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1. 发明申请

US20060246436A1 Method for judging sensibility to imatinib 审中-公开
标题翻译：判断伊马替尼敏感性的方法
公开(公告)号：US20060246436A1
公开(公告)日：2006-11-02
申请号：US10515051
申请日：2003-05-21
申请人： Ryuzo Ohno , Takashi Tsuruo , Yusuke Nakamura
发明人： Ryuzo Ohno , Takashi Tsuruo , Yusuke Nakamura
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： A method of judging whether a patient is sensitive to imatinib or not, in case where the patient is suffering from a disease such as CML to be treated by administration of imatinib, that is, a method for judging whether the administration of imatinib is effective for the therapy of the disease or not, is disclosed. Amounts of a plurality of genes selected from the group consisting of the specific 77 genes in sample cells separated from body are measured; and the measured amounts are compared with those of responders and non-responders to imatinib or a derivative thereof or a pharmaceutically acceptable salt thereof:
摘要翻译：判断患者是否对伊马替尼敏感的方法，在患者患有如待治疗伊马替尼治疗的CML等疾病的情况下，即判断伊马替尼的给药是否有效的方法公开了该疾病的治疗。测定从与身体分离的样品细胞中的特异性77个基因中选出的多个基因的量; 并将测量的量与伊马替尼或其衍生物或其药学上可接受的盐的应答者和无应答者的量进行比较：

2. 发明申请

US20060252056A1 Markers for responsiveness to an erbB receptor tyrosine kinase inhibitor 审中-公开
标题翻译：对erbB受体酪氨酸激酶抑制剂的反应的标记
公开(公告)号：US20060252056A1
公开(公告)日：2006-11-09
申请号：US11290173
申请日：2005-11-30
申请人： Takashi Tsuruo , Yusuke Nakamura , Saburo Sone , Masahiro Fukuoka
发明人： Takashi Tsuruo , Yusuke Nakamura , Saburo Sone , Masahiro Fukuoka
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to a set of isolated marker genes comprising at least one gene identified as having differential expression as between patients who are responders and non responders to an erbB receptor tyrosine kinase inhibitor; said gene set comprising one or more genes selected from at least the group consisting of the 51 genes listed herein including gene-specific oligonucleotides derived from said genes; and uses of such sets in diagnostic applications.
摘要翻译：本发明涉及一组分离的标记基因，其包含鉴定为具有差异表达的至少一个基因，所述差异表达在作为应答者的患者和对erbB受体酪氨酸激酶抑制剂的非应答者之间; 所述基因组包含一个或多个选自至少由本文所列的51个基因组成的组的基因，包括来源于所述基因的基因特异性寡核苷酸; 并在诊断应用中使用这样的组。

3. 发明授权

US09187556B2 SEMA5B peptides and vaccines including the same 有权
标题翻译： SEMA5B肽和疫苗包括它们
公开(公告)号：US09187556B2
公开(公告)日：2015-11-17
申请号：US14118693
申请日：2012-06-07
申请人： Takuya Tsunoda , Ryuji Osawa , Sachiko Yoshimura , Tomohisa Watanabe , Gaku Nakayama , Yusuke Nakamura
发明人： Takuya Tsunoda , Ryuji Osawa , Sachiko Yoshimura , Tomohisa Watanabe , Gaku Nakayama , Yusuke Nakamura
IPC分类号： C07K14/00 , C07K16/18 , C07K14/47 , G01N33/574 , A61K39/00 , A61K38/00
CPC分类号： C07K16/18 , A61K38/00 , A61K39/0011 , C07K14/4703 , G01N33/57492 , G01N2333/70539
摘要： As discussed in detail herein, isolated epitope peptides derived from SEMA5B bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines. The inventive peptides encompass both the above mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite HLA binding and/or CTL inducibility of the original sequences. Further provided are polynucleotides encoding any of the aforementioned peptides as well pharmaceutical agents or compositions that include any of the aforementioned peptides or polynucleotides. The peptides, polynucleotides, pharmaceutical agents or compositions of this invention find particular utility in the treatment and/or prevention of cancers and tumors, including, for example, esophageal cancer, NSCLC, RCC and SCLC.
摘要翻译：如本文详细讨论的，衍生自SEMA5B的分离的表位肽结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL），因此适合用于癌症免疫治疗，尤其是癌症疫苗的上下文中。本发明的肽包括上述氨基酸序列及其修饰形式，其中一个，两个或若干个氨基酸被取代，缺失，插入或添加，只要这些修饰版本保持必需的HLA结合和/或CTL诱导性原始序列。还提供了编码任何上述肽的多核苷酸以及包括任何上述肽或多核苷酸的药物试剂或组合物。本发明的肽，多核苷酸，药物或组合物特别用于治疗和/或预防癌症和肿瘤，包括例如食管癌，NSCLC，RCC和SCLC。

