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1. 发明授权

US07867452B2 Multi-well filtration device 有权
标题翻译：多孔过滤装置
公开(公告)号：US07867452B2
公开(公告)日：2011-01-11
申请号：US11801661
申请日：2007-05-09
申请人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
发明人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
IPC分类号： B01L11/00
CPC分类号： B01L3/50255 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851 , Y10T436/255
摘要： A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
摘要翻译：用于过滤悬浮液的多孔过滤装置包括具有过滤室的过滤板和具有收集井的收集板。过滤室连接到收集井，过滤室和收集井之间布置过滤元件。在过滤板和与过滤元件相邻的收集板之间布置有分离层。使用这样的分离层允许过滤板从收集板容易地分离。分离的过滤板可以舒适地转移到分析装置中，其中可以通过分离层分离过滤室的固相，而不需要更换固相。

2. 发明申请

US20070297950A1 Equilibration device 审中-公开
标题翻译：平衡装置
公开(公告)号：US20070297950A1
公开(公告)日：2007-12-27
申请号：US11818597
申请日：2007-06-14
申请人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
发明人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L9/06 , B01L2200/141 , B01L2300/044 , B01L2300/0829 , B01L2300/0887 , B01L2300/123
摘要： An equilibration device for equilibrating a comparably economic equilibration of a fluid. A first sealing layer is adjacent to the surface side between the plate and the cover. A second sealing layer is arrangeable adjacent to the cover between the plate and the cover and a tube with an open end, which is inside the well such that the open end of the tube projects above the opening of the well. The use of two sealing layers in the equilibration device allows combining the advantages of a material of the first sealing layer, e.g. high flexibility to seal uneven areas and to compensate the step formed by the tube projecting above the opening of the well, as well as the advantages of the second sealing layer, e.g. inexpensiveness, can come to combined effect when the two sealing layers are arranged appropriately.
摘要翻译：用于平衡流体相对经济平衡的平衡装置。第一密封层邻近板和盖之间的表面侧。第二密封层可布置成邻近板和盖之间的盖，以及具有开口端的管，其在井内，使得管的开口端突出在井的开口上方。在平衡装置中使用两个密封层允许组合第一密封层的材料的优点。高度的柔性以密封不均匀区域并且补偿由突出在井的开口上方的管形成的台阶以及第二密封层的优点，例如，当两个密封层适当布置时，可以实现廉价的组合效果。

3. 发明申请

US20070264163A1 Multi-well filtration device 有权
标题翻译：多孔过滤装置
公开(公告)号：US20070264163A1
公开(公告)日：2007-11-15
申请号：US11801661
申请日：2007-05-09
申请人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
发明人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
IPC分类号： B01L11/00
CPC分类号： B01L3/50255 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851 , Y10T436/255
摘要： A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
摘要翻译：用于过滤悬浮液的多孔过滤装置包括具有过滤室的过滤板和具有收集井的收集板。过滤室连接到收集井，过滤室和收集井之间布置过滤元件。在过滤板和与过滤元件相邻的收集板之间布置有分离层。使用这样的分离层允许过滤板从收集板容易地分离。分离的过滤板可以舒适地转移到分析装置中，其中可以通过分离层分离过滤室的固相，而不需要更换固相。

4. 发明授权

US07409041B2 Methods of transmission mode X-ray diffraction analysis and apparatuses therefor 有权
$Methods of transmission mode X-ray diffraction analysis and apparatuses therefor$
标题翻译：透射模式X射线衍射分析方法及其设备
公开(公告)号：US07409041B2
公开(公告)日：2008-08-05
申请号：US11416220
申请日：2006-05-02
申请人： Olaf Grassmann , Michael Hennig , Remo Anton Hochstrasser , Urs Schwitter
发明人： Olaf Grassmann , Michael Hennig , Remo Anton Hochstrasser , Urs Schwitter
IPC分类号： G01N23/20
CPC分类号： G01N23/20
摘要： Methods for transmission mode X-ray diffraction analysis of a sample by means of apparatuses comprising an X-ray radiation source that provides X-ray radiation for irradiating the sample and a detector for detecting X-ray radiation transmitted through and diffracted by the sample. The methods include: (a) placing a sample to be analyzed on a substrate, (b) generating X-ray radiation by means of an X-ray radiation source, (c) positioning the substrate and the sample in an initial position, (d) rotating the substrate and the sample with respect to the initial position around a rotation axis over a predetermined rotation angle, (e) tilting the substrate and the sample with respect to the initial position around a tilting axis over a tilting angle, (f) detecting with a detector the X-ray radiation transmitted through and diffracted by the sample during a time interval, and (g) analyzing the X-ray radiation that is detected.
摘要翻译：透射模式X射线衍射分析方法的方法是通过包含X射线辐射源的X射线辐射源，用于照射样品的检测器和用于检测被样品透射并衍射的X射线辐射的检测器的样品。所述方法包括：（a）将待分析的样品放置在基底上，（b）通过X射线辐射源产生X射线辐射，（c）将基底和样品定位在初始位置（（d）使基板和样品相对于围绕旋转轴线的初始位置旋转预定旋转角度，（e）相对于围绕倾斜轴线的倾斜角度的初始位置倾斜基板和样品，（f ）用检测器检测在时间间隔期间由样品透射并衍射的X射线辐射，以及（g）分析检测到的X射线辐射。

