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1. 发明申请

US20140134637A1 METHODS OF MODULATING SMYD3 FOR TREATMENT OF CANCER 审中-公开
标题翻译：调节SMYD3治疗癌症的方法
公开(公告)号：US20140134637A1
公开(公告)日：2014-05-15
申请号：US13092770
申请日：2011-04-22
申请人： Yusuke Nakamura , Yoichi Furukawa , Ryuji Hamamoto , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Yoichi Furukawa , Ryuji Hamamoto , Shuichi Nakatsuru
IPC分类号： G01N33/50
CPC分类号： G01N33/5011 , C12Q1/48 , C12Y201/01043 , G01N33/57407 , G01N2333/4736 , G01N2333/91011 , G01N2500/02
摘要： The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified.
摘要翻译：本发明的特征在于确定多肽的甲基转移酶活性并筛选甲基转移酶活性的调节剂的方法，更特别是用于通过SMYD3进行视网膜母细胞瘤甲基化的调节剂。本发明还提供了使用所鉴定的调节剂预防或治疗结肠直肠癌，肝细胞癌，膀胱癌和/或乳腺癌的方法或药物组合物。

2. 发明申请

US20130084578A1 BREAST CANCER RELATED GENE ZNFN3A1 审中-公开
公开(公告)号：US20130084578A1
公开(公告)日：2013-04-04
申请号：US13076137
申请日：2011-03-30
申请人： Yusuke Nakamura , Yoichi Furukawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Yoichi Furukawa , Shuichi Nakatsuru
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C07K14/4748 , C12N9/1007 , C12N15/1137 , C12N2310/14 , C12Q1/48 , C12Q1/6886 , C12Q2600/136 , G01N33/573 , G01N33/57415 , G01N2333/91011 , G01N2500/00
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. Also described are methods of treating and preventing breast cancer and breast cancer metastasis as well as methods of assessing the prognosis of a breast cancer subject and the efficacy of a breast cancer therapy. In one embodiment, the diagnostic method involves determining the expression level of ZNFN3A1, a gene whose expression is markedly elevated in breast cancers, that therefore can be used to discriminate between BRC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of BRC, methods of treating BRC and method for vaccinating a subject against BRC.

3. 发明申请

US20120149762A1 Gene and Protein Relating to Hepatocellular Carcinoma and Methods of Use Thereof 审中-公开
标题翻译：与肝细胞癌相关的基因和蛋白质及其使用方法
公开(公告)号：US20120149762A1
公开(公告)日：2012-06-14
申请号：US13403623
申请日：2012-02-23
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K31/713 , C12N15/62 , C12N5/10 , C12N1/21 , C12N9/10 , A61P35/00 , G01N33/573 , C12Q1/18 , C12Q1/68 , C07H21/02 , C07H21/00 , C12N15/113 , C12N15/54 , C07K16/40
CPC分类号： C07K14/4748 , C12Q1/6809 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides a novel human gene ZNFN3A1 whose expression is markedly elevated in a great majority of HCCs compared to corresponding non-cancerous liver tissues. The gene encodes a protein having a zinc finger domain as well as a SET domain and has been found to form a regulatory complex with RNA helicase and RNA polymerase.
摘要翻译：本发明提供了一种新的人基因ZNFN3A1，与相应的非癌性肝组织相比，其大部分HCC中的表达显着升高。该基因编码具有锌指结构域和SET结构域的蛋白质，并且已经发现与RNA解旋酶和RNA聚合酶形成调节复合物。

4. 发明申请

US20100291567A1 GENES AND POLYPEPTIDES RELATING TO HEPATOCELLULAR OR COLORECTAL CARCINOMA 有权
标题翻译：与肝细胞癌或染色体癌相关的基因和多肽
公开(公告)号：US20100291567A1
公开(公告)日：2010-11-18
申请号：US12699711
申请日：2010-02-03
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： C12Q1/68
CPC分类号： C07K16/303 , A61K38/00 , C07K14/4748 , C07K16/3046 , G01N33/57419 , G01N33/57438 , G01N33/6893 , G01N2500/00
摘要： The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译：本申请提供了新的人类基因WDRPUH和KRZFPUH，和PPIL1，其表达在大多数HCC和结肠直肠癌中分别与相应的非癌组织相比显着升高，以及新型人基因APCDD1，其表达升高原发性结肠癌并且响应于野生型APC1转导入结肠癌细胞而下调。由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

