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1. 发明授权

US5999678A Laser delivery means adapted for drug delivery 失效
标题翻译：用于药物输送的激光输送装置
公开(公告)号：US5999678A
公开(公告)日：1999-12-07
申请号：US773430
申请日：1996-12-27
申请人： Douglas Murphy-Chutorian , Richard L. Mueller , Stuart D. Harman , Steve A. Daniel , Larry Witham , Bruce Richardson
发明人： Douglas Murphy-Chutorian , Richard L. Mueller , Stuart D. Harman , Steve A. Daniel , Larry Witham , Bruce Richardson
IPC分类号： A61B17/00 , A61B18/24 , G02B6/06 , A61B17/36 , A61M31/00
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2018/00392
摘要： A drug delivery apparatus for dispensing a predetermined amount of one or more drugs into a laser created opening in the human body, the apparatus consisting of a laser delivery means such as an optical fiber or fiber bundle, a drug conduit which transfers the one or more drugs, drug solutions or other substances to the distal end of the laser delivery means, and the laser delivery means disposed essentially coaxially with the drug conduit. Laser delivery means is used to create a TMR channel or other opening in the body. Dispensed drug or other substance travels through the drug conduit and emanates from the drug conduit to be delivered into the TMR channel or other laser created opening. Drug is dispensed by manually or automatically activating an electric motor which actuates a piston element. A method of use is also disclosed.
摘要翻译：一种用于将预定量的一种或多种药物分配到人体内的激光产生开口中的药物输送装置，该装置由诸如光纤或纤维束的激光输送装置组成，药物导管将一个或多个药物，药物溶液或其它物质，并且激光输送装置基本上与药物导管同轴地设置。激光输送装置用于在体内产生TMR通道或其他开口。分配的药物或其他物质通过药物导管，并从药物导管发出，以被输送到TMR通道或其他激光产生的开口中。药物通过手动或自动激活致动活塞元件的电动机来分配。还公开了一种使用方法。

2. 发明授权

US06706011B1 Laser assisted drug delivery 失效
标题翻译：激光辅助药物输送
公开(公告)号：US06706011B1
公开(公告)日：2004-03-16
申请号：US09288251
申请日：1999-04-08
申请人： Douglas Murphy-Chutorian , Richard L. Mueller , Stuart D. Harman , Steve A. Daniel , Larry Witham , Bruce Richardson
发明人： Douglas Murphy-Chutorian , Richard L. Mueller , Stuart D. Harman , Steve A. Daniel , Larry Witham , Bruce Richardson
IPC分类号： A61M3100
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2018/00392
摘要： A drug delivery apparatus for dispensing predetermined volumes of drug, drug solution or other substances into an opening, such as a TMR channel in the human heart, or other laser treated area within the human body, the apparatus consisting of a bifurcated needle with a laser inlet for guiding a laser delivery means, such as an optical fiber or fiber bundle, to adjacent a surface of the human heart or other body structure for creating an opening, such as a TMR channel, or other laser treated area thereon. A drug inlet is for receiving the drug and transmitting the drug to the TMR channel or other laser treated area. Optionally, a piercing tip and/or suction device assists in positioning the apparatus adjacent the tissue to be treated. Drug is dispensed by manually or automatically actuating a piston or syringe element. A method of use is also disclosed.
摘要翻译：用于将预定体积的药物，药物溶液或其它物质分配到诸如人心脏中的TMR通道或人体内的其它激光处理区域的开口中的药物递送装置，该装置由具有激光的分叉针用于将诸如光纤或纤维束的激光传送装置引导到靠近人心或其他身体结构的表面以在其上形成诸如TMR通道或其他激光处理区域的开口。药物入口用于接收药物并将药物传输到TMR通道或其他激光治疗区域。可选地，刺穿尖端和/或抽吸装置有助于将装置定位在待处理组织附近。通过手动或自动启动活塞或注射器元件来分配药物。还公开了一种使用方法。

