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1. 发明申请

US20110201984A1 Medical Device Applications of Nanostructured Surfaces 有权
标题翻译：纳米结构表面的医疗器械应用
公开(公告)号：US20110201984A1
公开(公告)日：2011-08-18
申请号：US13096919
申请日：2011-04-28
申请人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
发明人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
IPC分类号： A61L15/58
CPC分类号： A61L31/10 , A61F13/02 , A61L27/34 , A61L2400/12 , A61L2420/04 , A61N1/05 , B82Y30/00 , Y10S977/762 , Y10S977/764 , Y10S977/773 , Y10S977/811 , Y10S977/813 , Y10S977/90 , Y10S977/904 , Y10S977/906 , Y10T428/12111 , Y10T428/249924 , Y10T428/29
摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
摘要翻译：本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。在一个具体实施例中，公开了用于增强医疗装置植入物表面上的细胞功能的方法，其通常包括提供包括在其上的多个纳米纤维（例如，纳米线）的医疗装置植入物，并将医疗装置植入物暴露于诸如成骨细胞。

2. 发明授权

US07972616B2 Medical device applications of nanostructured surfaces 失效
标题翻译：纳米结构表面的医疗器械应用
公开(公告)号：US07972616B2
公开(公告)日：2011-07-05
申请号：US11330722
申请日：2006-01-12
申请人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
发明人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
IPC分类号： A61K33/38 , A61K9/70 , B32B5/16 , B32B37/00 , B22F7/04
CPC分类号： A61L31/10 , A61F13/02 , A61L27/34 , A61L2400/12 , A61L2420/04 , A61N1/05 , B82Y30/00 , Y10S977/762 , Y10S977/764 , Y10S977/773 , Y10S977/811 , Y10S977/813 , Y10S977/90 , Y10S977/904 , Y10S977/906 , Y10T428/12111 , Y10T428/249924 , Y10T428/29
摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
摘要翻译：本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。在一个具体实施例中，公开了用于增强医疗装置植入物表面上的细胞功能的方法，其通常包括提供包括在其上的多个纳米纤维（例如，纳米线）的医疗装置植入物，并将医疗装置植入物暴露于诸如成骨细胞。

3. 发明授权

US08956637B2 Medical device applications of nanostructured surfaces 有权
标题翻译：纳米结构表面的医疗器械应用
公开(公告)号：US08956637B2
公开(公告)日：2015-02-17
申请号：US13096919
申请日：2011-04-28
申请人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
发明人： Robert S. Dubrow , Lawrence A. Bock , R. Hugh Daniels , Veeral D. Hardev , Chunming Niu , Vijendra Sahi
IPC分类号： A61F13/00 , A61F13/06 , A61L26/00 , B32B19/04 , A61L31/10 , A61F13/02 , A61L27/34 , A61F5/40 , A61F15/00 , A61N1/05 , B82Y30/00
CPC分类号： A61L31/10 , A61F13/02 , A61L27/34 , A61L2400/12 , A61L2420/04 , A61N1/05 , B82Y30/00 , Y10S977/762 , Y10S977/764 , Y10S977/773 , Y10S977/811 , Y10S977/813 , Y10S977/90 , Y10S977/904 , Y10S977/906 , Y10T428/12111 , Y10T428/249924 , Y10T428/29
摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
摘要翻译：本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。在一个具体实施例中，公开了用于增强医疗装置植入物表面上的细胞功能的方法，其通常包括提供包括在其上的多个纳米纤维（例如，纳米线）的医疗装置植入物，并将医疗装置植入物暴露于诸如成骨细胞。

4. 发明授权

US07651944B2 Methods of positioning and/or orienting nanostructures 有权
标题翻译：定位和/或定向纳米结构的方法
公开(公告)号：US07651944B2
公开(公告)日：2010-01-26
申请号：US12186405
申请日：2008-08-05
申请人： Xiangfeng Duan , R. Hugh Daniels , Chunming Niu , Vijendra Sahi , James M. Hamilton , Linda T. Romano
发明人： Xiangfeng Duan , R. Hugh Daniels , Chunming Niu , Vijendra Sahi , James M. Hamilton , Linda T. Romano
IPC分类号： H01L21/44 , H01L21/441 , B82B3/00
CPC分类号： H01L51/0048 , B01J23/52 , B81B2203/0361 , B81B2207/015 , B81C3/005 , B81C99/008 , B81C2203/057 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G11B5/743 , G11C2213/81 , H01L29/7869 , H01L51/0001 , H01L51/0595 , H01L2924/0002 , Y10S438/962 , Y10S977/762 , Y10S977/856 , Y10S977/857 , Y10S977/858 , Y10S977/89 , H01L2924/00
摘要： Methods of positioning and orienting nanostructures, and particularly nanowires, on surfaces for subsequent use or integration. The methods utilize mask based processes alone or in combination with flow based alignment of the nanostructures to provide oriented and positioned nanostructures on surfaces. Also provided are populations of positioned and/or oriented nanostructures, devices that include populations of positioned and/or oriented nanostructures, systems for positioning and/or orienting nanostructures, and related devices, systems and methods.
摘要翻译：在表面上定位和取向纳米结构，特别是纳米线的方法用于随后的使用或整合。该方法单独使用基于掩模的工艺，或者与纳米结构的基于流动的对准组合以在表面上提供定向和定位的纳米结构。还提供了定位和/或定向的纳米结构的群体，包括定位和/或定向纳米结构的群体，用于定位和/或取向纳米结构的系统以及相关设备，系统和方法。

