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1. 发明申请

US20050015009A1 Systems and methods for determining intracranial pressure non-invasively and acoustic transducer assemblies for use in such systems 有权
标题翻译：用于确定在这种系统中使用的非侵入性和声学换能器组件的颅内压的系统和方法
公开(公告)号：US20050015009A1
公开(公告)日：2005-01-20
申请号：US10861197
申请日：2004-06-03
申请人： Pierre Mourad , Brandt Mohr , Michel Kliot , Robert Frederickson , R. Thompson , Jason Seawall
发明人： Pierre Mourad , Brandt Mohr , Michel Kliot , Robert Frederickson , R. Thompson , Jason Seawall
IPC分类号： A61B5/03 , A61B8/00 , A61B8/04 , A61B8/06 , A61B8/08 , A61B8/14
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/7267 , A61B8/00 , A61B8/04 , A61B8/065 , A61B8/08 , A61B8/0808 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/488
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法，其中使用非线性关系来基于一个或多个可变输入来确定ICP。第一可变输入涉及颅血管和/或血流的一种或多种性质，例如来自具有在颅血管上训练的焦点的声学换能器的声学后向散射，颅血管中的流速等。另外的变量，例如动脉血压（ABP）可以与与颅血管的一种或多种性质（例如大脑中动脉（MCA）的流速）相关的第一可变输入组合使用，以便使用非线性关系。基于它们的声学特性和对于区域的声学扫描来定位目标区域的方法和系统也基于声学特性识别目标区域，以及声源和/或检测器在期望的目标区域上的自动聚焦也是提供。描述了声学换能器组件。

2. 发明申请

US20060100530A1 Systems and methods for non-invasive detection and monitoring of cardiac and blood parameters 审中-公开
标题翻译：用于非侵入性检测和监测心脏和血液参数的系统和方法
公开(公告)号：US20060100530A1
公开(公告)日：2006-05-11
申请号：US11234914
申请日：2005-09-26
申请人： Michel Kliot , Robert Frederickson , Kamran Forghani , Pierre Mourad
发明人： Michel Kliot , Robert Frederickson , Kamran Forghani , Pierre Mourad
IPC分类号： A61B5/02
CPC分类号： A61B8/06 , A61B5/0002 , A61B5/0205 , A61B5/08 , A61B5/145 , A61B5/681 , A61B5/6814 , A61B5/6822 , A61B5/6828 , A61B5/6831 , A61B8/04 , A61B8/0816 , A61B8/4472 , A61B8/485 , A61B8/543 , A61B8/56 , A61B8/58
摘要： Methods and systems for long term monitoring of one or more physiological parameters such as respiration, heart rate, body temperature, electrical heart activity, blood oxygenation, blood flow velocity, blood pressure, intracranial pressure, the presence of emboli in the blood stream and electrical brain activity are provided. Data is acquired non-invasively using ambulatory data acquisition techniques.
摘要翻译：用于长期监测一种或多种生理参数的方法和系统，例如呼吸，心率，体温，电心脏活动，血氧饱和度，血流速度，血压，颅内压，血液中血栓和电气的存在提供大脑活动。使用流动数据采集技术非侵入性地获取数据。

3. 发明申请

US20060079773A1 Systems and methods for making non-invasive physiological assessments by detecting induced acoustic emissions 审中-公开
标题翻译：通过检测诱发的声发射进行非侵入性生理评估的系统和方法
公开(公告)号：US20060079773A1
公开(公告)日：2006-04-13
申请号：US11050993
申请日：2005-02-04
申请人： Pierre Mourad , Michel Kliot , Robert Frederickson
发明人： Pierre Mourad , Michel Kliot , Robert Frederickson
IPC分类号： A61B8/00
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4058 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B8/04 , A61B8/08 , A61B8/0808 , A61B8/485 , A61B8/488
摘要： Systems and methods for assessing a physiological parameter of a target tissue wherein a pulse of focused ultrasound is applied to a target tissue site thereby inducing oscillation of the target tissue. By these systems and methods, a property of an acoustic signal emitted from the oscillating target tissue is measured and related to a physiological property of the tissue. Specific applications for systems and methods of the present invention include the assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.
摘要翻译：用于评估目标组织的生理参数的系统和方法，其中聚焦超声的脉冲被施加到目标组织位置，从而引起靶组织的振荡。通过这些系统和方法，测量从振荡目标组织发射的声信号的特性并与组织的生理特性相关。本发明的系统和方法的具体应用包括评估和监测颅内压（ICP），动脉血压（ABP），CNS自动调节状态，血管痉挛，中风，局部水肿，感染和血管，以及诊断和监测其特征在于组织性质的物理变化的疾病和病症。

