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1. 发明授权

US08193168B2 Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release 有权
标题翻译：使用TRPM5抑制剂调节胰岛素和GLP-1释放
公开(公告)号：US08193168B2
公开(公告)日：2012-06-05
申请号：US12025488
申请日：2008-02-04
申请人： S. Paul Lee , Peihong Zhou , M. N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
发明人： S. Paul Lee , Peihong Zhou , M. N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
IPC分类号： A61K31/655 , A61K31/415
CPC分类号： A61K31/397 , Y10S514/866
摘要： The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
摘要翻译：本发明涉及增强胰岛素释放，GLP-1释放和胰岛素敏感性的方法，增加胰岛素基因表达的方法，减少胃分泌和排空以及胰高血糖素分泌的方法，以及抑制食物摄取的方法以及治疗方法糖尿病，胰岛素抵抗综合征，高血糖症和肥胖症，包括向受试者施用有效量的TRPM5抑制剂。

2. 发明申请

US20080306030A1 Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release 有权
标题翻译：使用TRPM5抑制剂调节胰岛素和GLP-1释放
公开(公告)号：US20080306030A1
公开(公告)日：2008-12-11
申请号：US12025488
申请日：2008-02-04
申请人： S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
发明人： S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
IPC分类号： A61K31/15 , A61K31/655 , A61K31/47 , A61K31/4409 , A61K31/438 , A61P3/00 , A61P1/00 , C12N5/00 , A61K31/5375 , A61K31/165 , A61K31/404
CPC分类号： A61K31/397 , Y10S514/866
摘要： The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
摘要翻译：本发明涉及增强胰岛素释放，GLP-1释放和胰岛素敏感性的方法，增加胰岛素基因表达的方法，减少胃分泌和排空以及胰高血糖素分泌的方法，以及抑制食物摄取的方法以及治疗方法糖尿病，胰岛素抵抗综合征，高血糖症和肥胖症，包括向受试者施用有效量的TRPM5抑制剂。

3. 发明授权

US08609069B2 Rebaudioside C and its stereoisomers as natural product sweetness enhancers 有权
标题翻译：雷鲍迪甙C及其立体异构体作为天然产物甜味增强剂
公开(公告)号：US08609069B2
公开(公告)日：2013-12-17
申请号：US12782673
申请日：2010-05-18
申请人： F. Raymond Salemme , Daniel Long , Roy Kyle Palmer , Francis Xavier Brennan , Dennis Sprous
发明人： F. Raymond Salemme , Daniel Long , Roy Kyle Palmer , Francis Xavier Brennan , Dennis Sprous
IPC分类号： A23L1/236 , A61K8/60 , A61K47/26 , A61Q11/00
CPC分类号： A23L1/2366 , A21D2/14 , A23C9/1307 , A23K20/10 , A23K20/105 , A23L2/02 , A23L2/60 , A23L7/00 , A23L9/00 , A23L21/00 , A23L27/36 , A23L27/88 , A23L29/30 , A23L29/35 , A23L29/37 , A23L33/125 , A23V2002/00
摘要： The present invention is directed to the use of rebaudioside C, or a stereoisomer thereof, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and rebaudioside C, or a stereoisomer thereof.
摘要翻译：本发明涉及新蛇菊苷C或其立体异构体用于增强碳水化合物甜味剂如蔗糖和果糖的甜味的用途。本发明还涉及包含碳水化合物甜味剂和新蛇菊苷C或其立体异构体的组合的消耗品。

4. 发明授权

US06834239B2 Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks 有权
标题翻译：方法，系统和计算机程序产品，用于从库构建块的特征中确定组合图书馆产品的属性
公开(公告)号：US06834239B2
公开(公告)日：2004-12-21
申请号：US09934084
申请日：2001-08-22
申请人： Victor S. Lobanov , Dimitris K. Agrafiotis , F. Raymond Salemme
发明人： Victor S. Lobanov , Dimitris K. Agrafiotis , F. Raymond Salemme
IPC分类号： G06F1900
CPC分类号： G06N99/005 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00702 , B01J2219/0072 , G06N3/02
摘要： The present invention determines properties of combinatorial library products from features of library building blocks. At least one feature is determined for each building block of a combinatorial library having a plurality of products. A training subset of products is selected from the products, and at least one property is determined for each product of the training subset. A building block set is identified for each product of the training subset, and an input features vector is formed from the features of the identified building blocks for each product of the training subset. A supervised machine learning approach is used to infer a mapping function that transforms the input features vector for each product of the training subset to the corresponding at least one property for each product of the training subset. After the mapping function is inferred, it is used for determining properties of other products of the library from their corresponding input features vectors.
摘要翻译：本发明根据图书馆构件的特征确定组合图书馆产品的特性。为具有多个产品的组合库的每个构建块确定至少一个特征。从产品中选择产品的训练子集，并确定训练子集的每个产品的至少一个属性。为训练子集的每个乘积识别构建块集合，并且从训练子集的每个乘积的所识别的构建块的特征形成输入特征向量。监督机器学习方法被用于推断映射函数，该映射函数将训练子集的每个乘积的输入特征向量变换为训练子集的每个乘积的对应的至少一个属性。在推测出映射函数之后，它用于从其相应的输入特征向量确定库的其他产品的属性。

