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1. 发明授权

US07879801B2 Compositions comprising cell-impermeant duramycin derivatives 有权
标题翻译：包含细胞不渗透的耐久霉素衍生物的组合物
公开(公告)号：US07879801B2
公开(公告)日：2011-02-01
申请号：US10642059
申请日：2003-08-15
申请人： Philip E. Thorpe , Jin He
发明人： Philip E. Thorpe , Jin He
IPC分类号： A61K38/00
CPC分类号： A61K39/395 , A61K39/39558 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K2039/505 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
摘要翻译：公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

2. 发明授权

US07378386B2 Anti-viral treatment methods using phosphatidylethanolamine-binding peptide derivatives 有权
标题翻译：使用磷脂酰乙醇胺结合肽衍生物的抗病毒治疗方法
公开(公告)号：US07378386B2
公开(公告)日：2008-05-27
申请号：US10642117
申请日：2003-08-15
申请人： Philip E. Thorpe , M. Melina Soares , Jin He
发明人： Philip E. Thorpe , M. Melina Soares , Jin He
IPC分类号： A61K38/00 , A61K31/00
CPC分类号： A61K51/088 , A61K39/395 , A61K39/39558 , A61K47/48415 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K49/00 , A61K49/14 , A61K51/025 , A61K51/08 , A61K2039/505 , C07K2/00 , C07K7/64 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
摘要翻译：公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

3. 发明申请

US20120164071A1 Compositions and Methods Comprising Phosphatidylethanolamine-Binding Peptide Derivatives 有权
标题翻译：包含磷脂酰乙醇胺结合肽衍生物的组合物和方法
公开(公告)号：US20120164071A1
公开(公告)日：2012-06-28
申请号：US12117255
申请日：2008-05-08
申请人： Philip E. Thorpe , M. Melina Soares , Jin He
发明人： Philip E. Thorpe , M. Melina Soares , Jin He
IPC分类号： A61K51/08 , A61K38/38 , A61K39/395 , A61K38/16 , A61K51/00 , A61P31/12 , C12N7/06 , C07K2/00 , A61K49/00 , A61K49/14 , A61P35/00 , A61K38/02 , A61K38/19
CPC分类号： A61K51/088 , A61K39/395 , A61K39/39558 , A61K47/48415 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K49/00 , A61K49/14 , A61K51/025 , A61K51/08 , A61K2039/505 , C07K2/00 , C07K7/64 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
摘要翻译：公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

4. 发明授权

US07511124B2 Compositions comprising phosphatidylethanolamine-binding peptides linked to anti-viral agents 有权
标题翻译：包含与抗病毒剂连接的磷脂酰乙醇胺结合肽的组合物
公开(公告)号：US07511124B2
公开(公告)日：2009-03-31
申请号：US10642121
申请日：2003-08-15
申请人： Philip E. Thorpe , M. Melina Soares , Jin He
发明人： Philip E. Thorpe , M. Melina Soares , Jin He
IPC分类号： C07K14/00 , A61K31/00
CPC分类号： A61K39/395 , A61K39/39558 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K2039/505 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
摘要翻译：公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

5. 发明授权

US08653034B2 Compositions and methods comprising phosphatidylethanolamine-binding peptide derivatives 有权
标题翻译：包含磷脂酰乙醇胺结合肽衍生物的组合物和方法
公开(公告)号：US08653034B2
公开(公告)日：2014-02-18
申请号：US12117255
申请日：2008-05-08
申请人： Philip E. Thorpe , Jin He
发明人： Philip E. Thorpe , Jin He
IPC分类号： A61K38/00
CPC分类号： A61K51/088 , A61K39/395 , A61K39/39558 , A61K47/48415 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K49/00 , A61K49/14 , A61K51/025 , A61K51/08 , A61K2039/505 , C07K2/00 , C07K7/64 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
摘要翻译：公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

6. 发明授权

US07384909B2 Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents 有权
标题翻译：使用与抗病毒剂连接的磷脂酰乙醇胺结合肽的抗病毒治疗方法
公开(公告)号：US07384909B2
公开(公告)日：2008-06-10
申请号：US10642100
申请日：2003-08-15
申请人： Philip E. Thorpe , M. Melina Soares , Jin He
发明人： Philip E. Thorpe , M. Melina Soares , Jin He
IPC分类号： A61K38/00 , A61K31/00
CPC分类号： A61K39/395 , A61K39/39558 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K2039/505 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
摘要翻译：公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

