a metal and a water-insoluble salt of the metal which covers at least a part of the surface of the metal, an ion-selective membrane selectively responsive to the ion species to be determined, and an intermediate layer comprising a hydrophilic polymeric membrane provided between the inner electrode and the ion-selective membrane. The inner electrode comprises a metal and a halogenide of the metal which covers at least a part of the surface of the metal. In the hydrophilic polymeric membrane is dispersed a hydrophilic electrolyte having halogen ions same as or different from those constituting the halogenide with the weight ratio of the electrolyte and the polymer [(electrolyte) wt. %/(polymer) wt. %] being at least 1/100. A polymeric ion-conductor can be used as the hydrophilic polymeric membrane.
摘要翻译：本发明的固体离子传感器包括内部电极，其包含覆盖金属表面的至少一部分的金属和金属的水不溶性盐，选择性地响应离子种类的离子选择膜以及包含设置在内部电极和离子选择性膜之间的亲水性聚合物膜的中间层。内部电极包括覆盖金属表面的至少一部分的金属的金属和卤化物。在亲水性聚合物膜中分散有具有与构成卤化物的卤素离子相同或不同的卤素离子的亲水电解质，其电解质和聚合物的重量比[（电解质）wt。％/（聚合物）wt。％]至少为1/100。聚合物离子导体可用作亲水性聚合物膜。

5. 发明授权

US5988857A Automatic processing system 失效
标题翻译：自动处理系统
公开(公告)号：US5988857A
公开(公告)日：1999-11-23
申请号：US916667
申请日：1997-08-22
申请人： Satoshi Ozawa , Kootaroo Yamashita , Yuji Miyahara , Toshiyuki Ikeda
发明人： Satoshi Ozawa , Kootaroo Yamashita , Yuji Miyahara , Toshiyuki Ikeda
IPC分类号： G01N35/00 , G01N35/02 , G06F19/00 , G06G7/66
CPC分类号： G01N35/00732 , G01N35/0092 , G01N35/0095 , G01N35/02 , G01N2035/00782 , G01N2035/00881 , G01N2035/0093
摘要： An automatic processing system and method which has high flexibility, extendibility and failure resistance. An automatic processing system and method that provides for the decentralized control of processings of plural samples. The invention combines a plurality of processing instruments and makes use of sample containers for each sample. Each sample container includes an information processing mechanism, a memory mechanism and a communication mechanism. The sample container has stored therein an abstract processing procedure, and determines, based on information concerning the processing instruments obtained from the processing instruments and the abstract processing procedure, a processing procedure for processing the sample. Thereafter, the processing instruments process the sample based on the processing procedure determined by the sample container. The processing procedure of each sample container can allow for performing priority, and cooperative and concerted operations among the processing instruments and the sample containers.
摘要翻译：具有高灵活性，可扩展性和抗破坏性的自动处理系统和方法。一种自动处理系统和方法，其提供对多个样品的处理的分散控制。本发明组合了多个处理设备并且使用每个样品的样品容器。每个样本容器包括信息处理机构，存储机构和通信机制。样本容器在其中存储抽象处理过程，并且基于从处理工具获得的处理设备和抽象处理过程的信息确定处理样本的处理过程。此后，处理工具基于由样品容器确定的处理过程处理样品。每个样品容器的处理程序可以在处理设备和样品容器之间执行优先级和协作一致的操作。

