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1. 发明申请

US20050282997A1 Control of polymer surface molecular architecture via amphipathic endgroups 有权
标题翻译：通过两亲性端基控制聚合物表面分子结构
公开(公告)号：US20050282997A1
公开(公告)日：2005-12-22
申请号：US11211734
申请日：2005-08-26
申请人： Robert Ward , Keith McCrea , Yuan Tian , James Parakka
发明人： Robert Ward , Keith McCrea , Yuan Tian , James Parakka
IPC分类号： A61L27/14 , A61L27/18 , A61L29/06 , A61L31/06 , C08F20060101 , C08F2/00 , C08G18/08 , C08G18/12 , C08G18/28 , C08G18/50 , C08G18/62 , C08G18/67 , C08G65/00 , C08G65/329 , C08G69/08 , C08J5/00 , C08L53/00
CPC分类号： C08G18/6287 , A61L27/18 , A61L29/06 , A61L31/06 , C08G18/0823 , C08G18/12 , C08G18/283 , C08G18/2865 , C08G18/289 , C08G18/5024 , C08G18/5039 , C08G18/6283 , C08G18/6795 , C08L75/04 , C08G18/3228
摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.
摘要翻译：其表面被包括两亲表面改性部分的端基修饰的聚合物。聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于当该重新定位导致界面能量降低时，与身体接触的介质。两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶。在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。还公开了利用这些聚合物的方法和制品。

2. 发明申请

US20110124772A1 ANTIMICROBIAL POLYMERS AND THEIR USES 审中-公开
标题翻译：抗微生物聚合物及其用途
公开(公告)号：US20110124772A1
公开(公告)日：2011-05-26
申请号：US12994836
申请日：2009-05-26
申请人： Shanger Wang , Robert S. Ward , Yuan Tian , Li Li , Keith Mccrea , James Parakka , Robert L. Jones, JR.
发明人： Shanger Wang , Robert S. Ward , Yuan Tian , Li Li , Keith Mccrea , James Parakka , Robert L. Jones, JR.
IPC分类号： C09D175/04 , C08G71/04
CPC分类号： A01N33/12 , A01N47/44 , A01N25/10 , A01N2300/00
摘要： Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.
摘要翻译：具有非浸出抗菌活性的聚合物及其用作医疗器械的表面涂层或体积树脂。抗微生物聚合物通过共价键合到聚合物链末端的抗微生物部分或在侧链末端与聚合物主链一起制备。含抗微生物部分的端基包括表面活性（或表面组装）部分，其促进抗微生物端基在聚合物表面的富集，从而形成抗微生物活性表面。具有内置抗微生物端基的聚合物可用作散装树脂，作为抗微生物添加剂，或作为医疗器械制造中的感染预防性涂层（例如，导管，血管通路装置，外围线，IV部位，下水道，胃饲和管，和其他可植入装置）。在需要控制生物膜形成的环境中，例如海产品，这些材料也可用作与微生物接触的结构上的抗微生物和防污涂料。

3. 发明申请

US20060047134A1 Process for the production of (trimethylsilyloxy)silylalkylglycerol methacrylates 审中-公开
标题翻译：（三甲基甲硅烷氧基）甲硅烷基烷基甘油甲基丙烯酸酯的制备方法
公开(公告)号：US20060047134A1
公开(公告)日：2006-03-02
申请号：US10926425
申请日：2004-08-25
申请人： Frank Molock , Shivkumar Mahadevan , Robert Ward , Shanger Wang , James Parakka , Yuan Tian
发明人： Frank Molock , Shivkumar Mahadevan , Robert Ward , Shanger Wang , James Parakka , Yuan Tian
IPC分类号： C07F7/04
CPC分类号： C07F7/0879
摘要： The present invention relates to a process comprising the steps of reacting in the presence of a hydrosilylation catalyst, a first reaction mixture comprising a free radical reactive compound and a silicon containing compound to form a silicon substituted glyceryl (meth)acrylate.
摘要翻译：本发明涉及包括以下步骤的方法：在氢化硅烷化催化剂存在下，包含自由基反应性化合物和含硅化合物的第一反应混合物反应，形成硅取代的（甲基）丙烯酸甘油酯。

