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1. 发明授权

US5371246A Preparation of tetrahydropyran-4-carboxylic acid and esters thereof 失效
标题翻译：四氢吡喃-4-羧酸及其酯的制备
公开(公告)号：US5371246A
公开(公告)日：1994-12-06
申请号：US110219
申请日：1993-08-23
申请人： Dirk Borchers , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
发明人： Dirk Borchers , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
IPC分类号： B01J21/04 , C07B61/00 , C07D309/08 , C07D309/06
CPC分类号： C07D309/08
摘要： A process for the preparation of tetrahydropyran-4-carboxylic acid and esters thereof of the general formula I ##STR1## in which R.sup.1 denotes hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.8 cycloalkyl, or aryl by the reaction of a dihydro-2(3H)furanone of the general formula II ##STR2## in which R.sup.2 denotes hydrogen, C.sub.1 -C.sub.6 alkyl, or --CO--R.sup.3 andR.sup.3 denotes hydrogen or C.sub.1 -C.sub.6 alkyl, with water or an alcohol of the general formula IIIR.sup.1 --OH (III),in whichR.sup.1 has the aforementioned meaning,at temperatures ranging from 200.degree. to 350.degree. C. in the presence of a heterogenous acid catalyst, in which use is made of a fixed heterogenous acid catalyst.
摘要翻译：制备通式I的四氢吡喃-4-羧酸及其酯的方法，其中R 1表示氢，C 1 -C 6烷基，C 5 -C 8环烷基或芳基，其中二氢 -2（3H）呋喃酮，其中R 2表示氢，C 1 -C 6烷基或-CO-R 3，R 3表示氢或C 1 -C 6烷基，其中R 2表示氢或C 1 -C 6烷基，在异种酸催化剂的存在下，在200〜350℃的温度范围内，通式III的R1-OH（Ⅲ），其中R 1具有上述含义，其中使用固定的异种酸催化剂。

2. 发明授权

US5350863A Preparation of 3-(2'-oxyethyl)dihydro-2(3H)furanones 失效
标题翻译：制备3-（2'-氧乙基）二氢-2（3H）呋喃酮
公开(公告)号：US5350863A
公开(公告)日：1994-09-27
申请号：US120439
申请日：1993-09-14
申请人： Thomas Kuekenhoehner , Norbert Goetz , Rolf Fischer , Werner Schnurr , Dirk Borchers
发明人： Thomas Kuekenhoehner , Norbert Goetz , Rolf Fischer , Werner Schnurr , Dirk Borchers
IPC分类号： C07D307/33 , C07D307/20
CPC分类号： C07D307/33
摘要： A process for preparing 3-(2'-oxyethyl)dihydro-2(3H)furanones of the general formula I ##STR1## where R.sup.1 is hydrogen or acetyl, by reacting ethylene oxide with acetoacetic acid esters of the general formula II ##STR2## where R.sup.2 is C.sub.1 -C.sub.4 -alkyl, which comprises carrying out the reaction in alcoholic solutions in the presence of alkali metal alkoxides at from 20.degree. to 100.degree. C. and from 1 to 20 bar, is described.
摘要翻译：制备通式Ⅰ的3-（2'-氧乙基）二氢-2（3H）呋喃酮的方法，其中R1是氢或乙酰基，通过使环氧乙烷与通式II的乙酰乙酸酯反应其中R 2是C 1 -C 4 - 烷基，其包括在20至100℃和1至20巴的碱金属醇盐存在下，在醇溶液中进行反应。

3. 发明授权

US5580994A Preparation of tetrahydropyran-4-carboxylic acid and its esters 失效
标题翻译：制备四氢吡喃-4-羧酸及其酯
公开(公告)号：US5580994A
公开(公告)日：1996-12-03
申请号：US403769
申请日：1995-03-24
申请人： Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
发明人： Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： B01J21/04 , B01J21/06 , B01J23/08 , B01J23/14 , B01J23/16 , C07D309/08 , C07D493/10 , C07D309/06
CPC分类号： C07D309/08
摘要： A process for preparing tetrahydropyran-4-carboxylic acid and its esters of the formula I ##STR1## (R=H, C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, aryl, C.sub.7 -C.sub.12 -alkylphenyl and C.sub.7 -C.sub.12 -phenylalkyl) by reacting 2,7-dioxaspiro[4.4]nonane-1,6-dione II ##STR2## with water or alcohols IIIR--OH (III),in the presence of acidic catalysts at from 150.degree. to 350.degree. C. and from 0.01 to 100 bar.
摘要翻译： PCT No.PCT / EP93 / 03670 Sec。 371日期：1995年3月24日 102（e）1995年3月24日PCT 1993年12月23日PCT公布。第WO94 / 15931号公报日期：1994年7月21日制备四氢吡喃-4-羧酸及其式I的酯的方法（I）（R = H，C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，芳基，C 7 -C 12 - 烷基苯基和C 7 -C 12 - 苯基烷基），通过使二,7-二氧杂螺[4.4]壬烷-1,6-二酮IIIII）在酸性催化剂存在下，在150至350℃和0.01至100巴。

