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1. 发明申请

US20120283403A1 Phenylboronic Acid Monomer and Phenylboronic Acid Polymer 审中-公开
标题翻译：苯硼酸单体和苯硼酸聚合物
公开(公告)号：US20120283403A1
公开(公告)日：2012-11-08
申请号：US13520710
申请日：2010-12-27
申请人： Akira Matsumoto , Takehiko Ishii , Kazunori Kataoka , Yuji Miyahara
发明人： Akira Matsumoto , Takehiko Ishii , Kazunori Kataoka , Yuji Miyahara
IPC分类号： C07F5/02 , C08F230/06 , C08F30/06
CPC分类号： C07F5/025 , C08F220/56
摘要： Disclosed are a phenylboronic acid monomer and a phenylboronic acid polymer, each of which can have a pKa value suitable for the use under physiological environments and can be used for various applications. The pheanylboronic acid monomer has a structure represented by formula (13) and therefore has high hydrophilicity, can have a satisfactorily low pKa value when the phenyl ring is fluorinated, and can have a polymerizable unsaturated bond. The phenylboronic acid monomer has high hydrophilicity at a pKa value of 7.4 or less which is a physiological level, and can be polymerized with a wide variety of monomers to produce polymers suitable for the intended purposes.
摘要翻译：公开了苯基硼酸单体和苯基硼酸聚合物，其各自可以具有适合在生理环境下使用的pKa值，并可用于各种应用。苯基苯基硼酸单体具有式（13）所示的结构，因此具有高亲水性，当苯基环被氟化时，可以具有令人满意的低pKa值，并且可以具有可聚合的不饱和键。苯基硼酸单体在pKa值为7.4或更低的生物水平下具有高亲水性，并且可以与各种单体聚合以产生适合于预期目的的聚合物。

2. 发明申请

US20130066264A1 SUGAR-RESPONSIVE GEL AND MEDICINE ADMINISTERING DEVICE 审中-公开
标题翻译：糖果胶和药物管理装置
公开(公告)号：US20130066264A1
公开(公告)日：2013-03-14
申请号：US13699331
申请日：2011-05-24
申请人： Akira Matsumoto , Takehiko Ishii , Kazunori Kataoka , Yuji Miyahara
发明人： Akira Matsumoto , Takehiko Ishii , Kazunori Kataoka , Yuji Miyahara
IPC分类号： A61K31/69 , A61M5/00 , C07F5/02
CPC分类号： A61M5/1723 , A61K9/0014 , A61K9/0019 , A61K9/0026 , A61K47/32 , C07F5/025 , C07K14/62 , Y10S514/866
摘要： Disclosed are a sugar-responsive gel and a medicine administering device having a pKa more suitable for use in a body environment and capable of administering medicine more autonomously than before. A sugar-responsive gel and an insulin administering device having a pKa more suitable for use in a body environment and capable of administering insulin more autonomously than before, wherein under a body condition of pKa of 7.4 or less and temperature of 35° C.-40° C., when the glucose concentration increases, insulin can be released from a gel body in response thereto, and when the glucose concentration decreases, insulin release from the gel body can be suppressed.
摘要翻译：公开了一种糖应答凝胶和具有更适合用于身体环境并且能够比以前更自主地给予药物的pKa的给药装置。一种糖响应性凝胶和具有更适合用于身体环境并能够比以前更自主地施用胰岛素的pKa的胰岛素给药装置，其中在pKa为7.4以下，体温35℃的身体条件下， 40℃时，当葡萄糖浓度增加时，响应于胰岛素可以从凝胶体释放，并且当葡萄糖浓度降低时，可以抑制从凝胶体释放的胰岛素。

