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1. 发明申请

US20130275842A1 METHODS AND SYSTEMS FOR CONSISTENCY CHECKING AND ANOMALY DETECTION IN AUTOMATIC IDENTIFICATION SYSTEM SIGNAL DATA 有权
标题翻译：自动识别系统信号数据中一致性检查和异常检测的方法与系统
公开(公告)号：US20130275842A1
公开(公告)日：2013-10-17
申请号：US13445552
申请日：2012-04-12
申请人： Robert Peach
发明人： Robert Peach
IPC分类号： G06F11/07
CPC分类号： G06F11/0751 , H04B7/18513
摘要： Methods and systems for validating positions reported in AIS message signals by fitting suitably chosen functions to signal characteristic data, such as timing and Doppler shift data, derived from a plurality of AIS message signals. Ships whose reported positions deviate from the fitted function may be flagged as suspect.
摘要翻译：通过拟合适当选择的功能来信号从多个AIS消息信号导出的诸如定时和多普勒频移数据的特征数据来验证AIS消息信号中报告的位置的方法和系统。报告的位置偏离拟合功能的船舶可能被标记为可疑。

2. 发明申请

US20110075602A1 SYSTEMS AND METHODS FOR DECODING AUTOMATIC IDENTIFICATION SYSTEM SIGNALS 有权
标题翻译：用于解码自动识别系统信号的系统和方法
公开(公告)号：US20110075602A1
公开(公告)日：2011-03-31
申请号：US12567104
申请日：2009-09-25
申请人： Robert Peach , Weiguo Chen
发明人： Robert Peach , Weiguo Chen
IPC分类号： H04J3/08
CPC分类号： G01S13/9307 , G01S1/68 , G01S5/0018 , G08G3/00 , H04B7/18513
摘要： A method of extracting automatic identification system (AIS) message segments from AIS signals received by a satellite. The method includes: (a) receiving AIS signals from satellite antennas; (b) generating multiple versions of the AIS signals; (c) extracting message segments contained within each of the AIS signals using one or more AIS receivers; (d) sorting the message segments by time; and (e) deleting any duplicate message segments. Multiple versions of the AIS signals may be generated by one or more of the following methods: (i) processing the AIS signals multiple times, each time with different AIS receiver parameter settings; (ii) splitting each signal into multiple signals and filtering each of the multiple signals separately; (iii) receiving multiple AIS signals and combining them with different phases and amplitudes to produce a plurality of combined AIS signals; and (iv) removing extracted message segments from the received AIS signals and reprocessing the modified AIS signals.
摘要翻译：一种从卫星接收的AIS信号中提取自动识别系统（AIS）消息段的方法。该方法包括：（a）从卫星天线接收AIS信号; （b）产生AIS信号的多个版本; （c）使用一个或多个AIS接收机提取包含在每个AIS信号内的消息段; （d）按时间对消息片段进行排序; 和（e）删除任何重复的消息段。可以通过以下一种或多种方法产生AIS信号的多个版本：（i）每次使用不同的AIS接收机参数设置多次处理AIS信号; （ii）将每个信号分成多个信号并分别对多个信号中的每个信号进行滤波; （iii）接收多个AIS信号并将它们与不同的相位和振幅组合以产生多个组合的AIS信号; 以及（iv）从所接收的AIS信号中去除提取出的消息段，并重新处理修改后的AIS信号。

