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1. 发明申请

US20050001083A1 Comminuting apparatus and rotor therefor 失效
标题翻译：捣碎装置和转子
公开(公告)号：US20050001083A1
公开(公告)日：2005-01-06
申请号：US10485213
申请日：2002-07-30
申请人： Phillip Cook , Brian Court
发明人： Phillip Cook , Brian Court
IPC分类号： B02C18/12 , B02C18/06 , B02C18/18 , B02C18/22 , B02C18/24 , B02C21/02 , B02C23/04 , B02C23/02
CPC分类号： B02C21/02 , B02C18/067 , B02C18/24 , B02C23/04 , B02C2018/164
摘要： A rotor (1) for use in a comminuting apparatus (100) is described and claimed. The rotor (1) includes a hub (2) rotatable about a first axis (A) and one or more disc members (4) for comminuting material. The disc members (4) are secured to the hub (2) and rotatable about a second axis (B), removed from the first axis (A). Drive means is provided to simultaneously rotate the hub (2) disc members (4) about their respective axes. Guides (11) may be provided below the disc members (4) to remove comminuted material after it has passed through a screen (10). The screen (10) may include base portion (10A) and side wall portion C (10B), the side wall portion (10B) extending up to a level approximately level with the disc members (4). The guides (11) may include arms (11A) extending up beside the side wall portion (10B). A comminuting apparatus (100) including a rotor (1) is also claimed.
摘要翻译：描述和要求保护用于粉碎设备（100）的转子（1）。转子（1）包括可围绕第一轴线（A）旋转的毂（2）和用于粉碎材料的一个或多个盘构件（4）。盘构件（4）固定到轮毂（2）并且可绕第二轴线（B）旋转，从第一轴线（A）移除。提供驱动装置以同时使轮毂（2）围绕它们各自的轴线旋转。可以在盘构件（4）的下方设置引导件（11），以在其通过筛网（10）之后移除粉碎的材料。屏幕（10）可以包括基部（10A）和侧壁部分C（10B），侧壁部分（10B）延伸到与盘构件（4）大致水平的水平面。引导件（11）可以包括在侧壁部分（10B）旁边延伸的臂（11A）。还要求一种包括转子（1）的粉碎设备（100）。

2. 发明申请

US20060205686A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase 审中-公开
公开(公告)号：US20060205686A1
公开(公告)日：2006-09-14
申请号：US11236224
申请日：2005-09-27
申请人： Balkrishen Bhat , Anne Eldrup , Thazha Prakash , Phillip Cook , Steven Carroll , Malcolm MacCoss , David Olsen
发明人： Balkrishen Bhat , Anne Eldrup , Thazha Prakash , Phillip Cook , Steven Carroll , Malcolm MacCoss , David Olsen
IPC分类号： A61K31/7056 , A61K31/7076
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

3. 发明申请

US20050171052A1 Sucrose acetate isobutyrate formulation 审中-公开
标题翻译：醋酸蔗糖异丁酸酯制剂
公开(公告)号：US20050171052A1
公开(公告)日：2005-08-04
申请号：US10989064
申请日：2004-11-15
申请人： Phillip Cook , George Zima , Danessa Sexton
发明人： Phillip Cook , George Zima , Danessa Sexton
IPC分类号： A23L2/52 , A23L2/62 , A23L29/00 , A61K8/60 , A61K31/7024 , A61Q19/00
CPC分类号： A23L2/52 , A23L2/62 , A61K8/60 , A61Q19/00
摘要： The present invention provides a solid sucrose acetate isobutyrate formulation having improved handling characteristics.
摘要翻译：本发明提供具有改进的处理特性的固体蔗糖醋酸酯异丁酸酯制剂。

