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1. 发明授权

US07883613B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US07883613B2
公开(公告)日：2011-02-08
申请号：US11806889
申请日：2007-06-05
申请人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
发明人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
IPC分类号： G01N27/453
CPC分类号： G01N27/44721
摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.
摘要翻译：本发明提供了一种毛细管电泳装置，其中毛细管容易地连接到迁移介质填充单元并从迁移介质填充单元中分离而不将杂质混入毛细管中。当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。此外，在毛细管中有效地进行温度控制。在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。毛细管电泳装置包括可以同时存储样品和缓冲液的容器。毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

2. 发明授权

US07250098B2 Multi-capillary array electrophoresis device 有权
标题翻译：多毛细管阵列电泳装置
公开(公告)号：US07250098B2
公开(公告)日：2007-07-31
申请号：US10259492
申请日：2002-09-30
申请人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai
发明人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44721
摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.
摘要翻译：电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

3. 发明授权

US5756899A Integrated sensor 失效
标题翻译：集成传感器
公开(公告)号：US5756899A
公开(公告)日：1998-05-26
申请号：US846936
申请日：1997-04-30
申请人： Seiichi Ugai , Yasunori Shoji , Yasushi Shimizu
发明人： Seiichi Ugai , Yasunori Shoji , Yasushi Shimizu
IPC分类号： G01F23/14 , G01D21/00 , G01D21/02 , G01F1/38 , G01F23/18 , G01L9/00 , G01L13/06 , G01L19/00 , G01L19/06 , G01N27/06 , G01N33/18 , G01L7/00
CPC分类号： G01L9/0072 , G01F1/383 , G01F23/18 , G01L19/0092 , G01L19/0627 , G01N33/18
摘要： The first glass substrate having the first pressure admitting entrance for leading the pressure of fluid to be measured, is arranged at a side of a diaphragm of a pressure sensor, for measuring differential pressure. The second glass substrate is arranged at the side opposite to the first glass substrate, a spacer being sandwiched therebetween. The second pressure admitting entrance is formed at the second glass substrate, at the position opposite to the first presser admitting entrance of the first glass substrate. The first conductive film and the second conductive film are formed on two surfaces facing to each other, of the first and second glass substrates, respectively. By measuring the specific conductance and the dielectric constant of the object fluid between the two conductive films, these physical constants indicating the quality of the fluid, the quality of the fluid can be also detected. Thus, it becomes possible to realize and provide an integrated sensor capable of measuring the differential pressure (flow rate) and the quality of fluid by using one transmitter.
摘要翻译：具有用于引导要测量的流体的压力的第一加压入口的第一玻璃基板布置在用于测量压差的压力传感器的隔膜的一侧。第二玻璃基板布置在与第一玻璃基板相对的一侧，夹在其间的间隔件。第二加压入口形成在第二玻璃基板的与第一玻璃基板的第一加压件入口相对的位置处。第一导电膜和第二导电膜分别形成在彼此面对的第一和第二玻璃基板的两个表面上。通过测量两个导电膜之间的物体流体的比电导率和介电常数，这些物理常数表示流体的质量，也可以检测流体的质量。因此，可以实现并提供能够通过使用一个发射器来测量差压（流量）和流体质量的集成传感器。

4. 发明授权

US5537882A Semiconductor sensor for detecting physical amount without thermal hypsteresis where output wiring is disposed in a stress insensitive direction 失效
标题翻译：用于检测没有热电渗的物理量的半导体传感器，其中输出布线设置在不敏感的方向
公开(公告)号：US5537882A
公开(公告)日：1996-07-23
申请号：US317156
申请日：1994-10-03
申请人： Seiichi Ugai , Satoshi Shimada , Susumu Murakami , Yoshimi Yamamoto , Yukio Takahashi , Yasuo Maruyama
发明人： Seiichi Ugai , Satoshi Shimada , Susumu Murakami , Yoshimi Yamamoto , Yukio Takahashi , Yasuo Maruyama
IPC分类号： G01L9/04 , G01L9/00 , G01L9/06 , G01P1/00 , G01P15/12 , H01L29/84 , G01P15/09 , H01C10/10
CPC分类号： G01P1/006 , G01L9/0054 , G01P15/123
摘要： A sensor for detecting physical amount in which a gauge resistance value is made not to change even when a wiring material presents a yield phenomenon by wiring a wiring material Such as aluminum presenting a yield phenomenon by thermal stress in a stress insensitive direction of a piezogauge.
摘要翻译：用于检测物位量的传感器，即使当布线材料通过在压力计的应力不敏感方向上通过热应力布线布线材料（例如铝）而产生屈服现象时，也不会改变表面电阻值的物理量。

