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    • 4. 发明授权
    • Method for stabilizing anti-dementia drug
    • 稳定抗痴呆药物的方法
    • US08507527B2
    • 2013-08-13
    • US12712959
    • 2010-02-25
    • Yosuke UekiYasuyuki SuzukiSatoshi Fujioka
    • Yosuke UekiYasuyuki SuzukiSatoshi Fujioka
    • A01N43/42A61K9/14
    • A61K9/2054A61K9/1635A61K9/1652A61K9/2027A61K31/445
    • The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.
    • 本发明提供了通过向所述药物组合物中加入高分子量酸性物质,在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外,本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物,其中含有高分子量酸性物质以稳定抗痴呆药物。 此外,本发明提供了一种制备药物组合物的方法,其包括以下步骤:将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中, 稳定抗痴呆药物。
    • 5. 发明申请
    • Method for Stabilizing Anti-Dementia Drug
    • 稳定抗痴呆药物的方法
    • US20080213368A1
    • 2008-09-04
    • US11793722
    • 2005-12-27
    • Yosuke UekiYasuyuki SuzukiSatoshi Fujioka
    • Yosuke UekiYasuyuki SuzukiSatoshi Fujioka
    • A61K9/10A61K31/445
    • A61K9/2054A61K9/1635A61K9/1652A61K9/2027A61K31/445
    • The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.
    • 本发明提供了通过向所述药物组合物中加入高分子量酸性物质,在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外,本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物,其中含有高分子量酸性物质以稳定抗痴呆药物。 此外,本发明提供了一种制备药物组合物的方法,其包括以下步骤:将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中, 稳定抗痴呆药物。
    • 6. 发明申请
    • Method For Stabilizing Anti-Dementia Drug
    • 稳定抗痴呆药物的方法
    • US20100152164A1
    • 2010-06-17
    • US12712959
    • 2010-02-25
    • Yosuke UekiYasuyuki SuzukiSatoshi Fujioka
    • Yosuke UekiYasuyuki SuzukiSatoshi Fujioka
    • A61K31/445A61K31/27A61K31/55A61K31/454A61P25/28
    • A61K9/2054A61K9/1635A61K9/1652A61K9/2027A61K31/445
    • The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.
    • 本发明提供了通过向所述药物组合物中加入高分子量酸性物质,在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外,本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物,其中含有高分子量酸性物质以稳定抗痴呆药物。 此外,本发明提供了一种制备药物组合物的方法,其包括以下步骤:将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中, 稳定抗痴呆药物。