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1. 发明授权

US08465781B2 Preparation and use of a plant extract from Solanum glaucophyllum with an enriched content of 1,25-dihydroxyvitamin D3 glycosides and quercetin glycosides 有权
标题翻译：制备和使用浓缩番茄红素的植物提取物富含1,25-二羟基维生素D3糖苷和槲皮素糖苷
公开(公告)号：US08465781B2
公开(公告)日：2013-06-18
申请号：US12988598
申请日：2008-04-21
申请人： Sabrina Autzen , Heinrich Bachmann
发明人： Sabrina Autzen , Heinrich Bachmann
IPC分类号： A61K36/00
CPC分类号： A61K36/81 , A61K2236/00
摘要： The present invention relates to the preparation of an enriched and equilibrated plant extract from Solanum glaucophyllum with an enriched content of 1,25-dihydroxyvitamin D3 glycosides and flavonols, particularly quercetin glycosides. The present invention particularly describes a method for preparation of such a plant extract either in industrial or in laboratory scale. The present invention furthermore describes the use of such a plant extract or similar (synthetic) compositions for the prevention and treatment of bone mass reduction-related diseases, such as Osteopenia or Osteoporosis, for the prevention and treatment of Tibial Dyschondroplasia, preferably in poultry, for the treatment of milk fever, and as a dietary supplement for human or veterinary use.
摘要翻译：本发明涉及富含和平衡的来自番茄的富含和平衡的植物提取物，其富含含量为1,25-二羟基维生素D3糖苷和黄酮醇，特别是槲皮素苷。本发明特别描述了以工业或实验室规模制备这种植物提取物的方法。本发明还描述了这种植物提取物或类似（合成）组合物用于预防和治疗骨量减少相关疾病如骨质减少或骨质疏松症用于预防和治疗胫骨软骨发育不良，优选在家禽中的用途，用于治疗牛奶热，并作为人类或兽医用途的膳食补充剂。

2. 发明申请

US20120288573A1 USE OF EXTRACTS FROM SALONUM GLAUCOPHYLLUM FOR TREATING BONE METABOLISM DISORDERS AND KIDNEY DISORDERS 审中-公开
标题翻译：用于治疗骨代谢紊乱和儿童疾病的沙门氏菌提取物的使用
公开(公告)号：US20120288573A1
公开(公告)日：2012-11-15
申请号：US13502922
申请日：2010-10-20
申请人： Heinrich Bachmann , Sabrina Autzen
发明人： Heinrich Bachmann , Sabrina Autzen
IPC分类号： A61K31/7048 , A61P3/00 , A61K38/17 , A61P3/02 , A61K33/06 , A61K33/10 , A61P19/08 , A61P13/12
CPC分类号： A61K36/81
摘要： A method is provided for preventing or treating bone or musculoskeletal metabolism disorders or kidney malfunction in humans. It comprises providing to a subject in need of that a calcium containing or calcium enriched diet combined with the administration of an efficient amount of a plant extract of Solatium glaucophyllum comprising from about 0.8 to about 2.2 weight % of a mixture of 1,25-dihydroxyvitamin D3 glycosides and quercetin glycosides present in a ratio of about 1:100 to 1:200 parts by weight. There are also provided food or dietary composition and food supplement designed for preventing or treating bone or musculoskeletal metabolism disorders or kidney malfunction in humans which comprises an efficient amount of the said plant extract of Solanum glaucophyllum and a source of calcium.
摘要翻译：提供了一种用于预防或治疗人类骨骼或肌肉骨骼代谢紊乱或肾脏功能障碍的方法。它包括向需要补充钙或钙的饮食的受试者提供与施用有效量的绿叶藻的植物提取物相结合的组合物，其包含约0.8至约2.2重量％的1,25-二羟基维生素 D3糖苷和槲皮素糖苷以约1:100至1:200重量份的比例存在。还提供了用于预防或治疗人类骨骼或肌肉骨骼代谢紊乱或肾脏功能障碍的食物或膳食组合物和食品补充剂，其包含有效量的所述茄科植物提取物和钙源。

