专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120108918A1 Acoustic Palpation Using Non-Invasive Ultrasound Techniques for Identification of Target Sites and Assessment of Chronic Pain Disorders 审中-公开
标题翻译：声波触诊使用非侵入性超声技术鉴定目标位点和评估慢性疼痛疾病
公开(公告)号：US20120108918A1
公开(公告)日：2012-05-03
申请号：US13161214
申请日：2011-06-15
申请人： Jeffrey G. Jarvik , Pierre D. Mourad , Michel Kliot , Robert C.A. Frederickson , Abbi M. McClintic , Trevor C. Dickey , Michael Gofeld
发明人： Jeffrey G. Jarvik , Pierre D. Mourad , Michel Kliot , Robert C.A. Frederickson , Abbi M. McClintic , Trevor C. Dickey , Michael Gofeld
IPC分类号： A61B8/00 , A61B5/08 , A61B5/024 , A61B5/01 , A61B5/145 , A61B5/026 , A61B5/021 , A61B5/03 , A61B5/0476 , A61B5/04 , A61B5/00 , A61B5/0402
CPC分类号： A61B5/4827 , A61B5/4824 , A61B5/4893 , A61B8/00 , A61B8/08 , A61B8/0808 , A61B8/4218 , A61B8/4472 , A61B8/4494 , A61B2018/00642 , A61N7/02 , A61N2007/0078
摘要： Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.
摘要翻译：提供了用于鉴定和空间定位具有某些生理特性的组织的空间定位方法和系统，或者响应于强聚焦超声（声学探测或触诊）的应用而产生某些生物反应，例如疼痛的感觉。在一些实施方案中，使用目标声学探测来鉴定慢性疼痛敏化组织区域和慢性疼痛障碍的范围和严重程度。在其他应用中，使用目标声学探测来定位神经和其它致敏组织以引导针和其他递送装置，以及用于输送麻醉剂，止痛剂或治疗组合物。

2. 发明申请

US20090149751A1 SYSTEMS AND METHODS FOR DETERMINING INTRACRANIAL PRESSURE NON-INVASIVELY AND ACOUSTIC TRANSDUCER ASSEMBLIES FOR USE IN SUCH SYSTEMS 审中-公开
标题翻译：用于确定在这些系统中使用的非侵入性和声学传感器组件的系统和方法
公开(公告)号：US20090149751A1
公开(公告)日：2009-06-11
申请号：US12325977
申请日：2008-12-01
申请人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C.A. Frederickson , R. Lee Thompson , Jason L. Seawall
发明人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C.A. Frederickson , R. Lee Thompson , Jason L. Seawall
IPC分类号： A61B8/00
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/7267 , A61B8/00 , A61B8/04 , A61B8/065 , A61B8/08 , A61B8/0808 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/488
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided. Systems for acquiring acoustic data from a desired target site in a subject's body using various types of acoustic source and detector elements are also provided, including single use acoustic source/detector combinations are also provided. Acoustic arrays for use with these systems may include multiple capacitive micro-machined ultrasound transducer (cMUT) elements, and may include a combination of different types of acoustic arrays. Methods of targeting localized sites within a broad target area based on acoustic data having various properties are also disclosed.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法。还提供了使用各种类型的声源和检测器元件从受试者身体中期望的目标部位获取声学数据的系统，包括单用声源/检测器组合。用于这些系统的声学阵列可以包括多个电容微加工超声换能器（cMUT）元件，并且可以包括不同类型的声阵列的组合。还公开了基于具有各种性质的声学数据来定位广泛目标区域内的局部位置的方法。

3. 发明授权

US06875176B2 Systems and methods for making noninvasive physiological assessments 有权
标题翻译：进行无创生理评估的系统和方法
公开(公告)号：US06875176B2
公开(公告)日：2005-04-05
申请号：US09995897
申请日：2001-11-28
申请人： Pierre D. Mourad , Michel Kliot , Ali Mesiwala , Rex Patterson , Jeffrey G. Jarvik
发明人： Pierre D. Mourad , Michel Kliot , Ali Mesiwala , Rex Patterson , Jeffrey G. Jarvik
IPC分类号： A61B8/08 , A61B5/03 , A61B8/00 , A61B8/04 , A61B8/12
CPC分类号： A61B5/415 , A61B5/0048 , A61B5/031 , A61B5/4058 , A61B5/4064 , A61B5/418 , A61B5/4824 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0816 , A61B8/485 , A61B8/488
摘要： Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and/or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.
摘要翻译：提供了通过获取与内在和/或诱导的组织置换或相关生物反应的至少一个方面相关的数据来无组织地评估组织特性的系统和方法。可以通过使用超声询问脉冲检测组织的声学特性，优选地以散射或多普勒检测模式来获取与组织位移和相关联的生物变化有关的数据。基于该数据，对组织性质进行评估，表征和监测。本发明的系统和方法的具体应用包括颅内压（ICP），动脉血压（ABP），CNS自动调节状态，血管痉挛，中风，局部水肿，感染和血管炎的非侵入性评估和监测以及诊断并监测组织特性物理变化特征的疾病和病症。还提供了通过使用聚焦超声的应用来靶向和选择性探测组织来定位生理状况和/或生物反应（例如疼痛）的方法和系统。