4. 发明申请

US20050053712A1 Process for the recovery of a phytolipid composition 失效
标题翻译：回收植物油脂组合物的方法
公开(公告)号：US20050053712A1
公开(公告)日：2005-03-10
申请号：US10844074
申请日：2004-05-12
申请人： George Zima , Terry Oldfield , Suzanne Dobbs , Phillip Cook , Charles Kelly , Mary Crow , Craig Hoyme
发明人： George Zima , Terry Oldfield , Suzanne Dobbs , Phillip Cook , Charles Kelly , Mary Crow , Craig Hoyme
IPC分类号： A21D2/10 , A21D2/14 , A23D7/005 , A23D7/01 , A23D7/015 , A23D9/013 , A23L1/24 , A23L1/30 , A23L2/52 , A61K8/92 , A61Q19/00 , B01D1/06 , B01D1/22 , B01D1/26 , B01D3/10 , B01D3/12 , B01D3/14 , C07C7/04 , C07J9/00 , C11B11/00 , C11B13/00 , C07D311/04
CPC分类号： C07C7/04 , A21D2/10 , A21D2/14 , A23D7/0053 , A23D7/0056 , A23D7/011 , A23D7/013 , A23D7/015 , A23D9/013 , A23L2/52 , A23L27/60 , A23L33/105 , A23L33/11 , A61K8/922 , A61Q19/00 , A61Q19/001 , B01D1/065 , B01D1/22 , B01D1/222 , B01D1/26 , B01D3/10 , B01D3/12 , B01D3/14 , B01D3/143 , B01D3/146 , C07J9/00 , C11B11/00 , C11B13/00 , Y02W30/74
摘要： Disclosed is a process for the recovery of a phytolipid composition from a vegetable oil by-product. The phytolipid composition produced comprises squalene, phytosterols, mixed tocopherols and tocotrieneols, and vegetable wax and is useful as an emollient. The phytochemical composition may be applied directly to the skin to provide emolliency. Alternatively, the phytolipid composition may be formulated in various aqueous or anhydrous cosmetic compositions such as creams, lotions, gels, ointments, lip balms, sticks, or pencils for treatment of the skin and lips. The phytolipid composition also may be incorporated into foods, beverages, and nutraceuticals to provide health benefits.
摘要翻译：公开了从植物油副产物中回收植脂油组合物的方法。所生产的植物油脂组合物包括角鲨烯，植物甾醇，混合生育酚和邻苯三酚，以及植物蜡，并且可用作润肤剂。植物化学成分可以直接施用于皮肤以提供润肤性。或者，植物油脂组合物可以配制成各种水性或无水化妆品组合物，例如乳膏，洗剂，凝胶，软膏，唇膏，棒或铅笔，用于治疗皮肤和嘴唇。植物油脂组合物还可以并入食品，饮料和营养品中以提供健康益处。

5. 外观设计

USD491874S1 Car rim protector 失效
标题翻译：汽车保护罩
公开(公告)号：USD491874S1
公开(公告)日：2004-06-22
申请号：US29196342
申请日：2003-12-29
申请人： Phillip Cook
设计人： Phillip Cook

6. 发明申请

US20080032945A1 2'-MODIFIED OLIGONUCLEOTIDES 审中-公开
标题翻译： 2'-改性寡核苷酸
公开(公告)号：US20080032945A1
公开(公告)日：2008-02-07
申请号：US11764086
申请日：2007-06-15
申请人： Phillip Cook , Andrew Kawasaki
发明人： Phillip Cook , Andrew Kawasaki
IPC分类号： A61K31/7125
CPC分类号： C07H21/04 , A61K31/7125 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
摘要翻译：提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。提供了治疗各种病毒和其他致病因素引起的疾病。

