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1. 发明申请

US20140178648A1 Methods for Encapsulating Nanocrystals and Resulting Compositions 有权
标题翻译：封装纳米晶体和所得组合物的方法
公开(公告)号：US20140178648A1
公开(公告)日：2014-06-26
申请号：US14194996
申请日：2014-03-03
申请人： Robert S. Dubrow
发明人： Robert S. Dubrow
IPC分类号： C09K11/88 , C09K11/70
CPC分类号： C09K11/56 , B32B37/144 , C09K11/025 , C09K11/70 , C09K11/703 , C09K11/883 , C23C16/402 , C23C16/403 , C23C16/405 , C23C16/45555 , Y10T156/10 , Y10T428/24355 , Y10T428/24562 , Y10T428/24851 , Y10T428/2991
摘要： The present invention provides methods for hermetically sealing luminescent nanocrystals, as well as compositions and containers comprising hermetically sealed luminescent nanocrystals. By hermetically sealing the luminescent nanocrystals, enhanced lifetime and luminescence can be achieved.
摘要翻译：本发明提供了用于气密密封发光纳米晶体的方法，以及包括密封的发光纳米晶体的组合物和容器。通过气密密封发光纳米晶体，可以实现寿命延长和发光。

2. 发明授权

US08025960B2 Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production 有权
标题翻译：多孔基材，制品，系统和包含纳米纤维的组合物及其使用和生产方法
公开(公告)号：US08025960B2
公开(公告)日：2011-09-27
申请号：US10941746
申请日：2004-09-15
申请人： Robert S. Dubrow , Chunming Niu
发明人： Robert S. Dubrow , Chunming Niu
IPC分类号： A61F13/00 , B32B3/26 , A61M35/00
CPC分类号： B01D39/08 , B01D69/141 , B01D2239/0225 , B01D2239/0233 , B01D2239/0241 , B01D2239/025 , B01D2239/0428 , B01D2239/0492 , B01D2239/0613 , B01D2239/065 , B01D2239/1216 , B01D2323/283 , Y02E10/549 , Y10T428/249953 , Y10T428/24996 , Y10T442/30
摘要： Porous nanofiber bearing substrate materials are provided having enhanced surface area for a variety of applications including as electrical substrates, semipermeable membranes and barriers, structural lattices for tissue culturing and for composite materials, and the like.
摘要翻译：提供多孔纳米纤维轴承衬底材料，其具有用于各种应用的增强的表面积，包括电底物，半透膜和屏障，用于组织培养的结构晶格和复合材料等。

3. 发明授权

US07972616B2 Medical device applications of nanostructured surfaces 失效
标题翻译：纳米结构表面的医疗器械应用
公开(公告)号：US07972616B2
公开(公告)日：2011-07-05
申请号：US11330722
申请日：2006-01-12
申请人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
发明人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
IPC分类号： A61K33/38 , A61K9/70 , B32B5/16 , B32B37/00 , B22F7/04
CPC分类号： A61L31/10 , A61F13/02 , A61L27/34 , A61L2400/12 , A61L2420/04 , A61N1/05 , B82Y30/00 , Y10S977/762 , Y10S977/764 , Y10S977/773 , Y10S977/811 , Y10S977/813 , Y10S977/90 , Y10S977/904 , Y10S977/906 , Y10T428/12111 , Y10T428/249924 , Y10T428/29
摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
摘要翻译：本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。在一个具体实施例中，公开了用于增强医疗装置植入物表面上的细胞功能的方法，其通常包括提供包括在其上的多个纳米纤维（例如，纳米线）的医疗装置植入物，并将医疗装置植入物暴露于诸如成骨细胞。

4. 发明授权

US07755038B2 Nanostructured thin films and their uses 失效
标题翻译：纳米结构薄膜及其用途
公开(公告)号：US07755038B2
公开(公告)日：2010-07-13
申请号：US12121008
申请日：2008-05-15
申请人： Chunming Niu , Robert Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
发明人： Chunming Niu , Robert Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
IPC分类号： H01J49/04
CPC分类号： A61L27/303 , A61L31/122 , H01J49/0418 , Y10S977/701 , Y10T428/12736 , Y10T428/12743
摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.
摘要翻译：本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储，光学和传感器。

5. 发明授权

US07651769B2 Structures, systems and methods for joining articles and materials and uses therefor 有权
标题翻译：用于连接物品和材料的结构，系统和方法及其用途
公开(公告)号：US07651769B2
公开(公告)日：2010-01-26
申请号：US11835908
申请日：2007-08-08
申请人： Robert S. Dubrow
发明人： Robert S. Dubrow
IPC分类号： A61B17/03 , A61B17/08
CPC分类号： B81C3/008 , A61B17/00 , A61B17/00491 , B82Y30/00 , C09J5/00 , C09J7/00 , C09J2201/626 , C09J2400/123 , H01L23/373 , H01L2924/0002 , H01L2924/09701 , Y10S977/762 , Y10S977/766 , Y10S977/902 , Y10S977/931 , Y10S977/962 , Y10S977/963 , Y10T156/10 , Y10T428/23993 , Y10T428/24008 , Y10T428/26 , Y10T428/2913 , Y10T428/2922 , Y10T428/2925 , H01L2924/00
摘要： This invention provides novel nanofibers and nanofiber structures which posses adherent properties, as well as the use of such nanofibers and nanofiber comprising structures in the coupling and/or joining together of articles or material.
摘要翻译：本发明提供了新颖的纳米纤维和纳米纤维结构，其具有粘附性能，以及在物品或材料的联接和/或连接在一起的这种纳米纤维和纳米纤维包含结构的用途。

6. 发明授权

US07081190B2 Methods and compositions for performing molecular separations 有权
公开(公告)号：US07081190B2
公开(公告)日：2006-07-25
申请号：US10154557
申请日：2002-05-24
申请人： Robert S. Dubrow
发明人： Robert S. Dubrow
IPC分类号： G01N27/447
CPC分类号： G01N27/44747 , G01N27/44752 , G01N27/44791
摘要： The present invention provides methods of electrophoretically separating macromolecular species, as well as compositions and systems useful in carrying out such methods. Specifically, the methods of the present invention comprise providing a substrate that has at least a first capillary channel disposed therein. The surface of the channel has a first surface charge associated therewith, and is filled with a water soluble surface adsorbing polymer solution that bears a net charge that is the same as the charge on the capillary surface.

