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1. 发明授权

US06756074B2 Methods for the deposition and curing of coating compositions 失效
标题翻译：涂料组合物的沉积和固化方法
公开(公告)号：US06756074B2
公开(公告)日：2004-06-29
申请号：US10378326
申请日：2003-03-04
申请人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarvath Brennan , Jay Raghunandan Akhave , Mark Anthony Licon , Ali Reza Mehrabi , Dennis Lee Saunders , Bret Ja Chisholm
发明人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarvath Brennan , Jay Raghunandan Akhave , Mark Anthony Licon , Ali Reza Mehrabi , Dennis Lee Saunders , Bret Ja Chisholm
IPC分类号： C23C1600
CPC分类号： B01J19/0046 , B01J2219/0043 , B01J2219/00443 , B01J2219/00527 , B01J2219/00596 , B01J2219/00722 , B01J2219/00745 , B01J2219/00756 , C40B40/14 , C40B40/18 , C40B60/14
摘要： Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating layer on a surface of one or more substrates. The systems and methods also including a curing system operative to apply at least one of a plurality of curing environments to each of a plurality of regions associated with the at least one coating layer, the curing system comprising a plurality of waveguides each having a first end corresponding to at least one of the plurality of regions and a second end associated with at least one curing source. The combinatorial coating library comprising a predetermined combination of at least one of the plurality of materials and at least one of the plurality of curing environments associated with each of the plurality of regions.
摘要翻译：用于产生组合涂料库的系统和方法，其包括可操作地耦合到适于在一个或多个基材的表面上形成至少一个涂层的多种材料中的至少一种的涂层体系。所述系统和方法还包括固化系统，其操作以将多个固化环境中的至少一个施加到与所述至少一个涂层相关联的多个区域中的每一个上，所述固化系统包括多个波导，每个波导具有第一端对应于所述多个区域中的至少一个，以及与至少一个固化源相关联的第二端。组合涂料库包括多个材料中的至少一种材料和与多个区域中的每一个相关联的多个固化环境中的至少一个的预定组合。

2. 发明授权

US06544334B1 Systems and methods for the deposition and curing of coating compositions 有权
标题翻译：涂料组合物沉积和固化的系统和方法
公开(公告)号：US06544334B1
公开(公告)日：2003-04-08
申请号：US09682832
申请日：2001-10-23
申请人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarvath Brennan , Jay Raghunandan Akhave , Mark Anthony Licon , Ali Reza Mehrabi , Dennis Lee Saunders , Bret Ja Chisholm
发明人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarvath Brennan , Jay Raghunandan Akhave , Mark Anthony Licon , Ali Reza Mehrabi , Dennis Lee Saunders , Bret Ja Chisholm
IPC分类号： B05C914
CPC分类号： B01J19/0046 , B01J2219/0043 , B01J2219/00443 , B01J2219/00527 , B01J2219/00596 , B01J2219/00722 , B01J2219/00745 , B01J2219/00756 , C40B40/14 , C40B40/18 , C40B60/14
摘要： Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating layer on a surface of one or more substrates. The systems and methods also including a curing system operative to apply at least one of a plurality of curing environments to each of a plurality of regions associated with the at least one coating layer, the curing system comprising a plurality of waveguides each having a first end corresponding to at least one of the plurality of regions and a second end associated with at least one curing source. The combinatorial coating library comprising a predetermined combination of at least one of the plurality of materials and at least one of the plurality of curing environments associated with each of the plurality of regions.
摘要翻译：用于产生组合涂料库的系统和方法，其包括可操作地耦合到适于在一个或多个基材的表面上形成至少一个涂层的多种材料中的至少一种的涂层体系。所述系统和方法还包括固化系统，其操作以将多个固化环境中的至少一个施加到与所述至少一个涂层相关联的多个区域中的每一个上，所述固化系统包括多个波导，每个波导具有第一端对应于所述多个区域中的至少一个，以及与至少一个固化源相关联的第二端。组合涂料库包括多个材料中的至少一种材料和与多个区域中的每一个相关联的多个固化环境中的至少一个的预定组合。