5. 发明授权

US06569631B1 Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes 有权
标题翻译：使用5-（4'-二甲基氨基苯基）-2-（4'-苯基）恶唑衍生物荧光染料的配体发育的微板热转移测定
公开(公告)号：US06569631B1
公开(公告)日：2003-05-27
申请号：US09438357
申请日：1999-11-12
申请人： Michael W. Pantoliano , Eugenio C. Petrella , F. Raymond Salemme , Barry A. Springer
发明人： Michael W. Pantoliano , Eugenio C. Petrella , F. Raymond Salemme , Barry A. Springer
IPC分类号： G01N3353
CPC分类号： G01N33/582 , G01N33/5375
摘要： The present invention provides a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of unfolding due to a thermal change. The method comprises (a) contacting the target molecule with one molecule of a multiplicity of different molecules, in the presence of a 5-(4″-dimethylaminopheny-2-(4′-phenyl)oxazole derivative dye, in each of a multiplicity of containers; (b) simultaneously heating the multiplicity of containers; (c) measuring the fluorescence in each of the containers; (d) generating thermal unfolding information for the target molecule as a function of temperature for each of the containers; (e) comparing the thermal unfolding information obtained for each of the containers to the thermal unfolding information for the target molecule in the absence of any of the molecules in the multiplicity of different molecules; and (f) ranking the affinities of each of the molecules according to the difference in the thermal unfolding information between the target molecule in each of the containers and the target molecule in the absence of any of the molecules in the multiplicity of different molecules.
摘要翻译：本发明提供了一种用于对能够由于热变化而展开的靶分子的多种不同分子的亲和力进行排序的方法。该方法包括（a）在5-（4“ - 二甲基氨基苯基-2-（4'-苯基）恶唑衍生物染料存在下，将目标分子与多个不同分子的一个分子接触，容器的多样性;（b）同时加热多个容器;（c）测量每个容器中的荧光;（d）作为每个容器的温度的函数产生靶分子的热展开信息;（e ）在不存在多个不同分子中的任何分子的情况下将每个容器获得的热解折叠信息与目标分子的热解折叠信息进行比较;以及（f）根据在不同分子中多个分子中没有任何分子的情况下，每个容器中的目标分子与靶分子之间的热展开信息的差异。

6. 发明授权

US08820265B2 High-throughput operant sensory discrimination apparatus and method 有权
标题翻译：高通量手术感觉辨别装置及方法
公开(公告)号：US08820265B2
公开(公告)日：2014-09-02
申请号：US11275059
申请日：2005-12-06
申请人： R. Kyle Palmer , F. Raymond Salemme
发明人： R. Kyle Palmer , F. Raymond Salemme
IPC分类号： A01K29/00 , A01K15/02
CPC分类号： A61B5/4011 , A01K1/031 , A01K15/02 , A01K29/00 , A61B5/4017 , A61D3/00
摘要： Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.
摘要翻译：这里描述的是用于感觉辨别的各种装置和系统。通过使用多孔样品板，高通量分析装置和方法允许对大量样品的快速感官鉴别。

7. 发明授权

US09285363B2 Method of protein nanostructure fabrication 有权
标题翻译：蛋白质纳米结构制造方法
公开(公告)号：US09285363B2
公开(公告)日：2016-03-15
申请号：US13319989
申请日：2010-05-10
申请人： F. Raymond Salemme , Patricia C. Weber
发明人： F. Raymond Salemme , Patricia C. Weber
IPC分类号： B82Y5/00 , G01N33/543 , B81C1/00 , B82Y30/00
CPC分类号： G01N33/54386 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00725 , B81B2201/0214 , B81C1/00206 , B82Y30/00
摘要： A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the protein node to bond with the fixation site, so that the position and/or orientation of the protein node is constrained, and compositions.
摘要翻译：一种在表面上组装蛋白质纳米结构的方法，包括用固定部位选择性地图案化表面，使蛋白质节点与表面接触，并使蛋白质节点与固定部位结合，使得位置和/或取向的蛋白质节点被约束，并且组成。