6. 发明授权

US09232883B2 Endoscope apparatus 有权
标题翻译：内窥镜装置
公开(公告)号：US09232883B2
公开(公告)日：2016-01-12
申请号：US13017349
申请日：2011-01-31
申请人： Satoshi Ozawa , Takayuki Iida , Yasuhiro Minetoma , Akihiko Erikawa
发明人： Satoshi Ozawa , Takayuki Iida , Yasuhiro Minetoma , Akihiko Erikawa
IPC分类号： A61B1/06 , A61B1/00 , A61B1/04 , A61B1/07
CPC分类号： A61B1/00188 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0653 , A61B1/0684 , A61B1/07
摘要： To provide an endoscope apparatus in which the observation image can be varied continuously as the observation magnification is varied by a zoom magnification varying manipulation so that an observation image suitable for an endoscope diagnosis is obtained at each observation magnification, and to thereby prevent the operator from feeling uncomfortable and increase the accuracy of a diagnosis. An endoscope apparatus is equipped with illuminating unit having plural light sources which generate light beams having different spectra, for illuminating an observation subject; imaging unit for imaging the observation subject; observation magnification varying unit for varying observation magnification of the imaging of the imaging unit; and light quantity ratio varying unit for continuously varying an emission light quantity ratio between the plural light sources according to the observation magnification that is set by the observation magnification varying unit.
摘要翻译：为了提供一种内窥镜装置，其中，随着观察倍率通过变焦倍率变化操作而变化，观察图像可以连续变化，从而在每个观察放大倍数下获得适合于内窥镜诊断的观察图像，从而防止操作者感觉不舒服，提高了诊断的准确性。一种内窥镜装置具备：具有多个光源的照明单元，该光源产生具有不同光谱的光束，用于照明观察对象物; 用于对观察对象成像的成像单元; 用于改变所述成像单元的成像的观察倍率的观察倍率变化单元; 以及光量比变化单元，用于根据由观察倍率变化单元设定的观察倍率连续地改变多个光源之间的发射光量比。

7. 发明授权

US08936548B2 Method of controlling endoscope and endoscope 有权
标题翻译：内窥镜和内窥镜控制方法
公开(公告)号：US08936548B2
公开(公告)日：2015-01-20
申请号：US12890357
申请日：2010-09-24
申请人： Satoshi Ozawa , Akihiko Erikawa , Azuchi Endo
发明人： Satoshi Ozawa , Akihiko Erikawa , Azuchi Endo
IPC分类号： A61B1/06 , A61B6/00 , A61B1/05
CPC分类号： A61B1/0638 , A61B1/05 , A61B1/063 , A61B1/0646 , A61B1/0653
摘要： An endoscope 100 includes a first light source 45 that emits white illumination light, a second light source 47 that emits narrow-band light and an imaging section that has an imaging device 21 having plural detection pixels and images a region to be observed. The imaging section is caused to output a captured image signal including both a return light component of the white illumination light from the region to be observed by and a return light component of the narrow-band light the white illumination light. From the captured image signal, the return light component of the narrow-band light is selectively extracted, and a brightness level of the extracted return light component of the narrow-band light is changed by changing a light amount of light emitted from the second light source 47.
摘要翻译：内窥镜100包括发射白色照明光的第一光源45，发射窄带光的第二光源47和具有多个检测像素的成像装置21和要观察的区域的图像的摄像部。使得成像部分输出包括来自待观察区域的白色照明光的返回光分量和窄带光的白光照明光的返回光分量的捕获图像信号。从拍摄图像信号中，选择性地提取窄带光的返回光分量，并且通过改变从第二光发射的光的光量来改变所提取的窄带光的返回光分量的亮度水平来源47。

8. 发明申请

US20120225448A1 Substrate with Photo-Controllable Cell Adhesion Property, Method for Analyzing and Fractionating Cells, and Device for Analysis and Fractionation of Cells 审中-公开
标题翻译：具有光可控细胞粘附性质的基质，分析细胞分离方法和分离细胞分离装置
公开(公告)号：US20120225448A1
公开(公告)日：2012-09-06
申请号：US13509338
申请日：2010-11-04
申请人： Hisashi Sugiyama , Satoshi Takahashi , Kenko Uchida , Satoshi Ozawa
发明人： Hisashi Sugiyama , Satoshi Takahashi , Kenko Uchida , Satoshi Ozawa
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： C12M47/04 , C12N1/02 , C12N11/02
摘要： When cells are analyzed, fractionated, and incubated while keeping the cells alive, real-time operations can be performed more easily and the cells can be incubated while removing unnecessary cells from the incubated cells to purify the cells being incubated. Furthermore, desired cells are separated through analysis from the incubated cells, and the purity, recovery, and viability of the cells are heightened. Use is made of a substrate having photo-controllable cell adhesion properties, the substrate comprising a transparent base and, formed thereon, a film of a material which has photo-controllable cell adhesion properties and has been obtained by bonding a cell-adhesive material to a cell-non-adhesive material through photo-dissociable groups. Cell images are detected and analyzed to obtain information about the location of desired cells. On the basis of the information, a space is formed between cells and the material having photo-controllable cell adhesion properties is cut, by means of second light irradiation. Meanwhile, by means of first light irradiation, the surface of the substrate is changed from a cell-adhesive surface to a cell-non-adhesive surface, thereby separating the cell(s) from the substrate. Thus, cells can be analyzed and fractionated while keeping the cells alive.
摘要翻译：当细胞分析，分级和孵育同时保持细胞活着时，可以更容易地进行实时操作，并且可以孵育细胞，同时从培养的细胞中除去不需要的细胞以纯化待孵育的细胞。此外，通过从培养的细胞的分析分离所需的细胞，并且提高细胞的纯度，回收率和存活力。使用具有光可控细胞粘附性质的基材，所述基材包括透明基材，并且在其上形成具有光可控细胞粘附性的材料的膜，并且通过将细胞粘合剂材料粘合到通过光解离基团的细胞非粘合材料。检测和分析细胞图像以获得关于所需细胞位置的信息。基于该信息，在单元之间形成空间，通过第二次光照射切断具有光可控细胞粘附性的材料。同时，通过第一光照射，将基板的表面从电池 - 粘合剂表面改变为电池非粘合剂表面，从而将电池与基板分离。因此，可以在保持细胞活着的同时分析和分级细胞。

