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1. 发明授权

US08216224B2 Tissue surface treatment apparatus and method 有权
标题翻译：组织表面处理装置及方法
公开(公告)号：US08216224B2
公开(公告)日：2012-07-10
申请号：US11893911
申请日：2007-08-17
申请人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/14
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.
摘要翻译：控制消融体积深度的方法包括提供治疗装置。该装置包括具有包括组织接触表面的近端和远端的壳体。壳体限定具有可定位在内部的能量输送装置的内部。能量递送装置包括至少一个具有组织穿透远端的电极，并被构造成从内部前进到目标组织部位以限定消融体积。一个前进装置耦合到能量输送装置，并被配置成使该至少一个电极前进。将至少一个电极推进到组织表面下方的选定的部署深度，同时避免关键结构。能量从能量输送装置输送。在组织表面下方的受控深度处产生消融体积，以响应于部署深度，同时最小化对关键结构的损伤。

2. 发明授权

US07278991B2 Tissue surface treatment apparatus and method 有权
标题翻译：组织表面处理装置及方法
公开(公告)号：US07278991B2
公开(公告)日：2007-10-09
申请号：US09938276
申请日：2001-08-22
申请人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/18
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.
摘要翻译：控制消融体积深度的方法包括提供治疗装置。该装置包括具有包括组织接触表面的近端和远端的壳体。壳体限定具有可定位在内部的能量输送装置的内部。能量递送装置包括至少一个具有组织穿透远端的电极，并被构造成从内部前进到目标组织部位以限定消融体积。一个前进装置耦合到能量输送装置，并被配置成使该至少一个电极前进。将至少一个电极推进到组织表面下方的选定的部署深度，同时避免关键结构。能量从能量输送装置输送。在组织表面下方的受控深度处产生消融体积，以响应于部署深度，同时最小化对关键结构的损伤。

3. 发明申请

US20090076497A1 Tissue surface treatment apparatus and method 有权
公开(公告)号：US20090076497A1
公开(公告)日：2009-03-19
申请号：US11893911
申请日：2007-08-17
申请人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steve A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/14
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.

4. 发明授权

US07625371B2 Tissue surface treatment apparatus and method 失效
标题翻译：组织表面处理装置及方法
公开(公告)号：US07625371B2
公开(公告)日：2009-12-01
申请号：US11034435
申请日：2005-01-11
申请人： David L. Morris , Steven A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steven A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/18
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A tissue surface treatment apparatus includes a housing having a proximal end, a distal end including a tissue contacting surface, an interior defined by the housing and a handpiece coupled to the housing. The contactinc surface has a plurality of apertures. An energy delivery device including an electrode is positionable in the housing interior. The electrode includes a tissue penetrating distal end in substantial alignment with an aperture. The electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy delivery device and is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the electrode from the housing interior into the target tissue site and withdrawal the electrode into the housing interior. A cable is coupled to the housing or the energy delivery device and is configured to be coupled to an energy source.
摘要翻译：组织表面处理设备包括具有近端，远端包括组织接触表面的壳体，由壳体限定的内部和联接到壳体的手持件。触点表面具有多个孔。包括电极的能量输送装置可定位在壳体内部。电极包括与孔基本对准的穿透远端的组织。电极被配置为从壳体内部通过孔推进到目标组织部位以限定至少部分地由组织表面限定的消融体积。进给装置联接到能量输送装置，并且至少部分地可定位在壳体或手持件中的至少一个中。推进装置被配置为将电极从壳体内部推进到目标组织部位并将电极抽出到壳体内部。电缆耦合到壳体或能量输送装置，并且被配置为耦合到能量源。

5. 发明授权

US07422586B2 Tissue surface treatment apparatus and method 有权
标题翻译：组织表面处理装置及方法
公开(公告)号：US07422586B2
公开(公告)日：2008-09-09
申请号：US09797409
申请日：2001-02-28
申请人： David L. Morris , Steven A. Daniel , Daniel J. Balbierz
发明人： David L. Morris , Steven A. Daniel , Daniel J. Balbierz
IPC分类号： A61B18/18
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A tissue surface reatment apparatus includes a housing having a proximal end, a distal end including a tissue contacting surface, an interior defined by the housing and a handpiece coupled to the housing. The contactine surface has a plurality of apertures. An energy delivery device including an electrode is positionable in the housing interior. The electrode includes a tissue penetrating distal end in substantial alignment with an aperture. The electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy deliveru device and is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the electrode fdro the housing interior into the target tissuesite and withdrawal the electrode into the housing interior. A cable is coupled to the housing or the energy delivery device and is configured to be coupled to an energy source.
摘要翻译：组织表面恢复装置包括具有近端，远端包括组织接触表面的壳体，由壳体限定的内部和联接到壳体的手持件。接触面具有多个孔。包括电极的能量输送装置可定位在壳体内部。电极包括与孔基本对准的穿透远端的组织。电极被配置为从壳体内部通过孔推进到目标组织部位以限定至少部分地由组织表面限定的消融体积。进给装置联接到能量输送装置，并且至少部分地可定位在壳体或手持件中的至少一个中。推进装置被配置为使电极将壳体内部推进到目标组织中并将电极撤回到壳体内部。电缆耦合到壳体或能量输送装置，并且被配置为耦合到能量源。

