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1. 发明授权

US09994889B2 Advanced microplate, microtiter, and microarray technologies with per-well fluidics, gas exchange, electronic sensors, and imaging for cell culture and other applications 有权
公开(公告)号：US09994889B2
公开(公告)日：2018-06-12
申请号：US13844621
申请日：2013-03-15
申请人： Pooncharas Tipgunlakant , Lester F. Ludwig
发明人： Pooncharas Tipgunlakant , Lester F. Ludwig
IPC分类号： C12Q1/02 , C12M1/34 , G01N15/06 , G01N33/50 , B01L3/00 , C12M1/32 , C12M3/06
CPC分类号： C12Q1/025 , B01L3/5025 , B01L3/502715 , B01L2300/046 , B01L2300/047 , B01L2300/049 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , B01L2300/10 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , C12M23/12 , C12M23/16 , C12Q1/02 , G01N15/06 , G01N15/0656 , G01N33/5017 , G01N2015/0681 , G01N2015/0693
摘要： Arrangements for per-well fluidics, gas exchange, and electronic sensors for microplate, microtiter, and microarray technologies are presented. In example implementations, each individual well within in a conventional or specialized microplate can be fully or partially isolated with capping or other arrangements which can include conduits for controlled introduction, removal, and/or exchange of fluids and/or gases. Conduit networks can include small controllable valves that operate under software control, and micro-scale pumps can also be included. Conduit interconnections can include one or more of controllable-valve distribution buses, next-neighbor interconnections, and other active or passive interconnection topologies. Cap arrangements can include or provide one or more sensors of various types, including but not limited to selective gas sensors, chemical sensors, temperature sensors, pH sensors, biosensors, immunosensors, molecular-imprint sensors, optical sensors, fluorescence sensors, bioFETS, etc. Incubator interfacing and imaging are also described. The invention can be used for living cell culture or other applications.

2. 发明授权

US09802190B2 Modular computer-controlled multistep chemical processing system for use in laboratory automation or chemical production spanning a plurality of scales 有权
公开(公告)号：US09802190B2
公开(公告)日：2017-10-31
申请号：US14023292
申请日：2013-09-10
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/028 , B01L2200/10 , G01N2035/0094
摘要： A modular laboratory-style computer-controlled system for multistep chemical processing for use in laboratory automation or chemical production is disclosed. The system comprised a plurality of interconnectable electrically-powered controllable chemical process modules having chemical input and output ports and at least one communications interface. Interconnection among the chemical process modules include both chemical flow interconnections for the transport of chemical materials and network interconnections for the transport of communications signals. In some implementations chemical flow interconnections are software controllable.

3. 发明授权

US09646589B2 Joint and coordinated visual-sonic metaphors for interactive multi-channel data sonification to accompany data visualization 有权
公开(公告)号：US09646589B2
公开(公告)日：2017-05-09
申请号：US14176000
申请日：2014-02-07
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： G10H1/06
CPC分类号： G06F3/167 , G10H1/06 , G10H2210/301 , G10H2220/351 , G10H2250/471
摘要： Data sonification arrangements for use with data visualization so as to provide parallel perceptual channels for representing complex numerical data to a user seeking to identify correlations within the data are presented. In an implementation, several varying data quantities are represented by time-varying graphics while several other varying data quantities are represented by time-varying sound, both presented to a user to observe correlations between sonic and visual events or trends. Sonification can be used to offload some information-carrying information capacity from a visualization system, while other information can be rendered via both sonification and visualization to provide affirming or orienting redundancy. In an implementation joint and coordinated visual-sonic metaphors are used for this or other purposes. For example, data sonification can include multiple data-modulated sound timbre classes, each rendered within a stereo sound field according to a spatial metaphor that is shared with the visualization.

