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1. 发明授权

US5414097A Purification of esters of tetrahydro-pyran-4-carboxylic acid 失效
标题翻译：四氢 - 吡喃-4-羧酸酯的纯化
公开(公告)号：US5414097A
公开(公告)日：1995-05-09
申请号：US185179
申请日：1994-01-24
申请人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Harald Rust , Werner Schnurr
发明人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Harald Rust , Werner Schnurr
IPC分类号： C07D309/08
CPC分类号： C07D309/08
摘要： A process for purifying esters of tetrahydropyran-4-carboxylic acid of the formula I ##STR1## where R.sup.1 to R.sup.3 are each C.sub.1 -C.sub.4 -alkyl, and R.sup.2 and R.sup.3 are each additionally hydrogen, from mixtures produced in the reaction of butyrolactones of the formula II ##STR2## where R.sup.2 and R.sup.3 have the abovementioned meanings, and R.sup.4 is hydrogen, alkyl of 1-6 carbons or acyl of the formula --CO--R.sup.2, with alcohols of the formula R.sup.1 OH in the presence of oxide catalysts, by distillation, which entailsa) removing overhead, in a first column with 5-25 theoretical plates with a distillate pressure of 700-1100 mbar and a distillate temperature of 50.degree.-80.degree. C., an alcohol and up to 10% of the water,b) transferring the bottom product from the first column into a second column with 18-40 theoretical plates, into which a water entrainer is metered between plates 15 and 30, and is circulated, and which operates with a distillate pressure of 35-350 mbar and a distillate temperature of 18.degree.-70.degree. C., with the esters of tetrahydropyran-4-carboxylic acid being removed between plates 8 and 18 at 90.degree.-150.degree. C., and, where appropriate,c) feeding the bottom product from the second column into a third column with 5-25 theoretical plates, and returning the overhead products at a distillate pressure of 1-100 mbar and a distillate temperature of 90.degree.-140.degree. C. to the synthesis of the esters of tetrahydropyran-4-carboxylic acid.
摘要翻译：用于纯化式I的四氢吡喃-4-羧酸的酯的方法，其中R 1至R 3各自为C 1 -C 4 - 烷基，R 2和R 3各自为氢，其中R 2和R 3具有上述含义，R 4是氢，1-6个碳的烷基或式-CO-R 2的酰基，其中式R 1 OH的醇在存在下氧化物催化剂，通过蒸馏，其需要a）在具有5-25理论塔板的第一塔中，馏出物压力为700-1100毫巴，馏出物温度为50-80℃，醇和升高至10％的水，b）将底部产物从第一塔转移到具有18-40理论塔板的第二塔中，其中在15和30之间计量水夹带剂，并循环，并且其以馏出液压力为35-350毫巴，馏出物温度为18-70℃，其中四氢吡喃-4-羧酸的酯在90℃-150℃下在板8和18之间除去，并且在适当的情况下，c）将底部产物从第二塔进料到具有5-25理论值的第三塔将塔顶馏出物返回到馏出物压力为1-100毫巴，馏出液温度为90-140℃，以合成四氢吡喃-4-羧酸酯。

2. 发明授权

US5412120A Preparation of carboxylic esters 失效
标题翻译：羧酸酯的制备
公开(公告)号：US5412120A
公开(公告)日：1995-05-02
申请号：US158361
申请日：1993-11-29
申请人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
发明人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
IPC分类号： C07C67/475 , C07D309/08 , C07D315/00
CPC分类号： C07C67/475 , C07D309/08
摘要： A process for preparing monocarboxylic esters of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.3 -C.sub.8 -cyclo-alkyl acyl, aryl or C.sub.7 -C.sub.20 -aralkyl or together --(CH.sub.2).sub.n --X--(CH.sub.2).sub.m --,X is methylene, oxygen, sulfur, NH or NR.sup.3,R.sup.3 is C.sub.1 -C.sub.12 -alkyl, andn and m are each from 0 to 8, comprises reacting geminal dicarboxylic esters of the general formula II ##STR2## where R.sup.1 to R.sup.3 are each as defined above, at from 150.degree. to 400.degree. C. in the presence of catalysts.
摘要翻译：一种制备通式I的单羧酸的方法，其中R 1和R 2各自为氢，C 1 -C 12 - 烷基，C 3 -C 8 - 环烷基酰基，芳基或C 7 -C 20 - 芳烷基或一起 - （CH 2 ）nX-（CH 2）m - ，X是亚甲基，氧，硫，NH或NR 3，R 3是C 1 -C 12烷基，n和m各自为0至8，包括使通式II的偕二羧酸酯其中R 1至R 3各自如上所定义，在150℃至400℃下，在催化剂存在下。