4. 发明授权

US07547283B2 Methods for determining intracranial pressure non-invasively 有权
标题翻译：非侵入性确定颅内压的方法
公开(公告)号：US07547283B2
公开(公告)日：2009-06-16
申请号：US10861197
申请日：2004-06-03
申请人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C. A. Frederickson
发明人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C. A. Frederickson
IPC分类号： A61B8/14
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/7267 , A61B8/00 , A61B8/04 , A61B8/065 , A61B8/08 , A61B8/0808 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/488
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法，其中使用非线性关系来基于一个或多个可变输入来确定ICP。第一可变输入涉及颅血管和/或血流的一种或多种性质，例如来自具有在颅血管上训练的焦点的声学换能器的声学后向散射，颅血管中的流速等。另外的变量，例如动脉血压（ABP）可以与与颅血管的一种或多种性质（例如大脑中动脉（MCA）的流速）相关的第一可变输入组合使用，以便使用非线性关系。基于它们的声学特性和对于区域的声学扫描来定位目标区域的方法和系统也基于声学特性识别目标区域，以及声源和/或检测器在期望的目标区域上的自动聚焦也是提供。描述了声学换能器组件。

5. 发明申请

US20090149751A1 SYSTEMS AND METHODS FOR DETERMINING INTRACRANIAL PRESSURE NON-INVASIVELY AND ACOUSTIC TRANSDUCER ASSEMBLIES FOR USE IN SUCH SYSTEMS 审中-公开
标题翻译：用于确定在这些系统中使用的非侵入性和声学传感器组件的系统和方法
公开(公告)号：US20090149751A1
公开(公告)日：2009-06-11
申请号：US12325977
申请日：2008-12-01
申请人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C.A. Frederickson , R. Lee Thompson , Jason L. Seawall
发明人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C.A. Frederickson , R. Lee Thompson , Jason L. Seawall
IPC分类号： A61B8/00
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/7267 , A61B8/00 , A61B8/04 , A61B8/065 , A61B8/08 , A61B8/0808 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/488
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided. Systems for acquiring acoustic data from a desired target site in a subject's body using various types of acoustic source and detector elements are also provided, including single use acoustic source/detector combinations are also provided. Acoustic arrays for use with these systems may include multiple capacitive micro-machined ultrasound transducer (cMUT) elements, and may include a combination of different types of acoustic arrays. Methods of targeting localized sites within a broad target area based on acoustic data having various properties are also disclosed.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法。还提供了使用各种类型的声源和检测器元件从受试者身体中期望的目标部位获取声学数据的系统，包括单用声源/检测器组合。用于这些系统的声学阵列可以包括多个电容微加工超声换能器（cMUT）元件，并且可以包括不同类型的声阵列的组合。还公开了基于具有各种性质的声学数据来定位广泛目标区域内的局部位置的方法。

6. 发明申请

US20070016031A1 Systems and methods for making noninvasive assessments of cardiac tissue and parameters 有权
标题翻译：用于进行心脏组织和参数的无创评估的系统和方法
公开(公告)号：US20070016031A1
公开(公告)日：2007-01-18
申请号：US11395437
申请日：2006-03-31
申请人： Pierre Mourad , Michel Kliot , Rex Patterson , Alec Rooke
发明人： Pierre Mourad , Michel Kliot , Rex Patterson , Alec Rooke
IPC分类号： A61B8/00
CPC分类号： A61B8/065 , A61B5/0048 , A61B5/031 , A61B5/4519 , A61B5/4824 , A61B5/4869 , A61B6/503 , A61B6/504 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0808 , A61B8/0883 , A61B8/0891 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/485 , A61B8/488
摘要： Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
摘要翻译：公开了使用超声技术非心脏评估心脏组织特性和心脏参数的系统和方法。心肌组织刚度，张力，应变，应变速率等的测定可用于评估心肌收缩力，心肌缺血和梗死，心室充盈和心房压力以及舒张功能。公开了诸如超声波之类的声学技术来采集与内在组织位移有关的数据的非侵入式系统。还公开了其中使用超声技术来声学刺激或触诊靶心脏组织或诱导与心脏组织特性和/或心脏参数相关的心脏组织部位的应答的非侵入性系统。

7. 发明授权

US06875176B2 Systems and methods for making noninvasive physiological assessments 有权
标题翻译：进行无创生理评估的系统和方法
公开(公告)号：US06875176B2
公开(公告)日：2005-04-05
申请号：US09995897
申请日：2001-11-28
申请人： Pierre D. Mourad , Michel Kliot , Ali Mesiwala , Rex Patterson , Jeffrey G. Jarvik
发明人： Pierre D. Mourad , Michel Kliot , Ali Mesiwala , Rex Patterson , Jeffrey G. Jarvik
IPC分类号： A61B8/08 , A61B5/03 , A61B8/00 , A61B8/04 , A61B8/12
CPC分类号： A61B5/415 , A61B5/0048 , A61B5/031 , A61B5/4058 , A61B5/4064 , A61B5/418 , A61B5/4824 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0816 , A61B8/485 , A61B8/488
摘要： Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and/or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.
摘要翻译：提供了通过获取与内在和/或诱导的组织置换或相关生物反应的至少一个方面相关的数据来无组织地评估组织特性的系统和方法。可以通过使用超声询问脉冲检测组织的声学特性，优选地以散射或多普勒检测模式来获取与组织位移和相关联的生物变化有关的数据。基于该数据，对组织性质进行评估，表征和监测。本发明的系统和方法的具体应用包括颅内压（ICP），动脉血压（ABP），CNS自动调节状态，血管痉挛，中风，局部水肿，感染和血管炎的非侵入性评估和监测以及诊断并监测组织特性物理变化特征的疾病和病症。还提供了通过使用聚焦超声的应用来靶向和选择性探测组织来定位生理状况和/或生物反应（例如疼痛）的方法和系统。

