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    • 1. 发明授权
    • Process for the preparation of pesticides
    • 农药制备工艺
    • US6156923A
    • 2000-12-05
    • US762217
    • 1996-12-06
    • Saleem FarooqStephan TrahHugo ZieglerRene Zurfluh
    • Saleem FarooqStephan TrahHugo ZieglerRene Zurfluh
    • C07C249/04C07C249/12C07C251/48C07C251/60
    • C07C249/12C07C251/48C07C251/60
    • The invention relates to a process for the preparation of compounds of the formula ##STR1## or, if appropriate, a tautomer thereof, in each case in the free form or in salt form, in whichA, X, Y, Z, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.9 and n are as defined in claim 1 and the C.dbd.N double bond marked with E has the E configuration, which comprisesa1) reacting either a compound of the formula (II) mentioned above with a compound of the formula (III) mentioned above, in which X.sub.1 is a leaving group, ora2) a compound of the formula (IV) mentioned above, if appropriate in the presence of a base, with a compound of the formula (V) mentioned above, orb1) reacting a compound of the formula (VI) mentioned above with a compound of the formula R.sub.7 --A--X.sub.2 (VII), in which X.sub.2 is a leaving group, and either further reacting the compound thus obtainable, of the formula (IV), for example according to method a2), orb2) reacting it with hydroxylamine or a salt thereof, if appropriate in the presence of a basic or acid catalyst, and further reacting the compound thus obtainable, of the formula (II), for example according to method a1), orc) reacting a compound of the formula (VII), mentioned above with a C.sub.1 -C.sub.6 alkyl nitrite and further reacting the compound thus obtainable, of the formula (VI), for example according to method b), the E isomers of the compounds of the formulae (II), (IV) and (VI), a process for their preparation and their use for the preparation of compounds of the formula (I).
    • 本发明涉及一种制备下式的化合物或其合适的互变异构体的方法,其各自为游离形式或盐形式,其中A,X,Y,Z,R 2,R 3,R 4 ,R 5,R 7,R 9和n如权利要求1中所定义,并且用E标记的C = N双键具有E构型,其包括a1)使上述式(II)的化合物与 上述式(III),其中X1是离去基团,或a2)上述式(Ⅳ)化合物,如果合适,在碱的存在下,与上述式(Ⅴ)化合物, 或b1)使上述式(Ⅵ)化合物与式R7-A-X2(Ⅶ)化合物反应,其中X 2为离去基团,并进一步使由此得到的化合物(式(Ⅴ) IV),例如根据方法a2),或b2)如果合适,在碱性或酸性催化剂存在下,使其与羟胺或其盐反应, 进一步使由式(II)得到的化合物,例如按照方法a1)进行反应,或c)使上述式(Ⅶ)化合物与亚硝酸C 1 -C 6烷基酯反应,然后进一步使化合物 式(Ⅵ)化合物的E异构体,其制备方法及其制备方法(Ⅵ)的制备方法及其制备方法 式(I)的化合物。
    • 6. 发明授权
    • Triazoline and isoxazoline bis-oxime derivatives and their use as
pesticides
    • 三唑啉和异恶唑啉双肟衍生物及其作为农药的用途
    • US5932583A
    • 1999-08-03
    • US981116
    • 1997-12-23
    • Hugo ZieglerStephan TrahRene ZurfluhAnthony Cornelius O'Sullivan
    • Hugo ZieglerStephan TrahRene ZurfluhAnthony Cornelius O'Sullivan
    • A01N43/647A01N43/653A01N43/80C07C251/52C07C251/58C07C251/60C07C265/12C07C279/18C07C281/06C07C331/28C07C335/18C07D249/08C07D249/12C07D261/10C07D261/12C07D401/12C07D403/12C07D413/12C07D417/12A61K31/41A61K31/42C07C249/08
    • C07D261/10A01N43/647A01N43/80C07C251/52C07C251/58C07C251/60C07C265/12C07C279/18C07C331/28C07C335/18C07D249/12C07D261/12C07D401/12C07D403/12C07D413/12C07D417/12
    • Bis-oxime derivatives of the formula I ##STR1## W is oxygen or sulfur, and the other substituents defined as follows: R.sub.1 =hydrogen, C.sub.1 -C.sub.4 alkyl; cyclopropyl;R.sub.2 =hydrogen, C.sub.1 -C.sub.6 alkyl; halo(C.sub.1 -C.sub.6) alkyl; C.sub.2 -C.sub.6 alkoxyalkyl; C.sub.3 -C.sub.6 cycloalkyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; cyano; C.sub.1 -C.sub.6 alkoxycarbonyl; C.sub.1 -C.sub.6 alkyl-S(O).sub.n ; substituted or unsubstituted aryl-S(O).sub.n ; C.sub.1 -C.sub.6 alkoxy; substituted or unsubstituted aryloxy; substituted or unsubstituted heteroaryloxy; unsubstituted or mono- to trimethyl-substituted heterocyclyl; substituted or unsubstituted aryl-C.sub.1 -C.sub.6 alkyl; substituted or unsubstituted heteroaryl-C.sub.1 -C.sub.6 alkyl;R.sub.3 =hydrogen; C.sub.1 -C.sub.6 alkyl; C.sub.1 -C.sub.6 haloalkyl having 1 to 5 halogen atoms; C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.2 -alkyl; unsubstituted or mono- to trihalo-substituted C.sub.1 -C.sub.6 alkenyl; C.sub.2 -C.sub.6 alkynyl; unsubstituted or mono- to tetrahalo-substituted C.sub.3 -C.sub.6 cycloalkyl-C.sub.1 -C.sub.4 alkyl;n=0 to 2;R.sub.8 =H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.6 cycloalkyl;X=OR.sub.5, SR.sub.5, NR.sub.6 R.sub.7, halogen (especially Cl);R.sub.6, R.sub.7 =independently of one another H, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl;R.sub.5 =C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 haloalkyl, are fungicidal, acaricidal and insecticidal active ingredients for agriculture. They can be employed as formulated crop protection compositions.
