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1. 发明授权

US06406421B1 System and method of determining skeletal muscle contraction by serial lead impedance measurements 有权
标题翻译：通过串联引线阻抗测量来确定骨骼肌收缩的系统和方法
公开(公告)号：US06406421B1
公开(公告)日：2002-06-18
申请号：US09149021
申请日：1998-09-08
申请人： Pierre Andre Grandjean , David E. Francischelli , Kendra K. Gealow , Robert Leinders , Martinus A. G. M. Bakx , Koen J. Weijand
发明人： Pierre Andre Grandjean , David E. Francischelli , Kendra K. Gealow , Robert Leinders , Martinus A. G. M. Bakx , Koen J. Weijand
IPC分类号： A61M112
CPC分类号： A61N1/36042 , A61B5/053 , A61B5/1107 , A61B5/4519 , A61B5/6869 , A61M1/1003 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303
摘要： There is provided a system and method for continually monitoring the occurrence of contraction during stimulation of skeletal muscle which is employed in a cardiac assist-type system. During delivery of a periodic burst, or train of stimulus pulses, the impedance of the muscle between the electrodes through which the pulses are delivered is monitored, and evaluated to determine whether or not stimulation has been achieved. In a particular embodiment, the impedance and impedance derivative values are accumulated throughout the burst, and assessed to determine whether the impedance change corresponded to a full muscle contraction. In the event of failure to stimulate the muscle to contraction, the system can automatically adjust the pulse output parameters to achieve reliable contraction.
摘要翻译：提供了用于在心脏辅助型系统中使用的骨骼肌刺激期间持续监测收缩发生的系统和方法。在递送周期性突发或刺激脉冲序列期间，监测通过其传送脉冲的电极之间的肌肉的阻抗，并进行评估以确定是否已经实现刺激。在特定实施例中，阻抗和阻抗导数值在整个突发期间被累积，并被评估以确定阻抗变化是否对应于完全肌肉收缩。在无法刺激肌肉收缩的情况下，系统可以自动调节脉搏输出参数，达到可靠的收缩。

2. 发明授权

US5843135A Pacing system with lead having a single conductor for connecting to pressure sensor and electrode 失效
标题翻译：具有导体的起搏系统具有单个导体，用于连接到压力传感器和电极
公开(公告)号：US5843135A
公开(公告)日：1998-12-01
申请号：US954043
申请日：1997-10-20
申请人： Koen J. Weijand , Robert Leinders
发明人： Koen J. Weijand , Robert Leinders
IPC分类号： A61N1/05 , A61N1/365 , A61N1/362
CPC分类号： A61N1/365 , A61N1/056 , A61N1/36514
摘要： A pacing system is provided having a lead with a pressure transducer or other sensor, the lead being characterized by having only a single conductor connecting the pacemaker with the signals from the sensor and the signals to and from the lead tip electrode. A connecting circuit mounted in the lead near the distal end is powered by a low level alternating constant current square wave to provide multiplexed signals on the conductor. The lead connecting circuit comprises a switching device connected to a sensor, such as a piezoelectric pressure transducer, so that for positive current pulses delivered to the lead, the transducer output is added in series with any cardiac signal sensed by the tip electrode; while for negative currents the pressure transducer is isolated and only the tip electrode signal information is connected back to the pacemaker. The pacemaker contains processing circuitry for decoding the respective cardiac signals and pressure signals from the multiplexed signals.
摘要翻译：提供具有带有压力传感器或其他传感器的引线的起搏系统，该引线的特征在于仅具有将起搏器与来自传感器的信号和来自引线末端电极的信号连接起来的单个导体。安装在远端附近的引线中的连接电路由低电平交流恒流方波供电，以在导体上提供复用信号。引线连接电路包括连接到诸如压电压力传感器的传感器的开关装置，使得对于传递到引线的正电流脉冲，换能器输出与由尖端电极感测的任何心脏信号相加; 而对于负电流，压力传感器是隔离的，只有尖端电极信号信息被连接回起搏器。起搏器包含用于从复用的信号解码各个心脏信号和压力信号的处理电路。

