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1. 发明授权

US08666505B2 Wafer-scale package including power source 有权
标题翻译：晶圆级封装，包括电源
公开(公告)号：US08666505B2
公开(公告)日：2014-03-04
申请号：US13016253
申请日：2011-01-28
申请人： Richard J. O'Brien , John K. Day , Paul F. Gerrish , Michael F. Mattes , David A. Ruben , Malcolm K. Grief
发明人： Richard J. O'Brien , John K. Day , Paul F. Gerrish , Michael F. Mattes , David A. Ruben , Malcolm K. Grief
IPC分类号： A61N1/05
CPC分类号： H01L23/12 , A61B5/0031 , A61B5/01 , A61B5/03 , A61B5/11 , A61N1/37211 , A61N1/3758 , B81B2201/0214 , B81B2207/012 , B81C1/0023 , H01L23/58 , H01L25/0655 , H01L2223/6677 , H01L2224/16145 , H01L2224/16225 , H01L2924/1461 , H01L2924/15153 , H01L2924/15192 , H01L2924/15313 , H01L2924/16195 , H01L2924/16251 , H01L2924/19105 , H01L2924/00
摘要： A medical device includes a first substrate, a second substrate, a control module, and an energy storage device. The first substrate includes at least one of a first semiconductor material and a first insulating material. The second substrate includes at least one of a second semiconductor material and a second insulating material. The second substrate is bonded to the first substrate such that the first and second substrates define an enclosed cavity between the first and second substrates. The control module is disposed within the enclosed cavity. The control module is configured to at least one of determine a physiological parameter of a patient and deliver electrical stimulation to the patient. The energy storage device is disposed within the cavity and is configured to supply power to the control module.
摘要翻译：医疗装置包括第一基板，第二基板，控制模块和能量存储装置。第一基板包括第一半导体材料和第一绝缘材料中的至少一个。第二基板包括第二半导体材料和第二绝缘材料中的至少一个。第二基板被结合到第一基板，使得第一和第二基板在第一和第二基板之间限定封闭的空腔。控制模块设置在封闭腔内。控制模块被配置为至少确定患者的生理参数并向患者传递电刺激中的至少一个。能量存储装置设置在空腔内并被配置为向控制模块供电。

2. 发明申请

US20120101540A1 WAFER-SCALE PACKAGE INCLUDING POWER SOURCE 有权
标题翻译：包括电源的WAFER-SCALE包装
公开(公告)号：US20120101540A1
公开(公告)日：2012-04-26
申请号：US13016253
申请日：2011-01-28
申请人： Richard J. O'Brien , John K. Day , Paul F. Gerrish , Michael F. Mattes , David A. Ruben , Malcolm K. Grief
发明人： Richard J. O'Brien , John K. Day , Paul F. Gerrish , Michael F. Mattes , David A. Ruben , Malcolm K. Grief
IPC分类号： A61N1/05 , H01L23/538 , H01L29/84 , H01L31/12
CPC分类号： H01L23/12 , A61B5/0031 , A61B5/01 , A61B5/03 , A61B5/11 , A61N1/37211 , A61N1/3758 , B81B2201/0214 , B81B2207/012 , B81C1/0023 , H01L23/58 , H01L25/0655 , H01L2223/6677 , H01L2224/16145 , H01L2224/16225 , H01L2924/1461 , H01L2924/15153 , H01L2924/15192 , H01L2924/15313 , H01L2924/16195 , H01L2924/16251 , H01L2924/19105 , H01L2924/00
摘要： A medical device includes a first substrate, a second substrate, a control module, and an energy storage device. The first substrate includes at least one of a first semiconductor material and a first insulating material. The second substrate includes at least one of a second semiconductor material and a second insulating material. The second substrate is bonded to the first substrate such that the first and second substrates define an enclosed cavity between the first and second substrates. The control module is disposed within the enclosed cavity. The control module is configured to at least one of determine a physiological parameter of a patient and deliver electrical stimulation to the patient. The energy storage device is disposed within the cavity and is configured to supply power to the control module.
摘要翻译：医疗装置包括第一基板，第二基板，控制模块和能量存储装置。第一基板包括第一半导体材料和第一绝缘材料中的至少一个。第二基板包括第二半导体材料和第二绝缘材料中的至少一个。第二基板被结合到第一基板，使得第一和第二基板在第一和第二基板之间限定封闭的空腔。控制模块设置在封闭腔内。控制模块被配置为至少确定患者的生理参数并向患者传递电刺激中的至少一个。能量存储装置设置在空腔内并被配置为向控制模块供电。

