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1. 发明申请

US20110124772A1 ANTIMICROBIAL POLYMERS AND THEIR USES 审中-公开
标题翻译：抗微生物聚合物及其用途
公开(公告)号：US20110124772A1
公开(公告)日：2011-05-26
申请号：US12994836
申请日：2009-05-26
申请人： Shanger Wang , Robert S. Ward , Yuan Tian , Li Li , Keith Mccrea , James Parakka , Robert L. Jones, JR.
发明人： Shanger Wang , Robert S. Ward , Yuan Tian , Li Li , Keith Mccrea , James Parakka , Robert L. Jones, JR.
IPC分类号： C09D175/04 , C08G71/04
CPC分类号： A01N33/12 , A01N47/44 , A01N25/10 , A01N2300/00
摘要： Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.
摘要翻译：具有非浸出抗菌活性的聚合物及其用作医疗器械的表面涂层或体积树脂。抗微生物聚合物通过共价键合到聚合物链末端的抗微生物部分或在侧链末端与聚合物主链一起制备。含抗微生物部分的端基包括表面活性（或表面组装）部分，其促进抗微生物端基在聚合物表面的富集，从而形成抗微生物活性表面。具有内置抗微生物端基的聚合物可用作散装树脂，作为抗微生物添加剂，或作为医疗器械制造中的感染预防性涂层（例如，导管，血管通路装置，外围线，IV部位，下水道，胃饲和管，和其他可植入装置）。在需要控制生物膜形成的环境中，例如海产品，这些材料也可用作与微生物接触的结构上的抗微生物和防污涂料。

2. 发明申请

US20110293522A1 SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS 审中-公开
标题翻译：通过表面活性和反应性末端组合聚合物的表面改性
公开(公告)号：US20110293522A1
公开(公告)日：2011-12-01
申请号：US13129438
申请日：2009-11-16
申请人： Shanger Wang , Robert S. Ward , Yuan Tian , Xuwei Jiang , Keith Mccrea , Scott Curtin
发明人： Shanger Wang , Robert S. Ward , Yuan Tian , Xuwei Jiang , Keith Mccrea , Scott Curtin
IPC分类号： A61K49/00 , B29C45/00 , A61P31/00 , A61P7/02 , C08G18/83 , A61K31/785
CPC分类号： C08G18/837 , A61K2800/61 , C08G18/08 , C08J7/12 , C08J7/14
摘要： Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.
摘要翻译：聚合物表面改性方法包括以下步骤：在制品制造期间首先形成与聚合物链末端连接的主要反应性端基的表面，然后用生物活性分子，亲水和疏水单体，低聚物或聚合物改性活性表面以获得特定的表面性质。或者，多功能偶联剂可用于将主反应性基团与能够与与生物活性分子，亲水和疏水单体，低聚物和聚合物相关的官能团反应的第二反应性基团，以获得特定的表面性质。本发明涉及将表面活性隔离物连接到聚合物链末端的反应性端基引入表面。表面活性间隔物允许反应性端基在制造过程中迁移和富集到表面。本发明提供具有抗血栓形成性质，润滑性，选择性吸附和抗微生物性质的生物界面的医疗装置。

3. 发明申请

US20100179284A1 POLYMERS WITH BIO-FUNCTIONAL SELF ASSEMBLING MONOLAYER ENDGROUPS FOR THERAPEUTIC APPLICATIONS AND BLOOD FILTRATION 审中-公开
标题翻译：具有生物功能自组装单体终端用于治疗应用和血液过滤的聚合物
公开(公告)号：US20100179284A1
公开(公告)日：2010-07-15
申请号：US12601787
申请日：2008-05-28
申请人： Robert S. Ward , Keith McCrea , Yuan Tian , Shanger Wang , Larry Jones , Anfeng Wang , James P. Parakka
发明人： Robert S. Ward , Keith McCrea , Yuan Tian , Shanger Wang , Larry Jones , Anfeng Wang , James P. Parakka
IPC分类号： C08B37/10
CPC分类号： A61K31/785 , C08G18/3228 , C08G18/3271 , C08G18/44 , C08G18/5024
摘要： Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer≧1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety.
摘要翻译：由包含至少一种具有式R（LE）x的聚合物的聚合物主体组成的医疗装置，假体或包装组件，其中R是数均分子量为5000至70000道尔顿的聚合物芯，并且具有x个端基， x是整数≥1，E是通过连接L与聚合物核心R共价连接的端基，L是具有至少5个重复单元的二价低聚链，并且可以与L链相邻的分子自组装聚合物和聚合物中的部分L和/或E可以在组成和/或分子量上彼此相同或不同。聚合物主体包括位于体内内部的多个聚合物分子，其中至少一些内部聚合物分子具有形成身体表面的端基。表面端基包括至少一个自组装部分。