5. 发明申请

US20090136508A1 METHOD OF DIAGNOSING COLON AND GASTRIC CANCERS 审中-公开
标题翻译：诊断结肠癌和胃癌的方法
公开(公告)号：US20090136508A1
公开(公告)日：2009-05-28
申请号：US12250419
申请日：2008-10-13
申请人： Yusuke NAKAMURA , Yoichi Furukawa
发明人： Yusuke NAKAMURA , Yoichi Furukawa
IPC分类号： A61K39/395 , C07K14/435 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , A61K39/00 , A61K38/17 , C12N5/02 , C07K16/18 , C07H21/02 , C12Q1/68 , G01N33/53 , A61K31/7088
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/57419 , G01N33/57446 , G01N2500/00
摘要： Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer-associated gene that discriminate between colon or gastric cancer and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of colonic cancer and method of vaccinating a subject against colon or gastric cancer.
摘要翻译：本文描述了用于检测和诊断结肠直肠癌和胃癌的客观方法。在一个实施方案中，诊断方法涉及确定区分结肠癌或胃癌和正常细胞的结肠癌或胃癌相关基因的表达水平。本发明进一步提供筛选用于治疗结肠癌的治疗剂的方法以及接种对抗结肠癌或胃癌的方法。

6. 发明授权

US07425612B2 Genes and polypeptides relating to human colon cancers 有权
标题翻译：与人结肠癌相关的基因和多肽
公开(公告)号：US07425612B2
公开(公告)日：2008-09-16
申请号：US10916064
申请日：2004-08-10
申请人： Yusuke Nakamura , Yoichi Furukawa , Hideaki Tahara , Takuya Tsunoda
发明人： Yusuke Nakamura , Yoichi Furukawa , Hideaki Tahara , Takuya Tsunoda
IPC分类号： C07K14/00 , C07K5/00
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译：本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

7. 发明申请

US20080199468A1 Method For Diagnosing Colorectal Cancers 审中-公开
标题翻译：诊断结肠直肠癌的方法
公开(公告)号：US20080199468A1
公开(公告)日：2008-08-21
申请号：US10589594
申请日：2004-02-24
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/00 , C40B30/04 , C07H21/04 , A61P1/00 , C12N15/00 , A61K39/00 , C12Q1/34 , A61K31/70
CPC分类号： A61K39/0011 , C12Q1/6886 , C12Q2600/136 , G01N33/57419 , G01N2500/10
摘要： Objective methods for detecting and diagnosing colorectal cancer (CRC) are described herein. In one embodiment, the diagnostic method involves the determining an expression level of C10orf3 that discriminate between CRC and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CRC, methods of treating CRC and method of vaccinating a subject against CRC.
摘要翻译：本文描述了用于检测和诊断结肠直肠癌（CRC）的客观方法。在一个实施方案中，诊断方法涉及确定区分CRC和正常细胞的C10orf3的表达水平。本发明还提供了筛选用于治疗CRC的治疗剂的方法，CRC的治疗方法以及针对CRC接种个体的方法。

