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1. 发明授权

US06593300B1 (3R)-3-amino-4-carboxybutyraldehyde derivatives inhibiting the release of interleukin-1/beta 失效
标题翻译：（3R）-3-氨基-4-羧基丁醛衍生物抑制白细胞介素-1 /β的释放
公开(公告)号：US06593300B1
公开(公告)日：2003-07-15
申请号：US09423006
申请日：2000-02-07
申请人： Sandor Bajusz , Iren Veghelyi , Klara Nemeth , Eva Barabas , Attila Juhasz , Jozsef Lango , Emilia Lavich , Zsuzsanna Mohai , Imre Moravcsik , Zsuzsanna Taschler , Gabor Toth
发明人： Sandor Bajusz , Iren Veghelyi , Klara Nemeth , Eva Barabas , Attila Juhasz , Jozsef Lango , Emilia Lavich , Zsuzsanna Mohai , Imre Moravcsik , Zsuzsanna Taschler , Gabor Toth
IPC分类号： A61K3800
CPC分类号： C07K7/02 , A61K38/00 , C07K5/0202
摘要： The invention relates to a new (3R)-3-amino-4-carboxybutyraldehyde derivatives of general formula(I) wherein X represents a C1-4 alkyloxycarbonyl, an optionally substituted phenyl-(C1-2 alkyloxy)-carbonyl, a C1-4 alkylcarbonyl or an optionally substituted phenyl-(C1-3 alkyl)-carbonyl group, n represents 1 or 0, Y represents, in the case when n=1, a tetrapeptide of general formula Y4-Y3-Y2-Y1, a tripeptide of general formula Y3-Y2-Y1 or a dipeptide of general formula Y2-Y1 or an amino acid residue of general formula Y1, or in the case when n=0, an &agr;-hydroxyacyl-tripeptide of general formula Q4-Y3-Y2-Y1, an &agr;-hydroxyacyl-dipeptide of general formula Q3-Y2-Y1 or an &agr;-hydroxyacyl-aminoacyl residue of general formula Q2-Y1; wherein Y1-Y4 represent a residue selected from the group of the following L- or D-amino acids: alanine, alloisoleucine, cyclohexyl-glycine, phenyl-alanine, glutamine, histidine, isoleucine, leucine, lysine, methionine, pipecolic acid, proline, tyrosine and valine; and Q2-Q4 represent an acyl group selected from the following &agr;-hydroxyacids of R or S configuration: 2-cycloheptyl-2-hydroxy-acetic acid, 2-cyclohexyl-2-hydroxyacetic acid, 3-cyclohexyllactic acid, 3-phenyllactic acid, 2-hydroxy-3-methylbutyric acid, 2-hydroxy-3-methylvaleric acid, mandelic acid or lactic acid, and salts thereof formed with organic or inorganic bases, and pharmaceutical compositions containing the same. The compounds of general formula (I) of the invention are valuable inhibitors of the interleukin-1&bgr; converting enzyme.
摘要翻译：本发明涉及通式（I）的新的（3R）-3-氨基-4-羧基丁醛衍生物，其中X代表C1-4烷氧基羰基，任意取代的苯基 - （C 1-2烷氧基） - 羰基， 4烷基羰基或任选取代的苯基 - （C 1-3烷基） - 羰基，n表示1或0，Y表示在n = 1的情况下，通式Y4-Y3-Y2-Y1的四肽，三肽通式Y3-Y2-Y1或通式Y2-Y1的二肽或通式Y1的氨基酸残基，或在n = 0的情况下，通式为Q4-Y3-Y2的α-羟基酰基三肽 -Y1，通式为Q3-Y2-Y1的α-羟酰基二肽或通式为Q2-Y1的α-羟基酰基 - 酰基残基; 其中Y 1 -Y 4表示选自以下L-或D-氨基酸的残基：丙氨酸，异亮氨酸，环己基 - 甘氨酸，苯丙氨酸，谷氨酰胺，组氨酸，异亮氨酸，亮氨酸，赖氨酸，甲硫氨酸，哌可酸，脯氨酸，酪氨酸和缬氨酸; 和Q 2 -Q 4表示选自以下R或S构型的α-羟基酸的酰基：2-环庚基-2-羟基 - 乙酸，2-环己基-2-羟基乙酸，3-环己基乳酸，3-苯基乳酸，2-羟基-3-甲基丁酸，2-羟基-3-甲基戊酸，扁桃酸或乳酸，以及与有机或无机碱形成的盐，以及含有它们的药物组合物。本发明通式（I）的化合物是白细胞介素-1β转换酶的有价值的抑制剂。

