会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明申请
    • Method For The Production Of Porous Particles
    • 多孔颗粒生产方法
    • US20070275076A1
    • 2007-11-29
    • US11748095
    • 2007-05-14
    • Pratibhash ChattopadhyayBoris Y. ShekunovAdam K. Gibson
    • Pratibhash ChattopadhyayBoris Y. ShekunovAdam K. Gibson
    • A61K9/14
    • A61K9/0075A61K9/146
    • The present invention provides a method for the production of porous particles that involves extracting an organic solvent from a water-in-oil-in-water emulsion. In accordance with the method of the invention, a first aqueous solution including a porosity-promoting agent is emulsified into an organic solution including a therapeutic constituent and, optionally, a matrix material to form a water-in-oil emulsion. The water-in-oil emulsion is then emulsified into a second aqueous solution including a surfactant to form the water-in-oil-in-water emulsion. Extraction of the organic solvent from the water-in-oil-in-water emulsion, such as by supercritical fluid extraction, causes the therapeutic constituent and optional matrix material to precipitate and thus form an aqueous suspension of porous particles. The aqueous suspension can be centrifuged, filtered and lyophilized to obtain dry porous particles suitable for use in the deep lung delivery of drugs and other therapeutic agents.
    • 本发明提供了一种生产多孔颗粒的方法,其涉及从水包油包水乳液萃取有机溶剂。 根据本发明的方法,将包含孔隙促进剂的第一水溶液乳化成包括治疗成分和任选的基质材料的有机溶液,以形成油包水乳液。 然后将油包水乳液乳化成包含表面活性剂的第二水溶液以形成水包油包水乳液。 例如通过超临界流体萃取从水包油包水乳液中萃取有机溶剂使得治疗成分和任选的基质材料沉淀,从而形成多孔颗粒的水性悬浮液。 可以将水性悬浮液离心,过滤并冻干,得到适合用于深部肺部递送药物和其它治疗剂的干燥多孔颗粒。
    • 3. 发明授权
    • Method for the production of porous particles
    • 生产多孔颗粒的方法
    • US08207236B2
    • 2012-06-26
    • US11748095
    • 2007-05-14
    • Pratibhash ChattopadhyayBoris Y. ShekunovAdam K. Gibson
    • Pratibhash ChattopadhyayBoris Y. ShekunovAdam K. Gibson
    • C08J9/28C08J9/26A61K9/14
    • A61K9/0075A61K9/146
    • The present invention provides a method for the production of porous particles that involves extracting an organic solvent from a water-in-oil-in-water emulsion. In accordance with the method of the invention, a first aqueous solution including a porosity-promoting agent is emulsified into an organic solution including a therapeutic constituent and, optionally, a matrix material to form a water-in-oil emulsion. The water-in-oil emulsion is then emulsified into a second aqueous solution including a surfactant to form the water-in-oil-in-water emulsion. Extraction of the organic solvent from the water-in-oil-in-water emulsion, such as by supercritical fluid extraction, causes the therapeutic constituent and optional matrix material to precipitate and thus form an aqueous suspension of porous particles. The aqueous suspension can be centrifuged, filtered and lyophilized to obtain dry porous particles suitable for use in the deep lung delivery of drugs and other therapeutic agents.
    • 本发明提供了一种生产多孔颗粒的方法,其涉及从水包油包水乳液萃取有机溶剂。 根据本发明的方法,将包含孔隙促进剂的第一水溶液乳化成包括治疗成分和任选的基质材料的有机溶液,以形成油包水乳液。 然后将油包水乳液乳化成包含表面活性剂的第二水溶液以形成水包油包水乳液。 例如通过超临界流体萃取从水包油包水乳液中萃取有机溶剂使得治疗成分和任选的基质材料沉淀,从而形成多孔颗粒的水性悬浮液。 可以将水性悬浮液离心,过滤并冻干,得到适合用于深部肺部递送药物和其它治疗剂的干燥多孔颗粒。
    • 4. 发明授权
    • Method and apparatus for producing composite particles using supercritical fluid as plasticizing and extracting agent
    • 使用超临界流体作为增塑剂和提取剂生产复合颗粒的方法和装置
    • US07449136B2
    • 2008-11-11
    • US10531008
    • 2004-02-18
    • Boris Y. ShekunovPratibhash ChattopadhyayJeffrey S. Seitzinger
    • Boris Y. ShekunovPratibhash ChattopadhyayJeffrey S. Seitzinger
    • B29B9/00A61K9/14
    • B01D11/0411B01D11/0203B01D11/0403
    • The present invention provides methods for producing composite particles using supercritical fluid as a plasticizing and extracting agent, composite particles formed in accordance with the methods and an apparatus for carrying out the methods. In accordance with the methods of the invention, a polymer, a wax and/or a lipid that is a solid at standard temperature and pressure is contacted with a supercritical fluid to form a melt, either before or after the polymer, wax and/or lipid has been contacted with a solution comprising a solute dissolved in a solvent. The supercritical fluid plasticizes the polymer, wax and/or lip and extracts the solvent from the solution, resulting in the formation of a two-fraction system including a first melt-rich fraction that includes the plasticized melt and fine particles of precipitated solute that are dispersed in the melt, and a second fraction that includes the supercritical fluid and the solvent. Expansion of the first fraction across a pressure drop results in the formation of composite particles that include the polymer, wax and/or lipid and the solute.
    • 本发明提供了使用超临界流体作为增塑萃取剂,根据所述方法形成的复合颗粒和用于实施所述方法的装置来生产复合颗粒的方法。 根据本发明的方法,在标准温度和压力下作为固体的聚合物,蜡和/或脂质与超临界流体接触以形成熔体,在聚合物之前或之后,蜡和/或 脂质已经与包含溶解在溶剂中的溶质的溶液接触。 超临界流体使聚合物,蜡和/或脂肪增塑,并从溶液中提取溶剂,从而形成包括第一富熔体部分的双组分体系,其包括增塑的熔体和沉淀的溶质的细颗粒, 分散在熔体中,第二部分包括超临界流体和溶剂。 通过压降的第一级分的膨胀导致形成包括聚合物,蜡和/或脂质和溶质的复合颗粒。
    • 5. 发明授权
    • Lyophilization method and apparatus for producing particles
    • 冻干方法和生产颗粒的装置
    • US07073349B2
    • 2006-07-11
    • US11078554
    • 2005-03-11
    • Boris Y. ShekunovPratibhash ChattopadhyayJeffrey S. Seitzinger
    • Boris Y. ShekunovPratibhash ChattopadhyayJeffrey S. Seitzinger
    • B01D9/04C02F1/22
    • F25D3/102A61K9/1623A61K9/1694A61K9/19F25B9/02F26B5/065
    • A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.
    • 一种用于生产颗粒的方法和装置,该装置包括提供溶液的溶液源和供应流体的流体源。 溶液包括溶剂和溶质。 混合器接收来自源的溶液和流体,并将溶液和流体混合在一起形成混合物。 混合物在第一压力下从混合器供应到膨胀组件。 膨胀组件基本上同时喷雾和膨胀混合物以形成冷冻液滴,并且优选地形成冷冻液滴的低密度粉末。 冷冻干燥装置使颗粒中的溶剂升华。 粉末床的高质量转移率和均匀的开放结构提高了冷冻干燥过程。 获得具有受控尺寸分布的固体颗粒。 颗粒优选具有适于不同药物递送应用的中空或多孔形态以包括气溶胶制剂。