3. 发明授权

US06538725B2 Method for determination of structural defects of coatings 有权
公开(公告)号：US06538725B2
公开(公告)日：2003-03-25
申请号：US09765757
申请日：2001-01-22
申请人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarlath Brennan , James Norman Cawse , Bret Ja Chisholm
发明人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarlath Brennan , James Norman Cawse , Bret Ja Chisholm
IPC分类号： G01B1116
CPC分类号： G01N21/6452 , C09K11/06 , G01N21/25 , G01N21/31 , G01N21/8422 , G01N21/88 , G01N2021/6417 , G01N2021/646
摘要： The present invention provides a method for quantifying structural defects of a coating composition on a given substrate, where certain structural defect-inducing tests are performed. In this method, a coating formulation is doped with a colorimetric or luminescent material. Concentration of the material depends on the quantum efficiency, excitation and emission wavelengths, and employed detection techniques, and can range from about 1 fM to about 1 mM. Before, during and/or after such tests, the coating is illuminated with a wavelength of radiation at which the reflected or transmitted color or emitted luminescence of the material in the coating is detectable with an optical detector or by visual inspection. In this fashion, the percentage of failure of the coating can be quantified as well as the level of interdiffusion of coating into substrate or substrate into coating. The method of the invention is thus particularly well-suited for the combinatorial analysis of an array of coating samples. Additionally, when the structural defect-inducing material test is being performed, the removed coating material can be analyzed in like fashion.

4. 发明授权

US06460417B1 Formability testing of small-size coatings and materials 失效
标题翻译：小尺寸涂料和材料的成型性测试
公开(公告)号：US06460417B1
公开(公告)日：2002-10-08
申请号：US09682355
申请日：2001-08-24
申请人： Radislav Alexandrovich Potyrailo , Bret Ja Chisholm , Daniel Robert Olson , James Norman Cawse , Michael Matthew Laurin , George Frederic Medford , Hariklia Dris Reitz
发明人： Radislav Alexandrovich Potyrailo , Bret Ja Chisholm , Daniel Robert Olson , James Norman Cawse , Michael Matthew Laurin , George Frederic Medford , Hariklia Dris Reitz
IPC分类号： G01B1116
CPC分类号： G01B11/16
摘要： This invention relates to methods for testing elongation and cracking of coating arrays. The method includes simultaneously applying an elongating force to each of a plurality of coatings, and monitoring the coating integrity including cracks and thickness decrease in each coating. A relative performance characteristic of each coating is then determined based on a correlation between a detected crack and/or thickness decrease in the coating, and the corresponding elongating force.
摘要翻译：本发明涉及测试涂层阵列的伸长率和裂纹的方法。该方法包括同时向多个涂层中的每一个施加伸长力，并且监测涂层的完整性，包括每个涂层中的裂纹和厚度减小。然后基于检测到的裂纹和/或涂层的厚度减少与相应的拉伸力之间的相关性来确定每个涂层的相对性能特性。

5. 发明授权

US06626025B2 Devices and methods for high throughput screening of abrasion resistance of coatings 失效
公开(公告)号：US06626025B2
公开(公告)日：2003-09-30
申请号：US09770006
申请日：2001-01-26
申请人： Radislav Alexandrovich Potyrailo , Bret Ja Chisholm
发明人： Radislav Alexandrovich Potyrailo , Bret Ja Chisholm
IPC分类号： G01N356
CPC分类号： G01N29/036 , G01N3/567 , G01N5/04 , G01N2291/0256
摘要： A device and method for the high throughput screening of the abrasion resistance of coatings. The device includes a plurality of transducers, each of the plurality of transducers having at least one external surface, and a plurality of coatings, each of the plurality of coatings deposited onto the external surface(s) of one of the plurality of transducers. The device also includes a plurality of oscillation sources, coupled to the plurality of transducers, for generating and applying an oscillation potential to each of the plurality of transducers. Further, the device includes a plurality of oscillation detectors, coupled to the plurality of transducers, for measuring the oscillation frequency and a variation in oscillation frequency associated with abrasion resistance in each of the plurality of transducers. The method includes exposing each of the plurality of coatings to an abrasive material, the abrasive material causing a change in mass and/or viscoelastic property in each of the plurality of coatings. Further, the method includes detecting and measuring the oscillation parameters and a variation in oscillation parameters in each of the plurality of transducers, wherein the variation in oscillation parameters corresponds to the change in mass in each of the plurality of coatings.