4. 发明申请

US20090258048A1 Self-Assembling Monomers and Oligomers as Surface-Modifying Endgroups for Polymers 审中-公开
标题翻译：自组装单体和低聚物作为表面改性端基用于聚合物
公开(公告)号：US20090258048A1
公开(公告)日：2009-10-15
申请号：US12083927
申请日：2006-12-07
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka , Shanger Wang
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka , Shanger Wang
IPC分类号： A61F2/02 , C08G63/91 , C12M3/00 , B65D71/00
CPC分类号： A61K31/785 , C08G18/0895 , C08G18/2875 , C08G18/288 , C08G18/44 , C08G18/6266
摘要： Polymers having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.
摘要翻译：具有式R（LE）x的聚合物，其中R是数均分子量为5000-7,000,000道尔顿且具有x个端基的聚合物芯，E是通过连接L与聚合物核心R共价连接的端基，L是二价具有至少5个相同重复单元的低聚链，能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x可以彼此相同或不同。单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面修饰该聚合物的端基。使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

5. 发明授权

US07368589B2 Purification of silicone containing compounds by supercritical fluid extraction 失效
标题翻译：通过超临界流体萃取法纯化含硅化合物
公开(公告)号：US07368589B2
公开(公告)日：2008-05-06
申请号：US10699417
申请日：2003-10-31
申请人： Shivkumar Mahadevan , Frank Molock , Robert S. Ward , Yuan Tian , Shanger Wang , James M. Serpilio, Jr.
发明人： Shivkumar Mahadevan , Frank Molock , Robert S. Ward , Yuan Tian , Shanger Wang , James M. Serpilio, Jr.
IPC分类号： C07F7/00
CPC分类号： C08G77/34 , C07F7/20 , Y02P20/544
摘要： The present invention relates to a process for the purification of silicone containing compounds via supercritical fluid extraction. Specifically, the present invention relates to a process comprising the steps of contacting at least one silicone containing compound with a supercritical fluid having a density of between about 0.2 and about 0.8 g/ml, decreasing said density so that two phases are formed a first phase comprising said at least one silicone containing compound and a second phase comprising at least one impurity and separating said second phase from said first phase.
摘要翻译：本发明涉及通过超临界流体萃取纯化含硅氧烷化合物的方法。具体地说，本发明涉及一种方法，该方法包括以下步骤：使至少一种含硅氧烷的化合物与密度为约0.2至约0.8g / ml的超临界流体接触，降低所述密度，使得两相形成第一相包括所述至少一种含硅氧烷化合物和包含至少一种杂质的第二相，并将所述第二相与所述第一相分离。

6. 发明授权

US09393311B2 Intravaginal ring comprising polyurethane composition for drug delivery 有权
标题翻译：阴道环包含用于药物递送的聚氨酯组合物
公开(公告)号：US09393311B2
公开(公告)日：2016-07-19
申请号：US13885665
申请日：2011-11-15
申请人： Robert S. Ward , Shanger Wang , Li Li , Durgaprasad Chalasani , Patrick Kiser , Meredith Roberts Clark
发明人： Robert S. Ward , Shanger Wang , Li Li , Durgaprasad Chalasani , Patrick Kiser , Meredith Roberts Clark
IPC分类号： A61K47/34 , A61K9/00 , A61K31/341 , A61K31/675
CPC分类号： A61K47/34 , A61K9/0036 , A61K31/341 , A61K31/675
摘要： The invention is directed to an intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): The invention is further directed to administering one or more pharmaceutically active substances to a patient in need thereof.
摘要翻译：本发明涉及包含至少一种药物活性物质和聚氨酯共聚物的阴道内药物递送装置，其中所述共聚物具有根据式（I）的结构：本发明还涉及将一种或多种药物活性物质施用于有需要的患者。