3. 发明授权

US06305381B1 System for locating implantable medical device 有权
标题翻译：植入式医疗器械定位系统
公开(公告)号：US06305381B1
公开(公告)日：2001-10-23
申请号：US09239306
申请日：1999-01-29
申请人： Koen J. Weijand , Markus Haller , Marty Bakx , Robert Leinders , Todd Goblish , Jon Werder
发明人： Koen J. Weijand , Markus Haller , Marty Bakx , Robert Leinders , Todd Goblish , Jon Werder
IPC分类号： A61B1900
CPC分类号： A61M5/14276 , A61B5/06 , A61B34/20 , A61B2034/2051 , A61M5/427 , A61M2205/3523 , A61M2209/045
摘要： A system and method for locating an implantable medical device. The system consists of a flat “pancake” antenna coil positioned concentric with the implantable medical device target, e.g. the drug reservoir septum. The system further features a three location antenna array which is separate from the implantable device and external to the patient. The antenna array features three or more separate antennas which are used to sense the energy emitted from the implanted antenna coil. The system further features a processor to process the energy ducted by the antenna array. The system senses the proximity to the implant coil and, thus, the implant device by determining when an equal amount of energy is present in each of the antennas of the antenna array and if each such ducted energy is greater than a predetermined minimum. When such a condition is met, the antenna array is aligned with the implant coil. Thus the needle port through the antenna array is lined up with the septum of the drug reservoir. Alternative embodiments are further disclosed in which the processor and antenna array are positioned within the implanted device while the coil is external to the patient.
摘要翻译：一种用于定位可植入医疗装置的系统和方法。该系统包括与可植入医疗装置目标同心定位的扁平“煎饼”天线线圈。药物间隔。该系统还具有与可植入装置分离并且在患者外部的三位置天线阵列。天线阵列具有三个或更多个单独的天线，其用于感测从植入的天线线圈发射的能量。该系统进一步具有处理器以处理由天线阵列导管的能量。系统通过确定何时在天线阵列的每个天线中存在相等量的能量以及每个这样的管道能量是否大于预定的最小值来感测到植入物线圈的接近度，并因此感测植入装置。当满足这样的条件时，天线阵列与植入线圈对准。因此，通过天线阵列的针端口与药物储存器的隔膜排成一列。还公开了替代实施例，其中处理器和天线阵列定位在植入装置内，而线圈在患者外部。

4. 发明授权

US5948004A Implantable stimulator having an efficient output generator 失效
标题翻译：具有高效输出发生器的可植入刺激器
公开(公告)号：US5948004A
公开(公告)日：1999-09-07
申请号：US915677
申请日：1997-08-21
申请人： Koen J. Weijand , Robert Leinders
发明人： Koen J. Weijand , Robert Leinders
IPC分类号： A61N1/378 , A61N1/37 , H02M3/07 , A61N1/362
CPC分类号： A61N1/3706 , H02M3/07
摘要： An output pulse generator is provided which is particularly suitable for implantable medical simulators, such as cardiac pacemakers, where there is a high premium on efficient energy transfer from the battery source to the output load. A plurality of relatively small size output capacitor are utilized in combination with a switching circuit for alternately charging respective capacitors and then discharging them through the load in such a manner that there is always one capacitor providing a substantially constant output voltage while at least one other capacitors is being recharged. Different combinations of switching networks are used to provide programmable output voltage levels. The use of relatively small capacitors, e.g., in the range of 0.1-0.5 F, along with a relatively high drive frequency, e.g., 32 kHz, enables substantially continuous transfer of energy from the battery to the capacitors only during the time of pulse output, and high efficiency generation of a stimulus pulse with a substantially constant voltage level throughout the pulse duration. Variation of the drive frequency is done in order to adjust the generated pulses to the output load.
摘要翻译：提供了一种输出脉冲发生器，其特别适用于诸如心脏起搏器之类的可植入医疗模拟器，其中从电池源到输出负载的有效能量转移是非常重要的。多个相对小尺寸的输出电容器与开关电路组合使用，用于交替地对各个电容器进行充电，然后通过负载将其放电，使得总是有一个电容器提供基本上恒定的输出电压，而至少一个其他电容器正在补充。交换网络的不同组合用于提供可编程输出电压电平。使用相对较小的电容器，例如在0.1-0.5F的范围内以及相对较高的驱动频率（例如32kHz），仅在脉冲输出期间能够将电能从电池基本上连续地传输到电容器并且在整个脉冲持续时间内具有基本恒定的电压电平的刺激脉冲的高效率产生。完成驱动频率的变化，以便将产生的脉冲调整到输出负载。

