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1. 发明申请

US20140267670A1 MOBILE MICROSCOPY DEVICE AND METHOD THEREFOR 审中-公开
标题翻译：移动显微镜装置及其方法
公开(公告)号：US20140267670A1
公开(公告)日：2014-09-18
申请号：US13844634
申请日：2013-03-15
申请人： Pooncharas Tipgunlakant , Lester F. Ludwig
发明人： Pooncharas Tipgunlakant , Lester F. Ludwig
IPC分类号： G02B21/36 , H04N5/225
CPC分类号： G02B21/361 , G02B21/0008 , G02B21/082 , G02B21/16 , G02B21/24 , H04N5/2256
摘要： A mobile microscopy apparatus usable in connection with a mobile computing device comprising a memory unit and camera, the mobile microscopy apparatus comprising: an illumination module for illuminating a removable media with an illuminating light, an image acquisition optics for creating an image of the sample for acquisition by the camera of the mobile computing device, and a mounting frame assembly for detachably mounting the illumination module and the image acquisition optics to the mobile computing device and for holding the removable media in a predetermined position. In various implementations, the illumination module may provide either backside or frontside illumination of the removable media using the light generated by a light source of the mobile computing device. The mobile microscopy apparatus may operate in the microscope configuration, visible colormatic microarray configuration, and/or fluorescent microarray configuration.
摘要翻译：一种移动显微镜装置，其可与包括存储器单元和照相机的移动计算设备相关联地使用，所述移动显微镜装置包括：用照明光照射可移除介质的照明模块，用于创建所述样本的图像的图像采集光学器件，通过移动计算设备的相机的采集，以及用于将照明模块和图像采集光学器件可拆卸地安装到移动计算设备并用于将可移动介质保持在预定位置的安装框架组件。在各种实现中，照明模块可以使用由移动计算设备的光源产生的光来提供可移动介质的背面照射或前侧照明。移动显微镜装置可以在显微镜配置，可见的微阵列配置和/或荧光微阵列配置中操作。

2. 发明申请

US20140273191A1 Cell Incubator and Cellular Culture Laboratory Test bed 有权
标题翻译：细胞培养箱和细胞培养实验室试验台
公开(公告)号：US20140273191A1
公开(公告)日：2014-09-18
申请号：US13844621
申请日：2013-03-15
申请人： Pooncharas Tipgunlakant , LESTER F. LUDWIG
发明人： Pooncharas Tipgunlakant , LESTER F. LUDWIG
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , B01L3/5025 , B01L3/502715 , B01L2300/046 , B01L2300/047 , B01L2300/049 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , B01L2300/10 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , C12M23/12 , C12M23/16 , C12Q1/02 , G01N15/06 , G01N15/0656 , G01N33/5017 , G01N2015/0681 , G01N2015/0693
摘要： A cell incubation system and methods for using a cell incubation system are described. The incubator system comprises an incubation compartment for receiving a microplate for processing samples. The microplate comprises a plurality of wells, each of the plurality of wells including a collection chamber, and a plurality of fluidic structures coupled to the plurality of wells. The microplate further comprises a plurality of sensors coupled to the plurality of wells.
摘要翻译：描述了细胞培养系统和使用细胞孵育系统的方法。培养箱系统包括用于接收用于处理样品的微板的孵育室。微板包括多个孔，多个孔中的每一个包括收集室，以及耦合到多个孔的多个流体结构。微孔板还包括耦合到多个孔的多个传感器。