5. 发明授权

US5012677A Differential pressure transmitter 失效
标题翻译：差压变送器
公开(公告)号：US5012677A
公开(公告)日：1991-05-07
申请号：US275580
申请日：1988-11-23
申请人： Satoshi Shimada , Yasushi Shimizu , Seiichi Ugai
发明人： Satoshi Shimada , Yasushi Shimizu , Seiichi Ugai
IPC分类号： G01L13/06 , G01L9/00 , G01L13/02 , G01L19/00
CPC分类号： G01L19/147 , G01L13/025 , G01L19/0092 , G01L19/0645 , G01L19/148
摘要： A differential pressure transmitter is an improvement over the drawbacks of conventional apparatuses and provides a differential pressure transmitter which compensates for adverse effects of a static pressure by using a static pressure detecting piezoresistive gauge. The transmitter includes a highly sensitive static pressure sensor with high outputs, and a composite sensor with small crosstalk between the static pressure sensor and a differential pressure sensor. The differential pressure transmitter is constructed of semiconductor sensor substrate and a fixed mount on which the sensor substrate is securely mounted; whereby the differential pressure of a fluid is detected by utilizing the difference in Young's modulus between the sensor substrate and the mount. The sensor substrate is processed on one side or on both sides to make a part of the sensor substrate thinner than the surrounding parts and thereby cause a peak stress due to a static pressure load to occur at the thin part, and a change in resistance of a semiconductor piezoresistive gauge formed at that thin portion is detected.
摘要翻译：差压变送器是对常规设备的缺点的改进，并且提供了一种通过使用静压检测压阻式压力补偿静压的不利影响的差压变送器。变送器包括具有高输出的高灵敏度静压传感器，以及静压传感器和压差传感器之间具有小串扰的复合传感器。差压变送器由半导体传感器基板和传感器基板固定在其上的固定支架构成; 由此通过利用传感器基板和安装座之间的杨氏模量的差异来检测流体的压差。传感器基板在一侧或两侧进行处理，使得传感器基板的一部分比周围部分薄，从而在薄部分产生由于静压力引起的峰值应力，并且电阻变化检测在该薄部分处形成的半导体压阻计。

6. 发明授权

US4986127A Multi-functional sensor 失效
标题翻译：多功能传感器
公开(公告)号：US4986127A
公开(公告)日：1991-01-22
申请号：US333246
申请日：1989-04-05
申请人： Satoshi Shimada , Seiichi Ugai , Akira Sase , Yasushi Shimizu
发明人： Satoshi Shimada , Seiichi Ugai , Akira Sase , Yasushi Shimizu
IPC分类号： G01L9/04 , G01F1/38 , G01K7/16 , G01L9/00 , G01L13/02 , G01L27/00 , H01L29/84
CPC分类号： G01L19/147 , G01F1/383 , G01L13/026 , G01L19/003 , G01L19/0645 , G01L9/0054 , G01L9/045
摘要： Multi-functional sensor comprises a support base made from borosilicate, a diaphragm with a E-shaped section secured to the base, the diaphragm being made from single crystalline silicon, principal plane thereof being oriented to be a crystalline plane (110), a differential pressure sensor having p-doped piezoresistor elements formed in the principal plane of the diaphragm at a thin wall portion of the E-shaped sectional diaphragm, each element being arranged along a crystal axis , a static pressure sensor having p-doped piezoresistor elements formed in the principal plane at an outer peripheral thick wall portion of the E-shaped sectional diaphragm, each element being arranged along the crystal axis , and a temperature sensor having a p-doped piezoresistor element formed in the principal plane at the outer peripheral thick wall portion of the E-shaped sectional diaphragm, the element being arranged along the crystal axis . In the multi-functional sensor thus constructed, deviation of the output signal from the differential pressure sensor due to the influence of the temperature and static pressure can be removed easily to obtain the correct signal.
摘要翻译：多功能传感器包括由硼硅酸盐制成的支撑基座，具有固定到基部的E形截面的隔膜，隔膜由单晶硅制成，其主面被定向为晶面（110），差动压电传感器，其具有在E形截面光阑的薄壁部分处形成在膜片的主平面中的p掺杂的压电电阻元件，每个元件沿着晶轴<111>布置，静压传感器具有p掺杂的压电电阻在E形截面光阑的外周厚壁部分的主平面上形成的元件，每个元件沿着晶轴<111>布置，并且具有在主平面上形成的p掺杂的压电电阻元件的温度传感器 E形截面膜片的外周厚壁部分，该元件沿着晶轴<100>排列。在这样构成的多功能传感器中，由于温度和静压的影响，输出信号与差压传感器的偏差可以容易地消除，从而获得正确的信号。

