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1. 发明授权

US06329929B1 Telemetry system with phase-locking noise suppressing receiver 有权
标题翻译：具有锁相噪声抑制接收机的遥测系统
公开(公告)号：US06329929B1
公开(公告)日：2001-12-11
申请号：US09217127
申请日：1998-12-21
申请人： Koen J. Weijand , Richard Houben
发明人： Koen J. Weijand , Richard Houben
IPC分类号： G08C1916
CPC分类号： H04L25/062 , A61N1/08 , H04L27/10 , Y10S128/903
摘要： There is provided a telemetry system with a receiver which enables detection of pulsed high frequency data (hf) signals in a manner which suppresses noise which may be present within the high frequency bandwidth. The transmitter carrier, which may be subject to some instability, is encoded at a symbol rate which is generated at a lower frequency than the hf, but which is reliably stable. The receiver detects the phase of each received hf pulse, and generates a phase-locked signal which is synchronized to the transmitter symbol signal. The phase-locked signal in turn is used to demodulate the received pulsed signals. In a specific DSP embodiment, the phase-lock loop has a numerically controlled oscillator which has a center frequency which corresponds to the aliased phase difference between the hf carrier phase and the phase of each pulse, thereby obtaining a signal which carries information as to the exact symbol rate. This information is used either to calculate the timing of a narrow window which gates a pulse detector coincident with each next expected symbol time, or to trigger generation of a replica signal which is used in the detect circuit, thereby providing high resolution detection of the pulses and good noise rejection.
摘要翻译：提供了一种具有接收器的遥测系统，其能够以抑制可能存在于高频带宽内的噪声的方式检测脉冲高频数据（hf）信号。可能受到一些不稳定性的发射机载波以以比hf低的频率产生的符号速率被编码，但是其可靠地稳定。接收机检测每个接收到的hf脉冲的相位，并产生与发射机符号信号同步的锁相信号。锁相信号依次用于解调所接收的脉冲信号。在特定DSP实施例中，锁相环具有数控振荡器，其具有对应于hf载波相位和每个脉冲的相位之间的混叠相位差的中心频率，从而获得载有关于精确符号率。该信息用于计算与每个下一个预期符号时间一致的脉冲检测器的窄窗口的定时，或者触发在检测电路中使用的复制信号的产生，从而提供脉冲的高分辨率检测和良好的噪音抑制。

2. 发明授权

US06484054B2 Deep trench semiconductor capacitors having reverse bias diodes for implantable medical devices 有权
标题翻译：具有用于可植入医疗器件的反向偏置二极管的深沟槽半导体电容器
公开(公告)号：US06484054B2
公开(公告)日：2002-11-19
申请号：US09879282
申请日：2001-06-12
申请人： Koen J. Weijand , Richard Houben
发明人： Koen J. Weijand , Richard Houben
IPC分类号： A61N100
CPC分类号： H01L29/66181 , A61N1/05 , H01L27/0805 , H01L29/945
摘要： Floating and non-floating on-chip capacitors are formed by vertical walls and/or large aspect ratio deep trenches disposed in semiconductor material. By optimizing the through spacing and substrate voltage, a very small parasitic to intended capacitance ratio may be obtained. Capacitors so formed may be used as on-chip charge storage and other types of on-chip capacitors, and eliminate or reduce the number of off-chip capacitors that would otherwise be required. The deep trench capacitors find particularly efficacious application in implantable medical devices where volume, cost and electrical energy consumption must be minimized, and preferably have capacitances which range between about 10 nF and about 1000 uF.
摘要翻译：浮置和非浮动片上电容器由设置在半导体材料中的垂直壁和/或大纵横比深沟槽形成。通过优化通过间隔和衬底电压，可以获得非常小的寄生到预期电容比。如此形成的电容器可以用作片上电荷存储和其他类型的片上电容器，并且消除或减少否则将要求的片外电容器的数量。深沟槽电容器在体积，成本和电能消耗必须最小化的可植入医疗设备中特别有效，并且优选地具有介于约10nF至约1000uF之间的电容。