7. 发明申请

US20140045792A1 INTRAVAGINAL RING COMPRISING POLYURETHANE COMPOSITION FOR DRUG DELIVERY 有权
标题翻译：包含用于药物递送的聚氨酯组合物的内环
公开(公告)号：US20140045792A1
公开(公告)日：2014-02-13
申请号：US13885665
申请日：2011-11-15
申请人： Robert S. Ward , Shanger Wang , Li Li , Durgaprasad Chalasani , Patrick Kiser , Meredith Roberts Clark
发明人： Robert S. Ward , Shanger Wang , Li Li , Durgaprasad Chalasani , Patrick Kiser , Meredith Roberts Clark
IPC分类号： A61K47/34 , A61K31/675 , A61K31/341
CPC分类号： A61K47/34 , A61K9/0036 , A61K31/341 , A61K31/675
摘要： The invention is directed to an intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): The invention is further directed to administering one or more pharmaceutically active substances to a patient in need thereof.
摘要翻译：本发明涉及包含至少一种药物活性物质和聚氨酯共聚物的阴道内药物递送装置，其中所述共聚物具有根据式（I）的结构：本发明还涉及将一种或多种药物活性物质施用于有需要的患者。

8. 发明授权

US08153728B2 PDMS-PVP block copolymers 有权
标题翻译： PDMS-PVP嵌段共聚物
公开(公告)号：US08153728B2
公开(公告)日：2012-04-10
申请号：US12531200
申请日：2008-03-13
申请人： James Parakka , Keith R. McCrea , Robert S. Ward
发明人： James Parakka , Keith R. McCrea , Robert S. Ward
IPC分类号： C08F30/08 , C08F293/00
CPC分类号： C08F293/00 , A61L15/26 , A61L27/18 , C08F8/10 , C08F8/14 , C08F2810/40 , C08G77/442 , C08G77/452 , C08L53/00 , C08L83/10 , G02B1/043 , C08L39/06 , C08L83/06 , C08L83/04 , C08F126/10 , C08L2666/02
摘要： Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
摘要翻译：制备具有可聚合功能的官能化聚乙烯吡咯烷酮的方法。此外，两亲性聚二甲基硅氧烷-PVP嵌段共聚物如（甲基）丙烯酸酯化和（甲基）丙烯酰胺官能化的聚乙烯吡咯烷酮化合物如嵌段共聚物可用作生物医学装置中的生物材料组分。它们为生物医学装置例如眼科镜片提供改善的润湿性，润滑性和材料相容性。

9. 发明授权

US08344090B2 PDMS-PVP block copolymers 有权
标题翻译： PDMS-PVP嵌段共聚物
公开(公告)号：US08344090B2
公开(公告)日：2013-01-01
申请号：US13325584
申请日：2011-12-14
申请人： James Parakka , Keith R. McCrea , Robert S. Ward
发明人： James Parakka , Keith R. McCrea , Robert S. Ward
IPC分类号： C08F30/08 , C08F293/00
CPC分类号： C08F293/00 , A61L15/26 , A61L27/18 , C08F8/10 , C08F8/14 , C08F2810/40 , C08G77/442 , C08G77/452 , C08L53/00 , C08L83/10 , G02B1/043 , C08L39/06 , C08L83/06 , C08L83/04 , C08F126/10 , C08L2666/02
摘要： Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
摘要翻译：制备具有可聚合功能的官能化聚乙烯吡咯烷酮的方法。此外，两亲性聚二甲基硅氧烷-PVP嵌段共聚物如（甲基）丙烯酸酯化和（甲基）丙烯酰胺官能化的聚乙烯吡咯烷酮化合物如嵌段共聚物可用作生物医学装置中的生物材料组分。它们为生物医学装置例如眼科镜片提供改善的润湿性，润滑性和材料相容性。

10. 发明申请

US20120083573A1 NOVEL PDMS-PVP BLOCK COPOLYMERS 有权
标题翻译：新型PDMS-PVP嵌段共聚物
公开(公告)号：US20120083573A1
公开(公告)日：2012-04-05
申请号：US13325584
申请日：2011-12-14
申请人： James PARAKKA , Keith R. McCrea , Robert S. Ward
发明人： James PARAKKA , Keith R. McCrea , Robert S. Ward
IPC分类号： C08G81/02
CPC分类号： C08F293/00 , A61L15/26 , A61L27/18 , C08F8/10 , C08F8/14 , C08F2810/40 , C08G77/442 , C08G77/452 , C08L53/00 , C08L83/10 , G02B1/043 , C08L39/06 , C08L83/06 , C08L83/04 , C08F126/10 , C08L2666/02
摘要： Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
摘要翻译：制备具有可聚合功能的官能化聚乙烯吡咯烷酮的方法。此外，两亲性聚二甲基硅氧烷-PVP嵌段共聚物如（甲基）丙烯酸酯化和（甲基）丙烯酰胺官能化的聚乙烯吡咯烷酮化合物如嵌段共聚物可用作生物医学装置中的生物材料组分。它们为生物医学装置例如眼科镜片提供改善的润湿性，润滑性和材料相容性。

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