9. 发明授权

US07927886B2 Hazardous substance removing method, hazardous substance removing material used therein such as air filter, mask, wipe sheet, and the like, and storage method thereof 有权
标题翻译：有害物质去除方法，其中使用的危险物质去除材料如空气过滤器，掩模，擦拭纸等，及其储存方法
公开(公告)号：US07927886B2
公开(公告)日：2011-04-19
申请号：US12275500
申请日：2008-11-21
申请人： Satoshi Ozawa , Jun-ichiro Arai
发明人： Satoshi Ozawa , Jun-ichiro Arai
IPC分类号： G01N33/543
CPC分类号： D06M16/003 , A61L9/014 , A61L9/16
摘要： A hazardous substance (20) is removed by using a hazardous substance removing material (10) in which a support (11) supports an antibody (12). Humidity of the ambient atmosphere of the antibody (12) is controlled so that the antibody (12) becomes active.
摘要翻译：通过使用其中载体（11）支持抗体（12）的有害物质去除物质（10）除去有害物质（20）。控制抗体（12）的环境气氛的湿度，使得抗体（12）变得活性。

10. 发明授权

US07754478B2 Device for cell culture 有权
标题翻译：细胞培养装置
公开(公告)号：US07754478B2
公开(公告)日：2010-07-13
申请号：US10583511
申请日：2004-12-15
申请人： Tsutomu Suzuki , Hiroshi Inomata , Yoshihiro Komori , Hiroshi Tachikui , Naruo Watanabe , Satoshi Ozawa , Yuji Oka , Minoru Ueda , Yasushi Nomura , Masako Nomura, legal representative , Isao Shindo
发明人： Tsutomu Suzuki , Hiroshi Inomata , Yoshihiro Komori , Hiroshi Tachikui , Naruo Watanabe , Satoshi Ozawa , Yuji Oka , Minoru Ueda , Yasushi Nomura , Isao Shindo
IPC分类号： C12M1/02 , C12M1/34
CPC分类号： C12M41/14 , C12M23/22 , C12M27/10 , C12M41/48 , Y10S435/809
摘要： A device for cell culture capable of automatically performing operations for cell culture over several days to several months while minimizing the risk of contamination. A new medicine can be supplied to an incubator means by using a medicine supply means or unnecessary wastewater can be discharged from the incubator means by using a wastewater discharge means without taking out the incubator means disposed in heat insulation box means from a heat insulation box, and the state of the cell culture can be observed with the incubator means formed in the heat insulation box means. Accordingly, the outside air does not enter directly into the incubator means during culturing, and the risk of contamination is completely eliminated. As a result, the culturing operations can be automatically performed over a long period.
摘要翻译：用于细胞培养的装置，其能够在几天至几个月内自动执行细胞培养的操作，同时最小化污染的风险。可以通过使用药物供给装置向培养箱装置提供新药，或者可以通过使用废水排放装置将不需要的废水从培养箱装置排出，而不从隔热箱取出设置在隔热箱装置中的培养箱装置，并且可以用在隔热箱装置中形成的培养箱装置来观察细胞培养的状态。因此，外部空气在培养期间不直接进入培养箱装置，并且完全消除污染的风险。结果，可以长时间自动进行培养操作。

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