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    • 3. 发明授权
    • Gene from Hancenula polymorpha capable of controlling unfolded protein response and method for increasing effect of secretion using the same
    • 能够控制未折叠蛋白质反应的Hancenula polymorpha的基因和使用其分泌增加效果的方法
    • US08323926B2
    • 2012-12-04
    • US12304354
    • 2007-06-13
    • Hyun Ah KangHye-Yun MoonDoo-Byoung OhSang Ki Rhee
    • Hyun Ah KangHye-Yun MoonDoo-Byoung OhSang Ki Rhee
    • C12P21/06C12N15/00C12N1/00C07H21/04C07K1/00
    • C07K14/39C12P21/02
    • The present invention relates to a novel H. polymorpha gene regulating Unfolded Protein Response (UPR) and a method for improving the efficiency of secretory expression of a recombinant protein using the same, more particularly, a method for improving the efficiency of secretory expression of a recombinant protein by identifying, modifying, and optimizing the HpHAC1 gene, which encodes a key transcription regulatory factor of the UPR mechanism in H. polymorpha, and a regulatory mechanism mediated by the gene. According to the present invention, the secretory expression system of H. polymorpha can be used for the mass-production of secretory proteins for industrial and medical applications, thereby producing a large amount of the proteins at low cost. Accordingly, the method is employed in the production of the proteins for industrial and medical use, so as to reduce economic burden for a patient, and contribute to the improvement in the welfare of all mankind.
    • 本发明涉及调节未折叠蛋白质反应(UPR)的新型多形汉逊酵母基因和提高重组蛋白的分泌表达效率的方法,更具体地说,涉及提高分泌表达效率的方法 重组蛋白通过鉴定,修饰和优化HpHAC1基因,其编码多形汉逊酵母中UPR机制的关键转录调节因子,以及由该基因介导的调节机制。 根据本发明,多形汉逊酵母的分泌表达系统可用于大规模生产用于工业和医疗应用的分泌蛋白质,从而以低成本生产大量的蛋白质。 因此,该方法被用于生产用于工业和医疗用途的蛋白质,以减少患者的经济负担,并有助于改善全人类的福利。