3. 发明授权

US5466831A Preparation of 3-(2-acyloxyethyl)-dihydro-2(3H)furanones 失效
标题翻译： 3-（2-酰氧基乙基） - 二氢-2（3H）呋喃酮的制备
公开(公告)号：US5466831A
公开(公告)日：1995-11-14
申请号：US99232
申请日：1993-07-29
申请人： Werner Schnurr , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner
发明人： Werner Schnurr , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： C07D307/33 , C07D307/12
CPC分类号： C07D307/33
摘要： A process for the preparation of 3-(2'-acyloxyethyl)-dihydro-2(3H)furanones of the general formula I ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 aralkyl, or C.sub.7 -C.sub.12 alkylaryl, in which a 3-(2'-oxyethyl)-dihydro-2(3H)furanone of the general formula II ##STR2## in which R.sup.2 denotes C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 aralkyl, or C.sub.7 -C.sub.12 alkylaryl is caused to react with a carboxylic acid, a carboxylic anhydride, and/or an acyl halide in the presence of an acid catalyst at temperatures of from 50.degree. to 250.degree. C. and pressures of from 0.1 to 100 bar.
摘要翻译：制备通式I，C5-C8环烷基，芳基，C7-C12芳烷基或C7-C12烷基芳基的3-（2'-酰氧基乙基） - 二氢-2（3H）呋喃酮的方法，其中3 - （2'-氧乙基） - 二氢-2（3H）呋喃酮，其中R 2表示C 1 -C 12烷基，C 5 -C 8环烷基，芳基，C 7 -C 12芳烷基或C 7 -C 12芳烷基， C12烷基芳基在酸催化剂存在下，在50-250℃，压力为0.1-100巴的条件下，与羧酸，羧酸酐和/或酰卤反应。

4. 发明授权

US5371246A Preparation of tetrahydropyran-4-carboxylic acid and esters thereof 失效
标题翻译：四氢吡喃-4-羧酸及其酯的制备
公开(公告)号：US5371246A
公开(公告)日：1994-12-06
申请号：US110219
申请日：1993-08-23
申请人： Dirk Borchers , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
发明人： Dirk Borchers , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
IPC分类号： B01J21/04 , C07B61/00 , C07D309/08 , C07D309/06
CPC分类号： C07D309/08
摘要： A process for the preparation of tetrahydropyran-4-carboxylic acid and esters thereof of the general formula I ##STR1## in which R.sup.1 denotes hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.8 cycloalkyl, or aryl by the reaction of a dihydro-2(3H)furanone of the general formula II ##STR2## in which R.sup.2 denotes hydrogen, C.sub.1 -C.sub.6 alkyl, or --CO--R.sup.3 andR.sup.3 denotes hydrogen or C.sub.1 -C.sub.6 alkyl, with water or an alcohol of the general formula IIIR.sup.1 --OH (III),in whichR.sup.1 has the aforementioned meaning,at temperatures ranging from 200.degree. to 350.degree. C. in the presence of a heterogenous acid catalyst, in which use is made of a fixed heterogenous acid catalyst.
摘要翻译：制备通式I的四氢吡喃-4-羧酸及其酯的方法，其中R 1表示氢，C 1 -C 6烷基，C 5 -C 8环烷基或芳基，其中二氢 -2（3H）呋喃酮，其中R 2表示氢，C 1 -C 6烷基或-CO-R 3，R 3表示氢或C 1 -C 6烷基，其中R 2表示氢或C 1 -C 6烷基，在异种酸催化剂的存在下，在200〜350℃的温度范围内，通式III的R1-OH（Ⅲ），其中R 1具有上述含义，其中使用固定的异种酸催化剂。

5. 发明授权

US5580994A Preparation of tetrahydropyran-4-carboxylic acid and its esters 失效
标题翻译：制备四氢吡喃-4-羧酸及其酯
公开(公告)号：US5580994A
公开(公告)日：1996-12-03
申请号：US403769
申请日：1995-03-24
申请人： Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
发明人： Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： B01J21/04 , B01J21/06 , B01J23/08 , B01J23/14 , B01J23/16 , C07D309/08 , C07D493/10 , C07D309/06
CPC分类号： C07D309/08
摘要： A process for preparing tetrahydropyran-4-carboxylic acid and its esters of the formula I ##STR1## (R=H, C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, aryl, C.sub.7 -C.sub.12 -alkylphenyl and C.sub.7 -C.sub.12 -phenylalkyl) by reacting 2,7-dioxaspiro[4.4]nonane-1,6-dione II ##STR2## with water or alcohols IIIR--OH (III),in the presence of acidic catalysts at from 150.degree. to 350.degree. C. and from 0.01 to 100 bar.
摘要翻译： PCT No.PCT / EP93 / 03670 Sec。 371日期：1995年3月24日 102（e）1995年3月24日PCT 1993年12月23日PCT公布。第WO94 / 15931号公报日期：1994年7月21日制备四氢吡喃-4-羧酸及其式I的酯的方法（I）（R = H，C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，芳基，C 7 -C 12 - 烷基苯基和C 7 -C 12 - 苯基烷基），通过使二,7-二氧杂螺[4.4]壬烷-1,6-二酮IIIII）在酸性催化剂存在下，在150至350℃和0.01至100巴。

