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1. 发明申请

US20100062509A1 HIGHLY POROUS MAGNETIC TEMPORARY FIXED BED 失效
标题翻译：高多孔磁性固定床
公开(公告)号：US20100062509A1
公开(公告)日：2010-03-11
申请号：US12306345
申请日：2007-07-04
申请人： Rudolf Hausmann , Matthias Franzreb
发明人： Rudolf Hausmann , Matthias Franzreb
IPC分类号： B01D35/06 , C12N9/00 , C07K14/00 , C07K2/00 , C07H21/00 , C07H1/06
CPC分类号： B01J20/28026 , B01D15/1807 , B01J20/28004 , B01J20/28009 , B01J20/28033 , B01J20/3242 , B01J20/3244 , B03C1/286 , B03C1/288
摘要： The present invention relates to a fixed bed, for example for the isolation and/or purification of components originating from a biological system, which fixed bed comprises magnetic beads and a magnetizable fabric arranged at least in part in the fixed bed, a fluidized bed-fixed bed, which comprises the fixed bed of the invention after application of an alternating magnetic field, and also to a process for the isolation and/or purification of components originating from a biological system.
摘要翻译：本发明涉及一种固定床，例如用于分离和/或净化源自生物系统的组分，该固定床包括磁珠和至少部分地布置在固定床中的可磁化织物，流化床 - 固定床，其在施加交变磁场之后包括本发明的固定床，以及用于分离和/或纯化源自生物系统的组分的方法。

2. 发明授权

US08303822B2 Highly porous magnetic temporary fixed bed 失效
标题翻译：高度多孔磁性临时固定床
公开(公告)号：US08303822B2
公开(公告)日：2012-11-06
申请号：US12306345
申请日：2007-07-04
申请人： Rudolf Hausmann , Matthias Franzreb
发明人： Rudolf Hausmann , Matthias Franzreb
IPC分类号： B01D35/06 , B03C1/00
CPC分类号： B01J20/28026 , B01D15/1807 , B01J20/28004 , B01J20/28009 , B01J20/28033 , B01J20/3242 , B01J20/3244 , B03C1/286 , B03C1/288
摘要： The present invention relates to a fixed bed, for example for the isolation and/or purification of components originating from a biological system, which fixed bed comprises magnetic beads and a magnetizable fabric arranged at least in part in the fixed bed, a fluidized bed-fixed bed, which comprises the fixed bed of the invention after application of an alternating magnetic field, and also to a process for the isolation and/or purification of components originating from a biological system.
摘要翻译：本发明涉及一种固定床，例如用于分离和/或净化源自生物系统的组分，该固定床包括磁珠和至少部分地布置在固定床中的可磁化织物，流化床 - 固定床，其在施加交变磁场之后包括本发明的固定床，以及用于分离和/或纯化源自生物系统的组分的方法。

3. 发明授权

US09757767B2 Device and method for producing highly porous, crystalline surface coatings 有权
公开(公告)号：US09757767B2
公开(公告)日：2017-09-12
申请号：US14116014
申请日：2012-05-25
申请人： Christof Woell , Osama Shekhah , Matthias Franzreb , Hasan Arslan , Jonas Wohlgemuth , Roland Fischer
发明人： Christof Woell , Osama Shekhah , Matthias Franzreb , Hasan Arslan , Jonas Wohlgemuth , Roland Fischer
IPC分类号： B05D1/02 , B05D1/38 , B05D3/04 , H01L21/67 , B05D3/10 , B05D7/00 , B01D67/00 , B01D71/00 , B05B7/24
CPC分类号： B05D1/38 , B01D67/0072 , B01D71/00 , B01D2323/42 , B05B7/2489 , B05D1/02 , B05D3/0466 , B05D3/0486 , B05D3/107 , B05D7/56 , B05D2203/30 , B05D2401/10 , H01L21/6715 , Y10T428/249953
摘要： The present invention relates to a device, the use thereof and a method for producing highly porous, crystalline surface coatings comprising at least two spraying devices operating in sequential sequence for applying coating agents from the storage vessels (3, 4) to a material arranged on a sample holder (1) and at least one rinsing device (5, 13, 16) for removing unbound molecules from the coated surface.

