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1. 发明申请

US20090054867A1 Device for Administering of Medication in Fluid Form 有权
标题翻译：用于管理流体形式药物的装置
公开(公告)号：US20090054867A1
公开(公告)日：2009-02-26
申请号：US12195791
申请日：2008-08-21
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M5/14
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuously infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion for a short period. The device comprises a flow regulating device comprising a passage defined by at least a fact element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
摘要翻译：公开了一种用于持续输注药物的输注装置，其中输注通过两个单独的流体通信进行控制。在每个通过限制装置和阀装置控制的流体连通中的输注，并且流体通信中的一个进一步包含用于短时间的推注速率的保持装置。该装置包括流动调节装置，其包括由至少一个事实元件限定的通道，其是适于弹性变形以改变通道的横截面面积的主要可变形元件。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

2. 发明授权

US08945064B2 Device for administering of medication in fluid form 有权
标题翻译：用于以流体形式施用药物的装置
公开(公告)号：US08945064B2
公开(公告)日：2015-02-03
申请号：US12195791
申请日：2008-08-21
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M5/178 , A61M5/168 , A61M5/14 , A61M5/142 , A61M5/148 , A61M5/152
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuous infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
摘要翻译：公开了用于连续输注药物的输注装置，其中输注通过两个单独的流体通信来控制。在每个流体通路中通过限制装置和阀装置控制输注，并且流体通信中的一个进一步包含用于推注速率的保持装置。该装置包括流动调节装置，其包括由至少第一元件和第二元件限定的通道，其中第一和第二元件中的至少一个是适于弹性变形的主要可变形元件，以便改变横截面积的通道。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

3. 发明授权

US07517335B2 Device for administering of medication in fluid form 有权
标题翻译：用于以流体形式施用药物的装置
公开(公告)号：US07517335B2
公开(公告)日：2009-04-14
申请号：US10503845
申请日：2003-02-18
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M37/00
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuous infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications farther contains a holding device for bolus rate of infusion for a short period. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber Increases the volume of the second chamber decreases.
摘要翻译：公开了用于连续输注药物的输注装置，其中输注通过两个单独的流体通信来控制。在每个通过限制装置和阀装置控制的流体连通中的输注是，流体通信中的一个进一步包含用于短时间的推注速率的保持装置。该装置包括流动调节装置，其包括由至少第一元件和第二元件限定的通道，其中第一和第二元件中的至少一个是适于弹性变形的主要可变形元件，以便改变横截面积的通道。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

4. 发明申请

US20050165384A1 Device for administering of medication in gluid form 有权
标题翻译：用于以胶体形式施用药物的装置
公开(公告)号：US20050165384A1
公开(公告)日：2005-07-28
申请号：US10503845
申请日：2003-02-18
申请人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
发明人： Peter Gravesen , Per Brandt Rasmussen , Holger Dirac
IPC分类号： A61M5/00 , A61M5/142 , A61M5/145 , A61M5/168 , A61M39/00 , A61K9/22
CPC分类号： A61M5/16881 , A61M5/141 , A61M5/14244 , A61M5/14276 , A61M5/148 , A61M5/152 , A61M5/16804 , A61M5/16813 , A61M5/16854 , A61M2005/1405 , A61M2205/0244 , A61M2205/0294 , A61M2205/3306 , A61M2205/3331
摘要： An infusion device for continuously infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion for a short period. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
摘要翻译：公开了一种用于持续输注药物的输注装置，其中输注通过两个单独的流体通信进行控制。在每个通过限制装置和阀装置控制的流体连通中的输注，并且流体通信中的一个进一步包含用于短时间的推注速率的保持装置。该装置包括流动调节装置，其包括由至少第一元件和第二元件限定的通道，其中第一和第二元件中的至少一个是适于弹性变形的主要可变形元件，以便改变横截面积的通道。此外，该装置包括用于存储和供应流体形式的药物的容器，所述容器包括相对于彼此布置的第一和第二腔室，使得当第一腔室的体积增加时，第二腔室的体积减小。