4. 发明授权

US5414097A Purification of esters of tetrahydro-pyran-4-carboxylic acid 失效
标题翻译：四氢 - 吡喃-4-羧酸酯的纯化
公开(公告)号：US5414097A
公开(公告)日：1995-05-09
申请号：US185179
申请日：1994-01-24
申请人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Harald Rust , Werner Schnurr
发明人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Harald Rust , Werner Schnurr
IPC分类号： C07D309/08
CPC分类号： C07D309/08
摘要： A process for purifying esters of tetrahydropyran-4-carboxylic acid of the formula I ##STR1## where R.sup.1 to R.sup.3 are each C.sub.1 -C.sub.4 -alkyl, and R.sup.2 and R.sup.3 are each additionally hydrogen, from mixtures produced in the reaction of butyrolactones of the formula II ##STR2## where R.sup.2 and R.sup.3 have the abovementioned meanings, and R.sup.4 is hydrogen, alkyl of 1-6 carbons or acyl of the formula --CO--R.sup.2, with alcohols of the formula R.sup.1 OH in the presence of oxide catalysts, by distillation, which entailsa) removing overhead, in a first column with 5-25 theoretical plates with a distillate pressure of 700-1100 mbar and a distillate temperature of 50.degree.-80.degree. C., an alcohol and up to 10% of the water,b) transferring the bottom product from the first column into a second column with 18-40 theoretical plates, into which a water entrainer is metered between plates 15 and 30, and is circulated, and which operates with a distillate pressure of 35-350 mbar and a distillate temperature of 18.degree.-70.degree. C., with the esters of tetrahydropyran-4-carboxylic acid being removed between plates 8 and 18 at 90.degree.-150.degree. C., and, where appropriate,c) feeding the bottom product from the second column into a third column with 5-25 theoretical plates, and returning the overhead products at a distillate pressure of 1-100 mbar and a distillate temperature of 90.degree.-140.degree. C. to the synthesis of the esters of tetrahydropyran-4-carboxylic acid.
摘要翻译：用于纯化式I的四氢吡喃-4-羧酸的酯的方法，其中R 1至R 3各自为C 1 -C 4 - 烷基，R 2和R 3各自为氢，其中R 2和R 3具有上述含义，R 4是氢，1-6个碳的烷基或式-CO-R 2的酰基，其中式R 1 OH的醇在存在下氧化物催化剂，通过蒸馏，其需要a）在具有5-25理论塔板的第一塔中，馏出物压力为700-1100毫巴，馏出物温度为50-80℃，醇和升高至10％的水，b）将底部产物从第一塔转移到具有18-40理论塔板的第二塔中，其中在15和30之间计量水夹带剂，并循环，并且其以馏出液压力为35-350毫巴，馏出物温度为18-70℃，其中四氢吡喃-4-羧酸的酯在90℃-150℃下在板8和18之间除去，并且在适当的情况下，c）将底部产物从第二塔进料到具有5-25理论值的第三塔将塔顶馏出物返回到馏出物压力为1-100毫巴，馏出液温度为90-140℃，以合成四氢吡喃-4-羧酸酯。

5. 发明授权

US5466831A Preparation of 3-(2-acyloxyethyl)-dihydro-2(3H)furanones 失效
标题翻译： 3-（2-酰氧基乙基） - 二氢-2（3H）呋喃酮的制备
公开(公告)号：US5466831A
公开(公告)日：1995-11-14
申请号：US99232
申请日：1993-07-29
申请人： Werner Schnurr , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner
发明人： Werner Schnurr , Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： C07D307/33 , C07D307/12
CPC分类号： C07D307/33
摘要： A process for the preparation of 3-(2'-acyloxyethyl)-dihydro-2(3H)furanones of the general formula I ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 aralkyl, or C.sub.7 -C.sub.12 alkylaryl, in which a 3-(2'-oxyethyl)-dihydro-2(3H)furanone of the general formula II ##STR2## in which R.sup.2 denotes C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 aralkyl, or C.sub.7 -C.sub.12 alkylaryl is caused to react with a carboxylic acid, a carboxylic anhydride, and/or an acyl halide in the presence of an acid catalyst at temperatures of from 50.degree. to 250.degree. C. and pressures of from 0.1 to 100 bar.
摘要翻译：制备通式I，C5-C8环烷基，芳基，C7-C12芳烷基或C7-C12烷基芳基的3-（2'-酰氧基乙基） - 二氢-2（3H）呋喃酮的方法，其中3 - （2'-氧乙基） - 二氢-2（3H）呋喃酮，其中R 2表示C 1 -C 12烷基，C 5 -C 8环烷基，芳基，C 7 -C 12芳烷基或C 7 -C 12芳烷基， C12烷基芳基在酸催化剂存在下，在50-250℃，压力为0.1-100巴的条件下，与羧酸，羧酸酐和/或酰卤反应。