3. 发明授权

US06558345B1 System for delivering insulin 有权
标题翻译：输送胰岛素的系统
公开(公告)号：US06558345B1
公开(公告)日：2003-05-06
申请号：US09551216
申请日：2000-04-17
申请人： Richard P. M. Houben , Alexis C. M. Renirie , Koen J. Weijand
发明人： Richard P. M. Houben , Alexis C. M. Renirie , Koen J. Weijand
IPC分类号： A61M3100
CPC分类号： A61B5/14532 , A61B5/425 , A61B5/7207 , A61N1/36007
摘要： There is provided an implantable system and method for monitoring pancreatic beta cell electrical activity in a patient in order to obtain a measure of a patient's insulin demand and blood glucose level. A stimulus generator is controlled to deliver stimulus pulses so as to synchronize pancreatic beta cell depolarization, thereby producing an enhanced electrical signal which is sensed and processed. In a specific embodiment, the signal is processed to determine the start and end of beta cell depolarization, from which the depolarization duration is obtained. In order to reduce cardiac interference, each stimulus pulse is timed to be offset from the QRS signal which can interfere with the pancreas sensing. Additionally, the beta cell signals are processed by a correction circuit, e.g., an adaptive filter, to remove QRS artifacts, as well as artifacts from other sources, such as respiration. The thus obtained insulin demand signal is used either to control delivery of insulin from an implanted insulin pump, or to control ongoing pancreatic stimulation of a form to enhance insulin production.
摘要翻译：提供了一种用于监测患者胰腺β细胞电活动的可植入系统和方法，以便获得患者的胰岛素需求量和血糖水平的量度。控制刺激发生器以递送刺激脉冲，以使胰腺β细胞去极化同步，从而产生被感测和处理的增强的电信号。在具体实施方案中，处理信号以确定β细胞去极化的开始和结束，从中获得去极化持续时间。为了减少心脏干扰，每个刺激脉冲被定时偏离可能干扰胰腺感测的QRS信号。此外，β细胞信号由校正电路（例如，自适应滤波器）处理，以去除QRS伪影，以及来自其他来源（例如呼吸）的伪影。由此获得的胰岛素需求信号用于控制从植入的胰岛素泵输送胰岛素，或用于控制正在进行的胰腺刺激形式以增强胰岛素产生。

4. 发明授权

US06470212B1 Body heat powered implantable medical device 失效
标题翻译：车身动力植入医疗器械
公开(公告)号：US06470212B1
公开(公告)日：2002-10-22
申请号：US09529292
申请日：2000-04-11
申请人： Koen J. Weijand , Patrick J. Combs , Daniel R. Greeninger , Richard P. M. Houben
发明人： Koen J. Weijand , Patrick J. Combs , Daniel R. Greeninger , Richard P. M. Houben
IPC分类号： A61N108
CPC分类号： A61N1/3785 , A61N1/08
摘要： A system for and method of providing power to an implanted medical device within a patient is disclosed. The system (250) includes a first (262) and a second heat conduit (264) positioned within the patient. A thermoelectric device (252) is connected to the first and second heat conduits for thermally converting the temperature difference between the conduits to a voltage. A DC-DC converter (254) is connected to the thermoelectric element and increases the voltage. A storage element (256) is connected to the DC-DC converter-for receiving the increased voltage. The storage element is also connected to the implanted medical device (258), thereby providing power to the implanted medical device.
摘要翻译：公开了一种向患者内的植入医疗装置提供电力的系统和方法。系统（250）包括位于患者体内的第一（262）和第二热导管（264）。热电装置（252）连接到第一和第二导热管，用于将导管之间的温差热转换成电压。 DC-DC转换器（254）连接到热电元件并增加电压。存储元件（256）连接到DC-DC转换器，用于接收增加的电压。存储元件还连接到植入医疗设备（258），从而向植入的医疗设备提供电力。

