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1. 发明申请

US20080299042A1 Membrane Associated Molecules 审中-公开
标题翻译：膜相关分子
公开(公告)号：US20080299042A1
公开(公告)日：2008-12-04
申请号：US11579106
申请日：2005-05-02
申请人： Pamela Bechtel , Mark Daniels , Karen McLachlan , Yufeng Zhai , Benjamin L. Colson , Nicole W. O'Brien
发明人： Pamela Bechtel , Mark Daniels , Karen McLachlan , Yufeng Zhai , Benjamin L. Colson , Nicole W. O'Brien
IPC分类号： A61K49/00 , C40B40/08 , C40B50/02 , C07H21/00 , A61P31/00 , C07K14/00 , A61K39/395 , G01N33/574
CPC分类号： C07H21/04 , C07K14/47
摘要： The present invention is directed to novel methods of treating, identifying or diagnosing a hyperproliferative disorder in a patient in need thereof. The methods of the invention include administering to a patient a composition comprising a binding molecule which binds to a cell surface expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to a membrane associated molecule, variant polypeptide or fragment thereof. The present invention is based, at least in part, on the discovery of membrane associated proteins, i.e., nucleic acid molecules which encode membrane proteins and the use of these molecules to generate custom arrays to screen for markers associated with various diseases and disorders, e.g., cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders. The invention further relates to various methods, reagents and kits for diagnosing, staging, prognosing, monitoring and treating hyperproliferative diseases or disorders such as cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders.
摘要翻译：本发明涉及在有需要的患者中治疗，鉴定或诊断过度增殖性疾病的新方法。本发明的方法包括向患者施用包含与主要在肿瘤或肿瘤相关细胞中表达的表达糖蛋白结合的结合分子的组合物。特别地，本发明的治疗和诊断方法包括使用特异性结合膜相关分子，变体多肽或其片段的结合分子，例如抗体或其免疫特异性片段。本发明至少部分地基于膜相关蛋白的发现，即编码膜蛋白的核酸分子以及这些分子用于产生定制阵列以筛选与各种疾病和病症相关的标记的用途，例如，癌症，例如肺，结肠，胰腺和卵巢癌以及自身免疫性疾病或病症。本发明还涉及用于诊断，分期，预后，监测和治疗过度增殖性疾病或病症如癌症，例如肺，结肠，胰腺和卵巢癌以及自身免疫性疾病或病症的各种方法，试剂和试剂盒。

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