3. 发明申请

US20110038960A1 PREPARATION AND USE OF A PLANT EXTRACT FROM SOLANUM GLAUCOPHYLLUM WITH AN ENRICHED CONTENT OF 1,25-DIHYDROXYVITAMIN D3 GLYCOSIDES AND QUERCETIN GLYCOSIDES 有权
标题翻译：来自Solanum GLAUCOPHYLLUM的植物提取物的制备和使用与1,25-二羟基维生素D3果糖苷和奎特糖苷糖苷的富含量的含量
公开(公告)号：US20110038960A1
公开(公告)日：2011-02-17
申请号：US12988598
申请日：2008-04-21
申请人： Sabrina Autzen , Heinrich Bachmann
发明人： Sabrina Autzen , Heinrich Bachmann
IPC分类号： A61K36/18 , A61P19/10 , A61P43/00
CPC分类号： A61K36/81 , A61K2236/00
摘要： The present invention relates to the preparation of an enriched and equilibrated plant extract from Solanum glaucophyllum with an enriched content of 1,25-dihydroxyvitamin D3 glycosides and flavonols, particularly quercetin glycosides. The present invention particularly describes a method for preparation of such a plant extract either in industrial or in laboratory scale. The present invention furthermore describes the use of such a plant extract or similar (synthetic) compositions for the prevention and treatment of bone mass reduction-related diseases, such as Osteopenia or Osteoporosis, for the prevention and treatment of Tibial Dyschondroplasia, preferably in poultry, for the treatment of milk fever, and as a dietary supplement for human or veterinary use.
摘要翻译：本发明涉及富含和平衡的来自番茄的富含和平衡的植物提取物，其富含含量为1,25-二羟基维生素D3糖苷和黄酮醇，特别是槲皮素苷。本发明特别描述了以工业或实验室规模制备这种植物提取物的方法。本发明还描述了这种植物提取物或类似（合成）组合物用于预防和治疗骨量减少相关疾病如骨质减少或骨质疏松症用于预防和治疗胫骨软骨发育不良，优选在家禽中的用途，用于治疗牛奶热，并作为人类或兽医用途的膳食补充剂。

4. 发明授权

US06797498B1 B, B-carotene 15, 15′-dioxygenases, nucleic acid sequences coding therefor and their use 失效
标题翻译： B，β-胡萝卜素15,15'-双加氧酶，及其编码的核酸序列及其用途
公开(公告)号：US06797498B1
公开(公告)日：2004-09-28
申请号：US09504393
申请日：2000-02-15
申请人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
发明人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
IPC分类号： C12N902
CPC分类号： C12N9/0069 , C12P23/00
摘要： Nucleic acid sequences coding for a protein having &bgr;,&bgr;-carotene 15,15′ enzyme activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the &bgr;,&bgr;-carotene 15,15′ enzyme cDNA into host cells are disclosed.
摘要翻译：编码具有β，β-胡萝卜素15,15'酶活性的蛋白质的核酸序列及其在诊断中的应用，维生素A的合成以及将β，β-胡萝卜素15,15'酶cDNA引入宿主的方法细胞被公开。

5. 发明申请

US20050059061A1 Beta, beta-carotene 15,15'-enzymes, nucleic acid sequences coding therefor and their use 审中-公开
标题翻译： β，β-胡萝卜素15,15'-酶，其编码的核酸序列及其用途
公开(公告)号：US20050059061A1
公开(公告)日：2005-03-17
申请号：US10912754
申请日：2004-08-05
申请人： Heinrich Bachmann , Roland Brugger , Arno Friedlein , Gabriele Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
发明人： Heinrich Bachmann , Roland Brugger , Arno Friedlein , Gabriele Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
IPC分类号： C12N15/09 , C07K14/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/53 , C12P23/00 , C12Q1/68 , C07H21/04 , C12N9/10
CPC分类号： C12N9/0069 , C12P23/00
摘要： Nucleic acid sequences coding for a protein having β,β-carotene 15,15′ enzyme activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the β,β-carotene 15,15′ enzyme cDNA into host cells are disclosed.
摘要翻译：编码具有β，β-胡萝卜素15,15'酶活性的蛋白质的核酸序列及其在诊断中的应用，维生素A的合成以及将β，β-胡萝卜素15,15'酶cDNA引入宿主的方法细胞被公开。