4. 发明授权

US09181401B2 Phosphorylcholine-based amphiphilic silicones for medical applications 有权
标题翻译：用于医疗应用的基于磷酰胆碱的两亲性硅氧烷
公开(公告)号：US09181401B2
公开(公告)日：2015-11-10
申请号：US13378260
申请日：2010-06-07
申请人： James Parakka , Ananth V. Iyer , Anfeng Wang , Xuwei Jiang , Yuan Tian , Robert Ward
发明人： James Parakka , Ananth V. Iyer , Anfeng Wang , Xuwei Jiang , Yuan Tian , Robert Ward
IPC分类号： A61L15/24 , C08L83/08 , G02B1/04 , C08F30/02 , C08F230/02 , C07F7/02 , C07F9/02 , C08G77/395 , A61L31/10 , A61L15/26 , C07F9/6574 , A61L27/34 , C08F230/08 , C07F9/09 , A61F13/00 , A61L27/18 , C08L83/10 , A61L26/00
CPC分类号： C08G77/395 , A61F13/00017 , A61L15/26 , A61L26/0019 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , C07F9/091 , C07F9/092 , C07F9/65742 , C07F9/65746 , C08F230/02 , C08F230/08 , C08L83/08 , C08L83/10 , G02B1/043 , C08L83/04
摘要： Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.
摘要翻译：用于局部和内部应用的两亲仿生磷酰胆碱的硅氧烷化合物作为生物医学装置的组件。包含两性离子磷酰胆碱基团的硅氧烷化合物可以是可聚合的或不可聚合的。应用的具体实例包括用作眼科镜片中的活性功能组分，眼用晶状体护理溶液，液体绷带，伤口敷料以及润滑和抗血栓形成的涂层。

5. 发明申请

US20120136087A1 PHOSPHORYLCHOLINE-BASED AMPHIPHILIC SILICONES FOR MEDICAL APPLICATIONS 有权
标题翻译：用于医疗应用的基于磷酰胆碱的AMPHIPILILIC硅
公开(公告)号：US20120136087A1
公开(公告)日：2012-05-31
申请号：US13378260
申请日：2010-06-07
申请人： James Parakka , Ananth V. Iyer , Anfeng Wang , Xuwei Jiang , Yuan Tian , Robert Ward
发明人： James Parakka , Ananth V. Iyer , Anfeng Wang , Xuwei Jiang , Yuan Tian , Robert Ward
IPC分类号： C08L83/08 , C08F130/02 , C07F7/02 , A61L15/24
CPC分类号： C08G77/395 , A61F13/00017 , A61L15/26 , A61L26/0019 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , C07F9/091 , C07F9/092 , C07F9/65742 , C07F9/65746 , C08F230/02 , C08F230/08 , C08L83/08 , C08L83/10 , G02B1/043 , C08L83/04
摘要： Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.
摘要翻译：用于局部和内部应用的两亲仿生磷酰胆碱的硅氧烷化合物作为生物医学装置的组件。包含两性离子磷酰胆碱基团的硅氧烷化合物可以是可聚合的或不可聚合的。应用的具体实例包括用作眼科镜片中的活性功能组分，眼用晶状体护理溶液，液体绷带，伤口敷料以及润滑和抗血栓形成的涂层。

6. 发明申请

US20060229423A1 Process for the production of monodisperse and narrow disperse monofunctional silicones 审中-公开
标题翻译：用于生产单分散和窄分散单官能硅氧烷的方法
公开(公告)号：US20060229423A1
公开(公告)日：2006-10-12
申请号：US11377822
申请日：2006-03-16
申请人： James Parakka , Yuan Tian , Robert Ward , Wang Shanger
发明人： James Parakka , Yuan Tian , Robert Ward , Wang Shanger
IPC分类号： C08G77/06
CPC分类号： C08G77/045 , C07F7/0874 , C08G77/06 , C08G77/08 , C08G77/20 , C08G77/36 , C08G77/38 , G02B1/043 , C08L83/06
摘要： Synthesis and purification of mono and narrow disperse monofunctional polydimethylsiloxane methacrylate derivatives with different molecular weights are disclosed.
摘要翻译：公开了具有不同分子量的单分散和单分散单官能聚二甲基硅氧烷甲基丙烯酸酯衍生物的合成和纯化。

7. 发明申请

US20070265460A1 PROCESS FOR THE PRODUCTION OF (TRIMETHYLSILYLOXY)SILYLALKYLGLYCEROL METHACRYLATES 审中-公开
标题翻译：（三甲基硅氧烷）甲基丙烯酰氧基甲基丙烯酸酯的生产方法
公开(公告)号：US20070265460A1
公开(公告)日：2007-11-15
申请号：US11782727
申请日：2007-07-25
申请人： Shivkumar Mahadevan , Robert Ward , Shanger Wang , James Parakka , Yuan Tian , Frank Molock
发明人： Shivkumar Mahadevan , Robert Ward , Shanger Wang , James Parakka , Yuan Tian , Frank Molock
IPC分类号： C07F7/08
CPC分类号： C07F7/0879
摘要： The present invention relates to a process comprising the steps of reacting in the presence of a hydrosilylation catalyst, a first reaction mixture comprising a free radical reactive compound and a silicon containing compound to form a silicon substituted glyceryl (meth)acrylate.
摘要翻译：本发明涉及包括以下步骤的方法：在氢化硅烷化催化剂存在下，包含自由基反应性化合物和含硅化合物的第一反应混合物反应以形成硅取代的（甲基）丙烯酸甘油酯。