3. 发明授权

US07876865B2 System and method for decoding automatic identification system signals 有权
标题翻译：解码自动识别系统信号的系统和方法
公开(公告)号：US07876865B2
公开(公告)日：2011-01-25
申请号：US11760358
申请日：2007-06-08
申请人： Robert Peach
发明人： Robert Peach
IPC分类号： H03D1/00
CPC分类号： G08G3/02 , H04B7/18513
摘要： Various embodiments are described herein for a system and method of detecting Automatic Identification System (AIS) signals in space and decoding these signals. In one aspect, a system for performing this function is described which includes a receiver configured to receive the plurality of AIS signals and pre-process the plurality of AIS signals to produce digital input data, and a processing unit configured to process the digital input data to identify one or more candidate AIS message signals based on Doppler offsets associated with the digital input data, determine corresponding Doppler offset estimates and time estimates of the one or more candidate AIS message signals, decode the one or more candidate AIS message signals to obtain corresponding message segments and validate the decoded message segments for proper AIS formatting.
摘要翻译：这里描述了用于检测空间中的自动识别系统（AIS）信号并对这些信号进行解码的系统和方法的各种实施例。一方面，描述了一种用于执行该功能的系统，其包括被配置为接收多个AIS信号并预处理多个AIS信号以产生数字输入数据的接收器，以及处理单元，被配置为处理数字输入数据基于与数字输入数据相关联的多普勒偏移来识别一个或多个候选AIS消息信号，确定一个或多个候选AIS消息信号的相应多普勒偏移估计和时间估计，对一个或多个候选AIS消息信号进行解码以获得对应的消息段并验证解码的消息段以获得正确的AIS格式。

4. 发明申请

US20050208525A1 Polynucleotides encoding B7-related nucleic acid, BSL2vcvc-Ig 有权
标题翻译：编码B7相关核酸的多核苷酸，BSL2vcvc-Ig
公开(公告)号：US20050208525A1
公开(公告)日：2005-09-22
申请号：US10994824
申请日：2004-11-22
申请人： Glen Mikesell , Han Chang , Joshua Finger , Guchen Yang , Robert Peach
发明人： Glen Mikesell , Han Chang , Joshua Finger , Guchen Yang , Robert Peach
IPC分类号： A01K67/027 , A61K35/12 , A61K35/64 , A61K35/74 , A61K36/00 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/04 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P21/00 , A61P21/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/566 , C07H21/04 , C07K14/74
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译：本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。此外，本发明提供利用B7相关核酸，多肽或肽的测定法。本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

5. 发明授权

US6090914A CTLA4/CD28Ig hybrid fusion proteins and uses thereof 失效
标题翻译： CTLA4 / CD28Ig杂合融合蛋白及其用途
公开(公告)号：US6090914A
公开(公告)日：2000-07-18
申请号：US228208
申请日：1994-04-15
申请人： Peter S. Linsley , Jeffrey A. Ledbetter , Jurgen Bajorath , Robert Peach , William Brady
发明人： Peter S. Linsley , Jeffrey A. Ledbetter , Jurgen Bajorath , Robert Peach , William Brady
IPC分类号： C12N15/00 , A61K38/00 , A61K39/395 , A61P29/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/28 , C07K16/46 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/01 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C07K14/7155 , C07K14/70503 , C07K14/70521 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins including CTLA4/CD28 chimeric proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译：本发明鉴定CTLA4受体作为B7抗原的配体。提供编码人CTLA4受体基因的完整氨基酸序列。提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备包括CTLA4 / CD28嵌合蛋白的杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体来调节T 细胞相互作用和由这种相互作用介导的免疫应答。

6. 发明授权

US5822312A Repeaters for multibeam satellites 失效
标题翻译：多波束卫星的中继器
公开(公告)号：US5822312A
公开(公告)日：1998-10-13
申请号：US633676
申请日：1996-04-17
申请人： Robert Peach , Nigel Miller , Bharat Tailor , Kamal Ali , Gary Beauchamp , Simon Lam , Ken Lazaris-Brunner
发明人： Robert Peach , Nigel Miller , Bharat Tailor , Kamal Ali , Gary Beauchamp , Simon Lam , Ken Lazaris-Brunner
IPC分类号： H04B7/204 , H04B7/185
CPC分类号： H04B7/2041
摘要： A repeater for a multibeam communications satellite combines the features of coaxial channel interbeam switching and subchannelization of some of the channels. In one embodiment described, the input radio-frequency signals from the input beams are fed through the input multiplexers to form channels. Some, but not all, channels are subsequently subchannelized for interbeam switching. In another embodiment of the invention, a portion of the incoming radio frequency signals bypasses the input demultiplexer and is filtered for noise-limiting reasons, converted down to an intermediate frequency and then subchannelized using SAW filters. The specification also teaches that digital techniques can be used to obtain the same results. Especially in the case of satellites with a large number of beams and a large number of channels, it is not necessary to have full interbeam switching of all the subchannels derived from one channel: instead, the specification proposes the use of parallel configurations of smaller, less complex switching networks.
摘要翻译：用于多波束通信卫星的中继器结合了同轴信道交织切换和某些信道的子信道化的特征。在所描述的一个实施例中，来自输入光束的输入射频信号通过输入多路复用器馈送以形成信道。一些但不是全部的信道随后被子信道化以进行交换。在本发明的另一实施例中，输入射频信号的一部分绕过输入解复用器，并且由于噪声限制的原因而被滤波，转换成中频，然后使用SAW滤波器进行子信道化。该规范还教导可以使用数字技术获得相同的结果。特别是在具有大量波束和大量信道的卫星的情况下，不需要对从一个信道导出的所有子信道进行完全的交换机切换：相反，本说明书提出使用较小的，较不复杂的交换网络。

