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    • 8. 发明申请
    • Composition containing anti-dementia drug
    • 含有抗痴呆药物的组合物
    • US20060160852A1
    • 2006-07-20
    • US11317238
    • 2005-12-27
    • Susumu KimuraYosuke UekiSatoshi Fujioka
    • Susumu KimuraYosuke UekiSatoshi Fujioka
    • A61K31/445A61K31/13
    • A61K45/06A61K9/2018A61K9/209A61K31/13A61K31/445A61K2300/00
    • An object of the present invention is to provide, for the case of implementing a therapeutic method in which at least two kinds of anti-dementia drugs are used together, a composition that has a good therapeutic effect on the dementia, and also gives excellent compliance. Another object of the present invention is to provide a composition containing at least two kinds of the anti-dementia drugs, for which release of the anti-dementia drugs from the composition is controlled, whereby a combined effect of the anti-dementia drugs can be achieved well. Still another object of the present invention is to provide: a composition, for which the frequency of administration and the amount taken are reduced, and hence compliance can be improved; and a method of manufacturing such a composition. According to the present invention, there are provided a composition containing at least two kinds of the anti-dementia drugs; such a composition containing at least one sustained release portion containing an anti-dementia drug; and such a composition containing at least one cholinesterase inhibitor, and at least one N-methyl-D-aspartate receptor antagonist.
    • 本发明的目的是提供一种治疗方法,其中至少两种抗痴呆药物一起使用,具有对痴呆具有良好治疗效果的组合物,并且还具有优异的依从性 。 本发明的另一个目的是提供一种含有至少两种抗痴呆药物的组合物,其中控制抗痴呆药物从组合物中的释放,由此抗痴呆药物的组合效果可以是 做得很好 本发明的另一个目的是提供:给药频率和使用量减少的组合物,从而可以提高顺应性; 以及制造这种组合物的方法。 根据本发明,提供含有至少两种抗痴呆药物的组合物; 这种组合物含有至少一种含有抗痴呆药物的持续释放部分; 和含有至少一种胆碱酯酶抑制剂和至少一种N-甲基-D-天冬氨酸受体拮抗剂的组合物。