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1. 发明授权

US08628649B2 Nanopore and carbon nanotube based DNA sequencer and a serial recognition sequencer 有权
标题翻译：纳米孔和基于碳纳米管的DNA测序仪和序列识别测序仪
公开(公告)号：US08628649B2
公开(公告)日：2014-01-14
申请号：US12920809
申请日：2009-03-18
申请人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
发明人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
IPC分类号： G01N27/327
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/48721 , C12Q2565/631
摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
摘要翻译：本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的生物聚合物。

2. 发明授权

US5438131A 3-nitropyrrole nucleoside 失效
标题翻译： 3-硝基吡咯核苷
公开(公告)号：US5438131A
公开(公告)日：1995-08-01
申请号：US946971
申请日：1992-09-16
申请人： Donald E. Bergstrom , Philip C. Andrews , Ruthann Nichols , Peiming Zhang
发明人： Donald E. Bergstrom , Philip C. Andrews , Ruthann Nichols , Peiming Zhang
IPC分类号： C12Q1/68 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24 , C07H21/00 , C07H15/12 , C07H5/04 , C07H17/00 , C07H19/00
CPC分类号： C07H21/00 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24
摘要： Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;Z is a member of the group consisting of O, S and CH.sub.2 ; andB is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside;X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se;X.sub.2 and X.sub.4 are each members of the group consisting of N and C; andW is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.3, N.sub.3, CN, C(O)NH.sub.2, C(NOH)NH.sub.2, CSNH.sub.2 and CO.sub.2 H.
摘要翻译：具有至少十个核苷的寡核苷酸，其中至少两个选自A，T，C和G，以及至少一种核苷，其为下式通用核苷：其中：每个Rn为H， OH，F或OCH 3; Z是由O，S和CH2组成的组的成员; 并且B是具有至少两个双键的五元杂环碱基，并且还具有与其结合的吸电子基团，所述具有吸电子基团的碱基由下式表示：其中：所述具有吸电子基团的碱在X4键合到核苷的糖部分; X1，X3和X5分别是由N，O，C，S和Se组成的组的成员; X2和X4分别是由N和C组成的组的成员; 并且W是由F，Cl，Br，I，O，S，OH，SH，NH 2，NO 2，C（O）H，C（O）NHOH，C（S）NHOH， C（NOCH 3）NH 2，OCH 3，SCH 3，SeCH 3，ONH 2，NHOCH 3，N 3，CN，C（O）NH 2，C（NOH）NH 2，CSNH 2和CO 2 H。

3. 发明授权

US09395352B2 Devices and methods for target molecule characterization 有权
标题翻译：靶分子表征的装置和方法
公开(公告)号：US09395352B2
公开(公告)日：2016-07-19
申请号：US12594366
申请日：2008-04-07
申请人： Stuart Lindsay , Peiming Zhang
发明人： Stuart Lindsay , Peiming Zhang
IPC分类号： G01N33/487 , C12Q1/68
CPC分类号： G01N27/3278 , C12Q1/6869 , G01N27/028 , G01N27/3276 , G01N33/48721 , C12Q2565/631
摘要： The present invention provides a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. The device has a pair of spaced apart sensing electrodes that border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction.
摘要翻译：本发明提供了具有至少一个收缩部的装置，其尺寸确定为允许仅分解单个拷贝的易位。该装置具有一对间隔开的感测电极，该电极与收缩部分相邻，该电极可以是纳米孔。第一电极连接到第一亲和元件，第二电极连接到第二亲和元件。第一和第二亲和元件配置成与靶分子的第一和第二部分暂时形成氢键，因为它们经过收缩部。

4. 发明授权

US09140682B2 Controlled tunnel gap device for sequencing polymers 有权
标题翻译：用于测序聚合物的控制隧道间隙装置
公开(公告)号：US09140682B2
公开(公告)日：2015-09-22
申请号：US13395956
申请日：2011-01-31
申请人： Stuart Lindsay , Shuai Chang , Jin He , Peiming Zhang , Shuo Huang
发明人： Stuart Lindsay , Shuai Chang , Jin He , Peiming Zhang , Shuo Huang
IPC分类号： G01N27/00 , G01N33/487
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N27/3275 , Y10T436/143333
摘要： The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
摘要翻译：本发明包括用于分析聚合物和/或聚合物单元的组合物，装置和方法。聚合物可以是同质或异聚合物，例如DNA，RNA，多糖或肽。该装置包括形成隧道间隙的电极，聚合物可通过该间隙通过。电极用附着于其上的试剂进行功能化，并且试剂能够形成与聚合物单元的暂时结合。当试剂和单元之间形成瞬态键时，产生可检测的信号并用于分析聚合物。

5. 发明申请

US20100216658A1 Modified Nucleic Acid Nanoarrays and Uses Therefor 有权
标题翻译：改性核酸纳米粒子及其用途
公开(公告)号：US20100216658A1
公开(公告)日：2010-08-26
申请号：US12301884
申请日：2007-05-23
申请人： John Chaput , Stuart Lindsay , Hao Yan , Peiming Zhang
发明人： John Chaput , Stuart Lindsay , Hao Yan , Peiming Zhang
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： C12Q1/6809 , B01J19/0046 , B01J2219/00515 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C12Q1/6837 , C12Q2565/501 , C12Q2525/113 , C12Q2565/601 , C12Q2565/543 , C12Q2565/513
摘要： The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use.
摘要翻译：本发明提供有限的，可寻址的和自组装的核酸平铺阵列及其使用的方法。