6. 发明授权

US5412120A Preparation of carboxylic esters 失效
标题翻译：羧酸酯的制备
公开(公告)号：US5412120A
公开(公告)日：1995-05-02
申请号：US158361
申请日：1993-11-29
申请人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
发明人： Rolf Fischer , Norbert Goetz , Thomas Kuekenhoehner , Werner Schnurr
IPC分类号： C07C67/475 , C07D309/08 , C07D315/00
CPC分类号： C07C67/475 , C07D309/08
摘要： A process for preparing monocarboxylic esters of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.3 -C.sub.8 -cyclo-alkyl acyl, aryl or C.sub.7 -C.sub.20 -aralkyl or together --(CH.sub.2).sub.n --X--(CH.sub.2).sub.m --,X is methylene, oxygen, sulfur, NH or NR.sup.3,R.sup.3 is C.sub.1 -C.sub.12 -alkyl, andn and m are each from 0 to 8, comprises reacting geminal dicarboxylic esters of the general formula II ##STR2## where R.sup.1 to R.sup.3 are each as defined above, at from 150.degree. to 400.degree. C. in the presence of catalysts.
摘要翻译：一种制备通式I的单羧酸的方法，其中R 1和R 2各自为氢，C 1 -C 12 - 烷基，C 3 -C 8 - 环烷基酰基，芳基或C 7 -C 20 - 芳烷基或一起 - （CH 2 ）nX-（CH 2）m - ，X是亚甲基，氧，硫，NH或NR 3，R 3是C 1 -C 12烷基，n和m各自为0至8，包括使通式II的偕二羧酸酯其中R 1至R 3各自如上所定义，在150℃至400℃下，在催化剂存在下。

7. 发明授权

US5387701A Preparation of 4-hydroxymethyltetrahydropyran 失效
标题翻译： 4-羟甲基四氢吡喃的制备
公开(公告)号：US5387701A
公开(公告)日：1995-02-07
申请号：US130010
申请日：1993-09-30
申请人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
发明人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： C07D309/06
CPC分类号： C07D309/06
摘要： A process for preparing 4-hydroxymethyltetrahydropyran comprises reacting tetrahydrofurans of the general formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 - to C.sub.6 -alkyl or --CO--R.sup.2, andR.sup.2 is hydrogen or C.sub.1 - to C.sub.6 -alkyl,at from 0.degree. to 400.degree. C. and from 0.001 to 400 bar in the presence of acidic catalysts.
摘要翻译：制备4-羟甲基四氢吡喃的方法包括使通式Ⅰ的四氢呋喃与其中R 1是氢，C 1 -C 6烷基或-CO-R 2，R 2是氢或C 1 -C 6烷基，在0至400℃和0.001至400巴之间，在酸性催化剂存在下。

8. 发明授权

US5371242A Preparation of products of the reduction of 4-hydroxybutyric acid derivatives 失效
标题翻译：制备4-羟基丁酸衍生物的还原产物
公开(公告)号：US5371242A
公开(公告)日：1994-12-06
申请号：US110217
申请日：1993-08-23
申请人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
发明人： Hans-Juergen Weyer , Rolf Fischer , Werner Schnurr , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： C07C29/151 , C07C31/20 , C07C31/27 , C07D307/06 , C07D307/94 , C08G63/08
CPC分类号： C07D307/94 , C07C31/274
摘要： Abstract of the Disclosure: Products of the reduction of 4-hydroxybutyric acid derivatives of the formula IIa ##STR1## where one of A and B is methylene and the other is cyclopropylidene, or of C.sub.1 --C.sub.4 --alkyl esters (IIb) or lactones (IIc) of these acids IIa, are prepared by hydrogenating the compounds IIa or IIb or IIc catalytically using hydrogen in the presence of a heterogeneous hydrogenation catalyst, giving novel compounds which can be used to prepare polymers.
摘要翻译：公开内容摘要：A和B中的一个是亚甲基，另一个是亚环丙基或C 1 -C 4 - 烷基酯（IIb）或内酯的式IIa的化合物的4-羟基丁酸衍生物的还原产物（IIc）通过在异相氢化催化剂存在下使用氢催化化合物IIa或IIb或IIc制备，得到可用于制备聚合物的新化合物。