6. 发明申请

US20120214856A1 TREATMENT FOR CANCER 有权
标题翻译：癌症治疗
公开(公告)号：US20120214856A1
公开(公告)日：2012-08-23
申请号：US13457860
申请日：2012-04-27
申请人： David L. Morris , Mohammad Hossein Pourgholami
发明人： David L. Morris , Mohammad Hossein Pourgholami
IPC分类号： A61K31/4184 , A61P35/02 , A61P35/04 , A61P35/00
CPC分类号： A61K31/427 , A61K31/337 , A61K31/4184
摘要： The present invention provides methods for the treatment of tumors, comprising administration of an effective amount of at least one taxoid and an effective amount of at least one benzimidazol carbamate compound of formula (I). The invention also provides a method for the treatment of tumors insensitive to one or more anti-mitotic drugs, the method comprising administering a effective amount of at least one benzimidazole carbamate compound of formula (I). Also provide are compositions for carrying out methods of the invention.
摘要翻译：本发明提供了治疗肿瘤的方法，包括施用有效量的至少一种类紫杉素和有效量的至少一种式（I）的苯并咪唑氨基甲酸酯化合物。本发明还提供了治疗对一种或多种抗有丝分裂药物不敏感的肿瘤的方法，所述方法包括施用有效量的式（I）的至少一种苯并咪唑氨基甲酸酯化合物。还提供了用于实施本发明方法的组合物。

7. 发明申请

US20080319436A1 Devices and Methods for Thermal Ablation of Biological Tissue Using Geometric Ablation Patterns 有权
标题翻译：使用几何消融模式的生物组织热消融的装置和方法
公开(公告)号：US20080319436A1
公开(公告)日：2008-12-25
申请号：US12107034
申请日：2008-04-21
申请人： Steven A. Daniel , David L. Morris , Kee Sein Lee
发明人： Steven A. Daniel , David L. Morris , Kee Sein Lee
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/148 , A61B18/1477 , A61B18/1487 , A61B2018/00267
摘要： A tissue ablation system including numerous components and methods is described herein for encircling target tissue and generating tissue ablation volumes in various biological tissues. The biological tissue includes tissue of a variety of organs of the human body including the liver, spleen, kidney, lung, breast and other organs, but is not so limited. The tissue ablation device comprises an energy source and at least one trocar coupled to the energy source, the trocar having a body, a proximal end, and a distal end. The trocar carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the trocar when moved from a retracted state to a deployed state, and to have at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state.
摘要翻译：本文描述了包括许多组分和方法的组织消融系统，用于环绕靶组织并在各种生物组织中产生组织消融体积。生物组织包括人体各种器官的组织，包括肝，脾，肾，肺，乳腺和其他器官，但不限于此。组织消融装置包括能量源和耦合到能量源的至少一个套管针，套管针具有主体，近端和远端。套针针携带包括多个电极的电极阵列，多个电极中的每个电极构造成当套管针从缩回状态移动到展开状态时延伸，并且在所展开的部分中具有至少一个曲率半径使得电极阵列形成处于展开状态的一系列成形电极。

8. 发明申请

US20080312650A1 Thermal Ablation of Biological Tissue 审中-公开
标题翻译：生物组织热消融
公开(公告)号：US20080312650A1
公开(公告)日：2008-12-18
申请号：US12139912
申请日：2008-06-16
申请人： Steven A. Daniel , David L. Morris
发明人： Steven A. Daniel , David L. Morris
IPC分类号： A61B18/14
CPC分类号： A61B18/148 , A61B2018/00267
摘要： An ablation device is described comprising an introducer and an electrode array. The electrode array couples to a distal end of the introducer. The electrode array includes a center member having a distal end configured to penetrate tissue and a plurality of electrodes. Proximal and distal ends of each electrode are relatively fixed. The electrodes are dynamically configurable from a retracted state to a deployed state in which the electrodes form a relatively spherical shape in a tissue volume.
摘要翻译：描述了包括导引器和电极阵列的消融装置。电极阵列耦合到导引器的远端。电极阵列包括具有构造成穿透组织的远端和多个电极的中心构件。每个电极的近端和远端相对固定。电极可以从缩回状态动态地配置到展开状态，其中电极在组织体积中形成相对球形的形状。