8. 发明申请

US20110293522A1 SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS 审中-公开
标题翻译：通过表面活性和反应性末端组合聚合物的表面改性
公开(公告)号：US20110293522A1
公开(公告)日：2011-12-01
申请号：US13129438
申请日：2009-11-16
申请人： Shanger Wang , Robert S. Ward , Yuan Tian , Xuwei Jiang , Keith Mccrea , Scott Curtin
发明人： Shanger Wang , Robert S. Ward , Yuan Tian , Xuwei Jiang , Keith Mccrea , Scott Curtin
IPC分类号： A61K49/00 , B29C45/00 , A61P31/00 , A61P7/02 , C08G18/83 , A61K31/785
CPC分类号： C08G18/837 , A61K2800/61 , C08G18/08 , C08J7/12 , C08J7/14
摘要： Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.
摘要翻译：聚合物表面改性方法包括以下步骤：在制品制造期间首先形成与聚合物链末端连接的主要反应性端基的表面，然后用生物活性分子，亲水和疏水单体，低聚物或聚合物改性活性表面以获得特定的表面性质。或者，多功能偶联剂可用于将主反应性基团与能够与与生物活性分子，亲水和疏水单体，低聚物和聚合物相关的官能团反应的第二反应性基团，以获得特定的表面性质。本发明涉及将表面活性隔离物连接到聚合物链末端的反应性端基引入表面。表面活性间隔物允许反应性端基在制造过程中迁移和富集到表面。本发明提供具有抗血栓形成性质，润滑性，选择性吸附和抗微生物性质的生物界面的医疗装置。

9. 发明申请

US20100179284A1 POLYMERS WITH BIO-FUNCTIONAL SELF ASSEMBLING MONOLAYER ENDGROUPS FOR THERAPEUTIC APPLICATIONS AND BLOOD FILTRATION 审中-公开
标题翻译：具有生物功能自组装单体终端用于治疗应用和血液过滤的聚合物
公开(公告)号：US20100179284A1
公开(公告)日：2010-07-15
申请号：US12601787
申请日：2008-05-28
申请人： Robert S. Ward , Keith McCrea , Yuan Tian , Shanger Wang , Larry Jones , Anfeng Wang , James P. Parakka
发明人： Robert S. Ward , Keith McCrea , Yuan Tian , Shanger Wang , Larry Jones , Anfeng Wang , James P. Parakka
IPC分类号： C08B37/10
CPC分类号： A61K31/785 , C08G18/3228 , C08G18/3271 , C08G18/44 , C08G18/5024
摘要： Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer≧1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety.
摘要翻译：由包含至少一种具有式R（LE）x的聚合物的聚合物主体组成的医疗装置，假体或包装组件，其中R是数均分子量为5000至70000道尔顿的聚合物芯，并且具有x个端基， x是整数≥1，E是通过连接L与聚合物核心R共价连接的端基，L是具有至少5个重复单元的二价低聚链，并且可以与L链相邻的分子自组装聚合物和聚合物中的部分L和/或E可以在组成和/或分子量上彼此相同或不同。聚合物主体包括位于体内内部的多个聚合物分子，其中至少一些内部聚合物分子具有形成身体表面的端基。表面端基包括至少一个自组装部分。

10. 发明申请

US20050092680A1 Purification of silicone containing compounds by supercritical fluid extraction 失效
标题翻译：通过超临界流体萃取法纯化含硅化合物
公开(公告)号：US20050092680A1
公开(公告)日：2005-05-05
申请号：US10699417
申请日：2003-10-31
申请人： Shivkumar Mahadevan , Frank Molock , Robert Ward , Yuan Tian , Shanger Wang , James Serpilio
发明人： Shivkumar Mahadevan , Frank Molock , Robert Ward , Yuan Tian , Shanger Wang , James Serpilio
IPC分类号： C07F7/20 , C02F1/26
CPC分类号： C08G77/34 , C07F7/20 , Y02P20/544
摘要： The present invention relates to a process for the purification of silicone containing compounds via supercritical fluid extraction. Specifically, the present invention relates to a process comprising the steps of contacting at least one silicone containing compound with a supercritical fluid having a density of between about 0.2 and about 0.8 g/ml, decreasing said density so that two phases are formed a first phase comprising said at least one silicone containing compound and a second phase comprising at least one impurity and separating said second phase from said first phase.
摘要翻译：本发明涉及通过超临界流体萃取纯化含硅氧烷化合物的方法。具体地说，本发明涉及一种方法，该方法包括以下步骤：使至少一种含硅氧烷的化合物与密度为约0.2至约0.8g / ml的超临界流体接触，降低所述密度，使得两相形成第一相包括所述至少一种含硅氧烷化合物和包含至少一种杂质的第二相，并将所述第二相与所述第一相分离。

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