4. 发明授权

US09122906B2 Image processing device, image processing method, program, and recording medium for detection of epidermis pattern 有权
标题翻译：图像处理装置，图像处理方法，程序和用于检测表皮图案的记录介质
公开(公告)号：US09122906B2
公开(公告)日：2015-09-01
申请号：US13462949
申请日：2012-05-03
申请人： Yusuke Nakamura , Shinichiro Gomi
发明人： Yusuke Nakamura , Shinichiro Gomi
IPC分类号： G06K9/00 , G06T7/40
CPC分类号： G06K9/52 , A61B5/441 , G06K9/0014 , G06K9/46 , G06K2009/4666 , G06T7/0012 , G06T7/0014 , G06T7/40 , G06T2207/30088
摘要： An epidermis pattern detection unit detects epidermis patterns in an epidermis image captured from the epidermis of skin by an epidermis image capturing unit. An acquired element analysis unit analyzes uniformity of shapes of the epidermis patterns in the epidermis image. A texture evaluation unit evaluates a texture state of the skin based on the uniformity of shapes of the epidermis patterns. The present technology, for example, may be applied to systems that evaluate the texture state of the skin.
摘要翻译：表皮图案检测单元通过表皮图像捕获单元检测从皮肤表皮捕获的表皮图像中的表皮图案。获得性元素分析单元分析表皮形态中表皮形态的均匀性。纹理评估单元基于表皮图案的形状的均匀性来评估皮肤的纹理状态。例如，本技术可以应用于评估皮肤纹理状态的系统。

5. 发明授权

US09045557B2 NEIL3 peptides and vaccines including the same 有权
标题翻译： NEIL3肽和疫苗包括它们
公开(公告)号：US09045557B2
公开(公告)日：2015-06-02
申请号：US13256580
申请日：2010-03-15
申请人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe , Yusuke Nakamura , Yoichi Furukawa
发明人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe , Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K38/00 , C07K14/47 , A61K39/00
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , A61K39/39 , A61K2039/53 , A61K2039/572 , C12N9/88 , C12Y402/99018 , Y02A50/396
摘要： The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include the above mentioned amino acid sequence with substitution deletion, or addition of one, two, or several amino acids sequences. The invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for diagnosing or treating cancer.
摘要翻译：本发明提供分离的肽或衍生自SEQ ID NO：45的片段，其结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL）。肽可以包括具有取代缺失的上述氨基酸序列，或加入一个，两个或几个氨基酸序列。本发明还提供了包括这些肽的药物组合物。本发明的肽可用于诊断或治疗癌症。

6. 发明授权

US08951975B2 ECT2 peptides and vaccines including the same 有权
标题翻译： ECT2肽和疫苗包括它们
公开(公告)号：US08951975B2
公开(公告)日：2015-02-10
申请号：US13638272
申请日：2011-03-30
申请人： Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
发明人： Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
IPC分类号： A61K38/08 , A61K38/10 , A61K38/00 , A61K38/04 , C07K7/06 , A61K39/00
CPC分类号： C07K7/06 , A61K39/0011 , A61K2039/572
摘要： Isolated peptides derived from SEQ ID NO: 42 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines, are described herein. The inventive peptides encompass both the afore-mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite HLA binding and/or CTL inducibility of the original sequences. Further provided are nucleic acids encoding any of the aforementioned peptides as well as pharmaceutical agents, substances and/or compositions that include or incorporate any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical agents, substances and compositions of this invention find particular utility in the treatment of cancers and tumors, including, for example, bladder cancer, breast cancer, cervical cancer, cholangiocellular carcinoma, CML, colorectal cancer, esophageal cancer, NSCLC, lymphoma, pancreatic cancer, prostate cancer, renal carcinoma and SCLC.
摘要翻译：衍生自SEQ ID NO：42的分离的肽及其与HLA抗原结合并诱导细胞毒性T淋巴细胞（CTL）的片段，因此适用于癌症免疫治疗，特别是癌症疫苗的上下文中。本发明的肽包括上述氨基酸序列及其修饰形式，其中一个，两个或几个氨基酸被取代，缺失，插入或添加，只要这些修饰版本保留所需的HLA结合和/或CTL诱导性的原始序列。还提供了编码任何前述肽的核酸以及包括或掺入任何前述肽或核酸的药物，物质和/或组合物。本发明的肽，核酸，药物，物质和组合物在治疗癌症和肿瘤方面特别有用，包括例如膀胱癌，乳腺癌，子宫颈癌，胆管细胞癌，CML，结肠直肠癌，食管癌，NSCLC，淋巴瘤，胰腺癌，前列腺癌，肾癌和SCLC。