3. 发明授权

US09994889B2 Advanced microplate, microtiter, and microarray technologies with per-well fluidics, gas exchange, electronic sensors, and imaging for cell culture and other applications 有权
公开(公告)号：US09994889B2
公开(公告)日：2018-06-12
申请号：US13844621
申请日：2013-03-15
申请人： Pooncharas Tipgunlakant , Lester F. Ludwig
发明人： Pooncharas Tipgunlakant , Lester F. Ludwig
IPC分类号： C12Q1/02 , C12M1/34 , G01N15/06 , G01N33/50 , B01L3/00 , C12M1/32 , C12M3/06
CPC分类号： C12Q1/025 , B01L3/5025 , B01L3/502715 , B01L2300/046 , B01L2300/047 , B01L2300/049 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , B01L2300/10 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , C12M23/12 , C12M23/16 , C12Q1/02 , G01N15/06 , G01N15/0656 , G01N33/5017 , G01N2015/0681 , G01N2015/0693
摘要： Arrangements for per-well fluidics, gas exchange, and electronic sensors for microplate, microtiter, and microarray technologies are presented. In example implementations, each individual well within in a conventional or specialized microplate can be fully or partially isolated with capping or other arrangements which can include conduits for controlled introduction, removal, and/or exchange of fluids and/or gases. Conduit networks can include small controllable valves that operate under software control, and micro-scale pumps can also be included. Conduit interconnections can include one or more of controllable-valve distribution buses, next-neighbor interconnections, and other active or passive interconnection topologies. Cap arrangements can include or provide one or more sensors of various types, including but not limited to selective gas sensors, chemical sensors, temperature sensors, pH sensors, biosensors, immunosensors, molecular-imprint sensors, optical sensors, fluorescence sensors, bioFETS, etc. Incubator interfacing and imaging are also described. The invention can be used for living cell culture or other applications.

4. 发明申请

US20130217598A1 MICROPROCESSOR-CONTROLLED MICROFLUIDIC PLATFORM FOR PATHOGEN, TOXIN, BIOMARKER, AND CHEMICAL DETECTION WITH REMOVABLE UPDATABLE SENSOR ARRAY FOR FOOD AND WATER SAFETY, MEDICAL, AND LABORATORY APPLICATIONS 审中-公开
标题翻译：微生物控制微生物平台，用于病毒，毒素，生物标记和化学检测，具有可移除的可更新的传感器阵列，用于食品和水的安全，医学和实验室应用
公开(公告)号：US20130217598A1
公开(公告)日：2013-08-22
申请号：US13761142
申请日：2013-02-06
申请人： Lester F. Ludwig , Pooncharas Tipgunlakant
发明人： Lester F. Ludwig , Pooncharas Tipgunlakant
IPC分类号： G01N33/543
CPC分类号： G01N33/54373
摘要： The invention provides a platform technology with rich ability to flexibly perform, create, deploy, maintain, and update a wide range of panels, assay, array, and/or sequence of tests for a wide range of substances and pathogens. The invention provides a unifying framework for widely-ranging miniature sensor implementation, fluidic/gas interfacing, electrical interfaces and optical interfaces, and further by collocating, allowing the integration a large number highly-selective sensors and chemical sensors—together as needed with appropriately selected supplemental sensors (for example temperature, pH, selective ions, etc.), into a common readily-manufacturable framework. The diverse sensor arrays give rise to statistical enhancing through novel statistical processing approaches. The invention is deployable and useable in a wide range of situations previously unavailable, and addresses many otherwise problematic aspects of field testing for food safety, water safety, epidemic outbreaks, routine diagnosis, and disease monitoring.
摘要翻译：本发明提供了一种平台技术，其能够灵活地执行，创建，部署，维护和更新各种各样的物质和病原体的各种面板，测定，阵列和/或测序序列。本发明为广泛范围的微型传感器实施，流体/气体接口，电接口和光学接口提供了统一的框架，并且进一步通过并置，允许将大量高度选择性的传感器和化学传感器集成在一起，并根据需要进行适当选择补充传感器（例如温度，pH，选择性离子等）成为一个易于制造的共同框架。各种传感器阵列通过新的统计处理方法产生统计增强。本发明可以在以前不可用的广泛情况下部署和使用，并解决了食品安全，水安全，疫情爆发，常规诊断和疾病监测的现场测试的许多其他问题。