5. 发明授权

US07431052B2 Flow restrictor and system for delivering a flow of liquid in a microcapillary 有权
标题翻译：用于在微毛细管中输送液体流的限流器和系统
公开(公告)号：US07431052B2
公开(公告)日：2008-10-07
申请号：US10570979
申请日：2004-09-04
申请人： Peter Gravesen , Martin Manscher , Per Brandt Rasmussen
发明人： Peter Gravesen , Martin Manscher , Per Brandt Rasmussen
IPC分类号： F16L55/00
CPC分类号： F16K99/0001 , A61M5/141 , A61M5/14276 , A61M5/16877 , F15C5/00 , F16K99/0017 , F16K99/0026 , F16K99/0057 , F16K2099/0086
摘要： The present invention relates to apparatus for delivering a controlled or restricted flow of liquid and limiting bubble fragmentation at the inlet. This is achieved in flow restrictor with a flow channel having over most of its length a substantially constant, minimum hydraulic diameter D=4A/W wherein A is the minimum local cross-sectional area of the channel and W is the minimum local wetting perimeter of the channel, by smoothly widening the channel at its inlet such that: at distances z from the inlet face with 0
摘要翻译：本发明涉及用于输送受控或限制的液体流并限制入口处气泡破裂的装置。这是在流量限制器中实现的，其中流动通道的大部分长度基本上恒定，最小水力直径D = 4A / W，其中A是通道的最小局部横截面面积，W是最小局部润湿周长该通道通过在其入口处平滑地加宽通道，使得在距离入口面0和Z 的距离z处，通道具有液压直径D z >> = k * D其中k> = 1.3; 在与z <1 2的入口面的距离z处，通道具有水力直径D z z，其中k * D> = D z z / / SUB >> = D; 并且在距离入口面z z的距离z处，通道具有水力直径D z z，其中D z z = 1.02D ，除了可能在出口处的通道类似的扩大。已经发现，在入口处扩大流动通道，使得其直径在至少3个通道直径的长度上平滑且逐渐增加，优选至少为1.3倍，显着降低了微毛细管中气泡分裂的趋势流量限制器，并且还显着提高了运行良好的装置的产量。

6. 发明申请

US20100218834A1 MICRO FLUID DEVICE WITH A MULTI LUMEN HOSE 审中-公开
标题翻译：具有多个软管的微流体装置
公开(公告)号：US20100218834A1
公开(公告)日：2010-09-02
申请号：US12524896
申请日：2007-01-30
申请人： Per Brandt Rasmussen , Peter Gravesen
发明人： Per Brandt Rasmussen , Peter Gravesen
IPC分类号： F16L3/01
CPC分类号： B01L3/502715 , B01J2219/0081 , B01L3/565 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , Y10T137/8593
摘要： The invention provides a micro fluid device comprising a substrate with a channel forming a receiving cavity, an outer chamber, and an inner chamber, the device further comprising a multi lumen hose with a free end portion which is fixed in the receiving cavity. The multi lumen hose forming a first conduit and at least one second conduit located radially offset from the first conduit, and the outer chamber is in fluid communication with at least one second conduit, and the inner chamber is in fluid communication with the first conduit. The chambers are separated by an inner sealing member located between the substrate and the hose. To simplify the manufacturing of the device, the channel is formed by a groove in an upper surface of a body of the substrate, which groove closed by an essentially plane cover which is sealed to the upper surface.
摘要翻译：本发明提供了一种微流体装置，其包括具有形成容纳空腔的通道的衬底，外部腔室和内部腔室，该装置还包括多腔软管，其具有固定在容纳腔中的自由端部分。所述多腔软管形成第一导管和位于径向偏离所述第一导管的至少一个第二导管，并且所述外室与至少一个第二导管流体连通，并且所述内室与所述第一导管流体连通。这些室由位于基底和软管之间的内部密封构件分开。为了简化装置的制造，通道由衬底的主体的上表面中的凹槽形成，该凹槽由基本上平面的盖封闭，该盖子被密封到上表面。