9. 发明授权

US06176754B1 Method for forming a conductive focus waffle 失效
标题翻译：形成导电聚焦华夫饼的方法
公开(公告)号：US06176754B1
公开(公告)日：2001-01-23
申请号：US09087105
申请日：1998-05-29
申请人： David C. Chang , Arthur J. Learn , Bob L. Mackey , Paul M. Drumm , David L. Morris
发明人： David C. Chang , Arthur J. Learn , Bob L. Mackey , Paul M. Drumm , David L. Morris
IPC分类号： H01J916
CPC分类号： H01J9/148 , H01J9/025 , H01J29/467 , H01J2329/00
摘要： A conductive focus waffle structure for focusing electrons emitted from a cathode portion of a flat panel display device, and a method for forming the conductive focus waffle structure. In one embodiment, the present invention applies a first layer of photo-imagable material above a cathode portion of a flat panel display device. This embodiment then removes portions of the layer of photo-imagable material such that openings are formed therein. A layer of conductive material is then applied over the cathode such that conductive material is disposed within the openings in the layer of photo-imagable material. A dielectric layer of material is also disposed between the cathode and the bottom surface of the conductive material. This embodiment of the present invention then removes the layer of photo-imagable material such that at least a portion of the conductive focus waffle structure is formed disposed above the cathode. In so doing, at least a first portion of a conductive focus waffle structure having a dielectric bottom portion is formed.
摘要翻译：用于聚焦从平板显示装置的阴极部分发射的电子的导电聚焦华夫饼结构，以及用于形成导电聚焦华夫饼结构的方法。在一个实施例中，本发明在平板显示装置的阴极部分上方施加第一层可光成像材料。然后，该实施例移除可光成像材料层的部分，使得其中形成开口。然后将一层导电材料施加在阴极上，使得导电材料设置在可光成像材料层内的开口内。材料的电介质层也设置在导电材料的阴极和底表面之间。然后，本发明的该实施例移除可光成像材料层，使得形成设置在阴极上方的至少一部分导电聚焦楔形结构。这样做，形成具有电介质底部部分的导电聚焦华夫饼结构的至少第一部分。

10. 发明授权

US4493890A Activated apoglucose oxidase and its use in specific binding assays 失效
标题翻译：活性糖苷氧化酶及其在特异性结合测定中的应用
公开(公告)号：US4493890A
公开(公告)日：1985-01-15
申请号：US404427
申请日：1982-08-02
申请人： David L. Morris
发明人： David L. Morris
IPC分类号： C12Q1/26 , G01N33/542 , G01N33/573 , G01N33/58 , G01N33/54 , C12N9/96
CPC分类号： C12Q1/26 , G01N33/542 , G01N33/573 , G01N33/581 , Y10S435/81 , Y10S435/962 , Y10S435/966 , Y10S435/975
摘要： A method for increasing the ability of apoglucose oxidase to combine with flavin adenine dinucleotide (FAD) and derivatives thereof to form active glucose oxidase by interacting apoglucose oxidase with an immunologically derived binding substance, e.g., an antibody or a fragment thereof, having a specific binding affinity for glucose oxidase. The apoglucose oxidase/anti-glucose oxidase immune complex is characterized by enhanced ability to combine with FAD and FAD-derivatives to yield glucose oxidase activity. The activation is particularly significant at temperatures elevated from room temperature, e.g., between 30.degree.-45.degree. C. An improved homogeneous specific binding assay method is provided for determining ligands wherein an FAD label is used and is monitored by its ability to combine with apoglucose oxidase to form active glucose oxidase by including anti-glucose oxidase in the reaction mixture.
摘要翻译：一种增加糖醛酸氧化酶与黄素腺嘌呤二核苷酸（FAD）及其衍生物结合形成活性葡萄糖氧化酶的能力的方法，其通过与具有特异性结合的免疫学衍生的结合物质（例如抗体或其片段）相互作用而形成葡萄糖氧化酶对葡萄糖氧化酶的亲合力。葡萄糖氧化酶/抗葡萄糖氧化酶免疫复合物的特征在于与FAD和FAD衍生物结合以产生葡萄糖氧化酶活性的能力增强。在从室温升高的温度（例如在30°-45℃之间）的温度下，活化特别显着。提供改进的均相特异性结合测定方法用于测定其中使用FAD标记的配体，并通过其与葡萄糖结合的能力进行监测通过在反应混合物中包含抗葡萄糖氧化酶，氧化酶形成活性葡萄糖氧化酶。

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