2. 发明授权

US6121241A Anticoagulant peptide aldehyde derivatives 失效
标题翻译：抗凝血肽醛衍生物
公开(公告)号：US6121241A
公开(公告)日：2000-09-19
申请号：US11001
申请日：1999-04-02
申请人： Sandor Bajusz , Attila Juhasz , Eva Barabas , Andras Feher , Gabriella Szabo , Erzsebet Szell nee Hasenohrl , Iren Veghelyi nee Fauszt , Emilia Lavich nee Oszko , Eva Kaszas , Jozsef Lango , Imre Moravcsik , Agnes Szeker nee Peszeky , Zsuzsanna Taschler nee Pasztor , Gabor Toth , Zsuzsanna Mohai nee Nagy , Anna Maria Szalkay nee Hollosi , Klara Makk nee Ocskay
发明人： Sandor Bajusz , Attila Juhasz , Eva Barabas , Andras Feher , Gabriella Szabo , Erzsebet Szell nee Hasenohrl , Iren Veghelyi nee Fauszt , Emilia Lavich nee Oszko , Eva Kaszas , Jozsef Lango , Imre Moravcsik , Agnes Szeker nee Peszeky , Zsuzsanna Taschler nee Pasztor , Gabor Toth , Zsuzsanna Mohai nee Nagy , Anna Maria Szalkay nee Hollosi , Klara Makk nee Ocskay
IPC分类号： C07D207/16 , A61K38/05 , C07K5/00
CPC分类号： C07D207/16 , Y10S514/822
摘要： This invention relates to peptide aldehyde derivatives of formula (I): D-Xaa-Pro-Arg-H, wherein Xaa represent a 2-cycloheptyl-2-hydroxyacetyl or 2-cyclopentyl-2-hydroxyacetyl group, Pro represents an L-prolyl residue and Arg represents an L-arginyl residue, their acid-additon salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. The compounds of formula (I) of the invention have therapeutic, particularly anticoagulant, antiplatelet and antithrombotic properties.
摘要翻译： PCT No.PCT / HU97 / 00027 Sec。一九九九年四月二日 102（e）1999年4月2日PCT 1997年6月5日PCT公布。第WO97 / 46523号公报日期1997年12月11日本发明涉及式（I）的肽醛衍生物：D-Xaa-Pro-Arg-H，其中Xaa表示2-环庚基-2-羟基乙酰基或2-环戊基-2-羟基乙酰基，Pro 代表L-脯氨酰残基，Arg表示L-精氨酰残基，它们与有机或无机酸形成的酸加成盐和含有它们的药物组合物。本发明式（I）的化合物具有治疗性，特别是抗凝血，抗血小板和抗血栓形成的特性。