4. 发明申请

US20080035541A1 Semipermeable membrane system for magnetic particle fractions 失效
$Semipermeable membrane system for magnetic particle fractions$
标题翻译：用于磁性颗粒级分的半透膜系统
公开(公告)号：US20080035541A1
公开(公告)日：2008-02-14
申请号：US11705337
申请日：2007-02-12
申请人： Matthias Franzreb , Tilmann Rogge
发明人： Matthias Franzreb , Tilmann Rogge
IPC分类号： B03C1/30 , B01D21/30
CPC分类号： B01D61/002 , B01D69/02 , B01D69/06 , B01D71/022
摘要： In a semi-permeable membrane system for separating magnetic particle fractions from a mixture contained in a first fluid, comprising a membrane with opposite membrane surfaces between which passages extend and which separates the first fluid from a second fluid each of which is in contact with one of the membrane surfaces, means are provided for generating a reversible pressure differential between the two fluids across the membrane and means for generating and eliminating a magnetic field in the membrane for alternately causing a fluid flow through the membrane in opposite directions wherein, during the fluid flow in one direction, the magnetic field is switched on to hold the magnetic particles in place in the membrane and, during fluid flow in the opposite flow direction, the magnetic field is switched off to permit the magnetic particles to be moved through the membrane in the other direction.
摘要翻译：在用于从包含在第一流体中的混合物中分离磁性颗粒部分的半透膜系统中，包括具有相反膜表面的膜，通道延伸并且将第一流体与第二流体分离，第二流体与第一流体接触提供了用于在跨过膜的两种流体之间产生可逆压力差的装置，以及用于产生和消除膜中的磁场的装置，用于交替地使流体沿相反方向流过膜，其中在流体在一个方向上流动，磁场被接通以将磁性颗粒保持在膜中的适当位置，并且在相反流动方向的流体流动期间，磁场被切断以允许磁性颗粒通过膜移动通过膜另一个方向。

5. 发明授权

US07691264B2 Semipermeable membrane system for magnetic particle fractions 失效
$Semipermeable membrane system for magnetic particle fractions$
标题翻译：用于磁性颗粒级分的半透膜系统
公开(公告)号：US07691264B2
公开(公告)日：2010-04-06
申请号：US11705337
申请日：2007-02-12
申请人： Matthias Franzreb , Tilmann Rogge
发明人： Matthias Franzreb , Tilmann Rogge
IPC分类号： B01D35/06
CPC分类号： B01D61/002 , B01D69/02 , B01D69/06 , B01D71/022
摘要： In a semi-permeable membrane system for transferring magnetic particle fractions contained in a first fluid to a second fluid, comprising a membrane through which passages extend and which separates the first fluid from the second fluid being a pressure generation arrangement is provided for generating a reversible pressure differential between the two fluids across the membrane for alternately causing fluid movement in the membrane in opposite directions and a magnetic field generator is provided for alternately generating a magnetic field in the membrane wherein, during the fluid movement in one direction, the magnetic field is switched on to hold the magnetic particles in place in the membrane and, during fluid flow in the opposite flow direction, the magnetic field is switched off to permit the magnetic particles to be moved through the membrane in the other direction.
摘要翻译：在用于将包含在第一流体中的磁性颗粒部分转移到第二流体的半透膜系统中，包括通道延伸并且将第一流体与第二流体分离的膜是压力产生装置的膜，用于产生可逆的跨过膜的两种流体之间的压差用于交替地使相对方向上的膜中的流体运动和磁场发生器用于在膜中交替产生磁场，其中在一个方向上的流体运动期间磁场为接通以将磁性颗粒保持在膜中的适当位置，并且在相反流动方向的流体流动期间，磁场被切断以允许磁性颗粒在另一个方向上移动通过膜。