3. 发明授权

US06963780B2 Implantable medical device including a surface-mount terminal array 有权
标题翻译：可植入医疗器械，包括表面安装端子阵列
公开(公告)号：US06963780B2
公开(公告)日：2005-11-08
申请号：US10061718
申请日：2002-01-31
申请人： David A. Ruben , Andrew J. Ries , Juan G. Milla , Randy S. Roles , Terry W. Bruneau , Steve Craig Warren , David W. Parkin , John V. Anderson, II , John K. Day , Robert V. Hemann, Jr.
发明人： David A. Ruben , Andrew J. Ries , Juan G. Milla , Randy S. Roles , Terry W. Bruneau , Steve Craig Warren , David W. Parkin , John V. Anderson, II , John K. Day , Robert V. Hemann, Jr.
IPC分类号： A61N1/375
CPC分类号： A61N1/3754
摘要： An implantable medical device comprises an enclosure, a first plurality of electrical contacts disposed within the enclosure, at least a first electrical component secured within the enclosure, a second plurality of electrical contacts on the first electrical component, and a terminal array for providing electrical coupling between the first and second plurality of electrical contacts. The terminal array comprises a housing having a plurality of apertures therethrough, the housing having a first side and a second opposite side. Each of a plurality of conductive terminals is positioned within one of the plurality of apertures and has a first contact region proximate the first side of the housing and a second contact region proximate the second side of the housing. The first contact region is electrically coupled to one of the first plurality of electrical contacts, and the second contact region is electrically coupled to one of the second plurality of contacts.
摘要翻译：可植入医疗装置包括外壳，设置在外壳内的第一多个电触点，固定在外壳内的至少第一电气部件，第一电气部件上的第二多个电触点，以及用于提供电耦合的端子阵列在第一和第二多个电触头之间。端子阵列包括具有穿过其中的多个孔的壳体，壳体具有第一侧和第二相对侧。多个导电端子中的每一个定位在多个孔中的一个孔内，并且具有靠近壳体的第一侧的第一接触区域和靠近壳体的第二侧的第二接触区域。第一接触区域电耦合到第一多个电触头中的一个，并且第二接触区域电耦合到第二多个触点中的一个。