5. 发明授权

US6128671A Tactile feel device having a plurality of pins that allow a user to read information from the pins and make selection by depressing the pins 失效
标题翻译：触觉感觉装置具有多个引脚，允许用户从引脚读取信息并通过按压引脚进行选择
公开(公告)号：US6128671A
公开(公告)日：2000-10-03
申请号：US80851
申请日：1998-05-18
申请人： Koen J. Weijand
发明人： Koen J. Weijand
IPC分类号： G09B21/00 , G06F13/14
CPC分类号： G09B21/003
摘要： A Braille device includes a plurality of Braille cells that comprise a plurality of pins that are actively positioned to present information to a user via tactile feel. The Braille device also allows the user to depress at one or more of the pins in order to make a selection analogous to point and click of a mouse. To allow the user to move a screen cursor and make selections via the Braille pins, the Braille cell includes pin position sensing circuitry that senses the position of each of the plurality of Braille pins. A system controller (e.g., a CPU) reads the information from the sensing circuitry to determine which pins, if any have been depressed. Advantageously, the Braille pins are used as an output device that allows a user to read information, and also as an input device by allowing the user to depress the Braille pins in order to make a selection. In addition, depositing the electronics onto the piezoelectric bimorph reduces the overall size of the Braille device.
摘要翻译：盲文装置包括多个盲文单元，其包括多个引脚，所述多个引脚被主动地定位成通过触觉来向用户呈现信息。盲文设备还允许用户在一个或多个引脚处按下以进行类似于鼠标的点击的选择。为了允许用户移动屏幕光标并通过盲文引脚进行选择，盲文单元包括检测多个盲文引脚中的每一个的位置的引脚位置检测电路。系统控制器（例如，CPU）从感测电路读取信息以确定哪些引脚（如果有的话）被按下。有利地，盲文引脚用作允许用户读取信息的输出设备，并且还可以通过允许用户按下盲文引脚以进行选择来作为输入设备。此外，将电子元件沉积到压电双压电晶片上减小了盲文装置的总体尺寸。

6. 发明授权

US08326426B2 Implantable device with heat storage 有权
标题翻译：具有蓄热的植入式装置
公开(公告)号：US08326426B2
公开(公告)日：2012-12-04
申请号：US12417791
申请日：2009-04-03
申请人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
发明人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
IPC分类号： A61N1/375
CPC分类号： A61N1/3787 , A61N1/37229 , A61N1/375
摘要： Example embodiments of an implantable device are configured to be implanted within a patient to provide medical therapy to the patient. In general, an implantable rechargeable device includes a rechargeable battery and an electronic board assembly arranged within a case and an antenna electrically coupled to the rechargeable battery. The antenna is configured to receive power and to transfer at least a portion of the received power to the rechargeable battery for recharging. A phase change material is arranged within the case around at least a portion of the electronic board assembly. The phase change material is configured to transition from a first phase to a second phase at a transition temperature when the insulating material absorbs heat (e.g., from the electronic board assembly).
摘要翻译：可植入装置的示例性实施例被配置为植入患者体内以向患者提供药物治疗。通常，植入式可再充电装置包括可再充电电池和布置在壳体内的电子板组件和电耦合到可再充电电池的天线。天线被配置为接收电力并将接收的功率的至少一部分传送到可再充电电池用于再充电。相变材料围绕电子板组件的至少一部分布置在壳体内。相变材料配置成当绝缘材料吸收热量（例如，从电子板组件）时，在转变温度下从第一相转变到第二相。

7. 发明申请

US20100256708A1 IMPLANTABLE DEVICE WITH HEAT STORAGE 有权
标题翻译：具有热存储的可植入设备
公开(公告)号：US20100256708A1
公开(公告)日：2010-10-07
申请号：US12417791
申请日：2009-04-03
申请人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
发明人： Arnold W. Thornton , Adrianus P. Donders , Jason W. Sprain , Koen J. Weijand
IPC分类号： A61N1/08
CPC分类号： A61N1/3787 , A61N1/37229 , A61N1/375
摘要： Example embodiments of an implantable device are configured to be implanted within a patient to provide medical therapy to the patient. In general, an implantable rechargeable device includes a rechargeable battery and an electronic board assembly arranged within a case and an antenna electrically coupled to the rechargeable battery. The antenna is configured to receive power and to transfer at least a portion of the received power to the rechargeable battery for recharging. A phase change material is arranged within the case around at least a portion of the electronic board assembly. The phase change material is configured to transition from a first phase to a second phase at a transition temperature when the insulating material absorbs heat (e.g., from the electronic board assembly).
摘要翻译：可植入装置的示例性实施例被配置为植入患者体内以向患者提供药物治疗。通常，植入式可再充电装置包括可再充电电池和布置在壳体内的电子板组件和电耦合到可再充电电池的天线。天线被配置为接收电力并将接收的功率的至少一部分传送到可再充电电池用于再充电。相变材料围绕电子板组件的至少一部分布置在壳体内。相变材料配置成当绝缘材料吸收热量（例如，从电子板组件）时，在转变温度下从第一相转变到第二相。

