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1. 发明授权

US08226907B2 Microfluidic devices and methods of making the same 有权
标题翻译：微流体装置及其制作方法
公开(公告)号：US08226907B2
公开(公告)日：2012-07-24
申请号：US11440278
申请日：2006-05-25
申请人： Andrew Michael Leach , Thomas Paul Dunton , Christopher David Goewey , Radislav Alexandrovich Potyrailo , Caibin Xiao , Prashant Vishwanath Shrikhande
发明人： Andrew Michael Leach , Thomas Paul Dunton , Christopher David Goewey , Radislav Alexandrovich Potyrailo , Caibin Xiao , Prashant Vishwanath Shrikhande
IPC分类号： B01L3/00
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： A microfluidic channel is provided. The microfluidic channel includes a first substrate having at least one microfluidic channel pattern. Further, the microfluidic channel includes a porous material disposed on the first substrate and occupying the at least one microfluidic channel pattern.
摘要翻译：提供微流体通道。微流体通道包括具有至少一个微流体通道图案的第一基底。此外，微流体通道包括设置在第一基板上并占据至少一个微流体通道图案的多孔材料。

2. 发明授权

US07977660B2 Article, device, and method 有权
标题翻译：文章，设备和方法
公开(公告)号：US07977660B2
公开(公告)日：2011-07-12
申请号：US12045217
申请日：2008-03-10
申请人： Radislav Alexandrovich Potyrailo , Scott Martell Boyette , Glenn Alfred Johnson , William Guy Morris , Ronald James Wroczynski , Andrew Michael Leach , Peter Miller , Caibin Xiao
发明人： Radislav Alexandrovich Potyrailo , Scott Martell Boyette , Glenn Alfred Johnson , William Guy Morris , Ronald James Wroczynski , Andrew Michael Leach , Peter Miller , Caibin Xiao
IPC分类号： G01N33/00 , G01N15/00
CPC分类号： B01L3/5027 , B01L2200/025 , B01L2200/141 , B01L2200/143 , B01L2300/021 , B01L2300/0816 , B01L2300/0864 , B01L2300/168 , G01N21/03 , G01N2021/0325 , G01N2021/0346 , G01N2021/0382
摘要： An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window.
摘要翻译：一种物品包括用于检测器系统的基底组件。基板组件包括基板; 固定到所述基板的样品接收结构; 延伸穿过衬底的测试窗口; 以及由衬底的表面限定并从样品接收结构延伸到测试窗口的流体通道。

3. 发明申请

US20090044603A1 ARTICLE, DEVICE, AND METHOD 有权
标题翻译：文章，设备和方法
公开(公告)号：US20090044603A1
公开(公告)日：2009-02-19
申请号：US12045217
申请日：2008-03-10
申请人： Radislav Alexandrovich Potyrailo , Scott Martell Boyette , Glenn Alfred Johnson , William Guy Morris , Ronald James Wroczynski , Andrew Michael Leach , Peter Miller , Caibin Xiao
发明人： Radislav Alexandrovich Potyrailo , Scott Martell Boyette , Glenn Alfred Johnson , William Guy Morris , Ronald James Wroczynski , Andrew Michael Leach , Peter Miller , Caibin Xiao
IPC分类号： G01N33/00
CPC分类号： B01L3/5027 , B01L2200/025 , B01L2200/141 , B01L2200/143 , B01L2300/021 , B01L2300/0816 , B01L2300/0864 , B01L2300/168 , G01N21/03 , G01N2021/0325 , G01N2021/0346 , G01N2021/0382
摘要： An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window.
摘要翻译：一种物品包括用于检测器系统的基底组件。基板组件包括基板; 固定到所述基板的样品接收结构; 延伸穿过衬底的测试窗口; 以及由衬底的表面限定并从样品接收结构延伸到测试窗口的流体通道。

4. 发明授权

US07524455B2 Methods for deposition of sensor regions onto optical storage media substrates and resulting devices 失效
标题翻译：将传感器区域沉积到光学存储介质基板和所得到的装置上的方法
公开(公告)号：US07524455B2
公开(公告)日：2009-04-28
申请号：US10723536
申请日：2003-11-24
申请人： Radislav Alexandrovich Potyrailo , Marc Brian Wisnudel , Scott Martell Boyette , Andrew Michael Leach , Kasiraman Krishnan
发明人： Radislav Alexandrovich Potyrailo , Marc Brian Wisnudel , Scott Martell Boyette , Andrew Michael Leach , Kasiraman Krishnan
IPC分类号： G01N33/00
CPC分类号： B82Y5/00 , B82Y10/00 , B82Y30/00 , G01N33/54366 , G01N33/54393 , Y10T428/249994 , Y10T428/31935
摘要： Methods for applying sensor materials to optical storage media substrates are disclosed. After exposure to a sample of interest, the resulting sensors may be read in optical storage media drives for quantitative analysis of physical, chemical and biological parameters of the sample.
摘要翻译：公开了将传感器材料应用于光学存储介质基板的方法。在暴露于感兴趣的样品之后，所得到的传感器可以在光学存储介质驱动器中读取，用于定量分析样品的物理，化学和生物学参数。