7. 发明申请

US20070135363A1 NOVEL TRICYCLIC NUCLEOSIDES OR NUCLEOTIDES AS THERAPEUTIC AGENTS 失效
标题翻译：新型三核核苷酸或核苷酸作为治疗药物
公开(公告)号：US20070135363A1
公开(公告)日：2007-06-14
申请号：US11674954
申请日：2007-02-14
申请人： Phillip Cook , Gregory Ewing , Deborah Ewing , Yi Jin , John Lambert , Marija Prhavc , Vasanthankumar Rajappan , Vivek Rajwanshi , Kandasamy Sakthivel
发明人： Phillip Cook , Gregory Ewing , Deborah Ewing , Yi Jin , John Lambert , Marija Prhavc , Vasanthankumar Rajappan , Vivek Rajwanshi , Kandasamy Sakthivel
IPC分类号： A61K31/7052 , C07H19/04
CPC分类号： C07H19/04 , C07H19/23
摘要： Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
摘要翻译：含有三环碱基的核苷和核苷酸分别用于治疗感染性疾病和增殖性疾病，例如病毒感染或癌症。

8. 发明申请

US20060052589A1 Colorant compounds containing copolymerizable vinyl groups 审中-公开
公开(公告)号：US20060052589A1
公开(公告)日：2006-03-09
申请号：US11249578
申请日：2005-10-13
申请人： Michael Cyr , Max Weaver , Gerry Rhodes , Jason Pearson , Phillip Cook
发明人： Michael Cyr , Max Weaver , Gerry Rhodes , Jason Pearson , Phillip Cook
IPC分类号： C09B29/32 , C07D221/18
CPC分类号： C09B69/109 , C08F246/00 , C08F290/06 , C08F290/14 , C09B69/101 , C09B69/105 , C09B69/106
摘要： Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coatings and polymers, e.g., coatings and polymers produced from acrylate and methacrylate esters, colored polystyrenes, and similar colored polymeric materials derived from other ethylenically-unsaturated monomers. The present invention also pertains to processes for the preparation of certain of the photopolymerizable colorant compounds.

9. 发明申请

US20060052469A1 Colorant compounds containing copolymerizable vinyl groups 失效
公开(公告)号：US20060052469A1
公开(公告)日：2006-03-09
申请号：US11249793
申请日：2005-10-13
申请人： Michael Cyr , Max Weaver , Gerry Rhodes , Jason Pearson , Phillip Cook
发明人： Michael Cyr , Max Weaver , Gerry Rhodes , Jason Pearson , Phillip Cook
IPC分类号： C07D249/12 , C08F2/46
CPC分类号： C09B69/109 , C08F246/00 , C08F290/06 , C08F290/14 , C09B69/101 , C09B69/105 , C09B69/106
摘要： Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coatings and polymers, e.g., coatings and polymers produced from acrylate and methacrylate esters, colored polystyrenes, and similar colored polymeric materials derived from other ethylenically-unsaturated monomers. The present invention also pertains to processes for the preparation of certain of the photopolymerizable colorant compounds.

10. 发明申请

US20050112563A9 Gapped 2' modified oligonucleotides 审中-公开
标题翻译：间隙2'修饰寡核苷酸
公开(公告)号：US20050112563A9
公开(公告)日：2005-05-26
申请号：US09951052
申请日：2001-09-12
申请人： Phillip Cook , Brett Monia
发明人： Phillip Cook , Brett Monia
IPC分类号： A61K31/70 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07H19/04 , C07H21/00 , C07H21/04 , C07K9/00 , C07K14/00 , C07K14/82 , C12N15/09 , C12N15/113 , C12Q1/68
CPC分类号： C12Q1/6813 , C07H21/00 , C07H21/04 , C07K14/003 , C07K14/82 , C12N15/1135 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/6816 , C12Q1/6832 , C12Q2525/125 , C12Q2521/319 , C12Q2525/101
摘要： Oligonucleotides and other macromolecules are provided that have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and sub-sequences of 2′-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H enzyme. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to antisense therapeutics.
摘要翻译：提供具有增加的核酸酶抗性的寡核苷酸和其它大分子，用于增加对互补链的结合亲和力的取代基和激活核糖核酸酶H酶的2'-脱氧 - 赤 - 戊呋喃糖基核苷酸的亚序列。这样的寡核苷酸和大分子可用于诊断和其他研究目的，用于调节生物体中的蛋白质，以及诊断，检测和治疗对反义治疗剂敏感的其它病症。

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