5. 发明申请

US20140039002A1 SOLID FORMS OF A PHARMACEUTICALLY ACTIVE SUBSTANCE 有权
标题翻译：药物活性物质的固体形式
公开(公告)号：US20140039002A1
公开(公告)日：2014-02-06
申请号：US13817124
申请日：2012-02-21
申请人： Ralph Diodone , Karsten Fähnrich , Urs Schwitter , Shan-Ming Kuang , Baoshu Zhao , Prabha N. Ibrahim , Gary Conard Visor
发明人： Ralph Diodone , Karsten Fähnrich , Urs Schwitter , Shan-Ming Kuang , Baoshu Zhao , Prabha N. Ibrahim , Gary Conard Visor
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof. (I)
摘要翻译：本发明提供式1化合物的固体形式及其药物用途。（一世）

6. 发明授权

US07160881B2 Crystalline modifications of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1 λ6-thiomorpholin-4-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide 有权
标题翻译： 2-（3,5-双 - 三氟甲基 - 苯基）-N- [6-（1,1-二氧代-1λ6-硫代吗啉-4-基）-4-（4-氟-2-甲基 - 苯基） - 吡啶-3-基] -N-甲基 - 异丁酰胺
公开(公告)号：US07160881B2
公开(公告)日：2007-01-09
申请号：US10766122
申请日：2004-01-27
申请人： Torsten Hoffmann , Fabienne Hoffmann-Emery , Sonja Nick , Urs Schwitter , Pius Waldmeier
发明人： Torsten Hoffmann , Fabienne Hoffmann-Emery , Sonja Nick , Urs Schwitter , Pius Waldmeier
IPC分类号： C07D279/10 , C07D279/12 , C07D295/00 , A61K31/54
CPC分类号： C07D213/75
摘要： The present invention relates to a new crystalline modification of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1λ6-thiomorpholin-4-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide characterized by the following X-ray diffraction pattern obtained with a CuKα, radiation at 2θ (2Theta)=4.5, 6.4, 7.5, 7.7, 8.0, 8.2, 10.0, 10.2, 10.9, 11.1, 12.9, 13.4, 14.0, 14.5, 15.1, 15.6, 16.2, 16.5, 17.3, 17.5, 18.0, 18.9, 19.3, 19.5, 19.9, 20.1, 20.6, 21.0, 21.4, 22.7, 23.1 and 23.6 and an infrared spectrum having sharp bands at 2925, 2854, 1637, 1604, 1484, 1395, 1375, 1285, 1230, 1172, 1125, 1082, 999, 943, 893, 868, 860, 782, 705, 684 cm−1, and wherein the extrapolated melting point (DSC) is 137.2° C.
摘要翻译：本发明涉及2-（3,5-双 - 三氟甲基 - 苯基）-N- [6-（1,1-二氧代-1λ6'-硫代吗啉-4-基）吡啶-3-基）-4-（4-氟-2-甲基 - 苯基） - 吡啶-3-基] -N-甲基 - 异丁酰胺，其特征在于用CuCl 2 ，2θ处的辐射（2θ）= 4.5,6.4,7.5,7.7,8.0,8.2,10.0,10.2,10.9,11.1,12.9,13.4,14.0,14.5,15.1,15.6,16.2,16.5,17.3,17.5,18.0， 18.9,19.3,19.5,19.9,20.1,20.6,21.0,21.4,22.7,23.1和23.6以及在2925,2854,1637,1604,1484,1395,1375,1285,1230,1172,1125的尖锐谱带的红外光谱，1082,999,943,893,868,860,782,705,684cm -1，其中外推熔点（DSC）为137.2℃