7. 发明申请

US20090145502A1 FLOW SYSTEM AND A MICRO FLUIDIC SYSTEM COMPRISING A FLOW SYSTEM 审中-公开
标题翻译：流动系统和包含流动系统的微流体系统
公开(公告)号：US20090145502A1
公开(公告)日：2009-06-11
申请号：US12091134
申请日：2006-10-24
申请人： Holger Dirac , Peter Gravesen , Kasper Oktavio Schweitz
发明人： Holger Dirac , Peter Gravesen , Kasper Oktavio Schweitz
IPC分类号： G05D7/01 , F15C1/06
CPC分类号： G05D7/0186 , F16K31/002 , F16K99/0001 , F16K99/0026 , F16K99/0036 , F16K99/0061 , F16K2099/0084 , F16K2099/0086 , Y10T137/1963 , Y10T137/206 , Y10T137/2224
摘要： A flow system (1) comprising a first part (2) and a second part (3), the parts (2, 3) being made from materials having different coefficients of thermal expansion. The first (2) and second (3) parts are positioned relatively to each other in such a way that when the ambient temperature changes corresponding changes are caused in a flow channel (4) formed in the first part (2), thereby changing the flow resistance of the flow channel (4). Thereby a change in flow resistance caused by a change in viscosity of a fluid being transported by the flow system (1) can be counteracted. The resulting flow resistance of the flow system (1) is thereby at least substantially independent of the ambient temperature. Furthermore, a micro fluidic system comprising the flow system (1). The micro fluidic system may be or form part of a medical device, a fluid analysis system, e.g. a device for measuring blood glucose levels of blood samples, or an infusion device.
摘要翻译：一种包括第一部分（2）和第二部分（3）的流动系统（1），所述部分（2,3）由具有不同热膨胀系数的材料制成。第一（2）和第二（3）部分彼此相对定位，使得当在形成于第一部分（2）中的流动通道（4）中引起环境温度变化时，引起相应的变化，从而改变流动通道（4）的流动阻力。由此，可以抵消由流动系统（1）输送的流体的粘度变化引起的流动阻力的变化。因此，流动系统（1）的所得流动阻力至少基本上与环境温度无关。此外，包括流动系统（1）的微流体系统。微流体系统可以是或形成医疗装置的一部分，流体分析系统，例如，用于测量血液样本的血糖水平的装置或输注装置。

8. 发明申请

US20110043357A1 METHODS FOR DETECTING FAILURE STATES IN A MEDICINE DELIVERY DEVICE 有权
标题翻译：用于检测药物递送装置中的失败状态的方法
公开(公告)号：US20110043357A1
公开(公告)日：2011-02-24
申请号：US12542954
申请日：2009-08-18
申请人： Greg Peatfield , Peter Gravesen
发明人： Greg Peatfield , Peter Gravesen
IPC分类号： G08B19/00 , A61M5/14
CPC分类号： A61M5/5086 , A61M5/14 , A61M5/1413 , A61M5/14248 , A61M5/16831 , A61M5/16854 , A61M5/16886 , A61M2005/14252 , A61M2005/14264 , A61M2005/14268 , A61M2005/16863 , A61M2205/0244 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3358 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/587 , A61M2205/70 , A61M2207/00
摘要： A fluid medicament delivery device includes a patient attachment unit, containing the fluid medicament, and an indicator unit adapted to be detachably coupled to the patient attachment unit. A method for monitoring the fluid medicament includes independently setting a flow rate of a fluid medicament with the patient attachment unit. A pressure and/or a flow rate of the fluid medicament is sensed with a sensor located in a separate indicator unit in a sensing mode. A status of the fluid medicament delivery device is determined based at least in part on the pressure and/or the flow rate.
摘要翻译：流体药物输送装置包括容纳流体药物的患者附着单元和适于可拆卸地联接到患者附着单元的指示器单元。用于监测流体药物的方法包括独立地设置流体药物与患者附着单元的流速。用感测模式中位于分离的指示器单元中的传感器感测流体药物的压力和/或流速。至少部分地基于压力和/或流速来确定流体药物输送装置的状态。