6. 发明授权

US07506765B2 High gradient magnetic separator 有权
标题翻译：高梯度磁选机
公开(公告)号：US07506765B2
公开(公告)日：2009-03-24
申请号：US11156699
申请日：2005-06-20
申请人： Matthias Franzreb , Christian Reichert
发明人： Matthias Franzreb , Christian Reichert
IPC分类号： B03C1/00
CPC分类号： B03C1/0332 , B03C1/03 , B03C1/032
摘要： In a high-gradient magnetic separator for the selective separation of magnetic particles from a suspension which is conducted through a matrix of plate-like separation structures of a magnetic material which are disposed in a magnetic field and through which the suspension is conducted, alternate plates of the separation structures are movable relative to the other plates which are stationary and are all mounted on a carrier by which they can be moved relative to the stationary plates at least during cleaning of the plates for the removal of magnetic particles collected on the plates.
摘要翻译：在用于从悬浮液中选择性分离磁性颗粒的高梯度磁选机中，该悬浮液通过设置在磁场中的磁性材料的板状分离结构的基质导入并通过其悬挂，交替的板分离结构相对于静止的其他板可移动，并且都安装在载体上，至少在清洁板期间，它们可以相对于固定板移动以去除收集在板上的磁性颗粒。

7. 发明申请

US20100116747A1 METHOD FOR MAGNETICALLY SUPPORTED EXTRACTION 有权
标题翻译：用于磁性支持提取的方法
公开(公告)号：US20100116747A1
公开(公告)日：2010-05-13
申请号：US12597952
申请日：2008-04-23
申请人： Matthias Franzreb , Joerg Becker
发明人： Matthias Franzreb , Joerg Becker
IPC分类号： B03C1/30 , B03C1/02
CPC分类号： G01N33/54326 , B01D11/0419 , B01D11/0457 , B01D11/0488 , B03C1/002 , B03C1/28 , B03C2201/26
摘要： A method for magnetically assisted extraction of a target substance from an aqueous solution containing a plurality components includes mixing a surfactant and functional magnetic particles having affinity for the target substance into the aqueous solution containing the target substance so as to bind the target substance to the functional magnetic particles and form a particle-containing single-phase aqueous surfactant solution. The particle-containing single-phase aqueous surfactant solution is transitioned to a two-phase state, a first particle- and surfactant-containing disperse phase being formed within a surrounding second phase. The first particle- and surfactant-containing disperse phase and the surrounding second phase are separated using a magnetic field. The first particle- and surfactant-containing disperse phase are separated.
摘要翻译：从含有多种组分的水溶液中磁性辅助提取目标物质的方法包括将表面活性剂和对目标物质具有亲和性的功能性磁性颗粒混合到含有目标物质的水溶液中以将目标物质与功能性物质结合磁性颗粒并形成含颗粒的单相水性表面活性剂溶液。含颗粒的单相水性表面活性剂溶液转变成两相状态，在周围的第二相中形成含有第一颗粒和表面活性剂的分散相。使用磁场分离第一含颗粒和表面活性剂的分散相和周围的第二相。分离第一个含有颗粒和表面活性剂的分散相。

8. 发明授权

US07223345B2 High-gradient magnetic filter and method for the separation of weakly magnetisable particles from fluid media 有权
标题翻译：高梯度磁性过滤器和用于从流体介质中分离弱磁化颗粒的方法
公开(公告)号：US07223345B2
公开(公告)日：2007-05-29
申请号：US10473714
申请日：2002-04-04
申请人： Matthias Franzreb , Harald Leinen , Götz Warlitz
发明人： Matthias Franzreb , Harald Leinen , Götz Warlitz
IPC分类号： B03C1/033
CPC分类号： B03C1/0332 , B03C1/288 , B03C2201/18
摘要： High-gradient magnetic filter and method for the separation of weakly magnetisable particles from fluid media (2) in a circuit, embodied as a compact, low-maintenance unit with low repair requirements, comprising a housing (1), for the high gradient magnetic filter, with means for directing the flowing medium (2) in a pipe system with a feed (3) and return (4), a magnetic circuit (5), forming the high-gradient magnet filter in which at least one filter (8) is arranged in a filter chamber (7), formed between the pole faces (6) of the magnetic circuit (5), through which the medium (2) for purification flows, at least one permanent magnet (9), arranged in the magnetic circuit (5), for generation of a magnetic field between the pole faces (6). The magnetic circuit (5) is separated and sealed off from the flowing medium, the magnetic field between the pole faces (6) may be alternately switched on and off by means of the permanent magnet (9), whereupon the discharge and the operation of separating off the particles from the flowing medium may be achieved simply and economically.
摘要翻译：高梯度磁性过滤器和用于将弱可磁化颗粒与电路中的流体介质（2）分离的方法，体现为具有低修复要求的紧凑，低维护单元，包括用于高梯度磁性的壳体（1）过滤器，具有用于将管道系统中的流动介质（2）引导到具有进料（3）和返回件（4））的装置，形成高梯度磁体过滤器的磁路（5），其中至少一个过滤器（8））布置在过滤室（7）中，形成在磁路（5）的极面（6）之间，用于净化的介质（2）通过该过滤室流过，至少一个永磁体（9）磁路（5），用于在极面（6）之间产生磁场。磁流体（5）与流动介质分离并密封，磁极面（6）之间的磁场可以通过永磁体（9）交替地接通和断开，于是放电和操作从流动介质中分离颗粒可以简单且经济地实现。

