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1. 发明申请

US20090128813A1 Refractive Index Matching in Capillary Illumination 审中-公开
$Refractive Index Matching in Capillary Illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US20090128813A1
公开(公告)日：2009-05-21
申请号：US12360566
申请日：2009-01-27
申请人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/00 , G01N21/41
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

2. 发明授权

US07483136B2 Refractive index matching in capillary illumination 有权
$Refractive index matching in capillary illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US07483136B2
公开(公告)日：2009-01-27
申请号：US11356875
申请日：2006-02-16
申请人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/00
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

3. 发明申请

US20120248334A1 Refractive Index Matching In Capillary Illumination 审中-公开
$Refractive Index Matching In Capillary Illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US20120248334A1
公开(公告)日：2012-10-04
申请号：US13339169
申请日：2011-12-28
申请人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/64 , F21V33/00 , F21V13/04
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

4. 发明申请

US20100321692A1 Refractive Index Matching in Capillary Illumination 有权
$Refractive Index Matching in Capillary Illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US20100321692A1
公开(公告)日：2010-12-23
申请号：US12637717
申请日：2009-12-14
申请人： Richard T. REEL , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. REEL , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/00 , G01N21/41
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

5. 发明授权

US07316770B2 Method of electrophoresis, electrophoresis apparatus and capillary array 有权
标题翻译：电泳方法，电泳装置和毛细管阵列
公开(公告)号：US07316770B2
公开(公告)日：2008-01-08
申请号：US09814860
申请日：2001-03-23
申请人： Ryoji Inaba , Tomoyuki Sakai , Satoshi Takahashi , Muneo Maeshima , Miho Ozawa , Masaya Kojima , Daizo Tokinaga
发明人： Ryoji Inaba , Tomoyuki Sakai , Satoshi Takahashi , Muneo Maeshima , Miho Ozawa , Masaya Kojima , Daizo Tokinaga
IPC分类号： G01N27/26
CPC分类号： G01N27/44708 , G01N27/44782
摘要： A method of electrophoresis, an electrophoresis apparatus and a capillary array in which a fluorescently labelled sample is supplied into capillaries in a capillary array constituted by a plurality of capillaries and including a sample supply portion, an electrophoresis medium supply portion and a detection portion while controlling the temperature of the capillary array through gas circulation, the sample is caused to migrate and separated in the capillaries through electrophoresis, and at the region where the capillaries are contacted or come close each other a plurality of capillaries are contacted to a solid body so as to dissipate heat generated from the capillaries to the solid body.
摘要翻译：一种电泳方法，电泳装置和毛细管阵列，其中荧光标记的样品被供应到由多个毛细管构成的毛细管阵列的毛细管中，并且包括样品供应部分，电泳介质供应部分和检测部分，同时控制通过气体循环的毛细管阵列的温度，通过电泳使样品在毛细管中迁移和分离，并且在毛细管接触或彼此靠近的区域，多个毛细管与固体接触，以便以将从毛细管产生的热量散发到固体。

6. 发明申请

US20070053186A1 Refractive index matching in capillary illumination 有权
$Refractive index matching in capillary illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US20070053186A1
公开(公告)日：2007-03-08
申请号：US11356875
申请日：2006-02-16
申请人： Richard Reel , Eric Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard Reel , Eric Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： F21S6/00
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

7. 发明授权

US08012327B2 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US08012327B2
公开(公告)日：2011-09-06
申请号：US11653332
申请日：2007-01-16
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
IPC分类号： G01N27/447
CPC分类号： G01N27/44704 , G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。在本发明的毛细管电泳装置中设置毛细管位置测定光源。用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

8. 发明授权

US08102529B2 Refractive index matching in capillary illumination 有权
$Refractive index matching in capillary illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US08102529B2
公开(公告)日：2012-01-24
申请号：US12637717
申请日：2009-12-14
申请人： Richard Reel , Eric Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard Reel , Eric Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01J4/00
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

9. 发明申请

US20070163882A1 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US20070163882A1
公开(公告)日：2007-07-19
申请号：US11653332
申请日：2007-01-16
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G01N27/44704 , G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。在本发明的毛细管电泳装置中设置毛细管位置测定光源。用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

10. 发明授权

US08246806B2 Multi-capillary array electrophoresis device 有权
标题翻译：多毛细管阵列电泳装置
公开(公告)号：US08246806B2
公开(公告)日：2012-08-21
申请号：US11714222
申请日：2007-03-06
申请人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai , Eric S. Nordman
发明人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai , Eric S. Nordman
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44721
摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.
摘要翻译：电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

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