8. 发明申请

US20120108918A1 Acoustic Palpation Using Non-Invasive Ultrasound Techniques for Identification of Target Sites and Assessment of Chronic Pain Disorders 审中-公开
标题翻译：声波触诊使用非侵入性超声技术鉴定目标位点和评估慢性疼痛疾病
公开(公告)号：US20120108918A1
公开(公告)日：2012-05-03
申请号：US13161214
申请日：2011-06-15
申请人： Jeffrey G. Jarvik , Pierre D. Mourad , Michel Kliot , Robert C.A. Frederickson , Abbi M. McClintic , Trevor C. Dickey , Michael Gofeld
发明人： Jeffrey G. Jarvik , Pierre D. Mourad , Michel Kliot , Robert C.A. Frederickson , Abbi M. McClintic , Trevor C. Dickey , Michael Gofeld
IPC分类号： A61B8/00 , A61B5/08 , A61B5/024 , A61B5/01 , A61B5/145 , A61B5/026 , A61B5/021 , A61B5/03 , A61B5/0476 , A61B5/04 , A61B5/00 , A61B5/0402
CPC分类号： A61B5/4827 , A61B5/4824 , A61B5/4893 , A61B8/00 , A61B8/08 , A61B8/0808 , A61B8/4218 , A61B8/4472 , A61B8/4494 , A61B2018/00642 , A61N7/02 , A61N2007/0078
摘要： Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.
摘要翻译：提供了用于鉴定和空间定位具有某些生理特性的组织的空间定位方法和系统，或者响应于强聚焦超声（声学探测或触诊）的应用而产生某些生物反应，例如疼痛的感觉。在一些实施方案中，使用目标声学探测来鉴定慢性疼痛敏化组织区域和慢性疼痛障碍的范围和严重程度。在其他应用中，使用目标声学探测来定位神经和其它致敏组织以引导针和其他递送装置，以及用于输送麻醉剂，止痛剂或治疗组合物。

9. 发明申请

US20160262731A1 NERVE STIMULATION BIOPSY DEVICE 审中-公开
标题翻译：神经刺激生物设备
公开(公告)号：US20160262731A1
公开(公告)日：2016-09-15
申请号：US15064907
申请日：2016-03-09
申请人： Michel Kliot , John Bode , Michael Heiferman , Ryan Khanna , Yunli Ma , Komal Prem , Nick Messana , Colin Russi
发明人： Michel Kliot , John Bode , Michael Heiferman , Ryan Khanna , Yunli Ma , Komal Prem , Nick Messana , Colin Russi
IPC分类号： A61B10/02 , A61B5/04
CPC分类号： A61B10/0233 , A61B5/1104 , A61B5/4029 , A61B5/4824 , A61B5/4893
摘要： A nerve stimulation biopsy device configured to deliver a precise and adjustable stimulus signal into a biopsy site. The stimulus signal is used to distinguish between functioning nerve fibers and target tissue. Also disclosed is a method for safely performing a biopsy procedure on a biopsy site of a patient, which utilizes introducing a stimulus signal to the biopsy site.
摘要翻译：神经刺激活检装置，被配置为将精确和可调节的刺激信号递送到活检部位。刺激信号用于区分功能性神经纤维和靶组织。还公开了一种用于在患者的活检部位上安全地进行活检程序的方法，其利用向活检部位引入刺激信号。

10. 发明授权

US07022077B2 Systems and methods for making noninvasive assessments of cardiac tissue and parameters 失效
标题翻译：用于进行心脏组织和参数的无创评估的系统和方法
公开(公告)号：US07022077B2
公开(公告)日：2006-04-04
申请号：US10612483
申请日：2003-07-01
申请人： Pierre D. Mourad , Michel Kliot , Rex Patterson , Alec Rooke
发明人： Pierre D. Mourad , Michel Kliot , Rex Patterson , Alec Rooke
IPC分类号： A61B8/14
CPC分类号： A61B8/065 , A61B5/0048 , A61B5/031 , A61B5/4519 , A61B5/4824 , A61B5/4869 , A61B6/503 , A61B6/504 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0808 , A61B8/0883 , A61B8/0891 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/485 , A61B8/488
摘要： Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
摘要翻译：公开了使用超声技术非心脏评估心脏组织特性和心脏参数的系统和方法。心肌组织刚度，张力，应变，应变速率等的测定可用于评估心肌收缩力，心肌缺血和梗死，心室充盈和心房压力以及舒张功能。公开了诸如超声波之类的声学技术来采集与内在组织位移有关的数据的非侵入式系统。还公开了其中使用超声技术来声学刺激或触诊靶心脏组织或诱导与心脏组织特性和/或心脏参数相关的心脏组织部位的应答的非侵入性系统。

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