9. 发明授权

US5169958A Preparation of .alpha.,.beta.-unsaturated carbonyl compounds 失效
标题翻译：（ALPHA），（BETA） - 饱和碳化合物的制备
公开(公告)号：US5169958A
公开(公告)日：1992-12-08
申请号：US769022
申请日：1991-10-01
申请人： Heinz Isak , Norbert Goetz , Thomas Kuekenhoehner
发明人： Heinz Isak , Norbert Goetz , Thomas Kuekenhoehner
IPC分类号： C07C45/67 , C07C45/68 , C07C47/232 , C07C47/24 , C07C47/277 , C07C223/02 , C07C225/16 , C07C229/34
CPC分类号： C07C229/34 , C07C223/02 , C07C225/16 , C07C45/673 , C07C45/68 , C07C47/232 , C07C47/24 , C07C47/277
摘要： A process for the preparation of .alpha.,.beta.-unsaturated carbonyl compounds of the formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy or aryloxy,R.sup.2 is aryl which is unsubstituted or substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, trifluoromethyl and/or halogen andR.sup.3 is tetrahydrofuranyl or aryl which is substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, trifluoromethyl and/or halogen, which comprises reacting 3-amino-2-propen-1-ones of the formula II ##STR2## where R.sup.1 and R.sup.2 have the abovementioned meanings, and R.sup.4 and R.sup.5 are, independently of one another, hydrogen, C.sub.1 -C.sub.10 -alkyl or aryl, with a magnesium halide of the formula IIIR.sup.3 --Mg--Y (III) where Y is halogen, at from -20.degree. to 100.degree. C., and novel .alpha.,.beta.-unsaturated carbonyl compounds and novel 3-amino-2-propen-1-ones are described.
摘要翻译：制备式I的α，β-不饱和羰基化合物的方法，其中R1是氢，C1-C10-烷基，C1-C10-烷氧基或芳氧基，R2是未取代或取代的芳基 C1-C4-烷基，C1-C4-烷氧基，三氟甲基和/或卤素，R3是被C1-C4-烷基，C1-C4-烷氧基，三氟甲基和/或卤素取代的四氢呋喃基或芳基，其包括使3 - 氨基-2-丙烯-1-酮，其中R 1和R 2具有上述含义，并且R 4和R 5彼此独立地为氢，C 1 -C 10 - 烷基或芳基，与式III的卤化镁R3-Mg-Y（III）其中Y是卤素，在-20℃至100℃，和新的α，β-不饱和羰基化合物和新的3-氨基-2-丙烯描述-1。

10. 发明授权

US5252755A Preparation of 4-hydroxymethyltetrahydropyrans 失效
标题翻译： 4-羟甲基四氢吡喃的制备
公开(公告)号：US5252755A
公开(公告)日：1993-10-12
申请号：US990268
申请日：1992-12-14
申请人： Jochem Henkelmann , Thomas Ruehl , Horst Zimmermann , Norbert Goetz , Wolfgang Spiegler , Thomas Kuekenhoehner
发明人： Jochem Henkelmann , Thomas Ruehl , Horst Zimmermann , Norbert Goetz , Wolfgang Spiegler , Thomas Kuekenhoehner
IPC分类号： B01J23/62 , B01J23/656 , B01J23/72 , B01J23/86 , B01J23/88 , C07B61/00 , C07D309/06
CPC分类号： C07D309/06
摘要： A process for the preparation of 4-hydroxymethyltetrahydropyrans of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen, C.sub.1 - to C.sub.12 -alkyl, C.sub.3 - to C.sub.8 -cycloalkyl, aryl or C.sub.7 - to C.sub.20 -aralkyl, comprises reacting a tetrahydropyrancarboxylic ester of the formula II ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, and R.sup.5 is hydrogen or C.sub.1 - to C.sub.12 -alkyl, at from 50.degree. to 400.degree. C. and at from 1 to 400 bar in the presence of hydrogen and a hydrogenation catalyst.
摘要翻译：制备式I（I）的4-羟甲基四氢吡喃的方法，其中R 1，R 2，R 3和R 4是氢，C 1 -C 12烷基，C 3 -C 8环烷基，芳基或C 7 -C 20 - 烷基，包括使式II的四氢吡喃羧酸酯（II）与其中R 1，R 2，R 3和R 4如上所定义的R 5是氢或C 1至C 12烷基在50至400℃反应。在氢气和氢化催化剂的存在下在1至400巴下进行。

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