3. 发明授权

US08941049B2 Readout methodology for multi-channel acquisition of spatially distributed signal 有权
标题翻译：多通道采集空间分布信号的读出方法
公开(公告)号：US08941049B2
公开(公告)日：2015-01-27
申请号：US13172030
申请日：2011-06-29
申请人： Gabor Toth , Stuart Friedman , Khashayar Shadman
发明人： Gabor Toth , Stuart Friedman , Khashayar Shadman
IPC分类号： G06F19/00 , G01J3/28
CPC分类号： G01J3/2803
摘要： A readout apparatus and method for processing spatially distributed signals is disclosed. The readout apparatus and method may reduce/eliminate the impact gain variations among a plurality of sensing channels. This is done by continuously varying the dispersion properties of a signal distribution device, which may induce a spatial shift of the signal distribution during data acquisition, allowing the distributed signals to move across the sensor area. Shifting of the distributed signals may occur multiple times, hence eliminating the impact of gain variation across the sensor array. The accumulated data may be re-assembled subsequently to complete the readout operation.
摘要翻译：公开了一种用于处理空间分布信号的读出装置和方法。读出装置和方法可以减少/消除多个感测通道之间的冲击增益变化。这是通过连续地改变信号分配装置的色散特性来实现的，这可以在数据采集期间引起信号分布的空间偏移，从而允许分布式信号在传感器区域上移动。分布式信号的移位可能会发生多次，从而消除了传感器阵列上的增益变化的影响。可以随后重新组合累积的数据以完成读出操作。

4. 发明授权

US07394067B1 Systems and methods for reducing alteration of a specimen during analysis for charged particle based and other measurement systems 有权
标题翻译：用于减少基于带电粒子和其他测量系统的分析期间样品变化的系统和方法
公开(公告)号：US07394067B1
公开(公告)日：2008-07-01
申请号：US11185915
申请日：2005-07-20
申请人： David Soltz , Paul Wieczorek , Aaron Zuo , Gabor Toth
发明人： David Soltz , Paul Wieczorek , Aaron Zuo , Gabor Toth
IPC分类号： G01B15/04
CPC分类号： G03F1/84
摘要： Systems and methods for reducing alteration of a specimen during by charged particle based and other measurements systems are provided. One system configured to reduce alteration of a specimen during analysis includes a vacuum chamber in which the specimen is disposed during the analysis and an element disposed within the vacuum chamber. A surface of the element is cooled such that molecules in the vacuum chamber are adsorbed onto the surface and cannot cause alteration of a characteristic of the specimen during the analysis. One system configured to analyze a specimen includes an analysis subsystem configured to analyze the specimen while the specimen is disposed in a vacuum chamber and an element disposed within the vacuum chamber. A surface of the element is cooled such that molecules in the vacuum chamber are adsorbed onto the surface and cannot cause alteration of a characteristic of the specimen during the analysis.
摘要翻译：提供了通过基于带电粒子和其他测量系统来减少样品变化的系统和方法。被配置为减少分析期间样品变化的一个系统包括：真空室，其中在分析过程中放置试样并设置在真空室内的元件。元件的表面被冷却，使得真空室中的分子被吸附到表面上，并且在分析期间不能引起样品特性的改变。被配置为分析样本的一个系统包括分析子系统，该分析子系统构造成在样本被布置在真空室中并且设置在真空室内的元件时分析样本。元件的表面被冷却，使得真空室中的分子被吸附到表面上，并且在分析期间不能引起样品特性的改变。

5. 发明授权

US07148073B1 Methods and systems for preparing a copper containing substrate for analysis 有权
标题翻译：用于制备含铜底物的方法和系统用于分析
公开(公告)号：US07148073B1
公开(公告)日：2006-12-12
申请号：US11082039
申请日：2005-03-15
申请人： David Soltz , Mehran Nasser-Ghodsi , Harold Winters , John W. Coburn , Alexander Gubbens , Gabor Toth
发明人： David Soltz , Mehran Nasser-Ghodsi , Harold Winters , John W. Coburn , Alexander Gubbens , Gabor Toth
IPC分类号： H01L21/302
CPC分类号： C23F1/12 , C23F1/02 , G01N1/32 , H01J37/3056 , H01J2237/006 , H01J2237/2482 , H01J2237/3174 , H01J2237/31744 , H01L21/32135
摘要： Methods and systems for preparing a substrate for analysis are provided. One method includes removing a portion of a copper structure on the substrate using an etch chemistry in combination with an electron beam. The etch chemistry is substantially inert with respect to the copper structure except in the presence of the electron beam. Other methods involve forming masking layers on a substrate that will protect the substrate during etching. For example, one method includes exposing a first portion of the substrate to an electron beam. A second portion of the substrate not exposed to the electron beam includes a copper structure. The method also includes exposing the substrate to a fluorine containing chemical. The fluorine containing chemical bonds to the first portion but not the second portion to form a fluorine containing layer on the first portion.
摘要翻译：提供了用于制备用于分析的底物的方法和系统。一种方法包括使用与电子束组合的蚀刻化学法去除衬底上的一部分铜结构。除了存在电子束之外，蚀刻化学物质对于铜结构基本上是惰性的。其他方法包括在衬底上形成掩模层，其将在蚀刻期间保护衬底。例如，一种方法包括将基板的第一部分暴露于电子束。未暴露于电子束的基板的第二部分包括铜结构。该方法还包括将基底暴露于含氟化学品。含氟化学键合到第一部分而不是第二部分，以在第一部分上形成含氟层。