6. 发明授权

US06836362B2 Method for the rapid determination of the optical quality of combinatorial libraries 失效
标题翻译：快速确定组合库光学质量的方法
公开(公告)号：US06836362B2
公开(公告)日：2004-12-28
申请号：US09854718
申请日：2001-05-14
申请人： Radislav Alexandrovich Potyrailo , Michael Jarlath Brennan , Daniel Robert Olson
发明人： Radislav Alexandrovich Potyrailo , Michael Jarlath Brennan , Daniel Robert Olson
IPC分类号： G01N1104
CPC分类号： G01N21/47 , G01N2021/4735 , G01N2021/8427
摘要： This invention provides methodology for the measurement of both low and high levels of scattered radiation produced by decorative and barrier coatings and plastics. Measurements of low levels are especially important for coatings used in automotive applications. The method is based on the illumination of the sample with radiation and collection of only the portion of the radiation scattered from the coating before, during and after the testing step and relating the optical signal from the tested portion of the sample material to the untested portion of the material and/or a standard. Through the practice of the invention, a large number of coating samples, as in an array, may be analyzed for their optical quality, principally haze, either after coating and curing, and/or after subjection of such coatings samples to elongation stresses, and/or abrasion testing, solvent exposure, hydrolytic stability testing, and temperature exposure.
摘要翻译：本发明提供了用于测量装饰和阻隔涂层和塑料产生的低和高水平散射辐射的方法。低水平的测量对于汽车应用中使用的涂料尤为重要。该方法基于样品的照射，并且在测试步骤之前，之中和之后仅收集从涂层散射的辐射的部分，并将来自样品材料的测试部分的光学信号与未测试部分相关联的材料和/或标准。通过本发明的实践，如在阵列中，可以分析大量涂层样品的光学质量，主要是在涂层和固化之后和/或在将这样的涂层样品置于伸长应力之后的雾度，以及 /或磨损试验，溶剂暴露，水解稳定性试验和温度暴露。

7. 发明授权

US09052263B2 Methods for analyte detection 有权
标题翻译：分析物检测方法
公开(公告)号：US09052263B2
公开(公告)日：2015-06-09
申请号：US13484674
申请日：2012-05-31
申请人： Radislav Alexandrovich Potyrailo , Matthew Damian Pietrzykowski , Yongjae Lee
发明人： Radislav Alexandrovich Potyrailo , Matthew Damian Pietrzykowski , Yongjae Lee
IPC分类号： G01R27/28 , G01N27/02
CPC分类号： G01N27/028 , G01N27/026
摘要： A method is provided for selectively detecting the presence and concentration of at least four analytes in a mixture. In certain embodiments, the method comprises contacting a single sensor with the mixture of analytes, wherein the sensor comprises at least one resonant sensor circuit comprising a sensing material that comprises at least two material properties that change in the presence of four or more analytes in their mixtures, and generating a multivariate sensor response pattern. The methods disclosed herein further optionally comprise performing analyte classification and analyte quantitation. Methods for selectively detecting the concentration of at least one analyte in a mixture further comprising at least one interference are also described in the instant application.
摘要翻译：提供了一种用于选择性地检测混合物中至少四种分析物的存在和浓度的方法。在某些实施方案中，所述方法包括使单个传感器与分析物的混合物接触，其中所述传感器包括至少一个共振传感器电路，所述至少一个谐振传感器电路包括感测材料，所述传感材料包含至少两种材料性质，所述材料性质在它们混合物，并产生多变量传感器响应模式。本文公开的方法进一步任选地包括进行分析物分类和分析物定量。在本申请中还描述了选择性地检测混合物中至少一种分析物的浓度进一步包含至少一种干扰的方法。

