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1. 发明申请

US20120116447A1 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 有权
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：US20120116447A1
公开(公告)日：2012-05-10
申请号：US13303707
申请日：2011-11-23
申请人： Cleon Stanley , Ram H. Paul, JR. , Dennis Griffin , Sean Chambers
发明人： Cleon Stanley , Ram H. Paul, JR. , Dennis Griffin , Sean Chambers
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00407 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶形密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在与容器内部的适当位置。

2. 发明申请

US20120035708A1 BLOOD PERFUSION DEVICE 有权
标题翻译：血液灌注装置
公开(公告)号：US20120035708A1
公开(公告)日：2012-02-09
申请号：US13197511
申请日：2011-08-03
申请人： Ram H. Paul, JR. , Richard A. Swift , Oliver Bach , Ralf Steiner
发明人： Ram H. Paul, JR. , Richard A. Swift , Oliver Bach , Ralf Steiner
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61B2017/1107 , A61B2017/1132 , A61F2/06 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2250/0023 , A61F2250/0036 , A61F2250/0037
摘要： A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.
摘要翻译：灌注装置和用于修复身体血管损伤部分的输送系统。灌注装置可以包括可自膨胀的管状体，其具有近端部分，远端部分和中间部分。一个或多个串联的倒钩可以沿着中间部分周向设置。倒钩在将所述装置插入所述身体容器中时能够渗入所述血管壁的中膜和中膜，并且不会进入所述外膜。移植物可以与管状体相关联。移植物具有近端和远端，优选地沿管状体的腔壁完全延伸。移植物也可以在近端部分和远端部分沿管状体的外表面延伸。可以沿着中间部分施加可重塑的覆盖物。还提供用于灌注植入物的递送装置和递送灌注植入物的方法。

3. 发明申请

US20110178547A1 DEVICE AND METHOD FOR CLOSURE OF VESSEL ACCESS SITE 有权
标题翻译：用于船舶进入场地关闭的装置和方法
公开(公告)号：US20110178547A1
公开(公告)日：2011-07-21
申请号：US13059157
申请日：2009-08-17
申请人： Ram H. Paul, JR. , Brian L. Bates , Brandley L. Trembacki
发明人： Ram H. Paul, JR. , Brian L. Bates , Brandley L. Trembacki
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B18/1442 , A61B18/1445 , A61B18/1447 , A61B2017/00986 , A61B2017/2905 , A61B2017/2926 , A61B2017/2927 , A61B2017/301 , A61B2017/303 , A61B2017/305
摘要： A device for closure of an opening formed in a body vessel includes a grasping member and a sheath movable thereover. The grasping member comprises a tubular body having a plurality of grasping fingers extending from a distal end of the tubular body. The fingers radially extend from the tubular body at a first angle, and are collapsible therefrom to a second angle. The fingers have a distal tip configured for grasping an outer wall of the body vessel surrounding the vessel opening when the fingers are at the first angle. The sheath is slidable over the tubular body and at least a portion of the grasping fingers for collapsing the fingers from the first angle to the second angle, thereby causing the collapsed fingers to at least substantially close the opening.
摘要翻译：用于封闭形成在身体容器中的开口的装置包括抓握构件和可在其上移动的护套。抓持构件包括具有从管状体的远端延伸的多个抓取指状物的管状体。指状物从管状体以第一角度径向延伸，并且可从其收缩到第二角度。手指具有构造成当手指处于第一角度时抓住围绕容器开口的身体容器的外壁的远侧末端。护套可以在管状体上滑动并且至少一部分把持指状物用于将手指从第一角度折叠到第二角度，从而使折叠的手指至少基本上关闭开口。

4. 发明申请

US20100174361A1 PROSTHETIC VALVE WITH SEMI-RIGID AND FLEXIBLE LEAFLETS 审中-公开
标题翻译：具有半刚性和柔性叶片的前置阀
公开(公告)号：US20100174361A1
公开(公告)日：2010-07-08
申请号：US12723840
申请日：2010-03-15
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。

5. 发明申请

US20090177270A1 Flow-Deflecting Prosthesis for Treating Venous Disease 有权
标题翻译：用于治疗静脉疾病的流转假体
公开(公告)号：US20090177270A1
公开(公告)日：2009-07-09
申请号：US12350456
申请日：2009-01-08
申请人： Charles W. Agnew , Ram H. Paul, JR.
发明人： Charles W. Agnew , Ram H. Paul, JR.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016
摘要： The disclosure relates to a flow-deflecting medical device comprising a support structure and at least one flow-deflecting member attached to the support structure. The flow-deflecting member is at least partially evertible between a first position and a second position. In the first position, antegrade flow contacts the antegrade surface of the flow-deflecting member, urging the flow-deflecting member proximally in the body vessel such that antegrade flow is substantially uninterrupted. In the second position, retrograde flow contacts the retrograde surface of the flow-deflecting member, urging the flow-deflecting member distally in the body vessel, such that retrograde flow is received and redirecting by the flow-deflecting member. Also provided is a method for treating a body vessel valve-related condition comprising implanting a flow-deflecting medical device proximal to a native valve.
摘要翻译：本发明涉及一种包括支撑结构和连接到支撑结构的至少一个流动偏转构件的流动偏转医疗装置。流动偏转构件在第一位置和第二位置之间至少部分可逆。在第一位置，顺行流动接触流动偏转构件的顺行表面，在身体容器中向近侧推动流动偏转构件，使得顺行流动基本上不间断。在第二位置，逆行流动接触流动偏转构件的逆行表面，在体内容器中向远侧推动流动偏转构件，从而接收逆流并通过流动偏转构件重定向。还提供了一种用于治疗体内血管相关病症的方法，包括在靠近天然瓣膜的位置植入偏转转向的医疗装置。