    • PCT No.PCT / EP96 / 02695 Sec。 371 1997年12月23日第 102(e)1997年12月23日PCT PCT 1996年6月21日PCT公布。 出版物WO97 / 02255 日期1997年1月23日式I W的双肟衍生物是氧或硫,其它取代基定义如下:R1 =氢,C1-C4烷基; 环丙基 R2 =氢,C1-C6烷基; 卤代(C 1 -C 6)烷基; C2-C6烷氧基烷基; C 3 -C 6环烷基; 取代或未取代的芳基; 取代或未取代的杂芳基; 氰基; C1-C6烷氧基羰基; C 1 -C 6烷基-S(O)n; 取代或未取代的芳基-S(O)n; C1-C6烷氧基; 取代或未取代的芳氧基; 取代或未取代的杂芳氧基; 未取代或单 - 三甲基取代的杂环基; 取代或未取代的芳基-C 1 -C 6烷基; 取代或未取代的杂芳基-C 1 -C 6烷基; R3 =氢; C1-C6烷基; 具有1至5个卤素原子的C 1 -C 6卤代烷基; C 1 -C 4烷氧基-C 1 -C 2 - 烷基; 未取代或单 - 三卤代取代的C 1 -C 6烯基; C2-C6炔基; 未取代或单 - 四卤代取代的C 3 -C 6环烷基-C 1 -C 4烷基; n = 0〜2; R8 = H,C1-C4烷基,C1-C4卤代烷基,C3-C6环烷基; X = OR5,SR5,NR6R7,卤素(特别是Cl); R6,R7 =彼此独立地为H,C1-C4烷基,C3-C4链烯基,C3-C4炔基; R5 = C1-C4烷基,C1-C3卤代烷基,是农业的杀真菌,杀螨和杀虫活性成分。 它们可以用作配制的作物保护组合物。
    • 7. 发明授权
    • Process for the preparation of pesticides
    • 农药制备工艺
    • US06646151B1
    • 2003-11-11
    • US09670147
    • 2000-09-26
    • Saleem FarooqStephan TrahHugo ZieglerRené Zurflüh
    • Saleem FarooqStephan TrahHugo ZieglerRené Zurflüh
    • C07C24904
    • C07C249/12C07C251/48C07C251/60
    • The invention relates to a process for the preparation of compounds of the formula or, if appropriate, a tautomer thereof, in each case in the free form or in salt form, in which A, X, Y, Z, R2, R3, R4, R5, R7, R9 and n are as defined in claim 1 and the C═N double bond marked with E has the E configuration, which comprises a1) reacting either a compound of the formula (II) mentioned above with a compound of the formula (III) mentioned above, in which X1 is a leaving group, or a2) a compound of the formula (IV) mentioned above, if appropriate in the presence of a base, with a compound of the formula (V) mentioned above, or b1) reacting a compound of the formula (VI) mentioned above with a compound of the formula R7—A—X2 (VII), in which X2 is a leaving group, and either further reacting the compound thus obtainable, of the formula (IV), for example according to method a2), or b2) reacting it with hydroxylamine or a salt thereof, if appropriate in the presence of a basic or acid catalyst, and further reacting the compound thus obtainable, of the formula (II), for example according to method a1), or c) reacting a compound of the formula (VIII), mentioned above with a C1-C6alkyl nitrite and further reacting the compound thus obtainable, of the formula (VI), for example according to method b), the E isomers of the compounds of the formulae (II), (IV) and (VI), a process for their preparation and their use for the preparation of compounds of the formula (I).