3. 发明授权

US6015427A Heart stabilizer with controllable stay suture and cutting element 失效
标题翻译：心肌稳定器具有可控制的缝合和切割元件
公开(公告)号：US6015427A
公开(公告)日：2000-01-18
申请号：US882774
申请日：1997-07-07
申请人： Richard L. Mueller , Steve A. Daniel , Stuart D. Harman
发明人： Richard L. Mueller , Steve A. Daniel , Stuart D. Harman
IPC分类号： A61B17/02 , A61B17/04 , A61B17/122 , A61B17/00
CPC分类号： A61B17/02 , A61B17/0466 , A61B17/0487 , A61B17/1227 , A61B2017/0243 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496
摘要： A heart stabilizer and suture control device for stabilizing the heart and for occluding a preselected portion of coronary artery by developing a downward force on the heart and simultaneously developing an upward force across a coronary artery in a predetermined position. The device has at least two stabilization pads, the stabilization pads each having an operative size and shape, and each having a first end and a second end and a lower contacting surface. The second ends have suture retaining grooves, and the stabilization pad has a suture locking means for securing the distal end of a suture means thereto. The device also comprises a linking member locking the two stabilization pads an operative distance apart. The device has suture means with a proximal end coupled to the linking member and extending from the first end to the suture retaining groove of the second end, the suture means having a distal end which can be locked to the stabilization pad with the suture locking means thereon. The device also has means for rotating the linking member such that when operatively positioned adjacent a coronary artery to be occluded with the suture threaded between the coronary artery and the remaining portion of the heart muscle, rotating the linking member will cause the proximal end of the suture means to be wound onto the linking member and thus tighten the suture between the first end and the second end of each stabilization pad and urge the coronary artery against the contacting surface, thereby causing occlusion of the coronary artery as desired.
摘要翻译：一种心脏稳定器和缝合线控制装置，用于通过在心脏上产生向下的力同时在预定位置上跨越冠状动脉形成向上的力来稳定心脏并阻塞冠状动脉的预选部分。该装置具有至少两个稳定垫，稳定垫各自具有可操作的尺寸和形状，并且每个具有第一端和第二端和下接触表面。第二端具有缝合线保持槽，并且稳定垫具有用于将缝线装置的远端固定到其上的缝合线锁定装置。该装置还包括连接构件，其将两个稳定垫片间隔开操作距离。该装置具有缝合装置，其近端联接到连接构件并且从第一端的第一端延伸到缝合线保持槽，缝合线装置具有远端，该远端可利用缝合线锁定装置锁定到稳定垫上。该装置还具有用于旋转连接构件的装置，使得当可操作地定位成邻近冠状动脉以被缝合在冠状动脉与心脏肌肉的剩余部分之间的缝合线时，旋转连接构件将导致连接构件的近端缝合装置被缠绕到连接构件上，从而在每个稳定垫的第一端和第二端之间紧固缝合线，并且迫使冠状动脉抵靠接触表面，从而根据需要引起冠状动脉闭塞。

4. 发明授权

US5925012A Laser assisted drug delivery 失效
标题翻译：激光辅助药物输送
公开(公告)号：US5925012A
公开(公告)日：1999-07-20
申请号：US773872
申请日：1996-12-27
申请人： Douglas Murphy-Chutorian , Richard L. Mueller , Stuart D. Harman , Steve A. Daniel , Larry Witham , Robert Lincoln Lathrop, III , Bruce Richardson
发明人： Douglas Murphy-Chutorian , Richard L. Mueller , Stuart D. Harman , Steve A. Daniel , Larry Witham , Robert Lincoln Lathrop, III , Bruce Richardson
IPC分类号： A61B17/00 , A61B18/24 , A61M1/00
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2018/00392
摘要： A drug delivery apparatus for dispensing predetermined volumes of drug, drug solution or other substances into an opening, such as a TMR channel in the human heart, or other laser treated area within the human body, the apparatus consisting of a bifurcated needle with a laser inlet for guiding a laser delivery means, such as an optical fiber or fiber bundle, to adjacent a surface of the human heart or other body structure for creating an opening, such as a TMR channel, or other laser treated area thereon. A drug inlet is for receiving the drug and transmitting the drug to the TMR channel or other laser treated area. Optionally, a piercing tip and/or suction device assists in positioning the apparatus adjacent the tissue to be treated. Drug is dispensed by manually or automatically actuating a piston or syringe element. A method of use is also disclosed.
摘要翻译：用于将预定体积的药物，药物溶液或其它物质分配到诸如人心脏中的TMR通道或人体内的其它激光处理区域的开口中的药物递送装置，该装置由具有激光的分叉针用于将诸如光纤或纤维束的激光传送装置引导到靠近人心或其他身体结构的表面以在其上形成诸如TMR通道或其他激光处理区域的开口。药物入口用于接收药物并将药物传输到TMR通道或其他激光治疗区域。可选地，刺穿尖端和/或抽吸装置有助于将装置定位在待处理组织附近。通过手动或自动启动活塞或注射器元件来分配药物。还公开了一种使用方法。

