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1. 发明申请

US20100062487A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 失效
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20100062487A1
公开(公告)日：2010-03-11
申请号：US12387959
申请日：2009-05-08
申请人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
发明人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
IPC分类号： C12P21/02 , C07H21/04 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

2. 发明申请

US20120045777A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120045777A1
公开(公告)日：2012-02-23
申请号：US13169686
申请日：2011-06-27
申请人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
发明人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
IPC分类号： G01N33/53 , C12Q1/37 , C12P21/02 , C12N9/99 , C12N9/64 , C12N15/57 , C12N5/00 , C12N15/63 , G01N33/50 , C07K14/00 , C07K16/18 , C07H21/04 , G01N33/573 , C12N5/10
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

3. 发明申请

US20090136959A1 Novel genes encoding proteins having prognostic, diagnostic preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断性预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20090136959A1
公开(公告)日：2009-05-28
申请号：US12288775
申请日：2008-10-23
申请人： Sean A. McCarthy , Christopher C. Fraser , John D. Sharp , Thomas M. Barnes , Susan J. Kirst , Paul S. Myers , Nicholas Wrighton , Andrew D.J. Goodearl , Douglas A. Holtzman , Mehran Khodadoust
发明人： Sean A. McCarthy , Christopher C. Fraser , John D. Sharp , Thomas M. Barnes , Susan J. Kirst , Paul S. Myers , Nicholas Wrighton , Andrew D.J. Goodearl , Douglas A. Holtzman , Mehran Khodadoust
IPC分类号： C12Q1/68 , C12N15/11 , C12N15/00 , C12N5/06 , C07K14/00 , G01N33/00 , C07K1/00 , C07K16/18 , C12P21/04 , G01N33/53
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

4. 发明申请

US20120270219A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120270219A1
公开(公告)日：2012-10-25
申请号：US13540352
申请日：2012-07-02
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C07K14/47 , C12N5/10 , C12P21/02 , C07K16/18 , C12Q1/68 , C12N5/071 , C12N15/12 , C12N15/85 , G01N33/566
CPC分类号： C07K14/705 , C07K14/70503 , G01N33/54313
摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

5. 发明申请

US20110065124A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 有权
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20110065124A1
公开(公告)日：2011-03-17
申请号：US12800681
申请日：2010-05-20
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： G01N33/53 , C12N15/12 , C12N5/07 , C07K14/435 , C07K16/18 , C12P21/00 , G01N33/68 , G01N33/00
CPC分类号： C07K14/7151 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K2319/00 , Y10T436/143333
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

6. 发明申请

US20080213778A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20080213778A1
公开(公告)日：2008-09-04
申请号：US11983233
申请日：2007-11-08
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C12N15/11 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , C12P21/02 , G01N33/53 , C12Q1/68
CPC分类号： C07K14/7151 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K2319/00 , Y10T436/143333
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

7. 发明申请

US20100291579A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20100291579A1
公开(公告)日：2010-11-18
申请号：US12803671
申请日：2010-07-01
申请人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
发明人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
IPC分类号： C12Q1/68 , G01N33/53 , C12P21/06 , C12N5/10 , C12N5/02 , C12N15/63 , C07K14/435 , C07K16/18 , C07K1/00 , C07H21/04
CPC分类号： C07K16/18
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

8. 发明申请

US20090220977A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20090220977A1
公开(公告)日：2009-09-03
申请号：US12319689
申请日：2009-01-09
申请人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
发明人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
IPC分类号： C12Q1/68 , G01N33/53 , C12N5/10 , C12N15/63 , C07K14/435 , C07K16/00 , C07H21/04
CPC分类号： C07K16/18
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

9. 发明授权

US08076086B2 Methods of modulating the activity of TANGO332 失效
标题翻译：调节TANGO332活性的方法
公开(公告)号：US08076086B2
公开(公告)日：2011-12-13
申请号：US11499835
申请日：2006-08-04
申请人： Susan J. Kirst , Douglas A. Holtzman , Christopher C. Fraser , John D. Sharp , Thomas S. Barnes
发明人： Susan J. Kirst , Douglas A. Holtzman , Christopher C. Fraser , John D. Sharp , Thomas S. Barnes
IPC分类号： G01N33/53 , A61K38/00 , C07K17/00
CPC分类号： C07K16/18 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K16/28 , G01N33/5058
摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

10. 发明授权

US06960651B2 TANGO 332 polypeptides 失效
标题翻译： TANGO 332多肽
公开(公告)号：US06960651B2
公开(公告)日：2005-11-01
申请号：US10188495
申请日：2002-07-02
申请人： Susan J. Kirst , Douglas A. Holtzman , Christopher C. Fraser , John D. Sharp , Thomas S. Barnes
发明人： Susan J. Kirst , Douglas A. Holtzman , Christopher C. Fraser , John D. Sharp , Thomas S. Barnes
IPC分类号： A61K38/00 , C07K14/47 , A61K39/00
CPC分类号： C07K16/18 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K16/28 , G01N33/5058
摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

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