5. 发明授权

US07170609B2 Sensor systems and methods for quantification of physical parameters, chemical and biochemical volatile and nonvolatile compounds in fluids 失效
标题翻译：用于定量流体物理参数，化学和生物化学挥发性和非挥发性化合物的传感器系统和方法
公开(公告)号：US07170609B2
公开(公告)日：2007-01-30
申请号：US10723534
申请日：2003-11-24
申请人： Radislav Alexandrovich Potyrailo , William Guy Morris , Scott Martell Boyette , Marc Brian Wisnudel , Andrew Michael Leach , Mary Lynn Stanley
发明人： Radislav Alexandrovich Potyrailo , William Guy Morris , Scott Martell Boyette , Marc Brian Wisnudel , Andrew Michael Leach , Mary Lynn Stanley
IPC分类号： G01N21/00
CPC分类号： G01N21/5907 , G01N35/00069
摘要： A system and method employing optical disc drives for quantitative analysis of physical, chemical and biochemical parameters are provided. The system including a disc drive for supporting and rotating an optical disc including at least one sensor spot; a light source for directing light onto the sensor spot; at least one optical pickup for detecting light transmitted from the sensor spot, the transmitted light being indicative of a concentration of a compound; and an analog-to-digital converter for quantifying an intensity of the transmitted light. The method comprising the steps of preparing the optical disc with a plurality of sensor spots, the sensor spots being responsive to a compound; exposing the optical disc to a fluid; measuring intensity of transmitted light from at least one of the plurality of sensor spots; and correlating the measured intensity of transmitted light to an amount of compound exposed to the optical disc.
摘要翻译：提供了一种使用光盘驱动器进行物理，化学和生物化学参数定量分析的系统和方法。该系统包括用于支撑和旋转包括至少一个传感器点的光盘的盘驱动器; 用于将光引导到传感器点上的光源; 至少一个用于检测从传感器光点传输的光的光学拾取器，所述透射光指示化合物的浓度; 以及用于量化透射光强度的模拟 - 数字转换器。该方法包括以下步骤：准备具有多个传感器点的光盘，所述传感器点响应于化合物; 将光盘暴露于流体; 测量来自所述多个传感器光点中的至少一个的透射光的强度; 并将测得的透射光强度与暴露于光盘的化合物的量相关联。

6. 发明授权

US08318099B2 Chemical and biological sensors, systems and methods based on radio frequency identification 有权
标题翻译：基于射频识别的化学和生物传感器，系统和方法
公开(公告)号：US08318099B2
公开(公告)日：2012-11-27
申请号：US11259711
申请日：2005-10-26
申请人： Radislav Alexandrovich Potyrailo , William Guy Morris , Kenneth Brakeley Welles, II , Andrew Michael Leach , Andrew David Pris
发明人： Radislav Alexandrovich Potyrailo , William Guy Morris , Kenneth Brakeley Welles, II , Andrew Michael Leach , Andrew David Pris
IPC分类号： G01N27/00
CPC分类号： G06K19/07749 , G01N27/3275 , G01N27/3278 , G06K19/0717 , Y10T436/11 , Y10T436/25375
摘要： Embodiments of the invention include a wireless sensor, such as an RFID tag, that includes a substrate, an antenna disposed on the substrate, and an environmentally sensitive sensor material disposed over at least a portion of said substrate. Other embodiments an RFID tag and at least one antibody coupled to the RFID tag. The RFID tag includes a substrate, circuitry disposed on the substrate, and an antenna coupled to the substrate. The at least one antibody is capable of affecting the signals emanating from the RFID tag. Further embodiments include a detection system that includes a reader. Yet other embodiments include a method for detecting specific analytes. The method includes providing an RFID tag which emanates a first signal having a first frequency, and enabling the REID tag to emanate a second signal having a second frequency upon attraction of a specific analyte to the RFID tag.
摘要翻译：本发明的实施例包括诸如RFID标签的无线传感器，其包括基板，设置在基板上的天线以及设置在所述基板的至少一部分上的对环境敏感的传感器材料。其他实施例是RFID标签和耦合到RFID标签的至少一个抗体。 RFID标签包括衬底，设置在衬底上的电路和耦合到衬底的天线。所述至少一种抗体能够影响从RFID标签发出的信号。另外的实施例包括包括读取器的检测系统。其他实施方案包括用于检测特定分析物的方法。该方法包括提供发射具有第一频率的第一信号的RFID标签，并且使得REID标签在将特定分析物吸引到RFID标签时能够发出具有第二频率的第二信号。