7. 发明授权

US08828712B2 Genetic detection and determination apparatus and method, gene reactor, and incubator 有权
标题翻译：遗传检测和测定仪器和方法，基因反应器和培养箱
公开(公告)号：US08828712B2
公开(公告)日：2014-09-09
申请号：US12452345
申请日：2008-06-27
申请人： Masahiko Amano , Masaaki Chino , Hiroyuki Kuroki , Makiko Dejima , Tomoyuki Ozawa , Eiji Kawata , Ryoko Imagawa , Shuichi Akashi , Yusuke Nakamura , Eiji Yamamoto , Katsuhiro Tomaru , Hajime Mogi
发明人： Masahiko Amano , Masaaki Chino , Hiroyuki Kuroki , Makiko Dejima , Tomoyuki Ozawa , Eiji Kawata , Ryoko Imagawa , Shuichi Akashi , Yusuke Nakamura , Eiji Yamamoto , Katsuhiro Tomaru , Hajime Mogi
IPC分类号： C12M1/00 , C12M1/34 , C12M1/36 , C12M1/38 , C12M3/00 , B01L7/00 , B01L3/00 , G01N35/02 , G01N35/00
CPC分类号： B01L7/52 , B01L3/505 , B01L3/50851 , B01L7/5255 , B01L2200/0642 , B01L2300/0829 , B01L2300/123 , G01N35/026 , G01N2035/00346 , H01L2924/0002 , H01L2924/00
摘要： A genetic detection and determination apparatus which detects or determines genetic information, provided with a reaction container having a reaction vessel, including: a container set portion on which the reaction container is set; a moving mechanism which moves the container set portion along a track; a reaction vessel dividing portion which divides the reaction vessel into a plurality of reaction chambers by deforming the reaction vessel; a heating and cooling portion which heats and cools the reaction container; and a measuring portion which is movable above the container set portion in parallel to an upper surface of the reaction container provided on the container set portion and which measures a reaction within each of the reaction chambers.
摘要翻译：一种检测或确定遗传信息的遗传检测和确定装置，其具有包括反应容器的反应容器，包括：设置反应容器的容器组合部分; 移动机构，其沿着轨道移动容器设定部; 反应容器分隔部，其通过使反应容器变形而将反应容器分割成多个反应室; 加热和冷却反应容器的加热和冷却部分; 以及测量部分，其在容器设置部分上方平行于设置在容器组部分上的反应容器的上表面上移动并且测量每个反应室内的反应。