4. 发明授权

US07022077B2 Systems and methods for making noninvasive assessments of cardiac tissue and parameters 失效
标题翻译：用于进行心脏组织和参数的无创评估的系统和方法
公开(公告)号：US07022077B2
公开(公告)日：2006-04-04
申请号：US10612483
申请日：2003-07-01
申请人： Pierre D. Mourad , Michel Kliot , Rex Patterson , Alec Rooke
发明人： Pierre D. Mourad , Michel Kliot , Rex Patterson , Alec Rooke
IPC分类号： A61B8/14
CPC分类号： A61B8/065 , A61B5/0048 , A61B5/031 , A61B5/4519 , A61B5/4824 , A61B5/4869 , A61B6/503 , A61B6/504 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0808 , A61B8/0883 , A61B8/0891 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/485 , A61B8/488
摘要： Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
摘要翻译：公开了使用超声技术非心脏评估心脏组织特性和心脏参数的系统和方法。心肌组织刚度，张力，应变，应变速率等的测定可用于评估心肌收缩力，心肌缺血和梗死，心室充盈和心房压力以及舒张功能。公开了诸如超声波之类的声学技术来采集与内在组织位移有关的数据的非侵入式系统。还公开了其中使用超声技术来声学刺激或触诊靶心脏组织或诱导与心脏组织特性和/或心脏参数相关的心脏组织部位的应答的非侵入性系统。

5. 发明授权

US07815574B2 Systems and methods for determining blood pressure 有权
标题翻译：用于确定血压的系统和方法
公开(公告)号：US07815574B2
公开(公告)日：2010-10-19
申请号：US11395437
申请日：2006-03-31
申请人： Pierre D. Mourad , Michel Kliot , Rex Patterson , Alec Rooke
发明人： Pierre D. Mourad , Michel Kliot , Rex Patterson , Alec Rooke
IPC分类号： A61B8/00
CPC分类号： A61B8/065 , A61B5/0048 , A61B5/031 , A61B5/4519 , A61B5/4824 , A61B5/4869 , A61B6/503 , A61B6/504 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0808 , A61B8/0883 , A61B8/0891 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/485 , A61B8/488
摘要： Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
摘要翻译：公开了使用超声技术非心脏评估心脏组织特性和心脏参数的系统和方法。心肌组织刚度，张力，应变，应变速率等的测定可用于评估心肌收缩力，心肌缺血和梗死，心室充盈和心房压力以及舒张功能。公开了诸如超声波之类的声学技术来采集与内在组织位移有关的数据的非侵入式系统。还公开了其中使用超声技术来声学刺激或触诊靶心脏组织或诱导与心脏组织特性和/或心脏参数相关的心脏组织部位的应答的非侵入性系统。

6. 发明授权

US07547283B2 Methods for determining intracranial pressure non-invasively 有权
标题翻译：非侵入性确定颅内压的方法
公开(公告)号：US07547283B2
公开(公告)日：2009-06-16
申请号：US10861197
申请日：2004-06-03
申请人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C. A. Frederickson
发明人： Pierre D. Mourad , Brandt Mohr , Michel Kliot , Robert C. A. Frederickson
IPC分类号： A61B8/14
CPC分类号： A61B5/031 , A61B5/0051 , A61B5/4064 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/7267 , A61B8/00 , A61B8/04 , A61B8/065 , A61B8/08 , A61B8/0808 , A61B8/4236 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/488
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法，其中使用非线性关系来基于一个或多个可变输入来确定ICP。第一可变输入涉及颅血管和/或血流的一种或多种性质，例如来自具有在颅血管上训练的焦点的声学换能器的声学后向散射，颅血管中的流速等。另外的变量，例如动脉血压（ABP）可以与与颅血管的一种或多种性质（例如大脑中动脉（MCA）的流速）相关的第一可变输入组合使用，以便使用非线性关系。基于它们的声学特性和对于区域的声学扫描来定位目标区域的方法和系统也基于声学特性识别目标区域，以及声源和/或检测器在期望的目标区域上的自动聚焦也是提供。描述了声学换能器组件。