7. 发明申请

US20140162247A1 MOLECULAR TRANSISTOR 审中-公开
标题翻译：分子晶体管
公开(公告)号：US20140162247A1
公开(公告)日：2014-06-12
申请号：US14003851
申请日：2012-03-09
申请人： Stuart Lindsay , Pei Pang , Jin He
发明人： Stuart Lindsay , Pei Pang , Jin He
IPC分类号： G01N27/414
CPC分类号： G01N27/4146 , G01N33/48721
摘要： Fluidic nanotube devices and methods for their use are provided wherein the flow of charged molecules through a channel is controlled by the voltage potential of a gate electrode. In at least some embodiments, a molecular transistor is provided that includes a channel having a diameter such that only one target molecule at a time may traverse the channel. The channel may be a carbon nanotube that is electrically isolated from, and in communication with, a gate electrode. Methods are provided for controlling the flow of an individual molecule through the channel and for detecting a single chemical reaction.
摘要翻译：提供了流动的纳米管装置及其使用方法，其中通过通道的带电分子的流动由栅电极的电压电位来控制。在至少一些实施例中，提供了一种分子晶体管，其包括具有使得一次只能有一个靶分子可以穿过该通道的直径的通道。通道可以是与栅电极电隔离并与栅电极连通的碳纳米管。提供了用于通过通道控制单个分子的流动并用于检测单个化学反应的方法。

8. 发明申请

US20140047485A1 METHOD AND APPARATUS FOR DELIVERY OF APPLICATION SERVICES 有权
标题翻译：交付应用服务的方法和装置
公开(公告)号：US20140047485A1
公开(公告)日：2014-02-13
申请号：US13571464
申请日：2012-08-10
申请人： Venson Shaw , Jin He
发明人： Venson Shaw , Jin He
IPC分类号： H04N21/61
CPC分类号： H04W4/20 , H04L61/6068 , H04L65/1063 , H04L65/4069 , H04M2250/10 , H04N21/25841 , H04N21/61 , H04N21/8166 , H04W4/02 , H04W4/50 , H04W48/16 , H04W48/18 , H04W52/0245 , H04W52/0254 , H04W64/00 , H04W76/10 , H04W76/12 , H04W84/12 , Y02D70/00 , Y02D70/1224 , Y02D70/1242 , Y02D70/1244 , Y02D70/1262 , Y02D70/142 , Y02D70/144 , Y02D70/146 , Y02D70/162 , Y02D70/164 , Y02D70/166 , Y02D70/168 , Y02D70/23
摘要： Systems and processes that incorporate teachings of the subject disclosure may include, for example, receiving from a mobile device, by way of a cellular network, a request for delivery of high-bandwidth application service. A location of the mobile device can be obtained and used to determine availability of any nearby wireless packet-network services. If it is determined that a wireless packet-network service is available, a network connection between the mobile device and the wireless packet-network service can be established. The request for delivery of high-bandwidth services can then be forwarded to an application server that delivers the requested services by way of the wireless packet-network service. Other embodiments are disclosed.
摘要翻译：结合本公开的教导的系统和过程可以包括例如通过蜂窝网络从移动设备接收用于传送高带宽应用服务的请求。可以获得移动设备的位置并用于确定任何附近的无线分组网络服务的可用性。如果确定无线分组网络服务可用，则可以建立移动设备与无线分组网络服务之间的网络连接。然后可以将传送高带宽服务的请求转发到通过无线分组网络服务传递所请求的服务的应用服务器。公开了其他实施例。

9. 发明申请

US20120288948A1 CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS 有权
标题翻译：用于测序聚合物的控制隧道缝隙装置
公开(公告)号：US20120288948A1
公开(公告)日：2012-11-15
申请号：US13395956
申请日：2011-01-31
申请人： Stuart Lindsay , Shuai Chang , Jin He , Peiming Zhang , Shuo Huang
发明人： Stuart Lindsay , Shuai Chang , Jin He , Peiming Zhang , Shuo Huang
IPC分类号： G01N27/00 , C25B7/00 , B82Y5/00
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N27/3275 , Y10T436/143333
摘要： The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo- or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
摘要翻译：本发明包括用于分析聚合物和/或聚合物单元的组合物，装置和方法。聚合物可以是均聚物或异质聚合物，例如DNA，RNA，多糖或肽。该装置包括形成隧道间隙的电极，聚合物可通过该间隙通过。电极用附着于其上的试剂进行功能化，并且试剂能够形成与聚合物单元的暂时结合。当试剂和单元之间形成瞬态键时，产生可检测的信号并用于分析聚合物。

10. 发明申请

US20110168562A1 Nanopore and Carbon Nanotube Based DNA Sequencer 有权
标题翻译：纳米孔和碳纳米管的DNA测序仪
公开(公告)号：US20110168562A1
公开(公告)日：2011-07-14
申请号：US12920817
申请日：2009-03-18
申请人： Colin Nuckolls , Jinyao Tang , Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
发明人： Colin Nuckolls , Jinyao Tang , Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
IPC分类号： G01N27/00 , B32B37/24 , C23F1/00 , B82Y99/00
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2565/631
摘要： The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.
摘要翻译：本发明提供一种用于分析包含碳纳米管的杂聚物的组成的装置，通过该电极驱动该杂聚物。碳纳米管也用作读取电路中的一个电极。碳纳米管的一端保持靠近第二电极，并且碳纳米管的每一端用柔性系带的化学识别部分功能化，使得将结合新出现的聚合物上的一个位点，而第二个在另一个位置紧密接合，当通过化学识别过程完成电路时，在两个电极之间产生电信号。

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