8. 发明授权

US08771963B2 Method of diagnosing esophageal cancer 有权
标题翻译：诊断食管癌的方法
公开(公告)号：US08771963B2
公开(公告)日：2014-07-08
申请号：US13246639
申请日：2011-09-27
申请人： Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
IPC分类号： C12Q1/00 , G01N1/00 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y10T436/25
摘要： In order to identify the molecules involved in esophageal carcinogenesis and those to be useful for diagnostic markers as well as targets for new drugs and immunotherapy, a cDNA microarray representing 32,256 genes was constructed to analyze the expression profiles of 19 esophageal squamous-cell carcinomas (ESCCS) purified by laser-capture microdissection. A detailed genome-wide database for sets of genes that are significantly up- or down-regulated in esophageal cancer is disclosed herein. These genes find use in the development of therapeutic drugs or immunotherapy as well as tumor markers. Additionally, genes associated with lymph-node metastasis and post-surgery recurrence are disclosed herein. Among the candidate molecular target genes, ECT2, CDC45L and DKK1 are further characterized. Treatment of ESCC cells with small interfering RNAs (siRNAs) of ECT2 or CDC45L suppressed growth of the cancer cells. Thus, the data herein provide valuable information for identifying diagnostic systems and therapeutic target molecules for esophageal cancer.
摘要翻译：为了鉴定涉及食管癌发生的分子以及可用于诊断标志物以及新药和免疫治疗靶标的分子，构建了代表32,256个基因的cDNA微阵列，分析19例食管鳞状细胞癌（ESCCS）的表达谱）通过激光捕获显微切割纯化。本文公开了在食管癌中显着上调或下调的基因组的详细全基因组数据库。这些基因可用于治疗药物或免疫治疗以及肿瘤标志物的开发。此外，本文公开了与淋巴结转移和手术后复发相关的基因。在候选分子靶基因中，进一步表征ECT2，CDC45L和DKK1。用ECT2或CDC45L的小干扰RNA（siRNA）处理ESCC细胞抑制癌细胞的生长。因此，本文的数据提供了用于鉴定诊断系统和用于食管癌的治疗靶分子的有价值的信息。

9. 发明申请

US20140178409A1 SEMA5B PEPTIDES AND VACCINES INCLUDING THE SAME 有权
标题翻译： SEMA5B肽和疫苗，包括它们
公开(公告)号：US20140178409A1
公开(公告)日：2014-06-26
申请号：US14118693
申请日：2012-06-07
申请人： Takuya Tsunoda , Ryuji Osawa , Sachiko Yoshimura , Tomohisa Watanabe , Gaku Nakayama , Yusuke Nakamura
发明人： Takuya Tsunoda , Ryuji Osawa , Sachiko Yoshimura , Tomohisa Watanabe , Gaku Nakayama , Yusuke Nakamura
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K38/00 , A61K39/0011 , C07K14/4703 , G01N33/57492 , G01N2333/70539
摘要： As discussed in detail herein, isolated epitope peptides derived from SEMA5B bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines. The inventive peptides encompass both the above mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite HLA binding and/or CTL inducibility of the original sequences. Further provided are polynucleotides encoding any of the aforementioned peptides as well pharmaceutical agents or compositions that include any of the aforementioned peptides or polynucleotides. The peptides, polynucleotides, pharmaceutical agents or compositions of this invention find particular utility in the treatment and/or prevention of cancers and tumors, including, for example, esophageal cancer, NSCLC, RCC and SCLC.
摘要翻译：如本文详细讨论的，衍生自SEMA5B的分离的表位肽结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL），因此适合用于癌症免疫治疗，尤其是癌症疫苗的上下文中。本发明的肽包括上述氨基酸序列及其修饰形式，其中一个，两个或若干个氨基酸被取代，缺失，插入或添加，只要这些修饰版本保持必需的HLA结合和/或CTL诱导性原始序列。还提供了编码任何上述肽的多核苷酸以及包括任何上述肽或多核苷酸的药物试剂或组合物。本发明的肽，多核苷酸，药物或组合物特别用于治疗和/或预防癌症和肿瘤，包括例如食管癌，NSCLC，RCC和SCLC。

10. 发明授权

US08697068B2 Method for treating synovial sarcoma 有权
标题翻译：滑膜肉瘤治疗方法
公开(公告)号：US08697068B2
公开(公告)日：2014-04-15
申请号：US12769599
申请日：2010-04-28
申请人： Yusuke Nakamura , Toyomasa Katagiri , Chikako Fukukawa , Motoki Kuhara
发明人： Yusuke Nakamura , Toyomasa Katagiri , Chikako Fukukawa , Motoki Kuhara
IPC分类号： A61K39/395 , A61K35/12
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K2317/34 , C07K2317/732 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for treating or preventing a disease that is associated with Frizzled homologue 10 (FZD10) in a subject is provided.
摘要翻译：公开了使用差异表达基因检测滑膜肉瘤的方法。还公开了鉴定用于治疗滑膜肉瘤的药剂的方法。此外，提供了治疗或预防与受试者中的卷曲同源物10（FZD10）相关的疾病的方法。

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