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1. 发明申请

US20120108918A1 Acoustic Palpation Using Non-Invasive Ultrasound Techniques for Identification of Target Sites and Assessment of Chronic Pain Disorders 审中-公开
标题翻译：声波触诊使用非侵入性超声技术鉴定目标位点和评估慢性疼痛疾病
公开(公告)号：US20120108918A1
公开(公告)日：2012-05-03
申请号：US13161214
申请日：2011-06-15
申请人： Jeffrey G. Jarvik , Pierre D. Mourad , Michel Kliot , Robert C.A. Frederickson , Abbi M. McClintic , Trevor C. Dickey , Michael Gofeld
发明人： Jeffrey G. Jarvik , Pierre D. Mourad , Michel Kliot , Robert C.A. Frederickson , Abbi M. McClintic , Trevor C. Dickey , Michael Gofeld
IPC分类号： A61B8/00 , A61B5/08 , A61B5/024 , A61B5/01 , A61B5/145 , A61B5/026 , A61B5/021 , A61B5/03 , A61B5/0476 , A61B5/04 , A61B5/00 , A61B5/0402
CPC分类号： A61B5/4827 , A61B5/4824 , A61B5/4893 , A61B8/00 , A61B8/08 , A61B8/0808 , A61B8/4218 , A61B8/4472 , A61B8/4494 , A61B2018/00642 , A61N7/02 , A61N2007/0078
摘要： Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.
摘要翻译：提供了用于鉴定和空间定位具有某些生理特性的组织的空间定位方法和系统，或者响应于强聚焦超声（声学探测或触诊）的应用而产生某些生物反应，例如疼痛的感觉。在一些实施方案中，使用目标声学探测来鉴定慢性疼痛敏化组织区域和慢性疼痛障碍的范围和严重程度。在其他应用中，使用目标声学探测来定位神经和其它致敏组织以引导针和其他递送装置，以及用于输送麻醉剂，止痛剂或治疗组合物。

2. 发明申请

US20100087728A1 ACOUSTIC PALPATION USING NON-INVASIVE ULTRASOUND TECHNIQUES TO IDENTIFY AND LOCALIZE TISSUE ELICITING BIOLOGICAL RESPONSES 审中-公开
标题翻译：使用非侵入式超声技术识别和定位组织适应生物反应的声学性PALPATION
公开(公告)号：US20100087728A1
公开(公告)日：2010-04-08
申请号：US12563033
申请日：2009-09-18
申请人： Jeffrey G. JARVIK , Pierre D. MOURAD , Michel KLIOT , Robert C. A. FREDERICKSON
发明人： Jeffrey G. JARVIK , Pierre D. MOURAD , Michel KLIOT , Robert C. A. FREDERICKSON
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61B8/08 , A61B5/0048 , A61B5/031 , A61B5/4824 , A61B8/04 , A61B8/0808 , A61B8/4472 , A61B8/485 , A61B8/488 , A61B18/14 , A61N7/02 , A61N2007/0073 , A61N2007/0078
摘要： Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.
摘要翻译：提供了用于鉴定和空间定位具有某些生理特性的组织的空间定位方法和系统，或者响应于强聚焦超声（声学探测或触诊）的应用而产生某些生物反应，例如疼痛的感觉。在一些实施例中，使用诸如超声成像或其他类型的非侵入性成像技术的成像技术可以引导或可视化目标声学探测。

3. 发明申请

US20100081893A1 ACOUSTIC PALPATION USING NON-INVASIVE ULTRASOUND TECHNIQUES TO IDENTIFY AND LOCALIZE TISSUE ELICITING BIOLOGICAL RESPONSES AND TARGET TREATMENTS 审中-公开
标题翻译：使用非侵入式超声技术鉴定和定位组织生物反应和目标治疗的声学性宫廷
公开(公告)号：US20100081893A1
公开(公告)日：2010-04-01
申请号：US12563060
申请日：2009-09-18
申请人： Jeffrey G. JARVIK , Pierre D. MOURAD , Michel KLIOT , Robert C. A. FREDERICKSON
发明人： Jeffrey G. JARVIK , Pierre D. MOURAD , Michel KLIOT , Robert C. A. FREDERICKSON
IPC分类号： A61B5/00 , A61N7/00 , A61B8/14
CPC分类号： A61B8/08 , A61B5/0053 , A61B5/4824 , A61B8/0808 , A61B8/4218 , A61B8/4472 , A61B2018/00642 , A61N7/02 , A61N2007/0078
摘要： Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.
摘要翻译：提供了用于鉴定和空间定位具有某些生理特性的组织的空间定位方法和系统，或者响应于强聚焦超声（声学探测或触诊）的应用而产生某些生物反应，例如疼痛的感觉。在一些实施例中，使用诸如超声成像或其他类型的非侵入性成像技术的成像技术可以引导或可视化目标声学探测。

4. 发明授权

US06875176B2 Systems and methods for making noninvasive physiological assessments 有权
标题翻译：进行无创生理评估的系统和方法
公开(公告)号：US06875176B2
公开(公告)日：2005-04-05
申请号：US09995897
申请日：2001-11-28
申请人： Pierre D. Mourad , Michel Kliot , Ali Mesiwala , Rex Patterson , Jeffrey G. Jarvik
发明人： Pierre D. Mourad , Michel Kliot , Ali Mesiwala , Rex Patterson , Jeffrey G. Jarvik
IPC分类号： A61B8/08 , A61B5/03 , A61B8/00 , A61B8/04 , A61B8/12
CPC分类号： A61B5/415 , A61B5/0048 , A61B5/031 , A61B5/4058 , A61B5/4064 , A61B5/418 , A61B5/4824 , A61B8/00 , A61B8/04 , A61B8/08 , A61B8/0816 , A61B8/485 , A61B8/488
摘要： Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and/or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.
摘要翻译：提供了通过获取与内在和/或诱导的组织置换或相关生物反应的至少一个方面相关的数据来无组织地评估组织特性的系统和方法。可以通过使用超声询问脉冲检测组织的声学特性，优选地以散射或多普勒检测模式来获取与组织位移和相关联的生物变化有关的数据。基于该数据，对组织性质进行评估，表征和监测。本发明的系统和方法的具体应用包括颅内压（ICP），动脉血压（ABP），CNS自动调节状态，血管痉挛，中风，局部水肿，感染和血管炎的非侵入性评估和监测以及诊断并监测组织特性物理变化特征的疾病和病症。还提供了通过使用聚焦超声的应用来靶向和选择性探测组织来定位生理状况和/或生物反应（例如疼痛）的方法和系统。

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