4. 发明申请

US20130337313A1 POWER SOURCES SUITABLE FOR USE IN IMPLANTABLE MEDICAL DEVICES AND CORRESPONDING FABRICATION METHODS 有权
标题翻译：适用于可植入医疗器械和相关制造方法的电源
公开(公告)号：US20130337313A1
公开(公告)日：2013-12-19
申请号：US13524304
申请日：2012-06-15
申请人： Mohsen Askarinya , Andreas A. Fenner , Erik J. Herrmann , David A. Ruben , John K. Day
发明人： Mohsen Askarinya , Andreas A. Fenner , Erik J. Herrmann , David A. Ruben , John K. Day
IPC分类号： H01M2/22 , H01M10/04
CPC分类号： H01M2/204 , A61N1/3758 , A61N1/378 , H01M2/1066 , H01M2/202 , H01M2/22 , H01M2/24 , H01M2/266 , H01M6/40 , H01M6/46 , H01M10/0436 , H01M10/0525 , H01M10/0562 , H01M10/0585 , H01M10/647 , Y02E60/122 , Y10T29/49112
摘要： Arrays of planar solid state batteries are stacked in an aligned arrangement for subsequent separation into individual battery stacks. Prior to stacking, a redistribution layer (RDL) is formed over a surface of each wafer that contains an array; each RDL includes first and second groups of conductive traces, each of the first extending laterally from a corresponding positive battery contact, and each of the second extending laterally from a corresponding negative battery contact. Conductive vias, formed before or after stacking, ultimately couple together corresponding contacts of aligned batteries. If before, each via extends through a corresponding battery contact of each wafer and is coupled to a corresponding conductive layer that is included in another RDL formed over an opposite surface of each wafer. If after, each via extends through corresponding aligned conductive traces and, upon separation of individual battery stacks, becomes an exposed conductive channel of a corresponding battery stack.
摘要翻译：平面固态电池的阵列以对准的布置堆叠，以便随后分离成单独的电池堆叠。在堆叠之前，在包含阵列的每个晶片的表面上形成重分布层（RDL）; 每个RDL包括第一和第二组导电迹线，每个导体迹线首先从对应的正电池触点横向延伸，并且每个第二组从相应的负电池触点横向延伸。在堆叠之前或之后形成的导电通孔最终将对准的电池的相应触点耦合在一起。如果之前，每个通孔延伸穿过每个晶片的对应的电池触点并且耦合到相应的导电层，该导电层被包括在形成于每个晶片的相对表面上的另一个RDL中。如果之后，每个通孔延伸通过对应的对准的导电迹线，并且在单独的电池堆分离时，成为相应电池堆的暴露的导电通道。

5. 发明授权

US09252415B2 Power sources suitable for use in implantable medical devices and corresponding fabrication methods 有权
标题翻译：适用于植入医疗器械的电源和相应的制造方法
公开(公告)号：US09252415B2
公开(公告)日：2016-02-02
申请号：US13524304
申请日：2012-06-15
申请人： Mohsen Askarinya , Andreas A. Fenner , Erik J. Herrmann , David A. Ruben , John K. Day
发明人： Mohsen Askarinya , Andreas A. Fenner , Erik J. Herrmann , David A. Ruben , John K. Day
IPC分类号： H01M2/10 , H01M2/20 , H01M2/24 , H01M2/26 , H01M10/0562 , H01M10/0585 , H01M10/647 , H01M6/40 , H01M6/46 , H01M2/22 , H01M10/04 , H01M10/0525 , A61N1/378 , A61N1/375
CPC分类号： H01M2/204 , A61N1/3758 , A61N1/378 , H01M2/1066 , H01M2/202 , H01M2/22 , H01M2/24 , H01M2/266 , H01M6/40 , H01M6/46 , H01M10/0436 , H01M10/0525 , H01M10/0562 , H01M10/0585 , H01M10/647 , Y02E60/122 , Y10T29/49112
摘要： Arrays of planar solid state batteries are stacked in an aligned arrangement for subsequent separation into individual battery stacks. Prior to stacking, a redistribution layer (RDL) is formed over a surface of each wafer that contains an array; each RDL includes first and second groups of conductive traces, each of the first extending laterally from a corresponding positive battery contact, and each of the second extending laterally from a corresponding negative battery contact. Conductive vias, formed before or after stacking, ultimately couple together corresponding contacts of aligned batteries. If before, each via extends through a corresponding battery contact of each wafer and is coupled to a corresponding conductive layer that is included in another RDL formed over an opposite surface of each wafer. If after, each via extends through corresponding aligned conductive traces and, upon separation of individual battery stacks, becomes an exposed conductive channel of a corresponding battery stack.
摘要翻译：平面固态电池的阵列以对准的布置堆叠，以便随后分离成单独的电池堆叠。在堆叠之前，在包含阵列的每个晶片的表面上形成重分布层（RDL）; 每个RDL包括第一和第二组导电迹线，每个导体迹线首先从对应的正电池触点横向延伸，并且每个第二组从相应的负电池触点横向延伸。在堆叠之前或之后形成的导电通孔最终将对准的电池的相应触点耦合在一起。如果之前，每个通孔延伸穿过每个晶片的对应的电池触点并且耦合到相应的导电层，该导电层被包括在形成于每个晶片的相对表面上的另一个RDL中。如果之后，每个通孔延伸通过对应的对准的导电迹线，并且在单独的电池堆分离时，成为相应电池堆的暴露的导电通道。

