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1. 发明申请

US20090054867A1 Device for Administering of Medication in Fluid Form 有权
标题翻译：用于管理流体形式药物的装置
公开(公告)号：US20090054867A1
公开(公告)日：2009-02-26
申请号：US12195791
申请日：2008-08-21
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M5/14
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuously infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion for a short period. The device comprises a flow regulating device comprising a passage defined by at least a fact element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
摘要翻译：公开了一种用于持续输注药物的输注装置，其中输注通过两个单独的流体通信进行控制。在每个通过限制装置和阀装置控制的流体连通中的输注，并且流体通信中的一个进一步包含用于短时间的推注速率的保持装置。该装置包括流动调节装置，其包括由至少一个事实元件限定的通道，其是适于弹性变形以改变通道的横截面面积的主要可变形元件。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

2. 发明授权

US08945064B2 Device for administering of medication in fluid form 有权
标题翻译：用于以流体形式施用药物的装置
公开(公告)号：US08945064B2
公开(公告)日：2015-02-03
申请号：US12195791
申请日：2008-08-21
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M5/178 , A61M5/168 , A61M5/14 , A61M5/142 , A61M5/148 , A61M5/152
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuous infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
摘要翻译：公开了用于连续输注药物的输注装置，其中输注通过两个单独的流体通信来控制。在每个流体通路中通过限制装置和阀装置控制输注，并且流体通信中的一个进一步包含用于推注速率的保持装置。该装置包括流动调节装置，其包括由至少第一元件和第二元件限定的通道，其中第一和第二元件中的至少一个是适于弹性变形的主要可变形元件，以便改变横截面积的通道。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

3. 发明授权

US07517335B2 Device for administering of medication in fluid form 有权
标题翻译：用于以流体形式施用药物的装置
公开(公告)号：US07517335B2
公开(公告)日：2009-04-14
申请号：US10503845
申请日：2003-02-18
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M37/00
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuous infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications farther contains a holding device for bolus rate of infusion for a short period. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber Increases the volume of the second chamber decreases.
摘要翻译：公开了用于连续输注药物的输注装置，其中输注通过两个单独的流体通信来控制。在每个通过限制装置和阀装置控制的流体连通中的输注是，流体通信中的一个进一步包含用于短时间的推注速率的保持装置。该装置包括流动调节装置，其包括由至少第一元件和第二元件限定的通道，其中第一和第二元件中的至少一个是适于弹性变形的主要可变形元件，以便改变横截面积的通道。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

4. 发明申请

US20050165384A1 Device for administering of medication in gluid form 有权
标题翻译：用于以胶体形式施用药物的装置
公开(公告)号：US20050165384A1
公开(公告)日：2005-07-28
申请号：US10503845
申请日：2003-02-18
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M5/00 , A61M5/142 , A61M5/145 , A61M5/168 , A61M39/00 , A61K9/22
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuously infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion for a short period. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
摘要翻译：公开了一种用于持续输注药物的输注装置，其中输注通过两个单独的流体通信进行控制。在每个通过限制装置和阀装置控制的流体连通中的输注，并且流体通信中的一个进一步包含用于短时间的推注速率的保持装置。该装置包括流动调节装置，其包括由至少第一元件和第二元件限定的通道，其中第一和第二元件中的至少一个是适于弹性变形的主要可变形元件，以便改变横截面积的通道。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