6. 发明授权

US4620850A Composition and process for the oxidative dyeing of hair 失效
标题翻译：头发氧化染色的组成和工艺
公开(公告)号：US4620850A
公开(公告)日：1986-11-04
申请号：US641134
申请日：1984-08-08
申请人： Heinrich Bachmann , Plato Portmann
发明人： Heinrich Bachmann , Plato Portmann
IPC分类号： A61K8/00 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/41 , A61K8/44 , A61K8/49 , A61Q5/10 , A61K7/13
CPC分类号： A61K8/4973 , A61K8/49 , A61K8/4946 , A61Q5/10
摘要： A composition for oxidative dyeing of hair is disclosed, having at least one compound of the general formula ##STR1## wherein X is CH.sub.2, O, S, NH, NR', CH(OH), CHR', CH(NH.sub.2), or CH(CH.sub.3),Y is O, NH,Z is O, S, NH,R is H, OH, R', OR', NR'.sub.2, NO.sub.2, halogen, andR' is an alkyl group with one to five carbon atoms.
摘要翻译：公开了一种用于毛发氧化染色的组合物，其具有至少一种通式为“IMAGE”的化合物，其中X为CH 2，O，S，NH，NR'，CH（OH），CHR'，CH（NH 2） CH（CH3），Y是O，NH，Z是O，S，NH，R是H，OH，R'，OR'，NR'2，NO2，卤素，R'是一个到五个碳原子。

7. 发明授权

US4479803A Agent for oxidative dyeing of hair 失效
标题翻译：头发氧化染色剂
公开(公告)号：US4479803A
公开(公告)日：1984-10-30
申请号：US253510
申请日：1981-04-08
申请人： Heinrich Bachmann , Plato Portmann
发明人： Heinrich Bachmann , Plato Portmann
IPC分类号： A61K8/00 , A61K8/33 , A61K8/35 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/49 , A61Q5/10 , A61K7/13
CPC分类号： A61K8/40 , A61K8/37 , A61K8/42 , A61Q5/10
摘要： Use is made in the oxidative dyeing of hair of a preliminary coloring stage of the general formula ##STR1## wherein R signifies COOR', CONH.sub.2, CONHR', CONR'.sub.2, CONH--NH.sub.2, CONH--OH, CN, CH.sub.2 OH, CHO, CH(OH)(OR'), CH(OR').sub.2 and R' represents an alkyl group with 1 to 5 carbon atoms. The preliminary coloring stages as per formula (I) may be contained in the hair dyeing agents singly or in a mixture with known preliminary coloring stages and/or direct-acting hair dyeing agents. The hair dyeing agents may, in particular, additionally contain amino acids present in nature, their esters and/or their amides. The hair dyeing agents as described, are well compatible physiologically and it will particularly be brown to reddish-brown colorings having a natural effect, that may be obtained by their use.
摘要翻译： PCT No.PCT / EP80 / 00103 Sec。 371日期：1981年4月8日 102（e）日期1981年4月8日PCT申请日1980年9月25日PCT公布。出版物WO81 / 00810 日本1981年4月2日。使用通式（I）的预着色阶段的毛发氧化染色，其中R表示COOR'，CONH 2，CONHR'，CONR 2，CONH-NH 2， CONH-OH，CN，CH2OH，CHO，CH（OH）（OR'），CH（OR'）2，R'表示碳原子数1〜5的烷基。根据式（I）的初步着色阶段可以单独地或与已知的预着色阶段和/或直接作用的染发剂的混合物包含在染发剂中。染发剂特别可以另外包含天然存在的氨基酸，它们的酯和/或它们的酰胺。如上所述的染发剂在生理学上是良好相容的，并且特别是具有天然效果的棕色至红褐色的着色剂，可以通过其使用获得。