6. 发明授权

US09545215B2 Apparatus and method for detecting cardiac events 有权
标题翻译：用于检测心脏事件的装置和方法
公开(公告)号：US09545215B2
公开(公告)日：2017-01-17
申请号：US12184020
申请日：2008-07-31
申请人： Randal C. Schulhauser , John K. Day , Scott Wayne Haskin , Tho V. Huynh , Todd A. Kallmyer , Brian Bruce Lee , Jeffrey O. York , William Cope
发明人： Randal C. Schulhauser , John K. Day , Scott Wayne Haskin , Tho V. Huynh , Todd A. Kallmyer , Brian Bruce Lee , Jeffrey O. York , William Cope
IPC分类号： A61B5/0205 , A61N1/37 , A61B5/0452 , A61B5/145 , A61B5/00 , A61B5/021 , A61B5/024 , A61B5/08 , A61B5/11 , A61B7/00
CPC分类号： A61B5/0452 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/0816 , A61B5/11 , A61B5/14539 , A61B5/4839 , A61B7/00 , A61N1/37
摘要： A method and system which includes a minimally invasive, implantable device with a sensor configured for collecting electrical data associated with cardiac performance, a sensor configured for collecting mechanical data associated with cardiac performance, a sensor for collecting optical data associated with cardiac performance, a sensor for collecting biochemical data associated with cardiac performance, and a processor for deriving cardiac conditions and actuating an alarm upon identifying a cardiac event.
摘要翻译：一种方法和系统，其包括具有配置用于收集与心脏性能有关的电数据的传感器的微创可植入装置，配置用于收集与心脏性能相关的机械数据的传感器，用于收集与心脏性能相关的光学数据的传感器，传感器用于收集与心脏性能相关的生化数据，以及用于导出心脏状况并在识别心脏事件时致动警报的处理器。

7. 发明申请

US20100030034A1 Apparatus and Method for Detecting Cardiac Events 有权
标题翻译：用于检测心脏事件的装置和方法
公开(公告)号：US20100030034A1
公开(公告)日：2010-02-04
申请号：US12184020
申请日：2008-07-31
申请人： Randal C. Schulhauser , John K. Day , Scott Wayne Haskin , Tho V. Huynh , Todd A. Kallmyer , Brian Bruce Lee , Jeffrey O. York , William Cope
发明人： Randal C. Schulhauser , John K. Day , Scott Wayne Haskin , Tho V. Huynh , Todd A. Kallmyer , Brian Bruce Lee , Jeffrey O. York , William Cope
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/0816 , A61B5/11 , A61B5/14539 , A61B5/4839 , A61B7/00 , A61N1/37
摘要： A method and system which includes a minimally invasive, implantable device with a sensor configured for collecting electrical data associated with cardiac performance, a sensor configured for collecting mechanical data associated with cardiac performance, a sensor for collecting optical data associated with cardiac performance, a sensor for collecting biochemical data associated with cardiac performance, and a processor for deriving cardiac conditions and actuating an alarm upon identifying a cardiac event.
摘要翻译：一种方法和系统，其包括具有配置用于收集与心脏性能有关的电数据的传感器的微创可植入装置，配置用于收集与心脏性能有关的机械数据的传感器，用于收集与心脏性能相关的光学数据的传感器，传感器用于收集与心脏性能相关的生化数据，以及用于导出心脏状况并在识别心脏事件时致动警报的处理器。