8. 发明申请

US20120059156A1 METHOD OF PROTEIN NANOSTRUCTURE FABRICATION 有权
标题翻译：蛋白质纳米结构的制备方法
公开(公告)号：US20120059156A1
公开(公告)日：2012-03-08
申请号：US13319989
申请日：2010-05-10
申请人： F. Raymond Salemme , Patricia C. Weber
发明人： F. Raymond Salemme , Patricia C. Weber
IPC分类号： C07K16/46 , B82Y5/00 , B82Y40/00
CPC分类号： G01N33/54386 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00725 , B81B2201/0214 , B81C1/00206 , B82Y30/00
摘要： A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the protein node to bond with the fixation site, so that the position and/or orientation of the protein node is constrained, and compositions.
摘要翻译：一种在表面上组装蛋白质纳米结构的方法，包括用固定部位选择性地图案化表面，使蛋白质节点与表面接触，并使蛋白质节点与固定部位结合，使得位置和/或取向的蛋白质节点被约束，并且组成。

9. 发明申请

US20110224311A1 Natural Product Sweetness Enhancers 审中-公开
标题翻译：天然产品甜味增强剂
公开(公告)号：US20110224311A1
公开(公告)日：2011-09-15
申请号：US12838278
申请日：2010-07-16
申请人： R. Kyle Palmer , F. Raymond Salemme , Dennis Sprous
发明人： R. Kyle Palmer , F. Raymond Salemme , Dennis Sprous
IPC分类号： A61K47/26 , A23L1/221 , A61P43/00
CPC分类号： A23L2/60 , A23C9/1307 , A23L2/02 , A23L27/36 , A23V2002/00 , A23V2250/262 , A23V2250/6402 , A23V2250/606 , A23V2250/032 , A23V2250/628
摘要： The present invention is directed to the use of a compound of Formula I, or a stereoisomer thereof, wherein R2 is rhamnose, and R and R1 are each independently selected from the group consisting of hydrogen, glucose, and beta-sophorose, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and a compound of Formula I, or a stereoisomer thereof.
摘要翻译：本发明涉及式Ⅰ化合物或其立体异构体的用途，其中R 2是鼠李糖，R 1和R 2各自独立地选自氢，葡萄糖和β-槐糖，用于增强碳水化合物甜味剂如蔗糖和果糖的甜味。本发明还涉及包含碳水化合物甜味剂和式I化合物或其立体异构体的组合的消耗品。

10. 发明授权

US06940055B2 Microtiter plate with integral heater 有权
标题翻译：带有整体加热器的微量滴定板
公开(公告)号：US06940055B2
公开(公告)日：2005-09-06
申请号：US10172993
申请日：2002-06-18
申请人： Joseph Kwasnoski , F. Raymond Salemme
发明人： Joseph Kwasnoski , F. Raymond Salemme
IPC分类号： B01L3/00 , H05B6/00 , H05B6/64
CPC分类号： B01L3/50851 , Y10S435/809
摘要： A microtiter plate system includes an integral heater. In an embodiment, the integral heater includes a heater plate. In another embodiment, the integral heater includes resistive heater wires positioned beneath and/or between the wells of a microtiter plate. In an embodiment, the microtiter plate system includes optically clear well bottoms that permit sensing and measurement of samples through the optically clear well bottoms. In an implementation, an optically clear heater is positioned beneath the optically clear well bottoms. In an alternative implementation, resistive heater wires are positioned between the wells. In an embodiment, the microtiter plate system includes a microtiter plate lid with an integral heater, which can be implemented using a heater plate, resistive wires, and the like. In an embodiment, the microtiter plate system includes an integral non-contact heater, such as a ferrous plate and/or ferrous particles, powder and/or fibers, which generate heat when subjected to an electromagnetic field. An electromagnetic field can be generated by an inductive coil or the like. In an embodiment, the microtiter plate system includes an integral non-contact heater which generates heat when subjected to microwave radiation from a microwave generator. In an embodiment, the microtiter plate system includes an integral thermostat that maintains a substantially constant temperature in the microtiter plate system.
摘要翻译：微量滴定板系统包括一体式加热器。在一个实施例中，一体式加热器包括加热板。在另一个实施例中，积分加热器包括位于微量滴定板的孔之下和/或之间的电阻加热丝。在一个实施方案中，微量滴定板系统包括光学透明的井底，其允许通过光学透明的井底检测和测量样品。在一个实施方案中，光学透明加热器位于光学透明井底下方。在替代实施例中，电阻加热器线定位在井之间。在一个实施方案中，微量滴定板系统包括具有整体加热器的微量滴定板盖，其可以使用加热板，电阻丝等实现。在一个实施方案中，微量滴定板系统包括一体的非接触式加热器，例如铁质板和/或亚铁颗粒，粉末和/或纤维，其在经受电磁场时产生热量。可以通过感应线圈等产生电磁场。在一个实施方案中，微量滴定板系统包括一个整体的非接触式加热器，其在受到来自微波发生器的微波辐射时产生热量。在一个实施方案中，微量滴定板系统包括在微量滴定板系统中保持基本恒定的温度的整体恒温器。

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