6. 发明申请

US20090143851A1 METHOD AND DEVICE FOR VASCULAR THERAPY 有权
标题翻译：用于血管治疗的方法和装置
公开(公告)号：US20090143851A1
公开(公告)日：2009-06-04
申请号：US12324484
申请日：2008-11-26
申请人： Ram H. Paul, JR.
发明人： Ram H. Paul, JR.
IPC分类号： A61F2/82 , A61F2/84
CPC分类号： A61M29/02 , A61M2025/0024 , A61M2025/0096 , A61M2025/0188
摘要： Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device can have a middle region with a plurality of members. The members can expand radially outward away from a longitudinal axis of the tubular frame, which can urge the sleeve to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.
摘要翻译：提供医疗装置以及治疗和制造这种装置的方法，用于在体内血管局部施用血管治疗。医疗装置包括可扩张的管状框架和套筒。医疗装置可用于局部递送用于撕裂体血管的体内容器或填塞物中的治疗剂，同时允许灌注植入的医疗装置的远端的流体或血液流。医疗装置的管状框架可以具有带有多个构件的中间区域。构件可以从管状框架的纵向轴线径向向外膨胀，这可以促使套筒接触身体容器的壁。在扩展构型中，当套管抵靠身体血管壁时，该装置的一部分允许流体流动继续。

7. 发明申请

US20110288581A1 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 有权
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：US20110288581A1
公开(公告)日：2011-11-24
申请号：US13111338
申请日：2011-05-19
申请人： Ram H. Paul, JR. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osbrne , Sean Chambers
发明人： Ram H. Paul, JR. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osbrne , Sean Chambers
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/3468 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶形密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在与容器内部的适当位置。

8. 发明申请

US20090138078A1 Remodelable Prosthetic Valve 有权
标题翻译：可重塑假肢瓣膜
公开(公告)号：US20090138078A1
公开(公告)日：2009-05-28
申请号：US12273284
申请日：2008-11-18
申请人： Ram H. Paul, JR. , Sean D. Chambers , Chad E. Johnson
发明人： Ram H. Paul, JR. , Sean D. Chambers , Chad E. Johnson
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2230/0026 , A61F2230/0095 , A61F2250/0031
摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.
摘要翻译：提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医疗装置的方法和使用医疗装置的治疗方法。医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料液体接触可重塑材料。医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

9. 发明申请

US20090118745A1 PATENT FORAMEN OVALE CLOSURE APPARATUS AND METHOD 审中-公开
标题翻译：专利文件OVALE封闭装置和方法
公开(公告)号：US20090118745A1
公开(公告)日：2009-05-07
申请号：US11935500
申请日：2007-11-06
申请人： Ram H. Paul, JR.
发明人： Ram H. Paul, JR.
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/00893
摘要： An apparatus for closure of a patent foramen ovale of a patient comprises a frame member defining respective first, second and third frame segments, and a growth and/or clot promoting material positioned on at least one of the segments. The frame member is alignable in a generally elongated first position for deployment via a delivery catheter, and is elastically movable therefrom to a compressed second position when the frame member is deployed across the foramen ovale. The frame segments are structured and arranged such that upon deployment of the apparatus across the foramen ovale, the first frame segment is disposed distal of the atrial septum, the second frame segment is disposed intermediate the atrial septum and the tissue flap, and the third frame segment is disposed proximal of the tissue flap.
摘要翻译：用于封闭患者的卵孔卵孔的专利的装置包括限定相应的第一，第二和第三框架段的框架构件以及定位在至少一个区段上的生长和/或促凝块材料。框架构件可在通常细长的第一位置对齐，用于经由输送导管进行展开，并且当框架构件跨越卵孔孔时部分可弹性移动到压缩的第二位置。所述框架段被构造和布置成使得在所述装置穿过所述卵孔孔时，所述第一框架段设置在所述心房隔膜的远侧，所述第二框架段设置在所述心房隔膜和所述组织瓣部之间，并且所述第三框架片段设置在组织瓣的近侧。

10. 发明公开

US20230248241A1 Medical Systems, Devices, and Kits Useful in Performing Treatment under Magnetic Resonance Imaging and Related Methods 审中-公开
公开(公告)号：US20230248241A1
公开(公告)日：2023-08-10
申请号：US18106601
申请日：2023-02-07
申请人： Eric D. Anttila , Grant M. Baker , Eric Brandner , Sean D. Chambers , Neal Fearnot , David C. Gross , Joshua F. Krieger , Ram H. Paul, JR. , Andrew J. Robison , Jesse Roll
发明人： Eric D. Anttila , Grant M. Baker , Eric Brandner , Sean D. Chambers , Neal Fearnot , David C. Gross , Joshua F. Krieger , Ram H. Paul, JR. , Andrew J. Robison , Jesse Roll
IPC分类号： A61B5/00 , A61B90/00 , A61B5/055 , A61B10/02
CPC分类号： A61B5/0036 , A61B5/055 , A61B10/0233 , A61B90/39 , A61B2090/3954
摘要： Example medical systems for performing treatment under magnetic resonance imaging and related devices, kits, and methods are described. An example medical system includes a first medical device, a second medical device, and a marker. The first medical device is formed of a first material. The first material has a first magnetic susceptibility. The second medical device is formed of a second material. The second material has a second magnetic susceptibility. The marker is disposed on the second medical device and is formed of a third material. The third material has a third magnetic susceptibility that is different than the first magnetic susceptibility and the second magnetic susceptibility.

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