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1. 发明申请

US20110182879A1 NOVEL HUMAN TRANSFERASE FAMILY MEMBERS AND USES THEREOF 失效
标题翻译：新人类转移家族成员及其用途
公开(公告)号：US20110182879A1
公开(公告)日：2011-07-28
申请号：US12828319
申请日：2010-07-01
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： A61K39/395 , C07H21/04 , C12N5/10 , C07K14/435 , C07K16/18 , C12P21/02 , G01N33/50 , G01N33/53 , A61K38/02 , A61P43/00
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

2. 发明授权

US07301016B2 Human transferase family members and uses thereof 失效
标题翻译：人转移酶家族成员及其用途
公开(公告)号：US07301016B2
公开(公告)日：2007-11-27
申请号：US10184648
申请日：2002-06-27
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： C07H1/00 , C07H5/00 , C07H19/00 , C07H21/00 , C07H21/02 , C08B37/00 , C12Q1/68 , C12P21/06 , C12P19/34 , C12N1/12 , C12N1/20 , C12N15/00 , C12N15/06
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252和53320核酸分子，其编码新的人转移酶家族成员。本发明还提供反义核酸分子，含有33877,47179,26886,25552,32132,32244,23680,3262,47174,60491,46743,27417,27960,32252或53320核酸分子的重组表达载体，宿主细胞已经引入了表达载体的非人类转基因动物以及其中已经引入了33877,47179,26886,25552,32232,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320基因的非人类转基因动物，或中断了本发明还进一步提供了分离的33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179， 26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

3. 发明授权

US07972797B2 Compositions and methods for the diagnosis and treatment of immune disorders 有权
标题翻译：用于诊断和治疗免疫疾病的组合物和方法
公开(公告)号：US07972797B2
公开(公告)日：2011-07-05
申请号：US12284648
申请日：2008-09-24
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： G01N33/53
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.
摘要翻译：本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关疾病的方法和组合物。特别地，本发明描述了本领域已知的基因，或者作为ST2，T1和Fit-1，并且在本文中称为103基因。本文公开的103基因在TH2细胞中不差异表达，而不在TH1细胞中。此外，103基因产物在本文中被证明是体外和体内TH2和TH2样免疫应答的重要调节剂。因此，103基因，其基因产物和与其结合的抗体可以在诊断上用作治疗性干预的目标，用于治疗各种免疫疾病。在这方面，本发明提供了用于鉴定和治疗用于治疗免疫疾病，特别是TH细胞亚群相关病症并包括TH2和TH2样病症（即与TH2或TH2样介导的相关的病症）的化合物的方法免疫反应），如特应性病症（如过敏和哮喘）。另外，提供了用于TH细胞亚群相关疾病的诊断评价和预后的方法，用于鉴定表现出这种病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，并监测所用化合物的功效在临床试验中。

4. 发明申请

US20120045777A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120045777A1
公开(公告)日：2012-02-23
申请号：US13169686
申请日：2011-06-27
申请人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
发明人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
IPC分类号： G01N33/53 , C12Q1/37 , C12P21/02 , C12N9/99 , C12N9/64 , C12N15/57 , C12N5/00 , C12N15/63 , G01N33/50 , C07K14/00 , C07K16/18 , C07H21/04 , G01N33/573 , C12N5/10
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

5. 发明申请

US20090304703A1 Compositions and methods for the diagnosis and treatment of immune disorders 有权
公开(公告)号：US20090304703A1
公开(公告)日：2009-12-10
申请号：US12284648
申请日：2008-09-24
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： A61K39/395 , C12Q1/02 , G01N33/68 , A61P37/02
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.

6. 发明申请

US20100291579A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20100291579A1
公开(公告)日：2010-11-18
申请号：US12803671
申请日：2010-07-01
申请人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
发明人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
IPC分类号： C12Q1/68 , G01N33/53 , C12P21/06 , C12N5/10 , C12N5/02 , C12N15/63 , C07K14/435 , C07K16/18 , C07K1/00 , C07H21/04
CPC分类号： C07K16/18
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

7. 发明授权

US5317088A C-terminal conglutinin fragments coupled to solid support 失效
标题翻译： C末端凝集素片段与固体支持物偶联
公开(公告)号：US5317088A
公开(公告)日：1994-05-31
申请号：US921296
申请日：1992-07-28
申请人： Young M. Lee , Kevin R. Leiby , Thomas B. Okarma
发明人： Young M. Lee , Kevin R. Leiby , Thomas B. Okarma
IPC分类号： A61K38/16 , A61K38/00 , A61K38/17 , A61K38/36 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/42 , C07K14/47 , C07K14/705 , C07K14/78 , C12N5/06 , C12P21/06 , A61K37/02 , C07K3/00 , C07K5/00 , C07K17/00
CPC分类号： C07K14/78 , C07K14/47 , A61K38/00
摘要： Peptide fragments of conglutinin are provided for use in binding to complementary ligands. Particularly, an N-proximal region is provided having a hypervariable region with a collagen type structure for binding to complementary molecules, and a C-proximal region which provides for lectin binding activity.
摘要翻译：提供粘蛋白的肽片段用于结合互补配体。特别地，提供了具有具有用于结合互补分子的胶原型结构的高变区和提供凝集素结合活性的C-近端区的N-近端区。

8. 发明申请

US20120270219A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120270219A1
公开(公告)日：2012-10-25
申请号：US13540352
申请日：2012-07-02
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C07K14/47 , C12N5/10 , C12P21/02 , C07K16/18 , C12Q1/68 , C12N5/071 , C12N15/12 , C12N15/85 , G01N33/566
CPC分类号： C07K14/705 , C07K14/70503 , G01N33/54313
摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

9. 发明申请

US20100062487A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 失效
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20100062487A1
公开(公告)日：2010-03-11
申请号：US12387959
申请日：2009-05-08
申请人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
发明人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
IPC分类号： C12P21/02 , C07H21/04 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

10. 发明授权

US07452980B2 Compositions and methods for the diagnosis and treatment of immune disorders 失效
标题翻译：用于诊断和治疗免疫疾病的组合物和方法
公开(公告)号：US07452980B2
公开(公告)日：2008-11-18
申请号：US11599098
申请日：2006-11-14
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.
摘要翻译：本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关疾病的方法和组合物。特别地，本发明描述了本领域已知的基因，或者作为ST2，T1和Fit-1，并且在本文中称为103基因。本文公开的103基因在TH2细胞中不差异表达，而不在TH1细胞中。此外，103基因产物在本文中被证明是体外和体内TH2和TH2样免疫应答的重要调节剂。因此，103基因，其基因产物和与其结合的抗体可以在诊断上用作治疗性干预的目标，用于治疗各种免疫疾病。在这方面，本发明提供了用于鉴定和治疗用于治疗免疫疾病，特别是TH细胞亚群相关病症并包括TH2和TH2样病症（即与TH2或TH2样介导的相关的病症）的化合物的方法免疫反应），如特应性病症（如过敏和哮喘）。另外，提供了用于TH细胞亚群相关疾病的诊断评价和预后的方法，用于鉴定表现出这种病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，并监测所用化合物的功效在临床试验中。

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