3. 发明申请

US20140124383A1 ELECTRODE CHIP FOR DETECTING BIOLOGICAL MOLECULE, AND METHOD FOR DETECTING BIOLOGICAL MOLECULE 审中-公开
标题翻译：用于检测生物分子的电极芯片和用于检测生物分子的方法
公开(公告)号：US20140124383A1
公开(公告)日：2014-05-08
申请号：US14112383
申请日：2012-04-20
申请人： Yuji Miyahara , Akira Matsumoto , Tatsuro Goda , Yasuhiro Maeda , Chiho Kataoka
发明人： Yuji Miyahara , Akira Matsumoto , Tatsuro Goda , Yasuhiro Maeda , Chiho Kataoka
IPC分类号： G01N27/327
CPC分类号： G01N27/3276 , G01N27/3277 , G01N27/4145
摘要： An electrode chip for detecting a biomolecule includes a substrate; and an electrode that includes an electrode substrate, at least one of a metallic salt or a metallic oxide provided on an outermost surface on an opposite side of the electrode substrate from a side provided with the substrate, and a biomolecular probe-immobilizing material which is provided on the outermost surface and to which a biomolecular probe is fixed.
摘要翻译：用于检测生物分子的电极芯片包括：基板; 以及电极，包括电极基板，设置在电极基板的与设置有基板的一侧相反的一侧的最外表面上的金属盐或金属氧化物中的至少一种，以及生物分子探针固定化材料，其为提供在最外表面上并且固定有生物分子探针。

4. 发明授权

US08668871B2 Sensing device and biosensor 有权
标题翻译：感应装置和生物传感器
公开(公告)号：US08668871B2
公开(公告)日：2014-03-11
申请号：US13513939
申请日：2011-07-20
申请人： Akira Matsumoto , Yuji Miyahara
发明人： Akira Matsumoto , Yuji Miyahara
IPC分类号： G01N33/53
CPC分类号： C07F5/025 , C07B2200/11 , G01N5/02 , G01N27/4145
摘要： Provided are a sensing device and a biosensor that are capable of achieving stable performance in sensing saccharides or hydroxyl group-containing polymers, and that can be stored for a long time. The biosensor 8 of the present invention uses, as a component for sensing glucose, a sensing device 16 in which a completely synthetic phenylboronic acid compound 21 is bound without using enzymes that have been conventionally used. Consequently, the biosensor 8 can eliminate the problem of protein denaturation to achieve stable performance in sensing glucose, and it is possible to achieve the biosensor 8 can be stored for a long time.
摘要翻译：提供能够在感测糖类或含羟基聚合物中获得稳定性能的感测装置和生物传感器，并且可以长期储存。本发明的生物传感器8使用传感装置16作为检测葡萄糖的组分，其中完全合成的苯基硼酸化合物21不经过常规使用的酶结合。因此，生物传感器8可以消除蛋白质变性的问题，以实现感测葡萄糖的稳定性能，并且可以实现生物传感器8的存储长时间。

5. 发明申请

US20120244037A1 SENSING DEVICE AND BIOSENSOR 有权
标题翻译：传感装置和生物传感器
公开(公告)号：US20120244037A1
公开(公告)日：2012-09-27
申请号：US13513939
申请日：2011-07-20
申请人： Akira Matsumoto , Yuji Miyahara
发明人： Akira Matsumoto , Yuji Miyahara
IPC分类号： G01N33/53 , G01N21/00 , G01N27/00 , C07F5/02
CPC分类号： C07F5/025 , C07B2200/11 , G01N5/02 , G01N27/4145
摘要： Provided are a sensing device and a biosensor that are capable of achieving stable performance in sensing saccharides or hydroxyl group-containing polymers, and that can be stored for a long time. The biosensor 8 of the present invention uses, as a component for sensing glucose, a sensing device 16 in which a completely synthetic phenylboronic acid compound 21 is bound without using enzymes that have been conventionally used. Consequently, the biosensor 8 can eliminate the problem of protein denaturation to achieve stable performance in sensing glucose, and it is possible to achieve the biosensor 8 can be stored for a long time.
摘要翻译：提供能够在感测糖类或含羟基聚合物中获得稳定性能的感测装置和生物传感器，并且可以长期储存。本发明的生物传感器8使用传感装置16作为检测葡萄糖的组分，其中完全合成的苯基硼酸化合物21不经过常规使用的酶结合。因此，生物传感器8可以消除蛋白质变性的问题，以实现感测葡萄糖的稳定性能，并且可以实现生物传感器8的存储长时间。