6. 发明申请

US20050135274A1 Centralized link-scope configuration of an internet protocol (IP) network 有权
标题翻译：互联网协议（IP）网络的集中链路范围配置
公开(公告)号：US20050135274A1
公开(公告)日：2005-06-23
申请号：US10742731
申请日：2003-12-19
申请人： Gergely Molnar , Gabor Toth , Balazs Gero , Attila Nohl
发明人： Gergely Molnar , Gabor Toth , Balazs Gero , Attila Nohl
IPC分类号： H04L12/24 , H04L12/28
CPC分类号： H04L41/0806
摘要： A method of configuring link-scope-type managed objects in IP-based networks from a centralized management node. An IP-based network includes at least one management station, a set of network nodes, and communication links between the network nodes and between the management station and the network nodes. Preferably, an Open Shortest Path First (OSPF) topology graph of the network is prepared, and a set of target links to be configured is identified. The target links are then classified into N disjoint subsets, T1-TN. The links in each subset are then configured in parallel, starting with subset T1 and sequentially handling each subset one-by-one. The target links may be classified by removing non-target links that are not to be configured from the OSPF topology graph, building a LinkGraph to determine the dependencies between the links remaining in the OSPF topology graph, and building a LinkTree from the LinkGraph to classify the target links into the subsets based upon the dependencies between the links.
摘要翻译：一种从集中管理节点在基于IP的网络中配置链路范围类型管理对象的方法。基于IP的网络包括至少一个管理站，一组网络节点以及网络节点之间以及管理站和网络节点之间的通信链路。优选地，准备网络的开放最短路径优先（OSPF）拓扑图，并且识别要配置的一组目标链路。然后将目标链路分为N个不相交的子集，T 1，N 2，N 2，N 3。然后每个子集中的链接被并行地配置，从子集T 1开始，并逐个地依次处理每个子集。可以通过从OSPF拓扑图中去除不配置的非目标链路来分类目标链路，构建LinkGraph以确定OSPF拓扑图中剩余的链路之间的依赖关系，以及从LinkGraph构建LinkTree以对其进行分类基于链接之间的依赖关系，目标链接到子集中。

7. 发明授权

US06706435B1 Fuel cell with polymer electrolyte membrane 失效
标题翻译：燃料电池与聚合物电解质膜
公开(公告)号：US06706435B1
公开(公告)日：2004-03-16
申请号：US10009342
申请日：2002-04-08
申请人： Hubertus Biegert , Peter Britz , Arnold Lamm , Gabor Toth , Peter Urban
发明人： Hubertus Biegert , Peter Britz , Arnold Lamm , Gabor Toth , Peter Urban
IPC分类号： H01M0810
CPC分类号： H01M8/106 , H01M8/1004 , H01M8/1025 , H01M8/1027 , H01M8/103 , H01M8/1032 , H01M8/1062 , H01M2300/0082
摘要： A fuel cell includes at least one cell that contains a proton-conducting polymer electrolyte membrane, which separates an anode compartment and a cathode compartment. The membrane is comprised of a thermoplastic polymer that has a permanent service temperature of at least 100° C.
摘要翻译：燃料电池包括至少一个包含导电聚合物电解质膜的电池，其分离阳极室和阴极室。该膜由具有至少100℃的永久使用温度的热塑性聚合物组成。