4. 发明授权

US09636655B2 Software-reconfigurable conduit and reaction chamber microfluidic arrangements for lab-on-a-chip and miniature chemical processing techologies 有权
公开(公告)号：US09636655B2
公开(公告)日：2017-05-02
申请号：US13314170
申请日：2011-12-07
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , G01N35/00
CPC分类号： B01J19/0093 , B01J2219/00835 , B01J2219/00871 , B01J2219/00873 , B01J2219/00905 , B01J2219/00986 , B01J2219/00997 , B01L3/502715 , B01L3/502738 , B01L3/567 , B01L9/52 , B01L2200/10 , B01L2200/143 , B01L2200/146 , B01L2200/147 , B01L2300/0864 , B01L2300/0867 , B01L2300/18 , B01L2400/0421 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/086 , G01N35/0092 , Y10T436/12
摘要： Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or smallscale chemical manufacturing.

5. 发明授权

US09594239B1 Optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications 有权
标题翻译：光学断层扫描显微镜，细胞计数仪，微孔板阵列仪，晶体学等应用
公开(公告)号：US09594239B1
公开(公告)日：2017-03-14
申请号：US13963917
申请日：2013-08-09
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig , Karen Hao , Frank Hu , Alice Huang , Pooncharas Tipgunlakant
IPC分类号： H04N7/18 , G02B21/06
CPC分类号： G01N21/05 , G01N15/1475 , G01N2021/058 , G02B21/06 , G02B21/367
摘要： An electronic imaging flow-microscope for remote environmental sensing, bioreactor process monitoring, and optical microscopic tomography applications is described. A fluid conduit has a port on each end of a thin flat transparent fluid transport region. A planar illumination surface contacts one flat side of the transparent fluid transport region and a planar image sensing surface contacts the other flat side. Light from the illumination surface travels through the transparent fluid transport region to the planar image sensing surface, producing a light field affected by the fluid and objects present. The planar image sensing surface creates electrical image signals responsive to the light field. The planar illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET. whose illumination can be sequenced in an image formation process. The flow microscope can further comprise flow-restricting valves, pumps, energy harvesting arrangements, and power management.
摘要翻译：描述了用于远程环境感测，生物反应器过程监测和光学显微镜层析成像应用的电子成像流动显微镜。流体导管在薄平坦的透明流体输送区域的每一端具有一个端口。平面照明面接触透明流体输送区域的一个平坦侧面，平面摄像面与另一平坦面接触。来自照明表面的光穿过透明流体输送区域到达平面图像感测表面，产生受流体和存在的物体影响的光场。平面图像感测表面产生响应于光场的电图像信号。平面照明表面可以是诸如LED，OLED或OLET的发光元件。其照明可以在图像形成过程中被排序。流动显微镜还可以包括流量限制阀，泵，能量收集装置和电力管理。

6. 发明授权

US09442652B2 General user interface gesture lexicon and grammar frameworks for multi-touch, high dimensional touch pad (HDTP), free-space camera, and other user interfaces 有权
标题翻译：一般用户界面手势词汇和语法框架，用于多点触摸，高维度触摸板（HDTP），自由空间相机和其他用户界面
公开(公告)号：US09442652B2
公开(公告)日：2016-09-13
申请号：US13414705
申请日：2012-03-07
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： G06F3/033 , G06F3/0488
CPC分类号： G06F3/017 , G06F3/04883 , G06F17/2705 , G06F17/2755
摘要： A method for a multi-touch gesture-based user interface wherein a plurality of gestemes are defined as functions of abstract space and time and further being primitive gesture segments that can be concatenated over time and space to construct gestures. Various distinct subset of the gestemes can be concatenated in space and time to construct a distinct gestures. Real-time multi-touch gesture-based information provided by user interface is processed to at least a recognized sequence of specific gestemes and that the sequence of gestemes that the user's execution a gesture has been completed. The specific gesture rendered by the user is recognized according to the sequence of gestemes. Many additional features are then provided from this foundation, including gesture grammars, structured-meaning gesture-lexicon, context, and the use of gesture prosody.
摘要翻译：一种用于基于多触摸手势的用户界面的方法，其中多个准单位被定义为抽象空间和时间的函数，并且进一步是可以随时间和空间连接以构建手势的原始手势段。可以在空间和时间中连接各种不同的gestem子集，以构建不同的手势。由用户界面提供的基于实时多点触摸手势的信息被处理为至少一个识别出的特定的行为的序列，并且用户执行手势已经完成的行为的顺序。由用户呈现的特定手势根据gestemes的顺序被识别。然后从这个基础提供许多其他功能，包括手势语法，结构化意义的手势词典，上下文以及使用手势韵律。