6. 发明授权

US5350863A Preparation of 3-(2'-oxyethyl)dihydro-2(3H)furanones 失效
标题翻译：制备3-（2'-氧乙基）二氢-2（3H）呋喃酮
公开(公告)号：US5350863A
公开(公告)日：1994-09-27
申请号：US120439
申请日：1993-09-14
申请人： Thomas Kuekenhoehner , Norbert Goetz , Rolf Fischer , Werner Schnurr , Dirk Borchers
发明人： Thomas Kuekenhoehner , Norbert Goetz , Rolf Fischer , Werner Schnurr , Dirk Borchers
IPC分类号： C07D307/33 , C07D307/20
CPC分类号： C07D307/33
摘要： A process for preparing 3-(2'-oxyethyl)dihydro-2(3H)furanones of the general formula I ##STR1## where R.sup.1 is hydrogen or acetyl, by reacting ethylene oxide with acetoacetic acid esters of the general formula II ##STR2## where R.sup.2 is C.sub.1 -C.sub.4 -alkyl, which comprises carrying out the reaction in alcoholic solutions in the presence of alkali metal alkoxides at from 20.degree. to 100.degree. C. and from 1 to 20 bar, is described.
摘要翻译：制备通式Ⅰ的3-（2'-氧乙基）二氢-2（3H）呋喃酮的方法，其中R1是氢或乙酰基，通过使环氧乙烷与通式II的乙酰乙酸酯反应其中R 2是C 1 -C 4 - 烷基，其包括在20至100℃和1至20巴的碱金属醇盐存在下，在醇溶液中进行反应。

7. 发明授权

US5387701A Preparation of 4-hydroxymethyltetrahydropyran 失效
标题翻译： 4-羟甲基四氢吡喃的制备
公开(公告)号：US5387701A
公开(公告)日：1995-02-07
申请号：US130010
申请日：1993-09-30
申请人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
发明人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： C07D309/06
CPC分类号： C07D309/06
摘要： A process for preparing 4-hydroxymethyltetrahydropyran comprises reacting tetrahydrofurans of the general formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 - to C.sub.6 -alkyl or --CO--R.sup.2, andR.sup.2 is hydrogen or C.sub.1 - to C.sub.6 -alkyl,at from 0.degree. to 400.degree. C. and from 0.001 to 400 bar in the presence of acidic catalysts.
摘要翻译：制备4-羟甲基四氢吡喃的方法包括使通式Ⅰ的四氢呋喃与其中R 1是氢，C 1 -C 6烷基或-CO-R 2，R 2是氢或C 1 -C 6烷基，在0至400℃和0.001至400巴之间，在酸性催化剂存在下。

8. 发明授权

US5371242A Preparation of products of the reduction of 4-hydroxybutyric acid derivatives 失效
标题翻译：制备4-羟基丁酸衍生物的还原产物
公开(公告)号：US5371242A
公开(公告)日：1994-12-06
申请号：US110217
申请日：1993-08-23
申请人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
发明人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： C07C29/151 , C07C31/20 , C07C31/27 , C07D307/06 , C07D307/94 , C08G63/08
CPC分类号： C07D307/94 , C07C31/274
摘要： Abstract of the Disclosure: Products of the reduction of 4-hydroxybutyric acid derivatives of the formula IIa ##STR1## where one of A and B is methylene and the other is cyclopropylidene, or of C.sub.1 --C.sub.4 --alkyl esters (IIb) or lactones (IIc) of these acids IIa, are prepared by hydrogenating the compounds IIa or IIb or IIc catalytically using hydrogen in the presence of a heterogeneous hydrogenation catalyst, giving novel compounds which can be used to prepare polymers.
摘要翻译：公开内容摘要：A和B中的一个是亚甲基，另一个是亚环丙基或C 1 -C 4 - 烷基酯（IIb）或内酯的式IIa的化合物的4-羟基丁酸衍生物的还原产物（IIc）通过在异相氢化催化剂存在下使用氢催化化合物IIa或IIb或IIc制备，得到可用于制备聚合物的新化合物。