5. 发明授权

US08449772B2 Micro fluidic system and a method of attaching a membrane to a tube 有权
标题翻译：微流体系统和将膜附接到管的方法
公开(公告)号：US08449772B2
公开(公告)日：2013-05-28
申请号：US12064483
申请日：2006-08-22
申请人： Holger Dirac , Per Brandt Rasmussen , Arne Briest
发明人： Holger Dirac , Per Brandt Rasmussen , Arne Briest
IPC分类号： B01D63/00
CPC分类号： A61M1/1678 , A61B5/14532 , A61B10/0045 , Y10T29/49401
摘要： A micro fluidic system comprising at least one tube (1), a membrane (3) and at least one fitting member (4). The fitting member (4) is positioned around the membrane (3) and an end part (2) of the tube(s) (1), thereby fitting the membrane (3) to the end part(s) (2). The fitting member(s) (4) is/are made from a shrinkable material, and it/they is/are fitted tightly around the membrane (3) end part(s) (2). This is obtained by causing the shrinkable material to shrink, e.g. by heating the material, while the fitting member (4) is positioned around the membrane (3) and the end part(s) (2). It is an advantage that the fitting member (4) is made from a shrinkable material because this provides the possibility of fitting the membrane (3) tightly to the end part(s) (2) in an easy and cost effective manner. The micro fluidic system is very suitable for use in a probe, such as a dialysis probe. Also claimed is a method of manufacturing the micro fluidic system.
摘要翻译：一种微流体系统，包括至少一个管（1），膜（3）和至少一个配件（4）。装配构件（4）围绕膜（3）和管（1）的端部（2）定位，从而将膜（3）装配到端部（2）。装配构件（4）由可收缩材料制成，并且/它们紧密地配合在膜（3）端部（2）周围。这是通过使收缩材料收缩而获得的。通过加热材料，同时装配构件（4）围绕膜（3）和端部（2）定位。这是一种优点，即装配构件（4）由可收缩材料制成，因为这提供了以容易和成本有效的方式将膜（3）紧密地装配到端部（2）的可能性。微流体系统非常适合用于探针，例如透析探针。还要求保护的是制造微流体系统的方法。

6. 发明申请

US20090218272A1 MICRO FLUIDIC SYSTEM AND A METHOD OF ATTACHING A MEMBRANE TO A TUBE 有权
标题翻译：微流体系统和将膜连接到管的方法
公开(公告)号：US20090218272A1
公开(公告)日：2009-09-03
申请号：US12064483
申请日：2006-08-22
申请人： Holger Dirac , Per Brandt Rasmussen , Arne Briest
发明人： Holger Dirac , Per Brandt Rasmussen , Arne Briest
IPC分类号： B01D63/00 , B23P17/00
CPC分类号： A61M1/1678 , A61B5/14532 , A61B10/0045 , Y10T29/49401
摘要： A micro fluidic system comprising at least one tube (1), a membrane (3) and at least one fitting member (4). The fitting member (4) is positioned around the membrane (3) and an end part (2) of the tube(s) (1), thereby fitting the membrane (3) to the end part(s) (2). The fitting member(s) (4) is/are made from a shrinkable material, and it/they is/are fitted tightly around the membrane (3) end part(s) (2). This is obtained by causing the shrinkable material to shrink, e.g. by heating the material, while the fitting member (4) is positioned around the membrane (3) and the end part(s) (2). It is an advantage that the fitting member (4) is made from a shrinkable material because this provides the possibility of fitting the membrane (3) tightly to the end parts) (2) in an easy and cost effective manner. The micro fluidic system is very suitable for use in a probe, such as a dialysis probe. Also claimed is a method of manufacturing the micro fluidic system.
摘要翻译：一种微流体系统，包括至少一个管（1），膜（3）和至少一个配件（4）。装配构件（4）围绕膜（3）和管（1）的端部（2）定位，从而将膜（3）装配到端部（2）。装配构件（4）由可收缩材料制成，并且/它们紧密地配合在膜（3）端部（2）周围。这是通过使收缩材料收缩而获得的。通过加热材料，同时装配构件（4）围绕膜（3）和端部（2）定位。这是因为这样可以以容易且成本有效的方式将膜（3）紧密地装配到端部部件（2））的可能性，因此装配构件（4）由可收缩材料制成是有利的。微流体系统非常适合用于探针，例如透析探针。还要求保护的是制造微流体系统的方法。

7. 发明授权

US07431052B2 Flow restrictor and system for delivering a flow of liquid in a microcapillary 有权
标题翻译：用于在微毛细管中输送液体流的限流器和系统
公开(公告)号：US07431052B2
公开(公告)日：2008-10-07
申请号：US10570979
申请日：2004-09-04
申请人： Peter Gravesen , Martin Manscher , Per Brandt Rasmussen
发明人： Peter Gravesen , Martin Manscher , Per Brandt Rasmussen
IPC分类号： F16L55/00
CPC分类号： F16K99/0001 , A61M5/141 , A61M5/14276 , A61M5/16877 , F15C5/00 , F16K99/0017 , F16K99/0026 , F16K99/0057 , F16K2099/0086
摘要： The present invention relates to apparatus for delivering a controlled or restricted flow of liquid and limiting bubble fragmentation at the inlet. This is achieved in flow restrictor with a flow channel having over most of its length a substantially constant, minimum hydraulic diameter D=4A/W wherein A is the minimum local cross-sectional area of the channel and W is the minimum local wetting perimeter of the channel, by smoothly widening the channel at its inlet such that: at distances z from the inlet face with 0
摘要翻译：本发明涉及用于输送受控或限制的液体流并限制入口处气泡破裂的装置。这是在流量限制器中实现的，其中流动通道的大部分长度基本上恒定，最小水力直径D = 4A / W，其中A是通道的最小局部横截面面积，W是最小局部润湿周长该通道通过在其入口处平滑地加宽通道，使得在距离入口面0和Z 的距离z处，通道具有液压直径D z >> = k * D其中k> = 1.3; 在与z <1 2的入口面的距离z处，通道具有水力直径D z z，其中k * D> = D z z / / SUB >> = D; 并且在距离入口面z z的距离z处，通道具有水力直径D z z，其中D z z = 1.02D ，除了可能在出口处的通道类似的扩大。已经发现，在入口处扩大流动通道，使得其直径在至少3个通道直径的长度上平滑且逐渐增加，优选至少为1.3倍，显着降低了微毛细管中气泡分裂的趋势流量限制器，并且还显着提高了运行良好的装置的产量。