9. 发明申请

US20100281990A1 Low-Dead Volume Microfluidic Circuit and Methods 有权
标题翻译：低死体积微流体电路和方法
公开(公告)号：US20100281990A1
公开(公告)日：2010-11-11
申请号：US12436365
申请日：2009-05-06
申请人： Peter Gravesen , Heiko Arndt
发明人： Peter Gravesen , Heiko Arndt
IPC分类号： G01L7/08 , F17D3/00 , B65D25/04
CPC分类号： G01L19/0007 , A61M5/141 , A61M5/142 , A61M5/14248 , A61M5/152 , A61M5/158 , A61M2005/1405 , A61M2005/14252 , A61M2206/20 , B01L2200/0605 , B01L2300/14 , B01L2400/0633 , F04B19/006 , Y10T137/0402
摘要： A method is described for reducing a dead volume of a microfluidic circuit that includes, in one embodiment, a reservoir, an outlet, and a microfluidic flowpath fluidly connecting the reservoir and the outlet. The method includes providing a microfluidic flow component between the reservoir and the outlet for performing a function and in fluidic communication with the microfluidic flowpath, wherein the microfluidic flow component includes a total volume including a working volume and a dead volume. The working volume is a volume necessary for the microfluidic flow component to perform the function and the dead volume is a volume unnecessary for the microfluidic flow component to perform the function. The method includes configuring at least one of the reservoir, the microfluidic flowpath, and the microfluidic flow component to reduce the dead volume, such that the working volume of the component is substantially the same as the total volume.
摘要翻译：描述了一种用于减少微流体电路的死体积的方法，其在一个实施例中包括流体连接储存器和出口的储存器，出口和微流体流路。该方法包括在储存器和出口之间提供微流体流动部件，用于执行功能并与微流体流动路径流体连通，其中微流体流动部件包括包括工作容积和死体积的总体积。工作体积是微流体流动部件执行功能所需的体积，并且死体积是微流体流动部件执行功能所不需要的体积。该方法包括配置储存器，微流体流路和微流体流动分量中的至少一个以减少死体积，使得部件的工作体积基本上与总体积相同。

10. 发明申请

US20090072658A1 DIELECTRIC COMPOSITE AND A METHOD OF MANUFACTURING A DIELECTRIC COMPOSITE 有权
标题翻译：电介质复合材料和制造电介质复合材料的方法
公开(公告)号：US20090072658A1
公开(公告)日：2009-03-19
申请号：US11592506
申请日：2006-11-03
申请人： Mohamed Yahia Benslimane , Peter Gravesen
发明人： Mohamed Yahia Benslimane , Peter Gravesen
IPC分类号： H02N1/00
CPC分类号： H02N1/006 , B81B3/007 , B81B2201/038 , H01L41/0471 , H01L41/083 , H01L41/0836 , H01L41/0986 , H01L41/27 , H01L41/333 , H01L41/45 , H04R23/00 , Y10S310/80 , Y10T428/24612
摘要： A composite for a transducer facilitates an increased actuation force as compared to similar prior art composites for transducers. In accordance with the present invention, the composite also facilitates increased compliance of the transducer in one direction and an improved reaction time as compared to similar prior art composites for transducers, as well as provides an increased lifetime of the transducer in which it is applied.
摘要翻译：与用于换能器的类似的现有技术复合材料相比，用于换能器的复合材料促进了增加的致动力。根据本发明，与用于换能器的类似的现有技术复合材料相比，复合材料还有助于提高换能器在一个方向上的顺应性和改进的反应时间，并且提供其应用传感器的寿命增加。

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