8. 发明授权

US06897051B2 β, β-carotene 15, 15′-monooxygenases, nucleic acid sequences coding therefor and their use 失效
标题翻译： β，β-胡萝卜素15,15'-单加氧酶，对其编码的核酸序列及其用途
公开(公告)号：US06897051B2
公开(公告)日：2005-05-24
申请号：US10053192
申请日：2002-01-15
申请人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
发明人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
IPC分类号： C12N9/02 , C12P23/00 , C07H19/00 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12P23/00 , C12N9/0069
摘要： Nucleic acid sequences coding for a protein having β,β-carotene 15,15′-monooxygenase activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the β,β-carotene 15,15′-monooxygenase cDNA into host cells are disclosed.
摘要翻译：编码具有β，β-胡萝卜素15,15'-单加氧酶活性的蛋白质的核酸序列及其在诊断中的应用，维生素A的合成以及引入β，β-胡萝卜素15,15'-单加氧酶cDNA的方法公开了宿主细胞。

9. 发明申请

US20120301513A1 COMPOSITION COMPRISING SOLANUM GLAUCOPHYLLUM FOR PREVENTING AND/OR TREATING HYPOCALCAEMIA AND FOR STABILIZING BLOOD CALCIUM LEVELS 审中-公开
标题翻译：包含用于预防和/或治疗高血压并用于稳定血钙水平的Solanum GLAUCOPHYLLUM的组合物
公开(公告)号：US20120301513A1
公开(公告)日：2012-11-29
申请号：US13502971
申请日：2010-10-20
申请人： Heinrich Bachmann , Walter Rambeck
发明人： Heinrich Bachmann , Walter Rambeck
IPC分类号： A61K33/06 , A61K9/00 , A61P3/14 , A61K33/10
CPC分类号： A61K33/10 , A61K9/0068 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K36/81
摘要： The present invention provides a pharmaceutical and/or veterinary composition comprising a retard release formulation of a Solarium glaucophyllum preparation. The composition further preferably comprises a calcium source. The composition of the invention is suitable to prevent and/or treat hypocalcaemia. Furthermore, the composition is suitable to prevent milk fever in cows. Advantageously, the composition is administered only once before calving so as to prevent the occurrence of milk fever in cows.
摘要翻译：本发明提供了一种药物和/或兽医组合物，其包含日光浴玻璃绿假单胞菌制剂的缓释制剂。组合物还优选包含钙源。本发明的组合物适用于预防和/或治疗低钙血症。此外，该组合物适合于防止奶牛发热。有利地，组合物在产犊前仅施用一次，以防止奶牛发热。

10. 发明授权

US4515519A Raking apparatus 失效
标题翻译：耙装置
公开(公告)号：US4515519A
公开(公告)日：1985-05-07
申请号：US442124
申请日：1982-11-16
申请人： Heinrich Bachmann , Ulrich Kollmar
发明人： Heinrich Bachmann , Ulrich Kollmar
IPC分类号： B01D21/18 , B01D21/24 , E02B8/02 , B66C23/02
CPC分类号： B01D21/245 , E02B8/026
摘要： A raking apparatus comprises a guide track, a carriage supported on the guide track for displacement thereon along a traveling path, a linkage assembly supported on the carriage and comprising a plurality of linkage levers articulated to one another by respective joints, and a rake supported on the carriage and operatively connected to the linkage assembly for varying angular positions of the rake by the linkage assembly upon pivotal motion of the levers with respect to one another. There is further provided a slide track receiving one of the joints for guiding it upon pivotal motion of the levers and a locking mechanism mounted on the carriage and cooperating with the linkage assembly. The locking mechanism has a released position permitting a pivotal motion of the levers and a locking position immobilizing the levers of the linkage assembly with respect to one another.
摘要翻译：耙装置包括导轨，支撑在导轨上的滑架，用于沿着行进路径在其上移位;支撑在滑架上的连杆组件，包括通过各个接头彼此铰接的多个连杆杆，所述滑架并且可操作地连接到所述连杆组件，用于当所述杠杆相对于彼此枢转运动时，通过所述连杆组件改变所述耙的角度位置。还提供了一个滑动轨道，其接收用于在杠杆枢转运动时引导其的一个接头以及安装在滑架上并与连杆组件配合的锁定机构。锁定机构具有允许杆的枢转运动的释放位置和使连杆组件的杠杆相对于彼此固定的锁定位置。

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