8. 发明申请

US20100218834A1 MICRO FLUID DEVICE WITH A MULTI LUMEN HOSE 审中-公开
标题翻译：具有多个软管的微流体装置
公开(公告)号：US20100218834A1
公开(公告)日：2010-09-02
申请号：US12524896
申请日：2007-01-30
申请人： Per Brandt Rasmussen , Peter Gravesen
发明人： Per Brandt Rasmussen , Peter Gravesen
IPC分类号： F16L3/01
CPC分类号： B01L3/502715 , B01J2219/0081 , B01L3/565 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , Y10T137/8593
摘要： The invention provides a micro fluid device comprising a substrate with a channel forming a receiving cavity, an outer chamber, and an inner chamber, the device further comprising a multi lumen hose with a free end portion which is fixed in the receiving cavity. The multi lumen hose forming a first conduit and at least one second conduit located radially offset from the first conduit, and the outer chamber is in fluid communication with at least one second conduit, and the inner chamber is in fluid communication with the first conduit. The chambers are separated by an inner sealing member located between the substrate and the hose. To simplify the manufacturing of the device, the channel is formed by a groove in an upper surface of a body of the substrate, which groove closed by an essentially plane cover which is sealed to the upper surface.
摘要翻译：本发明提供了一种微流体装置，其包括具有形成容纳空腔的通道的衬底，外部腔室和内部腔室，该装置还包括多腔软管，其具有固定在容纳腔中的自由端部分。所述多腔软管形成第一导管和位于径向偏离所述第一导管的至少一个第二导管，并且所述外室与至少一个第二导管流体连通，并且所述内室与所述第一导管流体连通。这些室由位于基底和软管之间的内部密封构件分开。为了简化装置的制造，通道由衬底的主体的上表面中的凹槽形成，该凹槽由基本上平面的盖封闭，该盖子被密封到上表面。

9. 发明授权

US07520295B2 Capillary carrier with leak supervision 有权
标题翻译：毛细管载体带有泄漏监控
公开(公告)号：US07520295B2
公开(公告)日：2009-04-21
申请号：US10543676
申请日：2004-01-24
申请人： Per Brandt Rasmussen , Heiko Arndt
发明人： Per Brandt Rasmussen , Heiko Arndt
IPC分类号： F16L9/18 , F16L55/16
CPC分类号： A61M5/16877 , A61M5/141 , Y10T137/5762
摘要： In a capillary carrier with an inlet and an outlet, a channel is formed and extends between the inlet and the outlet. At least one capillary tube is arranged within the channel, and sealing elements, by which the capillary tube is sealingly fixed to the channel, are arranged at least near an inlet portion and an outlet portion of the capillary tube. An area is formed limited by a part of the channel, the sealing elements and the exterior of the capillary tube, which is in connection with the exterior of the carrier through a fluid communication pad, whereby a possible fluid leak across the sealing elements will be led to this area, and from there to the exterior of the carrier.
摘要翻译：在具有入口和出口的毛细管载体中，形成通道并在入口和出口之间延伸。至少一个毛细管布置在通道内，并且毛细管密封地固定到通道的密封元件至少布置在毛细管的入口部分和出口部分附近。一个区域由通道的一部分，密封元件和毛细管的外部限制，毛细管的外部通过流体连通垫与载体的外部连接，从而跨过密封元件的可能的流体泄漏将是导致这个地区，从那里到承运人的外部。

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