5. 发明授权

US6125300A Implantable device with output circuitry for simultaneous stimulation at multiple sites 有权
标题翻译：具有输出电路的植入式设备，用于在多个位置同步刺激
公开(公告)号：US6125300A
公开(公告)日：2000-09-26
申请号：US152072
申请日：1998-09-11
申请人： Koen J. Weijand , Robert Leinders
发明人： Koen J. Weijand , Robert Leinders
IPC分类号： A61N1/36 , A61N1/368 , A61N1/00
CPC分类号： A61N1/3605 , A61N1/368 , A61N1/378
摘要： There is provided an implantable device with two or more output stages for delivering concurrent output pulses to two or more sites within a patient's body. Each output circuit has a common architecture, including a switchable generator which has a plurality of storage capacitors and switches for arranging the capacitors either to be charged by the battery, or to discharge a stimulus pulse. A programmable regulator is provided for further regulation of the output voltage; and a multiplexer connects the output to the desired electrodes placed at the patient site. For concurrent dual pulse-dual site stimulation, a pair of active rectifier switches are connected between the negative terminal of each output stage and the battery positive terminal, whereby at the time of concurrent pulse delivery, the output stage having the greatest negative voltage relative to battery plus has its negative terminal connected to the battery plus terminal, while the other output stage is disconnected from the battery so that it floats. This arrangement reduces crosstalk current while ensuring continued positive biasing of the semi-conductor switches in each output stage.
摘要翻译：提供了一种具有两个或多个输出级的可植入装置，用于将同时的输出脉冲输送到患者体内的两个或多个位置。每个输出电路具有共同的架构，包括具有多个存储电容器的开关发生器和用于布置要由电池充电的电容器的开关或放电刺激脉冲。提供可编程调节器，用于进一步调节输出电压; 并且多路复用器将输出连接到放置在患者现场的期望电极。对于并发双脉冲双站点刺激，一对有源整流开关连接在每个输出级的负极端子和电池正极端子之间，由此在并发脉冲输送时，输出级相对于电池加上其负极端子连接到电池加端子，而另一个输出级与电池断开，使其浮动。这样可以降低串扰电流，同时确保在每个输出级中半导体开关的持续正偏置。

6. 发明授权

US5836983A Output stage with switchable constant current modes 失效
标题翻译：输出级可切换恒流模式
公开(公告)号：US5836983A
公开(公告)日：1998-11-17
申请号：US879214
申请日：1997-06-19
申请人： Koen J. Weijand , Robert Leinders
发明人： Koen J. Weijand , Robert Leinders
IPC分类号： A61N1/362 , A61N1/37 , H03K5/02
CPC分类号： A61N1/3706 , H03K5/02 , H03K5/023
摘要： An output circuit is provided for delivering output pulses in either a constant voltage or constant current mode. The output circuit has a simple architecture built around a pair of area-ratioed transistors which operate in a linear range carrying a ratio of currents corresponding to the area ratio. The circuit is mode controlled by a switch network which connects to a constant current source, which constant current source controls the pulse amplitude, either current or voltage. As used in a pacemaker embodiment, the circuit is controllable to control the mode and/or amplitude of the pulse following a cyclical decision to deliver a pulse, and with an amplitude derived from pacemaker data and controllable during delivery of the pulse. The circuit has high speed control which enables amplitude modulation of the pulse, for transmitting encoded data to an external device adapted to receive the data.
摘要翻译：提供输出电路用于以恒定电压或恒定电流模式传送输出脉冲。输出电路具有围绕一对面积比的晶体管构建的简单架构，其在线性范围内工作，该线性范围具有对应于面积比的电流比。电路由连接恒流源的开关网络进行模式控制，恒流源控制脉冲幅度，电流或电压。如在起搏器实施例中所使用的，电路是可控制的，以在循环决定传递脉冲之后，并且具有从起搏器数据导出的振幅并且在脉冲传递期间可控制的脉冲的模式和/或幅度。该电路具有高速度控制，其使能脉冲的幅度调制，用于将编码的数据发送到适于接收数据的外部设备。

7. 发明授权

US08326426B2 Implantable device with heat storage 有权
标题翻译：具有蓄热的植入式装置
公开(公告)号：US08326426B2
公开(公告)日：2012-12-04
申请号：US12417791
申请日：2009-04-03
申请人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
发明人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
IPC分类号： A61N1/375
CPC分类号： A61N1/3787 , A61N1/37229 , A61N1/375
摘要： Example embodiments of an implantable device are configured to be implanted within a patient to provide medical therapy to the patient. In general, an implantable rechargeable device includes a rechargeable battery and an electronic board assembly arranged within a case and an antenna electrically coupled to the rechargeable battery. The antenna is configured to receive power and to transfer at least a portion of the received power to the rechargeable battery for recharging. A phase change material is arranged within the case around at least a portion of the electronic board assembly. The phase change material is configured to transition from a first phase to a second phase at a transition temperature when the insulating material absorbs heat (e.g., from the electronic board assembly).
摘要翻译：可植入装置的示例性实施例被配置为植入患者体内以向患者提供药物治疗。通常，植入式可再充电装置包括可再充电电池和布置在壳体内的电子板组件和电耦合到可再充电电池的天线。天线被配置为接收电力并将接收的功率的至少一部分传送到可再充电电池用于再充电。相变材料围绕电子板组件的至少一部分布置在壳体内。相变材料配置成当绝缘材料吸收热量（例如，从电子板组件）时，在转变温度下从第一相转变到第二相。