5. 发明授权

US07164209B1 Methods of positioning and/or orienting nanostructures 有权
标题翻译：定位和/或定向纳米结构的方法
公开(公告)号：US07164209B1
公开(公告)日：2007-01-16
申请号：US11000557
申请日：2004-12-01
申请人： Xiangfeng Duan , R. Hugh Daniels , Chunming Niu , Vijendra Sahi , James M. Hamilton , Linda T. Romano
发明人： Xiangfeng Duan , R. Hugh Daniels , Chunming Niu , Vijendra Sahi , James M. Hamilton , Linda T. Romano
IPC分类号： H01L23/48 , H01L23/52 , H01L29/41
CPC分类号： H01L51/0048 , B01J23/52 , B81B2203/0361 , B81B2207/015 , B81C3/005 , B81C99/008 , B81C2203/057 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G11B5/743 , G11C2213/81 , H01L29/7869 , H01L51/0001 , H01L51/0595 , H01L2924/0002 , Y10S438/962 , Y10S977/762 , Y10S977/856 , Y10S977/857 , Y10S977/858 , Y10S977/89 , H01L2924/00
摘要： Methods of positioning and orienting nanostructures, and particularly nanowires, on surfaces for subsequent use or integration. The methods utilize mask based processes alone or in combination with flow based alignment of the nanostructures to provide oriented and positioned nanostructures on surfaces. Also provided are populations of positioned and/or oriented nanostructures, devices that include populations of positioned and/or oriented nanostructures, systems for positioning and/or orienting nanostructures, and related devices, systems and methods.
摘要翻译：在表面上定位和取向纳米结构，特别是纳米线的方法用于随后的使用或整合。该方法单独使用基于掩模的工艺，或者与纳米结构的基于流动的对准组合以在表面上提供定向和定位的纳米结构。还提供了定位和/或定向的纳米结构的群体，包括定位和/或定向纳米结构的群体，用于定位和/或取向纳米结构的系统以及相关设备，系统和方法。

6. 发明授权

US07422980B1 Methods of positioning and/or orienting nanostructures 有权
标题翻译：定位和/或定向纳米结构的方法
公开(公告)号：US07422980B1
公开(公告)日：2008-09-09
申请号：US11602784
申请日：2006-11-21
申请人： Xiangfeng Duan , R. Hugh Daniels , Chunming Niu , Vijendra Sahi , James M. Hamilton , Linda T. Romano
发明人： Xiangfeng Duan , R. Hugh Daniels , Chunming Niu , Vijendra Sahi , James M. Hamilton , Linda T. Romano
IPC分类号： H01L21/44 , H01L21/441
CPC分类号： H01L51/0048 , B01J23/52 , B81B2203/0361 , B81B2207/015 , B81C3/005 , B81C99/008 , B81C2203/057 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G11B5/743 , G11C2213/81 , H01L29/7869 , H01L51/0001 , H01L51/0595 , H01L2924/0002 , Y10S438/962 , Y10S977/762 , Y10S977/856 , Y10S977/857 , Y10S977/858 , Y10S977/89 , H01L2924/00
摘要： Methods of positioning and orienting nanostructures, and particularly nanowires, on surfaces for subsequent use or integration. The methods utilize mask based processes alone or in combination with flow based alignment of the nanostructures to provide oriented and positioned nanostructures on surfaces. Also provided are populations of positioned and/or oriented nanostructures, devices that include populations of positioned and/or oriented nanostructures, systems for positioning and/or orienting nanostructures, and related devices, systems and methods.
摘要翻译：在表面上定位和取向纳米结构，特别是纳米线的方法用于随后的使用或整合。该方法单独使用基于掩模的工艺，或者与纳米结构的基于流动的对准组合以在表面上提供定向和定位的纳米结构。还提供了定位和/或定向的纳米结构的群体，包括定位和/或定向纳米结构的群体，用于定位和/或取向纳米结构的系统以及相关设备，系统和方法。