5. 发明授权

US6027497A TMR energy delivery system 失效
标题翻译： TMR能量输送系统
公开(公告)号：US6027497A
公开(公告)日：2000-02-22
申请号：US794733
申请日：1997-02-03
申请人： Steve A. Daniel , Richard L. Mueller , Robert D. Dowling
发明人： Steve A. Daniel , Richard L. Mueller , Robert D. Dowling
IPC分类号： A61B18/20 , A61B1/018 , A61B1/267 , A61B1/313 , A61B17/00 , A61B17/30 , A61B18/24 , A61B19/00 , A61N5/06 , A61B17/36
CPC分类号： A61B1/00154 , A61B1/00098 , A61B1/018 , A61B18/24 , A61B1/267 , A61B1/3132 , A61B2017/00247 , A61B2017/306 , A61B2018/00291 , A61B2018/00392 , A61B90/37 , A61B90/39
摘要： A TMR energy delivery device is introduced through a first minimally invasive penetration of a patient's chest. Sufficient energy if delivered from the wave guide to the wall of the heart to form a channel through at least a portion of the wall. The device includes a visualization device or camera with a rigid portion and a distal end portion that is flexible, a cup member coupled to a distal end of the flexible distal portion, and a vacuum source coupled to the cup member for providing mechanical stability against the heart wall.
摘要翻译：通过患者胸部的第一微创穿透引入TMR能量输送装置。足够的能量，如果从波导传送到心脏的壁，以形成穿过壁的至少一部分的通道。该装置包括可视化装置或照相机，该可视化装置或相机具有柔性的刚性部分和远端部分，耦合到柔性远端部分的远端的杯状构件和联接到杯状构件的真空源，以提供抵抗心墙

6. 发明授权

US06315774B1 Minimally invasive apparatus for forming revascularization channels 失效
标题翻译：用于形成血运重建通道的微创装置
公开(公告)号：US06315774B1
公开(公告)日：2001-11-13
申请号：US09457461
申请日：1999-12-08
申请人： Steve A. Daniel , Richard L. Mueller , Robert D. Dowling
发明人： Steve A. Daniel , Richard L. Mueller , Robert D. Dowling
IPC分类号： A61B1818
CPC分类号： A61B1/00154 , A61B1/00098 , A61B1/018 , A61B1/267 , A61B1/3132 , A61B18/24 , A61B90/37 , A61B90/39 , A61B2017/00247 , A61B2017/306 , A61B2018/00291 , A61B2018/00392
摘要： An apparatus for performing transmyocardial revascularization provides a closed-chest formation of a channel in a wall of a heart. An articulating scope in one embodiment includes a flexible distal portion which provides for a coupling of a surface of the heart to the distal portion. The articulating distal portion is coupled to a control member to provide articulation. Movement of the control member causes deflection, including articulation, of the generally flexible working end of the scope. The coupler may be a two way valve to provide both vacuum and flushing solutions. The articulating scope can be supported by a scope holder that is table mounted or mounted to the patient. An access port provides for the introduction of tools and instruments. An adaptor couples the access port with a handle. The handle provides a working channel for the introduction of an energy delivery device.
摘要翻译：用于执行经心肌血运重建的装置提供在心脏壁中的通道闭合形成。一个实施例中的关节范围包括柔性远侧部分，其提供心脏表面与远端部分的联接。铰接远端部分联接到控制构件以提供铰接。控制构件的移动导致范围通常灵活的工作端的偏转（包括铰接）。联接器可以是双向阀，以提供真空和冲洗解决方案。关节范围可以由桌子安装或安装到患者的镜架支撑。访问端口用于引入工具和工具。适配器将访问端口与手柄相连。手柄提供了引入能量输送装置的工作通道。

7. 发明申请

US20090076497A1 Tissue surface treatment apparatus and method 有权
公开(公告)号：US20090076497A1
公开(公告)日：2009-03-19
申请号：US11893911
申请日：2007-08-17
申请人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/14
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.