5. 发明申请

US20110300232A1 EFFECTS OF NITRIC OXIDE (NO) AND iNOS ON EXPRESSION AND SIGNAL TRANSDUCTION IN CANCER AND ITS USE IN DRUG DISCOVERY AND CANCER THERAPY DESIGN 审中-公开
标题翻译：硝酸氧化酶（NO）和iNOS对癌症中表达和信号转导的影响及其在药物发现和癌症治疗设计中的应用
公开(公告)号：US20110300232A1
公开(公告)日：2011-12-08
申请号：US13155370
申请日：2011-06-07
申请人： Pooncharas Tipgunlakant
发明人： Pooncharas Tipgunlakant
IPC分类号： A61K33/26 , G01N33/573 , A61K38/06 , A61K31/15 , A61K31/04 , A61K31/19 , A61K31/196 , C12Q1/26 , A61P35/00
CPC分类号： A61K31/04 , A61K31/15 , A61K31/19 , A61K31/196 , A61K33/00 , G01N33/5011 , G01N2333/90254
摘要： Nitric Oxide (NO) acts as double-edged sword, which induces and prevents cell death, depending on various factors. The mechanism for the NO regulation of cells is not fully understood. The present invention provides experiment design methods and therapy design methods leveraging viable hypothesis supported by current research findings. This invention determines the effects of NO by controlling the majority parameters such as the steady-state concentration of NO, duration of NO exposure and the local level of oxygen. The experiment designs are structured to improve understanding of NO regulation of cells, and further can be directly adapted for therapy design. The invention directs these experiment design and therapy design methods to the study and treatment of cancer. In an application, the effects of exogenous NO on inducible Nitric Oxide Synthase (iNOS) expression and signal transduction in ovarian cancer is applied to drug discovery and therapy design for ovarian and other cancers.
摘要翻译：一氧化氮（NO）作为双刃剑，根据各种因素诱导和预防细胞死亡。细胞NO调节机制尚未完全了解。本发明提供了利用当前研究结果支持的可行假设的实验设计方法和治疗设计方法。本发明通过控制NO的稳态浓度，NO暴露持续时间和局部氧气浓度等多数参数来确定NO的作用。实验设计的结构是提高对细胞NO调节的理解，进一步可以直接适应治疗设计。本发明将这些实验设计和治疗设计方法指导给癌症的研究和治疗。在一个应用中，外源NO对卵巢癌诱导型一氧化氮合酶（iNOS）表达和信号转导的影响被应用于卵巢癌和其他癌症的药物发现和治疗设计。

6. 发明授权

US10274487B2 Microprocessor-controlled microfluidic platform for pathogen, toxin, biomarker, and chemical detection with removable updatable sensor array for food and water safety, medical, and laboratory applications 有权
公开(公告)号：US10274487B2
公开(公告)日：2019-04-30
申请号：US13761142
申请日：2013-02-06
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig , Pooncharas Tipgunlakant
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , B01L9/00 , G01N33/543
摘要： The invention provides a platform technology with rich ability to flexibly perform, create, deploy, maintain, and update a wide range of panels, assay, array, and/or sequence of tests for a wide range of substances and pathogens. The invention provides a unifying framework for widely-ranging miniature sensor implementation, fluidic/gas interfacing, electrical interfaces and optical interfaces, and further by collocating, allowing the integration a large number highly-selective sensors and chemical sensors—together as needed with appropriately selected supplemental sensors (for example temperature, pH, selective ions, etc.), into a common readily-manufacturable framework. The diverse sensor arrays give rise to statistical enhancing through novel statistical processing approaches. The invention is deployable and useable in a wide range of situations previously unavailable, and addresses many otherwise problematic aspects of field testing for food safety, water safety, epidemic outbreaks, routine diagnosis, and disease monitoring.

7. 发明授权

US10024791B2 Cylindrical optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications 有权
公开(公告)号：US10024791B2
公开(公告)日：2018-07-17
申请号：US15457963
申请日：2017-03-13
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig , Karen Hao , Frank Hu , Alice Huang , Pooncharas Tipgunlakant
IPC分类号： G01N21/59
摘要： A cylindrical optical tomography system includes a light emitting array having a plurality of light emitting elements, a cylindrical sample holding element, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample holding module.