7. 发明授权

US07057881B2 Nanofiber surface based capacitors 有权
公开(公告)号：US07057881B2
公开(公告)日：2006-06-06
申请号：US11075361
申请日：2005-03-08
申请人： Calvin Y. H. Chow , Robert S. Dubrow
发明人： Calvin Y. H. Chow , Robert S. Dubrow
IPC分类号： H01G9/04
CPC分类号： H01G4/008 , H01G4/005 , H01G4/06 , H01G4/203 , H01G4/33 , H01G9/04 , H01G11/36 , H01G11/46 , H01L28/82 , H05K1/162 , H05K2201/026 , Y02E60/13
摘要： This invention provides novel capacitors comprising nanofiber enhanced surface area substrates and structures comprising such capacitors, as well as methods and uses for such capacitors.

8. 发明授权

US06756019B1 Microfluidic devices and systems incorporating cover layers 有权
标题翻译：微流体装置和包含覆盖层的系统
公开(公告)号：US06756019B1
公开(公告)日：2004-06-29
申请号：US09544711
申请日：2000-04-06
申请人： Robert S. Dubrow , Colin B. Kennedy , Robert Nagle , David Chazan , Ernest C. W. Lee , Khushroo Gandhi , Calvin Y. H. Chow
发明人： Robert S. Dubrow , Colin B. Kennedy , Robert Nagle , David Chazan , Ernest C. W. Lee , Khushroo Gandhi , Calvin Y. H. Chow
IPC分类号： B01L300
CPC分类号： B01L3/502715 , B01L3/5085 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N27/44791 , G01N2035/00148 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports. Rings are optionally disposed between the cover layer and the body structure and circumferentially around pairs of aligned apertures and ports. The devices also optionally include conductive coatings and membranes. The invention additionally provides methods of controlling the delivery of a composition of material into a microfluidic device.
摘要翻译：本发明提供了包括主体结构的微流体装置，其包括至少设置在其中的第一微量通道网络。身体结构具有设置在身体结构中的多个端口，其中每个端口与第一通道网络中的一个或多个通道流体连通。这些装置还包括覆盖层，其包括穿过覆盖层设置的多个孔。覆盖层与主体结构配合，由此每个孔与多个端口中的单独一个对准。环可选地设置在覆盖层和主体结构之间，并且周向地围绕成对的对齐的孔和端口。所述装置还可选地包括导电涂层和膜。本发明另外提供了控制将组合物输送到微流体装置中的方法。

9. 发明授权

US06555067B1 Polymeric structures incorporating microscale fluidic elements 失效
标题翻译：结合微量流体元素的聚合物结构
公开(公告)号：US06555067B1
公开(公告)日：2003-04-29
申请号：US09590661
申请日：2000-06-07
申请人： Khushroo Gandhi , Robert S. Dubrow , Luc J. Bousse
发明人： Khushroo Gandhi , Robert S. Dubrow , Luc J. Bousse
IPC分类号： B01L300
CPC分类号： G01N27/44791 , B01L3/502707 , B01L2200/12 , B07C5/342 , B29C65/02 , B29C65/08 , B29C65/8253 , B29C66/30223 , B29C66/54 , B29C66/71 , B29C66/712 , B29C66/723 , B29C66/73115 , B29C66/73343 , B29C66/73365 , B29C66/8322 , B29L2031/756 , B32B37/0023 , B32B38/06 , B32B2037/0092 , B32B2310/028 , B32B2310/0843 , Y10T156/10 , Y10T428/2495 , Y10T428/266 , B29K2081/06 , B29K2069/00 , B29K2067/00 , B29K2055/02 , B29K2033/12 , B29K2027/18 , B29K2027/14 , B29K2027/06 , B29K2023/18 , B29K2023/12 , B29K2023/06
摘要： The present invention generally provides improved methods of fabricating polymeric microfluidic devices that incorporate microscale fluidic structures, whereby the fabrication process does not substantially distort or deform such structures. The methods of the invention generally provide enhanced bonding processes for mating and bonding substrate layers to define the microscale channel networks therebetween.
摘要翻译：本发明总体上提供了制造结合微流体结构的聚合微流体装置的改进方法，由此制造过程基本上不会使这种结构变形或变形。本发明的方法通常提供增强的接合方法，用于匹配和接合基底层以限定它们之间的微尺度通道网络。

10. 发明授权

US6153073A Microfluidic devices incorporating improved channel geometries 有权
公开(公告)号：US6153073A
公开(公告)日：2000-11-28
申请号：US372655
申请日：1999-08-11
申请人： Robert S. Dubrow , Colin B. Kennedy , Luc J. Bousse
发明人： Robert S. Dubrow , Colin B. Kennedy , Luc J. Bousse
IPC分类号： G01N31/20 , B01L3/00 , G01N27/447 , G01N37/00 , G01N27/26
CPC分类号： B01L3/50273 , B01L3/502753 , B01L3/502784 , G01N27/44791 , B01L2200/0605 , B01L2300/0816 , B01L2300/0829 , B01L2300/0861 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , Y10S366/02 , Y10S366/03
摘要： The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.

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