7. 发明授权

US08043493B2 Multi-capillary array electrophoresis device 有权
标题翻译：多毛细管阵列电泳装置
公开(公告)号：US08043493B2
公开(公告)日：2011-10-25
申请号：US11714221
申请日：2007-03-06
申请人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai
发明人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44721
摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.
摘要翻译：电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

8. 发明授权

US07658830B2 Capillary array and electrophoresis apparatus, and methods 有权
标题翻译：毛细管阵列和电泳装置及方法
公开(公告)号：US07658830B2
公开(公告)日：2010-02-09
申请号：US11604253
申请日：2006-11-27
申请人： Takayasu Furukawa , Nobuhiko Sato , Syozo Kasai , Seiichi Ugai , Motohiro Yamazaki , Hiroyuki Tanaka , Yuki Nonaka , Yoshio Onodera , Noriyuki Shimoda
发明人： Takayasu Furukawa , Nobuhiko Sato , Syozo Kasai , Seiichi Ugai , Motohiro Yamazaki , Hiroyuki Tanaka , Yuki Nonaka , Yoshio Onodera , Noriyuki Shimoda
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44704
摘要： A capillary array capable of being easily mounted on an electrophoresis apparatus without damaging the capillaries. The capillary array can include a plurality of capillaries that can be fixed via hollow electrodes on a load header in a matrix arrangement. The load header can be disposed on the electrophoresis apparatus. The capillary array can include a capillary frame onto which a capillary head and a detection portion can be detachably mounted. The structure allows the load header, the capillary head, the detection unit and other portions of the capillary array to be handled as a unit, thereby making it easier to mount the capillary array on the electrophoresis apparatus.
摘要翻译：一种能够容易地安装在电泳装置上而不损坏毛细管的毛细管阵列。毛细管阵列可以包括多个毛细管，其可以通过矩阵布置的负载头上的中空电极固定。负载头可以设置在电泳装置上。毛细管阵列可以包括毛细管框架，毛细管头和检测部分可以在其上可拆卸地安装在毛细管框架上。该结构允许负载头，毛细管头，检测单元和毛细管阵列的其它部分作为一个单元被处理，从而使毛细管阵列更容易安装在电泳装置上。

9. 发明授权

US07473342B2 Capillary array and capillary electrophoresis apparatus 有权
标题翻译：毛细管阵列和毛细管电泳仪
公开(公告)号：US07473342B2
公开(公告)日：2009-01-06
申请号：US11395158
申请日：2006-04-03
申请人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号： G01N27/00
CPC分类号： G01N27/44708
摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.
摘要翻译：在毛细管的温度不能根据毛细管产生的热量的变化而不能快速控制的情况下，不将样品的凝胶速度控制在一定程度以降低样品的分析性能。本发明旨在稳定电泳速度。其上布置有多个毛细管的基板的表面与能够进行温度控制的构件接触，从而控制毛细管的温度。由于根据本发明能够控制温度和毛细管的构件彼此直接接触，所以可以高精度地快速地控制毛细管的温度，使得电泳速度稳定。

10. 发明申请

US20060076239A1 Electrophoresis apparatus 审中-公开
标题翻译：电泳仪
公开(公告)号：US20060076239A1
公开(公告)日：2006-04-13
申请号：US11245491
申请日：2005-10-07
申请人： Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
发明人： Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
IPC分类号： G01N27/447
CPC分类号： G01N27/447
摘要： In an electrophoresis apparatus comprising capillaries for containing therein fluorescence-labeled substances, and a sensor for irradiating the capillaries with exciting light and detecting fluorescences, the sensor has a substrate including a datum surface for holding thereon the capillaries, and a groove sinking from the datum surface, and the groove has a plurality of reflecting surfaces for reflecting thereon the fluorescences emitted from the capillaries by a plurality of times.
摘要翻译：在包括用于在其中含有荧光标记物质的毛细管的电泳装置和用于用激发光照射毛细管并检测荧光的传感器中，传感器具有包括用于保持毛细管的基准表面的基底和从基准面凹下的凹槽表面，并且凹槽具有多个反射表面，用于在其上反射从毛细管发射的荧光多次。

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