8. 发明授权

US07285394B2 Discovery and diagnostic methods using 5-methylcytosine DNA glycosylase 失效
标题翻译：使用5-甲基胞嘧啶DNA糖基化酶的发现和诊断方法
公开(公告)号：US07285394B2
公开(公告)日：2007-10-23
申请号：US10389853
申请日：2003-03-14
申请人： Cathy E. Lofton-Day , John K. Day
发明人： Cathy E. Lofton-Day , John K. Day
IPC分类号： C12Q1/34 , C12Q1/68 , C12Q1/00
CPC分类号： C12Q1/6827 , C12Q2521/125 , C12Q2521/531 , C12Q2537/164 , C12Q2525/119 , C12Q2521/514
摘要： The present invention provides methods for identification of methylated, and/or potentially methylatable CpG dinucleotides in genomic DNA sequences, and methods for isolating genomic DNA sequences comprising methylated CpG dinucleotide sequences. The present invention further provides methods for comparison of the methylation status of specific CpG dinucleotides, and patterns thereof between normal and diseased genomic DNA sequences, along with methods for determining all potentially methylatable CpG dinucleotides in a genomic DNA sample. Specifically, the present invention discloses a novel use of 5-methylcytosine DNA glycosylase (5-MCDG) in combination with art-recognized DNA base excision repair (BER) enzymes, and in particular embodiments, in combination with DNA methyltransferase to specifically label methylated CpG dinucleotide sequences in genomic DNA sequences.
摘要翻译：本发明提供用于鉴定基因组DNA序列中甲基化和/或潜在可甲基化CpG二核苷酸的方法，以及用于分离包含甲基化CpG二核苷酸序列的基因组DNA序列的方法。本发明还提供了用于比较特定CpG二核苷酸的甲基化状态及其在正常和患病基因组DNA序列之间的模式的方法，以及用于确定基因组DNA样品中所有潜在可甲基化CpG二核苷酸的方法。具体地，本发明公开了5-甲基胞嘧啶DNA糖基化酶（5-MCDG）与本领域公认的DNA碱基切除修复（BER）酶的组合的新用途，并且在具体实施方案中，与DNA甲基转移酶组合以特异性标记甲基化CpG 基因组DNA序列中的二核苷酸序列。

9. 发明授权

US5817130A Implantable cardiac cardioverter/defibrillator with EMI suppression filter with independent ground connection 失效
标题翻译：具有独立接地连接的EMI抑制滤波器的可植入式心脏复律/除颤器
公开(公告)号：US5817130A
公开(公告)日：1998-10-06
申请号：US803536
申请日：1997-02-20
申请人： Timothy John Cox , John K. Day
发明人： Timothy John Cox , John K. Day
IPC分类号： A61N1/37 , A61N1/375 , A61N1/39
CPC分类号： A61N1/3931 , A61N1/37 , A61N1/3754 , A61N1/3718 , Y10S128/901
摘要： An implantable defibrillator, which may include cardioversion and pacemaker capabilities, which has EMI filters which are not susceptible to defibrillation shocks and which reduce or eliminate the effects of charging noise on sensing circuits used for continuous confirmation. A first filter capacitor is provided between a sense electrode, which may include pacing capabilities, and a ground reference within a hermetically sealed can containing a pulse/shock generator. A second filter capacitor is provided between a sensing/pacing reference electrode, which may also be a high voltage or shock electrode, and the ground reference. In addition, there is a third filter capacitor between the ground reference and the can. Preferably, the connections of the first, second and third filter capacitors are physically as well as electrically adjacent to each other. The filter capacitors are housed in the can and in or adjacent to a feedthrough assembly which passes through the can. Most preferably, the filter capacitors are discoidal capacitors mounted in or adjacent to the feedthrough.
摘要翻译：可植入除颤器，其可以包括心脏复律和起搏器功能，其具有不易于除颤冲击的EMI滤波器，并且其减少或消除了用于连续确认的感测电路上的充电噪声的影响。第一滤波电容器设置在可包括起搏能力的感测电极和包含脉冲/冲击发生器的密封罐内的接地基准之间。在感测/起搏参考电极（也可以是高电压或冲击电极）和接地参考之间提供第二滤波电容器。另外，接地参考和罐之间有一个第三个滤波电容。优选地，第一，第二和第三滤波电容器的连接在物理上以及彼此电气相邻。滤波电容器容纳在罐中并且位于或靠近通过罐的馈通组件。最优选地，滤波电容器是安装在馈通或邻近馈通的盘形电容器。

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