9. 发明授权

US06942806B2 Method for separating a dispersed or dissolved substance and magnet separator 有权
标题翻译：用于分离分散或溶解的物质和磁体分离器的方法
公开(公告)号：US06942806B2
公开(公告)日：2005-09-13
申请号：US10432030
申请日：2001-10-12
申请人： Matthias Franzreb , Jonas Wohlgemuth
发明人： Matthias Franzreb , Jonas Wohlgemuth
IPC分类号： G01N33/553 , B01D15/00 , B01D15/02 , B03C1/00 , B03C1/02 , B03C1/28 , G01N35/00 , G01N35/10 , G01N1/18
CPC分类号： G01N35/10 , B03C1/28 , B03C1/284 , G01N35/0098 , Y10T436/25375
摘要： The invention relates to a method for separating out a substance dispersed or dissolved in a first liquid by using the following steps: a) adding magnetizable particles to the first liquid, so that the substance is adsorbed on the particles; b) immersing a rod consisting of a soft magnetic material into the first liquid; c) magnetizing the rod along its longitudinal axis with an exciter coil, thus causing the particles with the adsorbed substance to be deposited on the rod; d) pulling the rod with thereon deposited particles from the first liquid while the rod is still magnetized; e) immersing the rod into a second liquid; f) turning off the exciter coil and washing off the particles deposited on the rod in the second liquid. Also proposed is a magnet separator for realizing the method.
摘要翻译：本发明涉及通过以下步骤分离或溶解在第一液体中的物质的方法：a）向第一液体中加入可磁化颗粒，使物质被吸附在颗粒上; b）将由软磁性材料组成的棒浸入第一液体中; c）用激励线圈使其沿其纵向轴线磁化，从而使具有吸附物质的颗粒沉积在杆上; d）当杆仍然被磁化时，从第一液体中拉出具有沉积颗粒的杆; e）将杆浸入第二液体中; f）关闭激励器线圈并清除沉积在第二液体中的棒上的颗粒。还提出了一种用于实现该方法的磁体分离器。

10. 发明申请

US20070144976A1 Micro-reactor 审中-公开
标题翻译：微反应器
公开(公告)号：US20070144976A1
公开(公告)日：2007-06-28
申请号：US11711188
申请日：2007-02-26
申请人： Matthias Franzreb , Tilmann Rogge
发明人： Matthias Franzreb , Tilmann Rogge
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2400/0487 , Y10T436/25
摘要： In an arrangement for the transport of at least one magnetic particle fraction through a microfluidic system including a structure with micro-channels and means for generating a back and forth flow of fluid in the channels in which the magnetic particle fraction is contained for movement of the magnetic particles through the micro channels, means are provided for generating a magnetic field to be switched on while the fluid flows in one direction for fixing the magnetic particles and to be switched off while the fluid flows in the opposite direction so that the magnetic particles are carried along with the fluid when flowing in that direction.
摘要翻译：在用于将至少一个磁性颗粒部分输送通过包括具有微通道的结构的微流体系统的装置以及用于在其中包含磁性颗粒部分的通道中产生流体的来回流动的装置，用于使提供通过微通道的磁性颗粒，用于产生磁场以在液体沿一个方向流动以固定磁性颗粒并在流体沿相反方向流动时关闭的装置，使得磁性颗粒为与流体一起沿着该方向流动。

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