8. 发明申请

US20070155689A1 METHODS OF REGULATING GROWTH AND DEATH OF CANCER CELLS 审中-公开
标题翻译：调节癌细胞生长和死亡的方法
公开(公告)号：US20070155689A1
公开(公告)日：2007-07-05
申请号：US11626540
申请日：2007-01-24
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K48/00 , C12Q1/68 , C12N15/09
CPC分类号： G01N33/57438 , A61K38/1709 , A61K48/00 , G01N33/5011 , G01N2500/00
摘要： This invention demonstrates that the PEG10 protein suppresses apoptosis and promotes cancer cell growth. Furthermore, PEG10 protein was found to be degraded through interaction with SIAH1 protein. This invention provides methods of regulating cell growth and cell death using the PEG10 protein. Furthermore, the present invention provides methods of screening for novel anticancer agents which use the PEG10 protein. The screening of this invention enables development of pharmaceutical agents that induce apoptosis and suppress cell growth by specifically targeting cancer cells. In particular, since the PEG10 protein is specifically expressed in hepatoma cells, it is an ideal target molecule for diagnosis and treatment of hepatoma.
摘要翻译：本发明证明PEG10蛋白抑制凋亡并促进癌细胞生长。此外，发现PEG10蛋白通过与SIAH1蛋白的相互作用而降解。本发明提供了使用PEG10蛋白调节细胞生长和细胞死亡的方法。此外，本发明提供筛选使用PEG10蛋白质的新型抗癌剂的方法。本发明的筛选能够开发诱导细胞凋亡并通过特异性靶向癌细胞抑制细胞生长的药剂。特别是由于PEG10蛋白在肝癌细胞中特异性表达，因此是用于诊断和治疗肝癌的理想靶分子。

9. 发明申请

US20070054849A1 Method for diagnosing hepatocellular carcinomas 审中-公开
标题翻译：诊断肝细胞癌的方法
公开(公告)号：US20070054849A1
公开(公告)日：2007-03-08
申请号：US10572932
申请日：2004-09-14
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K48/00 , A61K38/55 , C12Q1/68 , G01N33/567
CPC分类号： C12Q1/6886 , A61K39/0011 , A61K2039/57 , C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12Q2600/136 , G01N33/57438 , G01N2500/00
摘要： Objective methods for detecting, diagnosing, treating and preventing hepatocellular carcinoma (HCC) are described herein. In particular, the present invention relates to two genes up-regulated in HCC cells as compared to normal cells, referred to herein as MGC47816 and HES6. In one embodiment, the diagnostic method involves the determining the expression level of MGC47816 or HES6 that discriminate between hepatocellular carcinoma cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of HCC, methods of treating HCC, and methods for vaccinating a subject against HCC.
摘要翻译：本文描述了检测，诊断，治疗和预防肝细胞癌（HCC）的客观方法。特别地，本发明涉及与正常细胞相比，在本文中称为MGC47816和HES6的HCC细胞中上调的两种基因。在一个实施方案中，诊断方法涉及确定区分肝细胞癌细胞和正常细胞的MGC47816或HES6的表达水平。本发明还提供筛选用于治疗HCC的治疗剂，治疗HCC的方法，以及针对HCC接种受试者的方法。

10. 发明申请

US20060199179A1 Method for diagnosis of colorectal tumors 审中-公开
标题翻译：诊断结肠直肠肿瘤的方法
公开(公告)号：US20060199179A1
公开(公告)日：2006-09-07
申请号：US10518938
申请日：2002-12-05
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides objective methods for detecting and diagnosing colorectal cancers and pre-malignant lesions. For example, the methods disclosed herein can reliably detect very early-stage colorectal cancers. In one embodiment, the diagnostic method involves the scoring of gene expression profiles that discriminate between adenomas and carcinomas. The profile score calculated acts as diagnostic indicator that can objectively indicate whether a sample tissue is non-cancerous, pre-cancerous, or cancerous. The present invention further provides methods of diagnosing colorectal tumors in a subject, methods of screening for therapeutic agents useful in the treatment of colorectal tumors, methods of treating colorectal tumors and method of vaccinating a subject against colorectal tumors.
摘要翻译：本发明提供了用于检测和诊断结肠直肠癌和恶性前病变的客观方法。例如，本文公开的方法可以可靠地检测非常早期的结肠直肠癌。在一个实施方案中，诊断方法包括区分腺瘤和癌的基因表达谱的评分。计算出的分布分数作为诊断指标，可以客观地指示样品组织是否为非癌性，癌前或癌性。本发明还提供诊断受试者的结肠直肠肿瘤的方法，筛选用于治疗结肠直肠肿瘤的治疗剂的方法，治疗结肠直肠肿瘤的方法和接种受试者抵抗结肠直肠肿瘤的方法。

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