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1. 发明申请

US20080299042A1 Membrane Associated Molecules 审中-公开
标题翻译：膜相关分子
公开(公告)号：US20080299042A1
公开(公告)日：2008-12-04
申请号：US11579106
申请日：2005-05-02
申请人： Pamela Bechtel , Mark Daniels , Karen McLachlan , Yufeng Zhai , Benjamin L. Colson , Nicole W. O'Brien
发明人： Pamela Bechtel , Mark Daniels , Karen McLachlan , Yufeng Zhai , Benjamin L. Colson , Nicole W. O'Brien
IPC分类号： A61K49/00 , C40B40/08 , C40B50/02 , C07H21/00 , A61P31/00 , C07K14/00 , A61K39/395 , G01N33/574
CPC分类号： C07H21/04 , C07K14/47
摘要： The present invention is directed to novel methods of treating, identifying or diagnosing a hyperproliferative disorder in a patient in need thereof. The methods of the invention include administering to a patient a composition comprising a binding molecule which binds to a cell surface expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to a membrane associated molecule, variant polypeptide or fragment thereof. The present invention is based, at least in part, on the discovery of membrane associated proteins, i.e., nucleic acid molecules which encode membrane proteins and the use of these molecules to generate custom arrays to screen for markers associated with various diseases and disorders, e.g., cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders. The invention further relates to various methods, reagents and kits for diagnosing, staging, prognosing, monitoring and treating hyperproliferative diseases or disorders such as cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders.
摘要翻译：本发明涉及在有需要的患者中治疗，鉴定或诊断过度增殖性疾病的新方法。本发明的方法包括向患者施用包含与主要在肿瘤或肿瘤相关细胞中表达的表达糖蛋白结合的结合分子的组合物。特别地，本发明的治疗和诊断方法包括使用特异性结合膜相关分子，变体多肽或其片段的结合分子，例如抗体或其免疫特异性片段。本发明至少部分地基于膜相关蛋白的发现，即编码膜蛋白的核酸分子以及这些分子用于产生定制阵列以筛选与各种疾病和病症相关的标记的用途，例如，癌症，例如肺，结肠，胰腺和卵巢癌以及自身免疫性疾病或病症。本发明还涉及用于诊断，分期，预后，监测和治疗过度增殖性疾病或病症如癌症，例如肺，结肠，胰腺和卵巢癌以及自身免疫性疾病或病症的各种方法，试剂和试剂盒。

2. 发明申请

US20070073047A1 Genes overexpressed by ovarian cancer and their use in developing novel therapeutics 审中-公开
标题翻译：卵巢癌过度表达的基因及其在开发新药治疗中的应用
公开(公告)号：US20070073047A1
公开(公告)日：2007-03-29
申请号：US10530951
申请日：2003-06-10
申请人： Hariharan Kandasamy , Mark Daniels , Karen McLachlan
发明人： Hariharan Kandasamy , Mark Daniels , Karen McLachlan
IPC分类号： A61K48/00 , C07K14/82 , C07K16/30 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/3069 , C07K2319/00 , C07K2319/30 , G01N33/57449
摘要： Nucleic acid sequences encoding genes that are overexpressed by human ovarian cancers are provided. These genes and the corresponding antigens are useful diagnostic and therapeutic targets. The invention provides cancer therapies that target these antigens, especially using monoclonal antibodies that target the Anat-2 antigen.
摘要翻译：提供编码人卵巢癌过表达基因的核酸序列。这些基因和相应的抗原是有用的诊断和治疗靶点。本发明提供靶向这些抗原的癌症疗法，特别是使用靶向Anat-2抗原的单克隆抗体。

3. 发明申请

US20120064080A1 Human LY6-Big Molecules and Methods of Use 审中-公开
标题翻译：人类LY6大分子和使用方法
公开(公告)号：US20120064080A1
公开(公告)日：2012-03-15
申请号：US13070468
申请日：2011-03-23
申请人： Peter CHU , Mark Daniels , Robert Peach , Karen McLachlan , Jaeho Jung , Scott Glaser
发明人： Peter CHU , Mark Daniels , Robert Peach , Karen McLachlan , Jaeho Jung , Scott Glaser
IPC分类号： A61K39/395 , C07K14/00 , A61P35/00 , C07K16/00 , A61P37/02 , C07H21/04 , C12N5/071
CPC分类号： C07K16/28 , C07K14/705
摘要： The present invention is directed to human Ly6-BIG molecules and their use in diagnostic, prognostic, and treatment methods for colon, lung and other cancers, in preventing the reoccurrence of such cancers, and in diagnostic, prognostic, and treatment methods for autoimmune disorders and AIDS.
摘要翻译：本发明涉及人Ly6-BIG分子及其在结肠癌，肺癌和其他癌症的诊断，预后和治疗方法中的用途，用于预防这种癌症的复发，以及用于自身免疫疾病的诊断，预后和治疗方法和艾滋病。

