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1. 发明授权

US08535720B2 Method and apparatus for enhanced size reduction of particles 有权
标题翻译：增加颗粒尺寸减小的方法和装置
公开(公告)号：US08535720B2
公开(公告)日：2013-09-17
申请号：US10541909
申请日：2004-02-24
申请人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Jeffrey S. Seitzinger , Robert W. Huff
发明人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Jeffrey S. Seitzinger , Robert W. Huff
IPC分类号： A61K9/14 , B29B9/00
CPC分类号： B01F3/0853 , A61K9/146 , A61K9/1652 , A61K9/1694 , B01D3/06 , B01D11/0411 , B01F2003/0064 , B01J2/02 , C08J3/12 , C08J2305/00 , C08J2333/00 , C08J2367/00 , C08J2371/00 , C08J2389/00
摘要： The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composite particles.
摘要翻译：本发明提供了通过超临界流体处理生产颗粒的方法和装置。在一个实施方案中，该方法包括在压降下扩张超临界流体增塑的熔体，以形成同时分散，发泡和冷却的固体复合颗粒，并研磨生产的固体颗粒以达到所需的尺寸分布。在另一个实施方案中，将含有超临界流体增塑的熔体的压力容器减压以形成冷却的固体多孔质量块，然后将其研磨以获得固体复合颗粒。

2. 发明授权

US08642091B2 Method for producing solid-lipid composite drug particles 有权
标题翻译：固体 - 脂质复合药物颗粒的制备方法
公开(公告)号：US08642091B2
公开(公告)日：2014-02-04
申请号：US12124518
申请日：2008-05-21
申请人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Robert W. Huff
发明人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Robert W. Huff
IPC分类号： B29B9/00 , A61K9/14 , A61K9/00 , A61K9/16
CPC分类号： A61K9/167 , A61K9/5123 , B01D11/0403 , B01D11/0407 , B01D11/0411 , B01D11/0484 , B01J13/02
摘要： A method of producing solid composite lipid/drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid/drug nanoparticles suspended or dispersed in the liquid.
摘要翻译：一种生产固体复合脂质/药物纳米颗粒的方法，其包括以下步骤：（1）将脂质和药物溶解在合适的有机溶剂中以形成溶液; （2）将溶液乳化在液体中以形成具有包含有机溶剂，药物和脂质的胶束不连续相的乳液和包含液体的连续相; 和（3）在适合于使超临界流体处于超临界状态的条件下使乳液与超临界流体接触，由此超临界流体从胶束中提取有机溶剂，导致它们作为无机溶剂固体复合脂质/药物沉淀悬浮或分散在液体中的纳米颗粒。

3. 发明申请

US20080286365A1 Method For Producing Solid-Lipid Composite Drug Particles 有权
标题翻译：生产固体脂质复合药物颗粒的方法
公开(公告)号：US20080286365A1
公开(公告)日：2008-11-20
申请号：US12124518
申请日：2008-05-21
申请人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Robert W. Huff
发明人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Robert W. Huff
IPC分类号： A61K9/14 , A61K47/00 , A61P43/00
CPC分类号： A61K9/167 , A61K9/5123 , B01D11/0403 , B01D11/0407 , B01D11/0411 , B01D11/0484 , B01J13/02
摘要： A method of producing solid composite lipid/drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid/drug nanoparticles suspended or dispersed in the liquid.
摘要翻译：一种生产固体复合脂质/药物纳米颗粒的方法，其包括以下步骤：（1）将脂质和药物溶解在合适的有机溶剂中以形成溶液; （2）将溶液乳化在液体中以形成具有包含有机溶剂，药物和脂质的胶束不连续相的乳液和包含液体的连续相; 和（3）在适合于使超临界流体处于超临界状态的条件下使乳液与超临界流体接触，由此超临界流体从胶束中提取有机溶剂，导致它们作为无机溶剂固体复合脂质/药物沉淀悬浮或分散在液体中的纳米颗粒。