6. 发明申请

US20120283119A1 POTENTIOMETRIC DNA MICROARRAY, PROCESS FOR PRODUCING THE SAME AND METHOD OF ANALYZING NUCLEIC ACID 审中-公开
标题翻译：潜在的DNA微阵列，其生产方法和分析核酸的方法
公开(公告)号：US20120283119A1
公开(公告)日：2012-11-08
申请号：US13493534
申请日：2012-06-11
申请人： Yuji Miyahara , Kenji Yasuda , Kumiko Hattori
发明人： Yuji Miyahara , Kenji Yasuda , Kumiko Hattori
IPC分类号： C40B30/04
CPC分类号： B01J19/0046 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01L3/5085 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , G01N27/4145 , C12Q2565/501 , C12Q2565/607
摘要： A DNA microarray system whereby measurement can be performed at a low running cost, a low price and yet a high accuracy. A nucleic acid probe (3) is immobilized on the surface of a gate insulator of an electric field effect transistor and then hybridized with a target gene on the surface of the gate insulator. A change in the surface electric charge density thus arising is detected by using the electric effect.
摘要翻译：一种DNA微阵列系统，其可以以低运行成本，低价格和高精度进行测量。将核酸探针（3）固定在电场效应晶体管的栅极绝缘体的表面上，然后与栅极绝缘体的表面上的目标基因杂交。通过使用电效应来检测由此产生的表面电荷密度的变化。

7. 发明授权

US07888013B2 Method of analyzing DNA sequence using field-effect device, and base sequence analyzer 有权
标题翻译：使用场效应分析DNA序列的方法和碱基序列分析仪
公开(公告)号：US07888013B2
公开(公告)日：2011-02-15
申请号：US11574353
申请日：2005-08-26
申请人： Yuji Miyahara , Toshiya Sakata
发明人： Yuji Miyahara , Toshiya Sakata
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： B01L7/00 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , G01N27/4145
摘要： Since conventional DNA sequence analyzing technologies are based on the fundamental principle of fluorescent detection, expensive, complex optical systems and laser sources have been necessary.A field-effect device for gene detection of the present invention analyzes a base sequence by immobilizing a single-strand nucleic acid probe at a gate portion, inducing hybridization at the gate portion to form a double-stranded DNA, inducing elongation reaction by adding a DNA polymerase and one of the substrates, and measuring the electrical characteristic of the field-effect device caused by elongation reaction.Since the elongation reaction of one base induced at the gate portion can be directly converted to an electrical signal, expensive lasers or complex optical systems are not needed. Thus, a small gene polymorphism detection system that can conduct measurement at high precision can be provided.
摘要翻译：由于常规DNA序列分析技术是基于荧光检测的基本原理，因此必须使用昂贵的复杂光学系统和激光源。本发明的用于基因检测的场效应装置通过在门部固定单链核酸探针来分析碱基序列，在门部诱导杂交以形成双链DNA，通过加入 DNA聚合酶和其中一种底物，并测量由伸长反应引起的场效应装置的电特性。由于在栅极部分引起的一个基极的伸长反应可以直接转换成电信号，所以不需要昂贵的激光器或复杂的光学系统。因此，可以提供可以高精度地进行测量的小型基因多态性检测系统。

8. 发明申请

US20100197001A1 GENE DETECTION FIELD-EFFECT DEVICE AND METHOD OF ANALYZING GENE POLYMORPHISM THEREWITH 审中-公开
标题翻译：基因检测场效应装置及其分析基因多态性的方法
公开(公告)号：US20100197001A1
公开(公告)日：2010-08-05
申请号：US12696342
申请日：2010-01-29
申请人： Yuji Miyahara , Toshiya Sakata
发明人： Yuji Miyahara , Toshiya Sakata
IPC分类号： C12M1/00
CPC分类号： C12Q1/6825 , C12Q2600/156 , G01N27/4145 , C12Q2565/607 , C12Q2565/537
摘要： A gene detection field-effect device provided with an insulation film (2), a semiconductor substrate (3), and a reference electrode (4), includes: (a) the insulation film (2) including a nucleic acid probe (5) immobilized on one of the surfaces thereof and is in contact with a sample solution (6) containing at least one type of a target gene (601) for detection and analysis; (b) the semiconductor substrate (3) being installed so as to abut against the other surface of the insulation film (2); and (c) the reference electrode (4) being provided in the sample solution (6).
摘要翻译：设置有绝缘膜（2），半导体基板（3）和参考电极（4）的基因检测场效应元件包括：（a）包含核酸探针（5）的绝缘膜（2）固定在其一个表面上并与含有至少一种类型的目标基因（601）的样品溶液（6）接触以进行检测和分析; （b）半导体衬底（3）被安装成抵靠绝缘膜（2）的另一个表面; 和（c）参考电极（4）设置在样品溶液（6）中。