    • 本发明涉及一种制备式的化合物的方法,如果合适,其合适的是其互变异构体,其各自为游离形式或盐形式,其中A,X,Y,Z,R 2,R 3,R 4, R5,R7,R9和n如权利要求1中所定义,并且用E标记的C = N双键具有E构型,其包括a)使上述式(II)的化合物与式(II) III),其中X1是离去基团,ora2)如果合适的话,在碱的存在下,上述式(Ⅳ)的化合物与上述式(Ⅴ)的化合物相同,反应1)使 上述式(Ⅵ)化合物与式R7-A-X2(Ⅶ)化合物反应,其中X 2为离去基团,并进一步使由此得到的式(Ⅳ)化合物与 根据方法a2)的示例,orb2)如果合适,在碱性或酸性催化剂存在下,使其与羟胺或其盐反应,以及 进一步使由式(II)得到的化合物,例如按照方法a1)进行反应,或者使上述式(Ⅷ)化合物与亚硝酸C 1 -C 6烷基酯反应,并进一步使由此得到的化合物, 式(Ⅵ)化合物的方法,例如根据方法b),式(II),(Ⅳ)和(Ⅵ)化合物的E异构体,其制备方法及其制备方法 式(I)。
    • 10. 发明授权
    • O-benzyl oxime ether derivatives and their use as pesticides
    • O-苄基肟醚衍生物及其作为农药的用途
    • US5977182A
    • 1999-11-02
    • US836176
    • 1997-05-01
    • Rene ZurfluhHugo ZieglerStephan Trah
    • Rene ZurfluhHugo ZieglerStephan Trah
    • A01C1/08A01N35/10A01N37/34A01N37/50A01N37/52A01N55/10C07C251/38C07C251/48C07C251/52C07C251/54C07C251/60C07C255/62C07C255/64C07C257/06C07C257/14C07C257/22C07C317/32C07C323/47C07C327/40C07C327/58C07D213/76C07D277/10C07D277/12C07D277/28C07D295/185C07D295/30C07D521/00A01N33/24A01N43/40
    • C07D295/185A01N37/50A01N37/52C07C251/38C07C251/48C07C255/64C07C257/06C07C257/14C07C257/22C07D295/30C07C2101/02
    • Compounds of formula (I), wherein Y is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, OH, CN, NO.sub.2, Si(CH.sub.3).sub.3, CF.sub.3 or halogen, and T is a group (a) or (b), and wherein the remaining substituents have the following definitions: X is O, S or NR.sub.13 ; A is O or NR.sub.4 ; R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, cyclopropyl, C.sub.1 -C.sub.4 alkoxymethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio or cyano; R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, cyano unsubstituted or substituted C.sub.1 -C.sub.6 alkoxycarbonyl, unsubstituted or substituted di(C.sub.1 -C.sub.6 alkyl)aminocarbonyl, unsubstituted or substituted C.sub.1 -C.sub.6 alkyl-S(O).sub.q, unsubstituted or substituted aryl-S(O).sub.q, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocyclylcarbonyl or unsubstituted or substituted phenyl; and R.sub.3 is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted C.sub.3 -C.sub.6 cycloalkyl, unsubstituted or substituted phenyl or unsubstituted or substituted pyridyl; and wherein the remaining substituents are as defined herein, are pesticidal active ingredients. They can be used in pest control, especially as microbicides, insecticides and acaricides in agriculture, in horticulture and in the hygiene sector. ##STR1##
    • PCT No.PCT / EP95 / 04357 Sec。 371日期1997年5月1日 102(e)日期1997年5月1日PCT提交1995年11月6日PCT公布。 公开号WO96 / 16026 日期:5月30日,式(I)的化合物,其中Y为氢,C1-C4烷基,C1-C4烷氧基,OH,CN,NO2,Si(CH3)3,CF3或卤素,T为(a)或 b),其中其余取代基具有以下定义:X是O,S或NR 13; A为O或NR4; R 1是氢,C 1 -C 4烷基,卤代C 1 -C 4烷基,环丙基,C 1 -C 4烷氧基甲基,C 1 -C 4烷氧基,C 1 -C 4烷硫基或氰基; 未取代或取代的二(C 1 -C 6烷基)氨基羰基,未取代或取代的C 1 -C 6烷基-S(O)q,未取代或取代的芳基-S(O)q,C 1 -C 6烷基,C 3 -C 6环烷基,氰基未取代或取代的C 1 -C 6烷氧基羰基, (O)q,未取代或取代的杂芳基,未取代或取代的杂环基,未取代或取代的杂环基羰基或未取代或取代的苯基; 未取代或取代的烷基,未取代或取代的C 3 -C 6环烷基,未取代或取代的苯基或未取代或取代的吡啶基; 并且其中剩余的取代基如本文所定义,是杀虫活性成分。 它们可用于病虫害防治,特别是作为农业,园艺和卫生领域的杀菌剂,杀虫剂和杀螨剂。