8. 发明申请

US20100256708A1 IMPLANTABLE DEVICE WITH HEAT STORAGE 有权
标题翻译：具有热存储的可植入设备
公开(公告)号：US20100256708A1
公开(公告)日：2010-10-07
申请号：US12417791
申请日：2009-04-03
申请人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
发明人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
IPC分类号： A61N1/08
CPC分类号： A61N1/3787 , A61N1/37229 , A61N1/375
摘要： Example embodiments of an implantable device are configured to be implanted within a patient to provide medical therapy to the patient. In general, an implantable rechargeable device includes a rechargeable battery and an electronic board assembly arranged within a case and an antenna electrically coupled to the rechargeable battery. The antenna is configured to receive power and to transfer at least a portion of the received power to the rechargeable battery for recharging. A phase change material is arranged within the case around at least a portion of the electronic board assembly. The phase change material is configured to transition from a first phase to a second phase at a transition temperature when the insulating material absorbs heat (e.g., from the electronic board assembly).
摘要翻译：可植入装置的示例性实施例被配置为植入患者体内以向患者提供药物治疗。通常，植入式可再充电装置包括可再充电电池和布置在壳体内的电子板组件和电耦合到可再充电电池的天线。天线被配置为接收电力并将接收的功率的至少一部分传送到可再充电电池用于再充电。相变材料围绕电子板组件的至少一部分布置在壳体内。相变材料配置成当绝缘材料吸收热量（例如，从电子板组件）时，在转变温度下从第一相转变到第二相。

9. 发明授权

US06484054B2 Deep trench semiconductor capacitors having reverse bias diodes for implantable medical devices 有权
标题翻译：具有用于可植入医疗器件的反向偏置二极管的深沟槽半导体电容器
公开(公告)号：US06484054B2
公开(公告)日：2002-11-19
申请号：US09879282
申请日：2001-06-12
申请人： Koen J. Weijand , Richard Houben
发明人： Koen J. Weijand , Richard Houben
IPC分类号： A61N100
CPC分类号： H01L29/66181 , A61N1/05 , H01L27/0805 , H01L29/945
摘要： Floating and non-floating on-chip capacitors are formed by vertical walls and/or large aspect ratio deep trenches disposed in semiconductor material. By optimizing the through spacing and substrate voltage, a very small parasitic to intended capacitance ratio may be obtained. Capacitors so formed may be used as on-chip charge storage and other types of on-chip capacitors, and eliminate or reduce the number of off-chip capacitors that would otherwise be required. The deep trench capacitors find particularly efficacious application in implantable medical devices where volume, cost and electrical energy consumption must be minimized, and preferably have capacitances which range between about 10 nF and about 1000 uF.
摘要翻译：浮置和非浮动片上电容器由设置在半导体材料中的垂直壁和/或大纵横比深沟槽形成。通过优化通过间隔和衬底电压，可以获得非常小的寄生到预期电容比。如此形成的电容器可以用作片上电荷存储和其他类型的片上电容器，并且消除或减少否则将要求的片外电容器的数量。深沟槽电容器在体积，成本和电能消耗必须最小化的可植入医疗设备中特别有效，并且优选地具有介于约10nF至约1000uF之间的电容。

10. 发明授权

US5999857A Implantable device telemetry system and method 失效
标题翻译：植入式遥测系统及方法
公开(公告)号：US5999857A
公开(公告)日：1999-12-07
申请号：US768605
申请日：1996-12-18
申请人： Koen J. Weijand , Richard P. M. Houben , Jeff Wilkinson
发明人： Koen J. Weijand , Richard P. M. Houben , Jeff Wilkinson
IPC分类号： A61N1/372 , A61N1/37
CPC分类号： A61N1/3727 , Y10S128/903
摘要： There is provided an improved telemetry system for use with implantable devices such as cardiac pacemakers and the like, for two-way telemetry between the implanted device and an external programmer. The system employs highly energy efficient oscillators with encoding circuits for synchronous transmission of data symbols, which symbols form the telemetry carrier. The system provides improved circuits for higher density data encoding of sinusoidal symbols, including improved combinations of BPSK, FSK, and ASK encoding. Embodiments of transmitters for both the implanted device and the external programmer, as well as modulator and demodulator circuits, are also disclosed, and specifically include oscillators which switch capacitors between a tank circuit and a recharge path, the switching being controlled to occur at moments of substantially zero coil current, thereby providing high efficiency operation.
摘要翻译：提供了一种改进的遥测系统，用于诸如心脏起搏器等的可植入装置，用于植入装置和外部编程器之间的双向遥测。该系统采用具有编码电路的高能效振荡器，用于数据符号的同步传输，该符号形成遥测载体。该系统为正弦曲线符号的更高密度数据编码提供改进的电路，包括改进的BPSK，FSK和ASK编码的组合。还公开了用于植入装置和外部编程器的发射机的实施例，以及调制器和解调器电路，并且具体包括在电容器电路和再充电路径之间切换电容器的振荡器，该开关被控制在基本上为零线圈电流，从而提供高效率的操作。

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