4. 发明申请

US20090047737A1 Human LY6-Big Molecules and Methods of Use 审中-公开
标题翻译：人类LY6大分子和使用方法
公开(公告)号：US20090047737A1
公开(公告)日：2009-02-19
申请号：US11665986
申请日：2005-10-24
申请人： Peter Chu , Mark Daniels , Robert Peach , Karen McLachlan , Jaeho Jung , Scott Glaser
发明人： Peter Chu , Mark Daniels , Robert Peach , Karen McLachlan , Jaeho Jung , Scott Glaser
IPC分类号： C12N5/06 , C12N15/11 , C07K16/18 , C07K14/00
CPC分类号： C07K16/28 , C07K14/705
摘要： The present invention is directed to human Ly6-BIG molecules and their use in diagnostic, prognostic, and treatment methods for colon, lung and other cancers, in preventing the reoccurrence of such cancers, and in diagnostic, prognostic, and treatment methods for autoimmune disorders and AIDS.
摘要翻译：本发明涉及人Ly6-BIG分子及其在结肠癌，肺癌和其他癌症的诊断，预后和治疗方法中的用途，用于预防这种癌症的复发，以及用于自身免疫疾病的诊断，预后和治疗方法和艾滋病。

5. 发明申请

US20060204503A1 Treatment of cancer using antibodies to polypeptides differentially expressed in human lung tumors 审中-公开
标题翻译：使用在人肺肿瘤中差异表达的多肽的抗体治疗癌症
公开(公告)号：US20060204503A1
公开(公告)日：2006-09-14
申请号：US11343271
申请日：2006-01-31
申请人： Jonathon Fitchett , Mark Daniels , Michael Labarre , Karen McLachlan , Tony Rowe , Nicole O'Brien , Samuel Cho , Melissa Heller
发明人： Jonathon Fitchett , Mark Daniels , Michael Labarre , Karen McLachlan , Tony Rowe , Nicole O'Brien , Samuel Cho , Melissa Heller
IPC分类号： A61K39/395 , C07K16/30 , C40B40/10 , C12P21/04
CPC分类号： G01N33/57423 , A61K47/60 , A61K47/64
摘要： The present invention is directed to novel methods of treating, indentifying or diagnosing a hyperproliferative disorder in a patient in need thereof. The methods of the invention include administering to a patient a composition comprising a binding molecule which binds to a cell surface expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to a lung tumor-associated polypeptide, variant polypeptide or fragment thereof.
摘要翻译：本发明涉及在有需要的患者中治疗，鉴别或诊断过度增殖性疾病的新方法。本发明的方法包括向患者施用包含与主要在肿瘤或肿瘤相关细胞中表达的表达糖蛋白结合的结合分子的组合物。特别地，本发明的治疗和诊断方法包括使用特异性结合肺肿瘤相关多肽，变体多肽或其片段的结合分子，例如抗体或其免疫特异性片段。

6. 发明申请

US20070071674A1 Polynucleotides encoding novel isoforms of IGSF9 审中-公开
标题翻译：编码IGSF9新型同工型的多核苷酸
公开(公告)号：US20070071674A1
公开(公告)日：2007-03-29
申请号：US11488161
申请日：2006-07-18
申请人： Karen McLachlan , Scott Glaser , Robert Peach , Tony Rowe
发明人： Karen McLachlan , Scott Glaser , Robert Peach , Tony Rowe
IPC分类号： A61K51/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82
CPC分类号： C07K14/70503 , A61K51/1027 , A61K51/1045 , C07K14/47 , C07K16/2803 , C07K16/30 , C07K2319/30
摘要： Human IGSF9 and LIV-1 polypeptides and DNA (RNA) encoding such polypeptides are disclosed. The disclosed polypeptides and/or polynucleotide are particularly useful generating antibodies, both modified and native, which bind IGSF9 or LIV-1. Also disclosed are pharmaceutical compositions and vaccines comprising the antibodies, polypeptides and polynucleotides of the invention. Also disclosed are methods for utilizing such polypeptides for identifying ligands, antagonists and agonists to said polypeptides. Finally, methods comprising the above-mentioned compositions are disclosed for the treatment, diagnosis, and/or prognosis of neoplastic disorders.
摘要翻译：公开了人IGSF9和LIV-1多肽和编码这种多肽的DNA（RNA）。公开的多肽和/或多核苷酸是特别有用的，其产生结合IGSF9或LIV-1的经修饰和天然的抗体。还公开了包含本发明的抗体，多肽和多核苷酸的药物组合物和疫苗。还公开了利用这些多肽鉴定所述多肽的配体，拮抗剂和激动剂的方法。最后，公开了包含上述组合物的方法用于肿瘤性疾病的治疗，诊断和/或预后。