7. 发明授权

US09441308B2 Three-dimensional microfluidic micro-droplet arrays for electronic integrated circuit and component cooling, energy-harvesting, chemical and biochemical microreactors, miniature bioreactors, and other applications 有权
标题翻译：用于电子集成电路和部件冷却，能量收集，化学和生物化学微反应器，微型生物反应器和其他应用的三维微流体微滴阵列
公开(公告)号：US09441308B2
公开(公告)日：2016-09-13
申请号：US13770934
申请日：2013-02-19
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： B01L7/00 , C25B9/06 , B01L3/00 , H01L23/473 , H01L23/38 , F28D15/00
CPC分类号： B01L3/502784 , B01L3/50273 , B01L3/502792 , B01L7/525 , B01L2200/025 , B01L2300/0874 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1883 , B01L2300/1894 , B01L2400/0427 , F28D15/00 , F28F2250/08 , F28F2260/02 , G01N27/44773 , G01N27/44791 , H01L23/38 , H01L23/473 , H01L2924/0002 , H01L2924/00
摘要： A microfluidic transport system for transporting microdroplets in three spatial dimensions. In an example arrangement, a first planar arrangement for transporting microdroplets in two spatial dimensions responsive to electric fields created by electrical operation of electrodes is fluidically connected by one or more conduits to other planar arrangement for transporting microdroplets in two spatial dimensions responsive to electric fields created by electrical operation of electrodes. Microdroplets can be transported through the one or more conduits so as to be moved among the first and second planar arrangements.The system can be used for heat transfer, fluidic transfer, and other uses, and can be implemented within a printed circuit board, integrated circuit housing, or using materials such as metal, glass, polymer, plastic, layered materials, fibrous materials, etc. Example applications include integrated circuit cooling, energy harvesting, microfluidic systems, chemical reactors, biochemical reactors, chemical analysis arrangements, biochemical analysis arrangements, and other apparatus.
摘要翻译：该系统可用于传热，流体传输和其他用途，可用于印刷电路板，集成电路外壳，或使用金属，玻璃，聚合物，塑料，分层材料，纤维材料等材料。示例应用包括集成电路冷却，能量收集，微流体系统，化学反应器，生化反应器，化学分析装置，生化分析装置和其它装置。

8. 发明授权

US09031347B2 Correction of over-focus in digital images using centered discrete imaginary-power fractional fourier transformations with high-accuracy orthonormal eigenvectors 有权
$Correction of over-focus in digital images using centered discrete imaginary-power fractional fourier transformations with high-accuracy orthonormal eigenvectors$
标题翻译：使用具有高精度正交特征向量的中心离散虚功率分数傅立叶变换来校正数字图像中的过焦点
公开(公告)号：US09031347B2
公开(公告)日：2015-05-12
申请号：US14207186
申请日：2014-03-12
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： G06K9/40 , G06K9/36 , G06T5/00 , G06K9/52 , G06T5/10
CPC分类号： G06T5/003 , G06K9/52 , G06T5/10 , G06T2207/20056
摘要： A method for correcting overfocus of a digital image created from coherent imaging using centered fractional Fourier transforms or mathematical equivalents is described. A received image is presented to a numerical processor, and a first numerical value for an imaginary power variable is selected and used in an iterative algorithm, numerical procedure, system architecture, etc. A centered discrete fractional Fourier transform of an imaginary power and a phase restore operator associated are applied to the image file to produce a modified image. A change in mis-focused is determined and used in adjusting the specified imaginary power for a next iteration.
摘要翻译：描述了一种用于校正使用中心分数阶傅里叶变换或数学等价物从相干成像创建的数字图像的过度聚焦的方法。将接收到的图像呈现给数字处理器，并且选择虚拟功率变量的第一数值并以迭代算法，数值过程，系统架构等使用。虚拟功率和相位的中心离散分数阶Fourier变换恢复运算符相关联应用于图像文件以产生修改的图像。确定错误聚焦的变化，并用于调整下一次迭代的指定虚拟力。