8. 发明申请

US20170097298A1 ELECTRONIC IMAGING FLOW-MICROSCOPE FOR ENVIRONMENTAL REMOTE SENSING, BIOREACTOR PROCESS MONITORING, AND OPTICAL MICROSCOPIC TOMOGRAPHY 有权
公开(公告)号：US20170097298A1
公开(公告)日：2017-04-06
申请号：US15289815
申请日：2016-10-10
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig , Karen Hao , Frank Hu , Alice Huang , Pooncharas Tipgunlakant
IPC分类号： G01N21/05 , G02B21/36 , G02B21/06
CPC分类号： G01N21/05 , G01N15/1475 , G01N2021/058 , G02B21/06 , G02B21/367
摘要： An electronic imaging flow-microscope for remote environmental sensing, bioreactor process monitoring, and optical microscopic tomography applications is described. A fluid conduit has a port on each end of a thin flat transparent fluid transport region. A planar illumination surface contacts one flat side of the transparent fluid transport region and a planar image sensing surface contacts the other flat side. Light from the illumination surface travels through the transparent fluid transport region to the planar image sensing surface, producing a light field affected by the fluid and objects present. The planar image sensing surface creates electrical image signals responsive to the light field. The planar illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET whose illumination can be sequenced in an image formation process. The flow microscope can further comprise flow-restricting valves, pumps, energy harvesting arrangements, and power management.

9. 发明授权

US09594239B1 Optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications 有权
标题翻译：光学断层扫描显微镜，细胞计数仪，微孔板阵列仪，晶体学等应用
公开(公告)号：US09594239B1
公开(公告)日：2017-03-14
申请号：US13963917
申请日：2013-08-09
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig , Karen Hao , Frank Hu , Alice Huang , Pooncharas Tipgunlakant
IPC分类号： H04N7/18 , G02B21/06
CPC分类号： G01N21/05 , G01N15/1475 , G01N2021/058 , G02B21/06 , G02B21/367
摘要： An electronic imaging flow-microscope for remote environmental sensing, bioreactor process monitoring, and optical microscopic tomography applications is described. A fluid conduit has a port on each end of a thin flat transparent fluid transport region. A planar illumination surface contacts one flat side of the transparent fluid transport region and a planar image sensing surface contacts the other flat side. Light from the illumination surface travels through the transparent fluid transport region to the planar image sensing surface, producing a light field affected by the fluid and objects present. The planar image sensing surface creates electrical image signals responsive to the light field. The planar illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET. whose illumination can be sequenced in an image formation process. The flow microscope can further comprise flow-restricting valves, pumps, energy harvesting arrangements, and power management.
摘要翻译：描述了用于远程环境感测，生物反应器过程监测和光学显微镜层析成像应用的电子成像流动显微镜。流体导管在薄平坦的透明流体输送区域的每一端具有一个端口。平面照明面接触透明流体输送区域的一个平坦侧面，平面摄像面与另一平坦面接触。来自照明表面的光穿过透明流体输送区域到达平面图像感测表面，产生受流体和存在的物体影响的光场。平面图像感测表面产生响应于光场的电图像信号。平面照明表面可以是诸如LED，OLED或OLET的发光元件。其照明可以在图像形成过程中被排序。流动显微镜还可以包括流量限制阀，泵，能量收集装置和电力管理。

10. 发明授权

US10816467B2 Optical tomography optoelectronic arrangements for microplate wells 有权
公开(公告)号：US10816467B2
公开(公告)日：2020-10-27
申请号：US16036646
申请日：2018-07-16
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig , Karen Hao , Frank Hu , Alice Huang , Pooncharas Tipgunlakant
IPC分类号： G01N21/59 , G01N15/14 , G01N21/25 , G01N21/51 , G01N21/53 , G01N21/64 , G01N15/02 , G01N15/10 , G01N21/17
摘要： Optical tomography arrangements are disclosed for performing optical tomography on the transparent or translucent contents of individual microplate wells comprising a light emitting array having a plurality of light emitting elements, a sample module, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample module. The light emitting elements can comprise light emitting diodes (LEDs), organic light emitting diodes (OLEDs), organic light emitting transistors (OLETs), and/or other optoelectronic devices. The light sensing array can comprise organic light sensing devices, photodiodes, phototransistors, CMOS photodetectors, or charge-coupled devices (CCDs). The light emitting array can be flat or curved, and the light sensing array can be flat or curved. The collection of measurement values can be overspecified, and a generalized inverse operation can provide solutions rendering computational tomography data.

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