6. 发明授权

US06824669B1 Protein and peptide sensors using electrical detection methods 有权
标题翻译：使用电检测方法的蛋白质和肽类传感器
公开(公告)号：US06824669B1
公开(公告)日：2004-11-30
申请号：US09506178
申请日：2000-02-17
申请人： Changming Li , Jaymie Robin Sawyer , Vi-En Choong , George Maracas , Peiming Zhang
发明人： Changming Li , Jaymie Robin Sawyer , Vi-En Choong , George Maracas , Peiming Zhang
IPC分类号： G01N27327
CPC分类号： G01N33/5438
摘要： The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.
摘要翻译：本发明提供了用于电探测分子与蛋白质或肽靶分子之间的分子相互作用的装置和方法，但不需要使用电化学或其他记录来获得可测量的信号。该方法可用于电子检测结合到阵列的限定区域的探针分子与允许与探针分子相互作用的蛋白质或肽靶分子之间的分子相互作用。

7. 发明授权

US5681947A Oligonucleotides having universal nucleoside spacers 失效
标题翻译：具有通用核苷间隔物的寡核苷酸
公开(公告)号：US5681947A
公开(公告)日：1997-10-28
申请号：US330423
申请日：1994-10-28
申请人： Donald Eugene Bergstrom , Philip Charles Andrews , Ruthann Nichols , Peiming Zhang
发明人： Donald Eugene Bergstrom , Philip Charles Andrews , Ruthann Nichols , Peiming Zhang
IPC分类号： C12Q1/68 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24 , C07H21/00 , C07H5/04 , C07H5/06
CPC分类号： C07H21/00 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24
摘要： Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ; Z is a member of the group consisting of O, S and CH.sub.2 ; and B is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside; X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se; X.sub.2 and X.sub.4 are each members of the group consisting of N and C; and W is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.3, N.sub.3, CN, C(O)NH.sub.2, C(NOH)NH.sub.2, CSNH.sub.2 and CO.sub.2 H.
摘要翻译：具有至少十个核苷的寡核苷酸，其中至少两个选自A，T，C和G，以及至少一种核苷，其为下式通用核苷：其中：每个Rn为H， OH，F或OCH 3; Z是由O，S和CH2组成的组的成员; 并且B是具有至少两个双键的五元杂环碱基，并且还具有与其结合的吸电子基团，所述具有吸电子基团的碱基由下式表示：其中：所述具有吸电子基团的碱在X4键合到核苷的糖部分; X1，X3和X5分别是由N，O，C，S和Se组成的组的成员; X2和X4分别是由N和C组成的组的成员; 并且W是由F，Cl，Br，I，O，S，OH，SH，NH 2，NO 2，C（O）H，C（O）NHOH，C（S）NHOH， C（NOCH 3）NH 2，OCH 3，SCH 3，SeCH 3，ONH 2，NHOCH 3，N 3，CN，C（O）NH 2，C（NOH）NH 2，CSNH 2和CO 2 H。

8. 发明申请

US20190195856A1 NON-HYDROGEN-BONDING UNIVERSAL READER FOR DNA SEQUENCING 审中-公开
公开(公告)号：US20190195856A1
公开(公告)日：2019-06-27
申请号：US16327232
申请日：2017-08-21
申请人： Peiming ZHANG , Sovan BISWAS , Suman SEN , Stuart LINDSAY
发明人： Peiming ZHANG , Sovan BISWAS , Suman SEN , Stuart LINDSAY
IPC分类号： G01N33/487 , C07C321/10 , C12Q1/6869
CPC分类号： G01N33/48721 , C07C321/10 , C07C2603/50 , C12Q1/6869 , C12Q2563/116 , C12Q2563/157 , C12Q2565/607
摘要： The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.

9. 发明授权

US08685894B2 Modified nucleic acid nanoarrays and uses therefor 有权
标题翻译：修饰的核酸纳米阵列及其用途
公开(公告)号：US08685894B2
公开(公告)日：2014-04-01
申请号：US12301884
申请日：2007-05-23
申请人： John Chaput , Stuart Lindsay , Hao Yan , Peiming Zhang
发明人： John Chaput , Stuart Lindsay , Hao Yan , Peiming Zhang
IPC分类号： C40B40/06
CPC分类号： C12Q1/6809 , B01J19/0046 , B01J2219/00515 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C12Q1/6837 , C12Q2565/501 , C12Q2525/113 , C12Q2565/601 , C12Q2565/543 , C12Q2565/513
摘要： The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use.
摘要翻译：本发明提供有限的，可寻址的和自组装的核酸平铺阵列及其使用的方法。

10. 发明申请

US20110120868A1 Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer 有权
标题翻译：基于纳米孔和碳纳米管的DNA测序仪和串行识别测序仪
公开(公告)号：US20110120868A1
公开(公告)日：2011-05-26
申请号：US12920809
申请日：2009-03-18
申请人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
发明人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
IPC分类号： G01N27/447 , H05K3/06 , H05K3/02 , B82Y99/00
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/48721 , C12Q2565/631
摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
摘要翻译：本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的生物聚合物。

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