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1. 发明授权

US06660233B1 Analytical biochemistry system with robotically carried bioarray 失效
标题翻译：分析生物化学系统与机器人携带的生物阵列
公开(公告)号：US06660233B1
公开(公告)日：2003-12-09
申请号：US08586116
申请日：1996-01-16
申请人： Peter J. Coassin , Jack D. McNeal , David B. Helphrey
发明人： Peter J. Coassin , Jack D. McNeal , David B. Helphrey
IPC分类号： B01L900
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/00292 , B01J2219/00315 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00657 , B01J2219/00659 , B01J2219/00691 , B01J2219/00711 , B01J2219/00722 , B01L3/0275 , B01L3/508 , B01L3/5085 , B01L2300/0636 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/6452 , G01N35/00029 , G01N2035/00118 , G01N2035/00158 , G01N2035/1055 , G01N2035/1062 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： A system for detecting the presence of a target biomolecule in a sample where there is a robotic arm to move a pipette adaptor to the desired reagent locations to facilitate the detection.
摘要翻译：一种用于检测样品中目标生物分子的存在的系统，其中存在机器人臂将移液管适配器移动到期望的试剂位置以便于检测。

2. 发明授权

US5447692A On-line process flow and reaction monitor 失效
标题翻译：在线工艺流程和反应监测
公开(公告)号：US5447692A
公开(公告)日：1995-09-05
申请号：US337311
申请日：1994-11-10
申请人： Charles A. Keenan , Peter J. Coassin , David B. Helphrey , Roger Winer , Jiunn-Jye Dih
发明人： Charles A. Keenan , Peter J. Coassin , David B. Helphrey , Roger Winer , Jiunn-Jye Dih
IPC分类号： C12M1/00 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B60/14 , G01F1/708 , G05B17/00 , G01F13/00 , G01N21/00
CPC分类号： C07H21/00 , B01J19/0046 , C07K1/045 , G01F1/708 , G01F1/7086 , B01J2219/00353 , B01J2219/00391 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10T436/11
摘要： The present invention makes use of a single detector to monitor several process functions, e.g. reaction efficiency, reagent flow rates, the presence of empty reagent reservoirs, the absence of a chemical reactor column in the system, blockage of flow system, etc., at a single location in the flow system. In accordance with the detection scheme of the present invention, only one detector is required to accomplish the same, if not more, functions as many detectors in the prior art instruments. In the described embodiment, an optical detector is positioned downstream of a chemical reaction chamber. This detector monitors the effluent from the reaction chamber to monitor the reaction efficiency. It also monitors the system functions upstream of the reaction chamber. System flow rate is monitored by detecting the presence of a gas bubble which has been introduced into the system at a known instance. Depletion of reagents in the reservoirs can be detected by monitoring the absence of the reagents at the detector at times when the reagents are expected. The flow system may be periodically diagnosed to check for flow blockage or missing flow component, by monitoring the flow past the detector which corresponds to a predetermined succession of reagents introduced into the system. Any deviation from a predictable succession of changes in the flow monitored by the detector indicates possible blockage of the flow delivery system or missing flow components.
摘要翻译：本发明利用单个检测器来监视多个过程功能，例如，反应效率，试剂流量，空试剂储存器的存在，系统中没有化学反应器塔，堵塞流动系统等，在流动系统的单个位置。根据本发明的检测方案，仅需要一个检测器来实现与现有技术的仪器相同的（如果不是更多的）功能的检测器。在所描述的实施例中，光学检测器位于化学反应室的下游。该检测器监测来自反应室的流出物以监测反应效率。它还监控反应室上游的系统功能。通过检测在已知情况下已经引入到系统中的气泡的存在来监测系统流量。可以通过在预期的时候监测检测器处的试剂的不存在来检测储存器中试剂的消耗。可以通过监测通过检测器的流量来对应于引入到系统中的预定的一系列试剂，周期性地诊断流量系统来检查流体阻塞或缺少流动成分。由检测器监测的流量的可预测连续变化的任何偏差表明流量输送系统或缺少流动分量的可能的阻塞。

3. 发明授权

US4596462A Spectrophotometer purge apparatus 失效
标题翻译：分光光度计清洗装置
公开(公告)号：US4596462A
公开(公告)日：1986-06-24
申请号：US472421
申请日：1983-03-04
申请人： David B. Helphrey
发明人： David B. Helphrey
IPC分类号： G01N21/03 , G01N21/11 , G01J3/02
CPC分类号： G01N21/11 , G01N2021/036
摘要： Spectrophotometer purge apparatus comprising a sample compartment including a plurality of walls defining a first sample purge volume. The apparatus may further include a volume reducing wall and fastening means for removably fixing the volume reducing wall within the sample compartment to thereby define a second sample purge volume smaller than the first sample purge volume. A purge gas inlet introduces purge gas into the sample purge volumes. Further the apparatus may comprise a movable partition forming one of the plurality of walls and the volume reducing wall. In such an embodiment, the fastening means may further include means for removably fixing the movable partition to thereby define the first sample purge volume. The apparatus advantageously enables the sample purge volume to be adjusted as required to thereby optimize purge efficiency in a spectrophotometer.
摘要翻译：分光光度计清洗装置，其包括样品室，其包括限定第一样品净化体积的多个壁。该装置还可以包括容积减小壁和紧固装置，用于将体积减小壁可移除地固定在样品室内，从而限定小于第一样品吹扫体积的第二样品吹扫体积。吹扫气体入口将吹扫气体引入样品吹扫体积。此外，该装置可以包括形成多个壁之一和容积减小壁的可移动分隔件。在这样的实施例中，紧固装置还可以包括用于可移除地固定可移动隔板的装置，从而限定第一样品净化容积。该设备有利地使得可以根据需要调节样品吹扫体积，从而在分光光度计中优化吹扫效率。

4. 发明授权

US4396288A Control of multi-position filter mechanism in an optical measuring system 失效
标题翻译：光学测量系统中多位置滤光器机构的控制
公开(公告)号：US4396288A
公开(公告)日：1983-08-02
申请号：US353466
申请日：1982-03-01
申请人： David B. Helphrey
发明人： David B. Helphrey
IPC分类号： G01J3/06 , G01J3/12 , G01J3/50
CPC分类号： G01J3/12 , G01J3/06
摘要： A method of identifying an operating position of a multiple-position filter changing mechanism situated in an optical path of a spectrophotometer by detecting and measuring a spectral characteristic(s) of light passed along the optical path to the spectrophotometer detector for one or more operating positions of the filter mechanism and comparing the measured spectral characteristic(s) with stored spectral characteristic information for one or more operating positions of the filter mechanism.
摘要翻译：一种通过检测和测量沿着一条或多条操作位置的分光光度计检测器的光路的光谱特性来确定位于分光光度计的光路中的多位置滤波器改变机构的操作位置的方法并将测量的光谱特性与存储的过滤机构的一个或多个操作位置的光谱特征信息进行比较。

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