7. 发明授权

US08865735B2 Solid forms of a pharmaceutically active substance 有权
标题翻译：药物活性物质的固体形式
公开(公告)号：US08865735B2
公开(公告)日：2014-10-21
申请号：US13817124
申请日：2012-02-21
申请人： Prabha N. Ibrahim , Gary Conard Visor , Shan-Ming Kuang , Baoshu Zhao , Ralph Diodone , Karsten Fähnrich , Urs Schwitter
发明人： Prabha N. Ibrahim , Gary Conard Visor , Shan-Ming Kuang , Baoshu Zhao , Ralph Diodone , Karsten Fähnrich , Urs Schwitter
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
摘要翻译：本发明提供了式1化合物及其药学用途的固体形式。

8. 发明授权

US08748455B2 Solid forms of a pharmaceutically active substance 有权
公开(公告)号：US08748455B2
公开(公告)日：2014-06-10
申请号：US13817124
申请日：2012-02-21
申请人： Prabha N. Ibrahim , Gary Conard Visor , Shan-Ming Kuang , Baoshu Zhao , Ralph Diodone , Karsten Fähnrich , Urs Schwitter
发明人： Prabha N. Ibrahim , Gary Conard Visor , Shan-Ming Kuang , Baoshu Zhao , Ralph Diodone , Karsten Fähnrich , Urs Schwitter
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02
摘要： The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.

9. 发明申请

US20120309969A1 SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE 审中-公开
标题翻译： [4-（3-氟-5-三氟甲基 - 吡啶-2-基） - 哌嗪-1-基] - [5-甲磺酰基-2 - （（S）-2,2,2-三氟-1- 甲基 - 乙氧基） - 苯基] - 甲基
公开(公告)号：US20120309969A1
公开(公告)日：2012-12-06
申请号：US13495093
申请日：2012-06-13
申请人： André Bubendorf , Annette Deynet-Vucenovic , Ralph Diodone , Olaf Grassmann , Kai Lindenstruth , Emmanuel Pinard , Franziska E. Rohrer , Urs Schwitter
发明人： André Bubendorf , Annette Deynet-Vucenovic , Ralph Diodone , Olaf Grassmann , Kai Lindenstruth , Emmanuel Pinard , Franziska E. Rohrer , Urs Schwitter
IPC分类号： C07D401/04
CPC分类号： C07D213/74
摘要： The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译：本发明涉及四种不同的结晶形式和无定形形式的[4-（3-氟-5-三氟甲基 - 吡啶-2-基） - 哌嗪-1-基] - [5-甲磺酰基-2 - （（ S）-2,2,2-三氟-1-甲基 - 乙氧基） - 苯基] - 甲酮，以及它们在制备药物组合物中的用途。本发明的化合物适合于治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病。

10. 发明授权

US08039473B2 Solid forms of [4-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone 有权
标题翻译：固体形式的[4-（3-氟-5-三氟甲基 - 吡啶-2-基） - 哌嗪-1-基 - [5-甲磺酰基-2 - （（S）-2,2,2-三氟-1- 甲基 - 乙氧基） - 苯基] - 甲酮
公开(公告)号：US08039473B2
公开(公告)日：2011-10-18
申请号：US12841195
申请日：2010-07-22
申请人： Andre Bubendorf , Annette Deynet-Vucenovic , Ralph Diodone , Olaf Grassmann , Kai Lindenstruth , Emmanuel Pinard , Franziska E. Rohrer , Urs Schwitter
发明人： Andre Bubendorf , Annette Deynet-Vucenovic , Ralph Diodone , Olaf Grassmann , Kai Lindenstruth , Emmanuel Pinard , Franziska E. Rohrer , Urs Schwitter
IPC分类号： A61K31/496 , C07D213/74
CPC分类号： C07D213/74
摘要： The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译：本发明涉及四种不同的结晶形式和无定形形式的[4-（3-氟-5-三氟甲基 - 吡啶-2-基） - 哌嗪-1-基] - [5-甲磺酰基-2 - （（ S）-2,2,2-三氟-1-甲基 - 乙氧基） - 苯基] - 甲酮，以及它们在制备药物组合物中的用途。本发明的化合物适合于治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病。

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