9. 发明授权

US08743068B2 Touch screen method for recognizing a finger-flick touch gesture 有权
标题翻译：用于识别手指轻触触摸手势的触摸屏方法
公开(公告)号：US08743068B2
公开(公告)日：2014-06-03
申请号：US13549285
申请日：2012-07-13
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： G06F3/041
CPC分类号： G06F3/04883 , G06F3/005 , G06F3/017 , G06F3/041 , G06F3/0412 , G06F3/0416 , G06F3/04847 , G06F3/0488 , G10H1/00 , G10H1/0058 , G10H1/0066 , G10H1/348 , G10H1/46 , G10H3/18 , G10H3/26 , G10H2220/521 , G10H2220/525 , G10H2230/095 , G10H2230/101 , G10H2230/115 , G10H2230/145 , G10H2230/271 , Y10S84/10
摘要： A touch screen method for recognizing a finger-flick touch gesture for an electronic device including a overlaying a plurality of transparent sensors on top of a visual display associated with the electronic device and where the transparent sensors are configured to be responsive to touch by at least one user finger and the visual display is for rendering visual information provided by the electronic device is disclosed. Control parameters associated with sensor measurements include parameter derived from recognizing a finger-flick touch gesture.
摘要翻译：一种用于识别用于电子设备的手指轻触触摸手势的触摸屏方法，包括在与所述电子设备相关联的视觉显示器的顶部上覆盖多个透明传感器，并且其中所述透明传感器被配置为响应于至少触摸一个用户手指和视觉显示器用于呈现由电子设备提供的视觉信息。与传感器测量相关的控制参数包括从识别手指轻触触摸手势得到的参数。

10. 发明申请

US20140132548A1 TOUCH SCREEN WITH DISPLAY AND SENSOR ARRAY IN CONTACT WITH THE DISPLAY 有权
标题翻译：触摸屏与显示器和传感器阵列接触显示器
公开(公告)号：US20140132548A1
公开(公告)日：2014-05-15
申请号：US14160505
申请日：2014-01-21
申请人： Lester F. Ludwig
发明人： Lester F. Ludwig
IPC分类号： G06F3/041
CPC分类号： G06F3/04883 , G06F3/005 , G06F3/017 , G06F3/041 , G06F3/0412 , G06F3/0416 , G06F3/04847 , G06F3/0488 , G10H1/00 , G10H1/0058 , G10H1/0066 , G10H1/348 , G10H1/46 , G10H3/18 , G10H3/26 , G10H2220/521 , G10H2220/525 , G10H2230/095 , G10H2230/101 , G10H2230/115 , G10H2230/145 , G10H2230/271 , Y10S84/10
摘要： Touch screen user interfaces for controlling software applications, computers, devices, machinery, and process environments with touch gestures. Such user interfaces can be manipulated by users and provide a wide range of uses with computer applications, assistance to the disabled, and control of electronic devices, machines, and processes. Enhancements can include velocity and pressure sensing capabilities. The touch screen can be realized with a touchscreen having a touch sensor array in physical contact with a visual display. Implementations can include a touch screen having a transparent sensor array in physical contact with a visual display to form a touch screen configured to process a touch on the touch screen.
摘要翻译：触摸屏用户界面，用于通过触摸手势控制软件应用程序，计算机，设备，机械和过程环境。这样的用户界面可以由用户操纵并且提供与计算机应用程序的广泛使用，对残疾人的帮助，以及电子设备，机器和过程的控制。增强功能可以包括速度和压力感测功能。触摸屏可以用具有与视觉显示器物理接触的触摸传感器阵列的触摸屏来实现。实施方案可以包括具有与视觉显示器物理接触的透明传感器阵列的触摸屏，以形成配置成处理触摸屏上的触摸的触摸屏。

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