9. 发明授权

US07695907B2 Gene detection field-effect device and method of analyzing gene polymorphism therewith 有权
标题翻译：基因检测场效应仪及其分析基因多态性的方法
公开(公告)号：US07695907B2
公开(公告)日：2010-04-13
申请号：US10587941
申请日：2005-02-03
申请人： Yuji Miyahara , Toshiya Sakata
发明人： Yuji Miyahara , Toshiya Sakata
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q2600/156 , G01N27/4145 , C12Q2565/607 , C12Q2565/537
摘要： A gene detection field-effect device provided with an insulation film (2), a semiconductor substrate (3), and a reference electrode (4), includes: (a) the insulation film (2) including a nucleic acid probe (5) immobilized on one of the surfaces thereof and is in contact with a sample solution (6) containing at least one type of a target gene (601) for detection and analysis; (b) the semiconductor substrate (3) being installed so as to abut against the other surface of the insulation film (2); and (c) the reference electrode (4) being provided in the sample solution (6).
摘要翻译：设置有绝缘膜（2），半导体基板（3）和参考电极（4）的基因检测场效应元件包括：（a）包含核酸探针（5）的绝缘膜（2）固定在其一个表面上并与含有至少一种类型的目标基因（601）的样品溶液（6）接触以进行检测和分析; （b）半导体衬底（3）被安装成抵靠绝缘膜（2）的另一个表面; 和（c）参考电极（4）设置在样品溶液（6）中。

10. 发明授权

US06381015B1 Inspection apparatus using optical interferometer 失效
标题翻译：检测装置采用光干涉仪
公开(公告)号：US06381015B1
公开(公告)日：2002-04-30
申请号：US09380268
申请日：1999-08-27
申请人： Tsuyoshi Sonehara , Yuji Miyahara , Masao Suga
发明人： Tsuyoshi Sonehara , Yuji Miyahara , Masao Suga
IPC分类号： G01B902
CPC分类号： G01N21/45 , A61B5/14532 , A61B5/1455 , A61B5/7257 , G01J2003/4538
摘要： According to an aspect of the present invention, there is provided an inspection apparatus using an optical interferometer including splitting and combining means (3) for splitting light from a light source (1) into incident light (41) irradiated on a sample and reference light (40) and combining signal light which is light scattered or reflected by the sample (7, 42) and the reference light, a modulator (4, 5, 10) for subjecting the reference light to phase modulation and a photo detector (9) for detecting light combined by the splitting and combining means (3), the inspection apparatus further including first detecting means (12-1) for detecting amplitudes of first signal components having frequencies of multiples of odd numbers of a fundamental modulation frequency of the modulator in a signal from the photo detector (9), second detecting means (12-2) for separating and detecting amplitudes of second signal components having frequencies of multiples of even numbers of the fundamental modulation frequency in the signal from the photo detector and means (14) for calculating an intensity of the signal light by using the amplitudes of the first and the second signal components for providing high signal stability and signal-to-noise ratio and in measuring a sample of a biomedical tissue or the like having large scattering or attenuation of light, distributions of a refractive index and an extinction coefficient up to a portion having a large depth can be measured with high accuracy.
摘要翻译：根据本发明的一个方面，提供了一种使用光学干涉仪的检查装置，该光学干涉仪包括用于将来自光源（1）的光分解成照射在样品上的入射光（41）和参考光（40），并且组合由所述样品（7,42）和所述参考光散射或反射的信号光，用于使所述参考光进行相位调制的调制器（4,5,10）和光电检测器（9）用于检测由分割和组合装置（3）组合的光，检查装置还包括第一检测装置（12-1），用于检测具有调制器的基本调制频率的奇数倍数的第一信号分量的振幅来自光检测器（9）的信号，第二检测装置（12-2），用于分离和检测具有基数的偶数倍数的第二信号分量的振幅来自光电检测器的信号中的调制频率和用于通过使用用于提供高信号稳定性和信噪比的第一和第二信号分量的幅度来计算信号光强度的装置（14）可以高精度地测量具有大的散射或衰减光的生物医学组织样品，折射率和消光系数的分布直到具有较大深度的部分。

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