8. 发明授权

US08216224B2 Tissue surface treatment apparatus and method 有权
标题翻译：组织表面处理装置及方法
公开(公告)号：US08216224B2
公开(公告)日：2012-07-10
申请号：US11893911
申请日：2007-08-17
申请人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/14
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.
摘要翻译：控制消融体积深度的方法包括提供治疗装置。该装置包括具有包括组织接触表面的近端和远端的壳体。壳体限定具有可定位在内部的能量输送装置的内部。能量递送装置包括至少一个具有组织穿透远端的电极，并被构造成从内部前进到目标组织部位以限定消融体积。一个前进装置耦合到能量输送装置，并被配置成使该至少一个电极前进。将至少一个电极推进到组织表面下方的选定的部署深度，同时避免关键结构。能量从能量输送装置输送。在组织表面下方的受控深度处产生消融体积，以响应于部署深度，同时最小化对关键结构的损伤。

9. 发明授权

US07160296B2 Tissue ablation apparatus and method 有权
标题翻译：组织消融装置及方法
公开(公告)号：US07160296B2
公开(公告)日：2007-01-09
申请号：US10142713
申请日：2002-05-10
申请人： Rob Pearson , Steve A. Daniel , Daniel J. Balbierz , Kee S. Lee , Jessica Liang , Martha Getaneh
发明人： Rob Pearson , Steve A. Daniel , Daniel J. Balbierz , Kee S. Lee , Jessica Liang , Martha Getaneh
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/0016 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00714 , A61B2018/00791 , A61B2018/00797 , A61B2018/00875 , A61B2018/143 , A61B2018/1472 , A61B2018/1475
摘要： A tissue-ablation method and apparatus are disclosed. The apparatus includes a plurality of RF ablation electrodes, and a plurality of sensor elements, each movable from retracted to deployed positions in a tissue to be ablated. A control device in the apparatus is operatively connected to the electrodes for supplying an RF power to the electrodes, to produce tissue ablation that advances from individual-electrode ablation regions to fill a combined-electrode ablation volume. The control device is operatively connected to the sensor elements for determining the extent of ablation in the regions of the sensor elements. The supply of RF power to the electrodes can thus be regulated to control the level and extent of tissue ablation throughout the combined-electrode volume. The electrodes are preferably hollow-needle electrodes through which liquid can be infused into the tissue, also under the control of the control unit, to modulate and optimize tissue ablation.
摘要翻译：公开了组织消融方法和装置。该装置包括多个RF消融电极和多个传感器元件，每个传感器元件可从收缩的组织中的缩回到展开位置移动以进行烧蚀。设备中的控制装置可操作地连接到电极，以向电极提供RF功率，以产生从单个电极消融区域前进以填充组合电极消融体积的组织消融。控制装置可操作地连接到传感器元件，以确定传感器元件区域中的消融程度。因此，可以调节对电极的RF功率的供应以控制整个组合电极体积中的组织消融的水平和程度。电极优选是中空针电极，液体也可以在控制单元的控制下输注到组织中，以调节和优化组织消融。

10. 发明授权

US07278991B2 Tissue surface treatment apparatus and method 有权
标题翻译：组织表面处理装置及方法
公开(公告)号：US07278991B2
公开(公告)日：2007-10-09
申请号：US09938276
申请日：2001-08-22
申请人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/18
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.
摘要翻译：控制消融体积深度的方法包括提供治疗装置。该装置包括具有包括组织接触表面的近端和远端的壳体。壳体限定具有可定位在内部的能量输送装置的内部。能量递送装置包括至少一个具有组织穿透远端的电极，并被构造成从内部前进到目标组织部位以限定消融体积。一个前进装置耦合到能量输送装置，并被配置成使该至少一个电极前进。将至少一个电极推进到组织表面下方的选定的部署深度，同时避免关键结构。能量从能量输送装置输送。在组织表面下方的受控深度处产生消融体积，以响应于部署深度，同时最小化对关键结构的损伤。

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