7. 发明申请

US20060018795A1 Fabrication methods and multifunctional substrate materials for chemical and biological analysis in microfluidic systems 审中-公开
标题翻译：微流体系统中化学和生物分析的制备方法和多功能底物材料
公开(公告)号：US20060018795A1
公开(公告)日：2006-01-26
申请号：US10896675
申请日：2004-07-23
申请人： Radislav Alexandrovich Potyrailo , Jeffrey Bernard Fortin , Andrew Michael Leach , Joshua Isaac Wright , Scott Boyette
发明人： Radislav Alexandrovich Potyrailo , Jeffrey Bernard Fortin , Andrew Michael Leach , Joshua Isaac Wright , Scott Boyette
IPC分类号： G01N3/00
CPC分类号： B01L3/502738 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2200/16 , B01L2300/0816 , B01L2300/16 , B01L2300/1855 , B01L2400/0661 , B01L2400/0677 , B01L2400/082
摘要： Methods for making multifunctional microfluidic systems, and apparatuses prepared thereby are disclosed comprising an environmentally responsive component integrated into the substrate and exposed to the channels of a microfluidic chip.
摘要翻译：公开了制造多功能微流体系统的方法，以及由此制备的装置，其包括集成到基板中并暴露于微流体芯片的通道的环境响应部件。

8. 发明授权

US09052263B2 Methods for analyte detection 有权
标题翻译：分析物检测方法
公开(公告)号：US09052263B2
公开(公告)日：2015-06-09
申请号：US13484674
申请日：2012-05-31
申请人： Radislav Alexandrovich Potyrailo , Matthew Damian Pietrzykowski , Yongjae Lee
发明人： Radislav Alexandrovich Potyrailo , Matthew Damian Pietrzykowski , Yongjae Lee
IPC分类号： G01R27/28 , G01N27/02
CPC分类号： G01N27/028 , G01N27/026
摘要： A method is provided for selectively detecting the presence and concentration of at least four analytes in a mixture. In certain embodiments, the method comprises contacting a single sensor with the mixture of analytes, wherein the sensor comprises at least one resonant sensor circuit comprising a sensing material that comprises at least two material properties that change in the presence of four or more analytes in their mixtures, and generating a multivariate sensor response pattern. The methods disclosed herein further optionally comprise performing analyte classification and analyte quantitation. Methods for selectively detecting the concentration of at least one analyte in a mixture further comprising at least one interference are also described in the instant application.
摘要翻译：提供了一种用于选择性地检测混合物中至少四种分析物的存在和浓度的方法。在某些实施方案中，所述方法包括使单个传感器与分析物的混合物接触，其中所述传感器包括至少一个共振传感器电路，所述至少一个谐振传感器电路包括感测材料，所述传感材料包含至少两种材料性质，所述材料性质在它们混合物，并产生多变量传感器响应模式。本文公开的方法进一步任选地包括进行分析物分类和分析物定量。在本申请中还描述了选择性地检测混合物中至少一种分析物的浓度进一步包含至少一种干扰的方法。

9. 发明授权

US08542024B2 Temperature-independent chemical and biological sensors 有权
公开(公告)号：US08542024B2
公开(公告)日：2013-09-24
申请号：US12977599
申请日：2010-12-23
申请人： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman
发明人： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman
IPC分类号： G01N27/02
CPC分类号： G01N27/02 , G01N27/025 , G01N33/48792 , Y10T29/49007
摘要： Methods and sensors for selective fluid sensing are provided. A sensor includes a resonant inductor-capacitor-resistor (LCR) circuit and a sensing material disposed over a sensing region. The sensing region comprises at least a portion of the LCR circuit. Temperature-dependent response coefficients of inductance L, capacitance C, and resistance R properties of the LCR circuit and the sensing material are at least approximately 5 percent different from one another. The difference in the temperature-dependent response coefficients of the properties of the LCR circuit and the sensing material enables the sensor to selectively detect analyte fluids from an analyzed fluid mixture substantially independent of temperature.

10. 发明授权

US08364419B2 Sensor system and methods for selective analyte detection using resonance sensor circuit 有权
标题翻译：使用谐振传感器电路进行选择性分析物检测的传感器系统和方法
公开(公告)号：US08364419B2
公开(公告)日：2013-01-29
申请号：US12424016
申请日：2009-04-15
申请人： Radislav Alexandrovich Potyrailo , James Anthony Cella , Cheryl Margaret Surman , Kelly Scott Chichak , Steven Go
发明人： Radislav Alexandrovich Potyrailo , James Anthony Cella , Cheryl Margaret Surman , Kelly Scott Chichak , Steven Go
IPC分类号： G01N31/00
CPC分类号： G01N27/026
摘要： A system, device and methods, for determining at least two analytes, wherein the system and device include at least one resonant sensor circuit that includes a sensing material that predictably affects the resonant complex impedance response of a sensor electrode. The sensing material has at least two material properties that change when the materials are exposed to two or more analytes. The system and device also include a processor that generates a multivariate sensor response pattern that is based at least in part on a change in the two material properties of the sensing material.
摘要翻译：一种用于确定至少两种分析物的系统，装置和方法，其中所述系统和装置包括至少一个谐振传感器电路，其包括可预测地影响传感器电极的谐振复阻抗响应的感测材料。当材料暴露于两种或多种分析物时，传感材料具有至少两种材料性质。该系统和装置还包括一个处理器，该处理器至少部分地基于传感材料的两种材料特性的变化而生成多变量传感器响应图案。

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