7. 发明申请

US20060089493A1 Novel gene targets and ligands that bind thereto for treatment and diagnosis of colon carcinomas 审中-公开
标题翻译：结合其的新型基因靶标和配体用于结肠癌的治疗和诊断
公开(公告)号：US20060089493A1
公开(公告)日：2006-04-27
申请号：US10509131
申请日：2003-03-28
申请人： Karen McLachlan , Dennis Gately
发明人： Karen McLachlan , Dennis Gately
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30 , A61K48/00
CPC分类号： G01N33/57419 , C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： Nucleic acids and proteins that are overexpressed in colon or colorectal tumor tissues, and which are useful diagnostic and therapeutic targets.
摘要翻译：在结肠或结肠直肠肿瘤组织中过表达的核酸和蛋白质，是有用的诊断和治疗靶点。

8. 发明申请

US20050239700A1 Treatment of cancer using antibodies to LRRC15 审中-公开
标题翻译：使用LRRC15抗体治疗癌症
公开(公告)号：US20050239700A1
公开(公告)日：2005-10-27
申请号：US10963987
申请日：2004-10-14
申请人： William Kloetzer , Karen McLachlan , Michael La Barre , Jonathon Fitchett , Robert Peach , Bill Shestowsky , Scott Glaser
发明人： William Kloetzer , Karen McLachlan , Michael La Barre , Jonathon Fitchett , Robert Peach , Bill Shestowsky , Scott Glaser
IPC分类号： A61K38/17 , A61K39/395 , A61K48/00 , C07K16/30 , C12N20060101
CPC分类号： C07K16/30 , C07K2319/30
摘要： The present invention is directed to novel methods of treating or diagnosing a hyperproliferative disease or disorder in an patient, where the methods include administrating to the patient a binding molecule which binds to a cell surface-expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to the human LRRC15 protein. The present invention further provides a method of isolating and identifying cell surface expressed glycoproteins expressed in tumor or tumor associated tissues, where the method includes isolating desired glycoproteins via their affinity for specific lectins.
摘要翻译：本发明涉及治疗或诊断患者过度增殖性疾病或病症的新方法，其中所述方法包括向患者施用结合分子，其结合主要在肿瘤或肿瘤相关细胞中表达的细胞表达的糖蛋白。特别地，本发明的治疗和诊断方法包括使用与人LRRC15蛋白特异性结合的结合分子，例如抗体或其免疫特异性片段。本发明还提供了分离和鉴定在肿瘤或肿瘤相关组织中表达的细胞表面表达的糖蛋白的方法，其中所述方法包括通过其对特异性凝集素的亲和力分离所需的糖蛋白。

9. 发明申请

US20100266587A1 Compositions and Methods to Treat Acute Myelogenous Leukemia 审中-公开
标题翻译：治疗急性骨髓性白血病的组合物和方法
公开(公告)号：US20100266587A1
公开(公告)日：2010-10-21
申请号：US12761853
申请日：2010-04-16
申请人： Karen McLachlan
发明人： Karen McLachlan
IPC分类号： A61K39/395 , A61P35/02
CPC分类号： C07K16/2842 , C07K2317/24 , C07K2317/76
摘要： Compositions and methods for treating or preventing a hematologic malignancy, such as AML, using an anti-alpha4 antibody are described.
摘要翻译：描述了使用抗α4抗体治疗或预防血液恶性肿瘤（例如AML）的组合物和方法。

10. 发明申请

US20080213166A1 Novel Gene Targets and Ligands that Bind Thereto for Treatment and Diagnosis of Colon Carcinomas 审中-公开
标题翻译：用于治疗和诊断结肠癌的新型基因靶标和配体
公开(公告)号：US20080213166A1
公开(公告)日：2008-09-04
申请号：US10535458
申请日：2003-11-20
申请人： Karen McLachlan , Dennis P. Gately
发明人： Karen McLachlan , Dennis P. Gately
IPC分类号： A61K51/10 , C07H21/00 , C07K16/18 , C12Q1/68 , A61K31/7105 , A61K31/711 , A61K38/00 , G01N33/53 , C07K2/00 , A61K39/395 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Isolated nucleic acids and proteins that are overexpressed in human cancers, and antibodies that specifically bind the proteins, which are useful diagnostic and therapeutic targets.
摘要翻译：在人类癌症中过表达的分离的核酸和蛋白质，以及特异性结合蛋白质的抗体，这是有用的诊断和治疗靶点。

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