8. 发明授权

US08542024B2 Temperature-independent chemical and biological sensors 有权
公开(公告)号：US08542024B2
公开(公告)日：2013-09-24
申请号：US12977599
申请日：2010-12-23
申请人： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman
发明人： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman
IPC分类号： G01N27/02
CPC分类号： G01N27/02 , G01N27/025 , G01N33/48792 , Y10T29/49007
摘要： Methods and sensors for selective fluid sensing are provided. A sensor includes a resonant inductor-capacitor-resistor (LCR) circuit and a sensing material disposed over a sensing region. The sensing region comprises at least a portion of the LCR circuit. Temperature-dependent response coefficients of inductance L, capacitance C, and resistance R properties of the LCR circuit and the sensing material are at least approximately 5 percent different from one another. The difference in the temperature-dependent response coefficients of the properties of the LCR circuit and the sensing material enables the sensor to selectively detect analyte fluids from an analyzed fluid mixture substantially independent of temperature.

9. 发明授权

US08364419B2 Sensor system and methods for selective analyte detection using resonance sensor circuit 有权
标题翻译：使用谐振传感器电路进行选择性分析物检测的传感器系统和方法
公开(公告)号：US08364419B2
公开(公告)日：2013-01-29
申请号：US12424016
申请日：2009-04-15
申请人： Radislav Alexandrovich Potyrailo , James Anthony Cella , Cheryl Margaret Surman , Kelly Scott Chichak , Steven Go
发明人： Radislav Alexandrovich Potyrailo , James Anthony Cella , Cheryl Margaret Surman , Kelly Scott Chichak , Steven Go
IPC分类号： G01N31/00
CPC分类号： G01N27/026
摘要： A system, device and methods, for determining at least two analytes, wherein the system and device include at least one resonant sensor circuit that includes a sensing material that predictably affects the resonant complex impedance response of a sensor electrode. The sensing material has at least two material properties that change when the materials are exposed to two or more analytes. The system and device also include a processor that generates a multivariate sensor response pattern that is based at least in part on a change in the two material properties of the sensing material.
摘要翻译：一种用于确定至少两种分析物的系统，装置和方法，其中所述系统和装置包括至少一个谐振传感器电路，其包括可预测地影响传感器电极的谐振复阻抗响应的感测材料。当材料暴露于两种或多种分析物时，传感材料具有至少两种材料性质。该系统和装置还包括一个处理器，该处理器至少部分地基于传感材料的两种材料特性的变化而生成多变量传感器响应图案。

10. 发明授权

US08226907B2 Microfluidic devices and methods of making the same 有权
标题翻译：微流体装置及其制作方法
公开(公告)号：US08226907B2
公开(公告)日：2012-07-24
申请号：US11440278
申请日：2006-05-25
申请人： Andrew Michael Leach , Thomas Paul Dunton , Christopher David Goewey , Radislav Alexandrovich Potyrailo , Caibin Xiao , Prashant Vishwanath Shrikhande
发明人： Andrew Michael Leach , Thomas Paul Dunton , Christopher David Goewey , Radislav Alexandrovich Potyrailo , Caibin Xiao , Prashant Vishwanath Shrikhande
IPC分类号： B01L3/00
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： A microfluidic channel is provided. The microfluidic channel includes a first substrate having at least one microfluidic channel pattern. Further, the microfluidic channel includes a porous material disposed on the first substrate and occupying the at least one microfluidic channel pattern.
摘要翻译：提供微流体通道。微流体通道包括具有至少一个微流体通道图案的第一基底。此外，微流体通道包括设置在第一基板上并占据至少一个微流体通道图案的多孔材料。

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