8. 发明授权

US07635842B2 Method and instrument for chemical defect characterization in high vacuum 失效
标题翻译：高真空化学缺陷表征方法与仪器
公开(公告)号：US07635842B2
公开(公告)日：2009-12-22
申请号：US12032526
申请日：2008-02-15
申请人： Mehran Nasser-Ghodsi , Ming Lun Yu , Stuart Friedman , Gabor Toth
发明人： Mehran Nasser-Ghodsi , Ming Lun Yu , Stuart Friedman , Gabor Toth
IPC分类号： H01J49/08 , G01N23/227 , G01N23/22
CPC分类号： G01N23/2276
摘要： A method and the instrument for characterization of the defects on a surface with Auger electron spectroscopy in a high vacuum environment are disclosed. Defects on the surface of a sample may be characterized with Auger electron spectroscopy in a high vacuum environment.
摘要翻译：公开了一种在高真空环境中用俄歇电子能谱表征表面缺陷的方法和仪器。样品表面的缺陷可以在高真空环境下用俄歇电子能谱表征。

9. 发明授权

US07030375B1 Time of flight electron detector 失效
标题翻译：飞行时间电子探测器
公开(公告)号：US07030375B1
公开(公告)日：2006-04-18
申请号：US10836635
申请日：2004-04-29
申请人： Anne L. Testoni , Gabor Toth
发明人： Anne L. Testoni , Gabor Toth
IPC分类号： H01J49/40
CPC分类号： H01J49/446
摘要： Methods and apparatus for determining the material composition of a semiconductor device at an area of interest are described. An electron time-of-flight spectrometer is used within a semiconductor inspection system. The spectrometer is placed on the opposite side of an objective lens from the area of interest. In one embodiment, the electron time-of-flight spectrometer is an electron drift tube. A computing module produces an electron emission spectrum for the materials at the area of interest.
摘要翻译：描述了用于确定感兴趣区域的半导体器件的材料组成的方法和装置。在半导体检测系统内使用电子飞行时间分光计。光谱仪被放置在距离感兴趣区域的物镜的相对侧。在一个实施例中，电子飞行时间分光计是电子漂移管。计算模块为感兴趣区域的材料产生电子发射光谱。

10. 发明申请

US20060060780A1 Apparatus and method for e-beam dark field imaging 有权
标题翻译：用于电子束暗场成像的装置和方法
公开(公告)号：US20060060780A1
公开(公告)日：2006-03-23
申请号：US10935834
申请日：2004-09-07
申请人： Douglas Masnaghetti , Gabor Toth , Eric Munro , Jeffrey Keister
发明人： Douglas Masnaghetti , Gabor Toth , Eric Munro , Jeffrey Keister
IPC分类号： G21K7/00 , H01J3/14
CPC分类号： H01J37/28 , H01J37/05 , H01J37/244 , H01J37/265 , H01J2237/053 , H01J2237/15 , H01J2237/1536 , H01J2237/2446 , H01J2237/24485
摘要： One embodiment disclosed relates to a scanning electron beam apparatus including an objective lens, scan deflectors, de-scan deflectors, an energy-filter drift tube, and a segmented detector. The objective lens may be an immersion lens configured with a high extraction field so as to preserve azimuthal angle discrimination of the electrons scattered from the specimen surface. The de-scan deflectors may be used to compensate for the scanning of the incident electron beam. The energy-filter drift tube is configured to align the scattered electrons according to polar angles of trajectory from the specimen surface.
摘要翻译：公开的一个实施例涉及包括物镜，扫描偏转器，去扫描偏转器，能量滤波器漂移管和分段检测器的扫描电子束装置。物镜可以是配置有高提取场的浸没透镜，以便保留从样本表面散射的电子的方位角鉴别。去扫描偏转器可以用于补偿入射电子束的扫描。能量滤波器漂移管被配置为根据来自样品表面的极化轨迹角对准散射电子。

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