8. 发明授权

US5999857A Implantable device telemetry system and method 失效
标题翻译：植入式遥测系统及方法
公开(公告)号：US5999857A
公开(公告)日：1999-12-07
申请号：US768605
申请日：1996-12-18
申请人： Koen J. Weijand , Richard P. M. Houben , Jeff Wilkinson
发明人： Koen J. Weijand , Richard P. M. Houben , Jeff Wilkinson
IPC分类号： A61N1/372 , A61N1/37
CPC分类号： A61N1/3727 , Y10S128/903
摘要： There is provided an improved telemetry system for use with implantable devices such as cardiac pacemakers and the like, for two-way telemetry between the implanted device and an external programmer. The system employs highly energy efficient oscillators with encoding circuits for synchronous transmission of data symbols, which symbols form the telemetry carrier. The system provides improved circuits for higher density data encoding of sinusoidal symbols, including improved combinations of BPSK, FSK, and ASK encoding. Embodiments of transmitters for both the implanted device and the external programmer, as well as modulator and demodulator circuits, are also disclosed, and specifically include oscillators which switch capacitors between a tank circuit and a recharge path, the switching being controlled to occur at moments of substantially zero coil current, thereby providing high efficiency operation.
摘要翻译：提供了一种改进的遥测系统，用于诸如心脏起搏器等的可植入装置，用于植入装置和外部编程器之间的双向遥测。该系统采用具有编码电路的高能效振荡器，用于数据符号的同步传输，该符号形成遥测载体。该系统为正弦曲线符号的更高密度数据编码提供改进的电路，包括改进的BPSK，FSK和ASK编码的组合。还公开了用于植入装置和外部编程器的发射机的实施例，以及调制器和解调器电路，并且具体包括在电容器电路和再充电路径之间切换电容器的振荡器，该开关被控制在基本上为零线圈电流，从而提供高效率的操作。

9. 发明授权

US5989192A Cardiac flow sensor 失效
标题翻译：心脏流量传感器
公开(公告)号：US5989192A
公开(公告)日：1999-11-23
申请号：US937442
申请日：1997-09-25
申请人： Koen J. Weijand , Vincent J. A. Schouten
发明人： Koen J. Weijand , Vincent J. A. Schouten
IPC分类号： A61B5/028 , A61B5/029 , A61N1/36 , A61B5/00
CPC分类号： A61B5/028 , A61B5/029 , A61N1/36007
摘要： Apparatus and method are provided for obtaining a measure of blood flow, and more specifically cardiac output, by analyzing blood temperature variations in the arterial tract. In a first embodiment, a lead carrying two closely spaced temperature sensors is positioned so that the sensors are in the atrial tract and produce temperature signals representative of small cyclical temperature variations of the blood outputted from the heart. The two signals have substantially similar patterns for each cardiac cycle, but the signals are separated by a short time (.increment.T) representative of the distance between the two sensors. The patterns are correlated to find .increment.T, from which cardiac output is calculated. In an alternate embodiment, a single blood temperature sensor is employed along with a sensor for determining cardiac contractions, and a measure of cardiac output is obtained by comparing the time difference between a feature of the blood temperature signal with the time of cardiac contraction.
摘要翻译：提供装置和方法，用于通过分析动脉道中的血液温度变化来获得血流量的测量，更具体地说是心输出量。在第一实施例中，承载两个紧密间隔的温度传感器的引线被定位成使得传感器在心房中并且产生表示从心脏输出的血液的小的周期性温度变化的温度信号。两个信号对于每个心动周期具有基本相似的模式，但是这些信号由表示两个传感器之间的距离的短时间（INCREMENT T）分开。模式相关，以找到INCREMENT T，计算心输出量。在替代实施例中，单个血液温度传感器与用于确定心脏收缩的传感器一起使用，并且通过比较血液温度信号的特征与心脏收缩时间之间的时间差来获得心输出量的测量。

10. 发明授权

US08103349B2 Neural electrode treatment 有权
标题翻译：神经电极治疗
公开(公告)号：US08103349B2
公开(公告)日：2012-01-24
申请号：US12638266
申请日：2009-12-15
申请人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
发明人： Adrianus P. Donders , Koen J. Weijand , Mark B. Knudson
IPC分类号： A61N1/06 , A61N1/36
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。每个电极适于固定到患者的神经。信号发生器电连接到第一和第二电极中的每一个。信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。波形具有选择的参数以阻止神经动作电位的传播。这些波形具有脉冲周期的重复模式，其中所述脉冲中的至少一个选择之间具有延迟周期。在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

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