7. 发明申请

US20080199957A1 ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS 有权
标题翻译：使用薄膜破坏剂加强运输
公开(公告)号：US20080199957A1
公开(公告)日：2008-08-21
申请号：US12105983
申请日：2008-04-18
申请人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , Niren Murthy , Chantal Lackey Reed , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter , David Tirrell
发明人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , Niren Murthy , Chantal Lackey Reed , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter , David Tirrell
IPC分类号： C12N5/06
CPC分类号： A61K47/481 , A61K41/0028 , A61K41/0047 , A61K47/48376 , A61K47/6801
摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents.
摘要翻译：描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。待递送的药剂可以是治疗和/或诊断剂。增强交付如超声波，离子电渗疗法和/或电泳的治疗也可与破坏剂一起使用。

8. 发明授权

US06444217B1 Drug delivery devices, and methods of use 有权
标题翻译：药物输送装置和使用方法
公开(公告)号：US06444217B1
公开(公告)日：2002-09-03
申请号：US09844659
申请日：2001-04-25
申请人： Connie Sau-Kuen Kwok , Buddy D. Ratner , Pierre D. Mourad , Lawrence A. Crum
发明人： Connie Sau-Kuen Kwok , Buddy D. Ratner , Pierre D. Mourad , Lawrence A. Crum
IPC分类号： A61F202
CPC分类号： A61K9/0024 , A61K9/0009 , A61L31/16 , A61L2300/602
摘要： The present invention provides biomedical devices, such as implantable drug delivery devices that possess a surface layer adapted to retain, and controllably release, drug molecules for administration to a subject. The present invention also provides methods of delivering a drug to a subject, the methods utilizing biomedical devices of the invention.
摘要翻译：本发明提供生物医学装置，例如可植入药物递送装置，其具有适于保持和可控地释放用于给予受试者的药物分子的表面层。本发明还提供了将药物递送到受试者的方法，所述方法利用了本发明的生物医学装置。

9. 发明申请

US20100279248A1 DEVICE AND METHOD FOR PREDICTING THE LIKELIHOOD OF CARIES DEVELOPMENT 审中-公开
标题翻译：用于预测发展契约的装置和方法
公开(公告)号：US20100279248A1
公开(公告)日：2010-11-04
申请号：US12718879
申请日：2010-03-05
申请人： Pierre D. Mourad , Joel Berg , Paul Ray Illian
发明人： Pierre D. Mourad , Joel Berg , Paul Ray Illian
IPC分类号： A61B6/14 , G06N5/02
CPC分类号： A61B6/145 , A61B5/0534 , A61B5/7275 , A61C19/04 , G16H50/30
摘要： A hand-held intra-oral dental device and method are described for the detection of pre-caries lesions and the prediction of evolution and prognosis of same. The present invention has as its foundation a low-cost tool for predicting the likelihood of the development of Early Childhood Caries (ECC), in contrast to other techniques and associated devices, where their focus is to identify individual pre-caries lesions. This method focuses on the detection of caries precursors or of their patterns and the relationship of those precursors and patterns to the likelihood of subsequent dental disease. The implications for the establishment for early preventive treatment are profound, namely the earliest implementation of preventative therapy for our approach relative to that of the other approaches.
摘要翻译：描述了一种手持口腔内牙科装置和方法，用于检测龋前病变及其进展和预后的预测。与其他技术和相关设备相比，本发明作为其基础是用于预测幼儿龋齿（ECC）发展的可能性的低成本工具，其中他们的重点是识别龋前病变。该方法着重于检测龋齿前体或其模式，以及这些前体和模式与随后牙齿疾病的可能性的关系。对早期预防治疗的建立的影响是深刻的，即我们的方法相对于其他方法最早实施预防性治疗。

10. 发明授权

US06835393B2 Enhanced transport using membrane disruptive agents 有权
标题翻译：增强运输使用膜破坏剂
公开(公告)号：US06835393B2
公开(公告)日：2004-12-28
申请号：US09226044
申请日：1999-01-05
申请人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , David Tirrell , Niren Murthy , Chantal Lackey , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter
发明人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , David Tirrell , Niren Murthy , Chantal Lackey , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter
IPC分类号： A61K9127
CPC分类号： A61K47/481 , A61K41/0028 , A61K41/0047 , A61K47/48376 , A61K47/6801
摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.
摘要翻译：描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。待递送的药剂可以是治疗和/或诊断剂。增强递送的治疗如超声波，离子分离和/或电泳也可与破坏剂一起使用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式