4. 发明授权

US06998051B2 Particles from supercritical fluid extraction of emulsion 有权
标题翻译：超临界流体萃取乳液颗粒
公开(公告)号：US06998051B2
公开(公告)日：2006-02-14
申请号：US10423492
申请日：2003-04-25
申请人： Pratibhash Chattopadhyay , Boris Y. Shekunov , Jeffrey S. Seitzinger , Robert W. Huff
发明人： Pratibhash Chattopadhyay , Boris Y. Shekunov , Jeffrey S. Seitzinger , Robert W. Huff
IPC分类号： B01D11/00 , B29B9/00 , A61K9/14
CPC分类号： B01D11/0411 , B01J13/02
摘要： A method of producing microparticles and nanoparticles of a solute via the extraction of solvent, having the solute dissolved therein, from an emulsion using a supercritical fluid. The solute to be precipitated is dissolved in the solvent to form a solution, and the solution is dispersed in an immiscible or partially miscible liquid to form an emulsion. The particles are produced via the extraction of the solvent from the emulsion using the supercritical fluid. The process can produce an aqueous suspension of particles that are substantially insoluble in water, and the solvents used in the process to form the emulsion initially can be recovered and recycled.
摘要翻译：通过使用超临界流体从乳液中提取溶质溶解溶剂的方法来生产溶质的微粒和纳米颗粒。待沉淀的溶质溶解在溶剂中以形成溶液，并将溶液分散在不混溶或部分混溶的液体中以形成乳液。通过使用超临界流体从乳液中提取溶剂来生产颗粒。该方法可以产生基本上不溶于水的颗粒的水性悬浮液，并且可以回收和再循环用于形成乳液的方法中使用的溶剂。

5. 发明授权

US06966990B2 Composite particles and method for preparing 有权
标题翻译：复合颗粒及其制备方法
公开(公告)号：US06966990B2
公开(公告)日：2005-11-22
申请号：US10441137
申请日：2003-05-19
申请人： Pratibhash Chattopadhyay , Boris Y. Shekunov , Jeffrey S. Seitzinger , Robert W. Huff
发明人： Pratibhash Chattopadhyay , Boris Y. Shekunov , Jeffrey S. Seitzinger , Robert W. Huff
IPC分类号： B01D11/04 , B01J2/02 , B01J13/02 , B01D11/02
CPC分类号： B01D11/0411 , B01J13/02
摘要： A method for producing composite particles using a supercritical fluid extraction technique on an emulsion. First and second materials (for example; a polymer and a biologically active material) are dissolved or suspended in a preferably solvent to form a solution or dispersion. The solution or dispersion is emulsified in a polar solvent to form an oil-in-water or water-in-oil-in-water emulsion. The emulsion is contacted with a supercritical fluid to extract the solvent. Removal of the solvent by the supercritical fluid from the emulsion supersaturates at least the first material in the solution causing the first material to precipitate out of the solution as composite particles that include both the first and second materials.
摘要翻译：一种使用超临界流体萃取技术在乳液上制备复合颗粒的方法。将第一和第二材料（例如，聚合物和生物活性材料）溶解或悬浮在优选溶剂中以形成溶液或分散体。将溶液或分散体在极性溶剂中乳化以形成水包油或水包油包水乳液。将乳液与超临界流体接触以萃取溶剂。由超临界流体从乳液中除去溶剂至少使溶液中的第一种材料过饱和，导致第一种材料沉淀出溶液，作为包括第一和第二种材料的复合颗粒。

6. 发明授权

US5686312A Method of determining emissions from powder coatings 失效
标题翻译：确定粉末涂料排放的方法
公开(公告)号：US5686312A
公开(公告)日：1997-11-11
申请号：US593208
申请日：1996-01-29
申请人： Robert W. Huff , Susan M. Miller , Joanne M. Szydlowski
发明人： Robert W. Huff , Susan M. Miller , Joanne M. Szydlowski
IPC分类号： G01N30/06 , G01N30/12
CPC分类号： G01N30/06 , G01N2030/121 , G01N2030/125 , Y10T436/12
摘要： A method for reducing residue formation caused by volatile materials during the curing of powder coating compositions which includes the steps of applying different powder coating compositions to separate bases; placing each coated base in a separate extraction chamber; placing each separate extraction chamber in a curing oven; heating the coated base in its respective extraction chamber in the curing oven to curing temperature to cure the coating composition, and simultaneously flowing a stream of air through the respective extraction chamber to capture volatile emissions from the volatile materials in the air stream during the curing process; simultaneously flowing the respective stream of air out of the curing oven and chilling the stream to condense the volatile emissions from each of the compositions to a collectable form; determining the quantity of the emitted product from each of the compositions; and comparing the quantity of emitted product from each of the compositions to determine the composition that produced the least emissions.
摘要翻译：一种在粉末涂料组合物固化期间减少由挥发性物质引起的残留物形成的方法，包括以下步骤：将不同的粉末涂料组合物施加到分离的碱; 将每个涂覆的基底放置在单独的提取室中; 将每个单独的提取室放置在固化炉中; 在固化炉中的相应提取室中加热涂覆的基底以固化温度以固化涂料组合物，同时使空气流通过相应的萃取室，以在固化过程中捕获来自空气流中的挥发性物质的挥发性排放物 ; 同时使相应的空气流从固化炉中流出并冷却流以将来自每个组合物的挥发性发射物冷凝成可收集的形式; 确定每种组合物排放的产品的数量; 并比较来自每种组合物的排放产物的量以确定产生最少排放物的组成。

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