7. 发明申请

US20090192429A1 RESORBABLE NANOENHANCED HEMOSTATIC STRUCTURES AND BANDAGE MATERIALS 有权
标题翻译：可再生的纳米化催化结构和粘合材料
公开(公告)号：US20090192429A1
公开(公告)日：2009-07-30
申请号：US12329431
申请日：2008-12-05
申请人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
发明人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
IPC分类号： A61F13/00 , A61B17/064
CPC分类号： A61F13/00034 , A61B17/0057 , A61B17/064 , A61B2017/00601 , A61B2017/00884 , A61B2017/00893 , A61F13/00008 , A61F13/00991 , A61F13/36 , A61F2013/00472 , A61F2013/0054 , A61F2013/00744 , A61F2013/00927 , A61F2013/00931 , A61L15/18 , A61L15/42 , A61L17/145 , A61L26/0004 , A61L26/0095 , A61L31/082 , A61L31/128 , A61L2400/04 , A61L2400/12 , D06M23/08
摘要： Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.
摘要翻译：提供了纳米材料增强型止血医疗装置的方法，系统和装置。提供止血材料和结构，其在创伤，外科手术，溃疡或其他原因引起的伤口/开口处引起血液凝血。止血材料和结构可以结合纳米结构和/或其它止血元件，例如聚合物和/或玻璃珠。止血材料和结构可以是可再吸收的。示例性实施例包括止血绷带，止血塞和止血配方。

8. 发明授权

US08304595B2 Resorbable nanoenhanced hemostatic structures and bandage materials 有权
标题翻译：可再吸收的纳米增强止血结构和绷带材料
公开(公告)号：US08304595B2
公开(公告)日：2012-11-06
申请号：US12329431
申请日：2008-12-05
申请人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
发明人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
IPC分类号： A61F13/00 , A61F13/02
CPC分类号： A61F13/00034 , A61B17/0057 , A61B17/064 , A61B2017/00601 , A61B2017/00884 , A61B2017/00893 , A61F13/00008 , A61F13/00991 , A61F13/36 , A61F2013/00472 , A61F2013/0054 , A61F2013/00744 , A61F2013/00927 , A61F2013/00931 , A61L15/18 , A61L15/42 , A61L17/145 , A61L26/0004 , A61L26/0095 , A61L31/082 , A61L31/128 , A61L2400/04 , A61L2400/12 , D06M23/08
摘要： Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.
摘要翻译：提供了纳米材料增强型止血医疗装置的方法，系统和装置。提供止血材料和结构，其在创伤，外科手术，溃疡或其他原因引起的伤口/开口处引起血液凝血。止血材料和结构可以结合纳米结构和/或其它止血元件，例如聚合物和/或玻璃珠。止血材料和结构可以是可再吸收的。示例性实施例包括止血绷带，止血塞和止血配方。

9. 发明申请

US20090124034A1 Nanostructured Thin Films and Their Uses 失效
标题翻译：纳米结构薄膜及其用途
公开(公告)号：US20090124034A1
公开(公告)日：2009-05-14
申请号：US12121008
申请日：2008-05-15
申请人： Chunming Niu , R. Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
发明人： Chunming Niu , R. Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
IPC分类号： H01L21/30
CPC分类号： A61L27/303 , A61L31/122 , H01J49/0418 , Y10S977/701 , Y10T428/12736 , Y10T428/12743
摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.
摘要翻译：本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储，光学和传感器。

10. 发明授权

US07803574B2 Medical device applications of nanostructured surfaces 有权
标题翻译：纳米结构表面的医疗器械应用
公开(公告)号：US07803574B2
公开(公告)日：2010-09-28
申请号：US11677680
申请日：2007-02-22
申请人： Tejal Desai , R. Hugh Daniels , Vijendra Sahi
发明人： Tejal Desai , R. Hugh Daniels , Vijendra Sahi
IPC分类号： C12P1/00 , A61M37/00 , B82B3/00 , A61F6/14
CPC分类号： A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/622 , A61L2400/12 , Y10S514/926 , Y10S514/927 , Y10S977/722 , Y10S977/742 , Y10S977/762 , Y10S977/902 , Y10S977/906
摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, a method of administering a composition to a patient is disclosed which comprises providing a composition-eluting device, said composition-eluting device comprising at least a first surface and a plurality of nanostructures attached to the first surface, and introducing the composition-eluting device into the body of the patient.
摘要翻译：本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。在一个具体实施方案中，公开了向患者施用组合物的方法，其包括提供组合物洗脱装置，所述组合物洗脱装置至少包括连接到第一表面的第一表面和多个纳米结构，组合物洗脱装置进入患者体内。

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