9. 发明授权

US6147208A Process for simultaneously preparing caprolactam and hexamethylene diamine 失效
标题翻译：同时制备己内酰胺和己二胺的方法
公开(公告)号：US6147208A
公开(公告)日：2000-11-14
申请号：US91130
申请日：1998-06-16
申请人： Gunther Achhammer , Peter Bassler , Rolf Fischer , Eberhard Fuchs , Hermann Luyken , Werner Schnurr , Guido Voit , Lutz Hilprecht
发明人： Gunther Achhammer , Peter Bassler , Rolf Fischer , Eberhard Fuchs , Hermann Luyken , Werner Schnurr , Guido Voit , Lutz Hilprecht
IPC分类号： C07C209/48 , C07C209/86 , C07C211/12 , C07D201/08 , C07D201/02
CPC分类号： C07D201/08 , C07C209/48 , Y02P20/52
摘要： Caprolactam and hexamethylenediamine are prepared simultaneously starting from adiponitrile.
摘要翻译： PCT No.PCT / EP96 / 05521 Sec。 371日期：1998年6月16日 102（e）日期1998年6月16日PCT 1996年12月11日PCT公布。公开号WO97 / 23454 日期1997年7月3日由己二腈起始制备己内酰胺和六亚甲基二胺。

10. 发明授权

US5801268A Preparation of aliphatic alpha omega-aminonitriles 失效
标题翻译：脂肪族α-ω-氨基腈的制备
公开(公告)号：US5801268A
公开(公告)日：1998-09-01
申请号：US846240
申请日：1997-04-28
申请人： Klemens Flick , Johann-Peter Melder , Werner Schnurr , Klaus Ebel , Tom Witzel , Wolfgang Harder , Alwin Rehfinger , Rolf Fischer
发明人： Klemens Flick , Johann-Peter Melder , Werner Schnurr , Klaus Ebel , Tom Witzel , Wolfgang Harder , Alwin Rehfinger , Rolf Fischer
IPC分类号： B01J23/76 , B01J23/78 , B01J23/889 , B01J37/02 , C07C253/30 , C07C255/24 , C07C255/03
CPC分类号： B01J23/76 , B01J23/78 , B01J23/8892 , B01J23/8898 , B01J37/0201 , C07C253/30
摘要： Aliphatic alpha,omega-aminonitriles are prepared by partial hydrogenation of aliphatic alpha,omega-dinitriles at elevated temperatures and superatmospheric pressure in the presence of a solvent and of a catalyst by a process which comprises using a catalyst which (a) contains a compound based on a metal selected from the group consisting of nickel, cobalt, iron, ruthenium and rhodium and (b) contains from 0.01 to 25% by weight, based on (a), of a promoter based on a metal selected from the group consisting of palladium, platinum, iridium, osmium, copper, silver, gold, chromium, molybdenum, tungsten, manganese, rhenium, zinc, cadmium, lead, aluminum, tin, phosphorus, arsenic, antimony, bismuth and rare earth metals and (c) from 0 to 5% by weight, based on (a), of a compound based on an alkali metal or on an alkaline earth metal, with the proviso that the component (a) is not based on iron or iron and one of the metals selected from the group consisting of cobalt, ruthenium and rhodium when (b) is a promoter based on a metal selected from the group consisting of titanium, manganese, chromium and molybdenum, and with the further proviso that, when a compound based on only ruthenium or rhodium or ruthenium and rhodium or nickel and rhodium is selected as component (a), the promoter (b) may be dispensed with.
摘要翻译：脂肪族α，ω-氨基腈通过脂肪族α，ω-二腈在升高的温度和超大气压下，在溶剂和催化剂存在下通过包括使用（a）含有基于化合物的催化剂在选自镍，钴，铁，钌和铑的金属上，和（b）含有基于（a）0.01至25重量％的基于选自以下的金属的促进剂：钯，铂，铱，锇，铜，银，金，铬，钼，钨，锰，铼，锌，镉，铅，铝，锡，磷，砷，锑，铋和稀土金属和（c）基于（a），基于碱金属或碱土金属的化合物为0至5重量％，条件是组分（a）不以铁或铁为基准，并且所选择的金属之一来自由钴，钌和铑组成的组母体（b）是基于选自钛，锰，铬和钼的金属的促进剂，进一步的条件是当仅基于钌或铑或钌和铑或镍和铑的化合物为作为组分（a）选择，可以不用启动子（b）。

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