7. 发明授权

US5773253A MYPPPY variants of CTL A4 and uses thereof 失效
标题翻译： CTL A4的MYPPPY变体及其用途
公开(公告)号：US5773253A
公开(公告)日：1998-06-30
申请号：US505058
申请日：1995-07-21
申请人： Peter S. Linsley , Jeffrey A. Ledbetter , Robert Peach
发明人： Peter S. Linsley , Jeffrey A. Ledbetter , Robert Peach
IPC分类号： C12N15/09 , A61K38/00 , C07H21/04 , C07K1/22 , C07K14/495 , C07K14/52 , C07K14/525 , C07K14/53 , C07K14/54 , C07K14/55 , C07K14/555 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/00 , C07K16/18 , C07K19/00 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号： C07K14/7155 , C07K14/70521 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The invention provides CTLA4 mutant molecules as ligands for the B7 antigen. Methods are provided for expressing CTLA4 mutant molecules as soluble, functional molecules, for preparing CTLA4 mutant fusion proteins, and for using these soluble molecules to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译：本发明提供CTLA4突变体分子作为B7抗原的配体。提供了用于表达CTLA4突变体分子作为可溶性功能分子的方法，用于制备CTLA4突变融合蛋白，以及使用这些可溶性分子调节由这种相互作用介导的T细胞相互作用和免疫应答。

8. 发明申请

US20070071674A1 Polynucleotides encoding novel isoforms of IGSF9 审中-公开
标题翻译：编码IGSF9新型同工型的多核苷酸
公开(公告)号：US20070071674A1
公开(公告)日：2007-03-29
申请号：US11488161
申请日：2006-07-18
申请人： Karen McLachlan , Scott Glaser , Robert Peach , Tony Rowe
发明人： Karen McLachlan , Scott Glaser , Robert Peach , Tony Rowe
IPC分类号： A61K51/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82
CPC分类号： C07K14/70503 , A61K51/1027 , A61K51/1045 , C07K14/47 , C07K16/2803 , C07K16/30 , C07K2319/30
摘要： Human IGSF9 and LIV-1 polypeptides and DNA (RNA) encoding such polypeptides are disclosed. The disclosed polypeptides and/or polynucleotide are particularly useful generating antibodies, both modified and native, which bind IGSF9 or LIV-1. Also disclosed are pharmaceutical compositions and vaccines comprising the antibodies, polypeptides and polynucleotides of the invention. Also disclosed are methods for utilizing such polypeptides for identifying ligands, antagonists and agonists to said polypeptides. Finally, methods comprising the above-mentioned compositions are disclosed for the treatment, diagnosis, and/or prognosis of neoplastic disorders.
摘要翻译：公开了人IGSF9和LIV-1多肽和编码这种多肽的DNA（RNA）。公开的多肽和/或多核苷酸是特别有用的，其产生结合IGSF9或LIV-1的经修饰和天然的抗体。还公开了包含本发明的抗体，多肽和多核苷酸的药物组合物和疫苗。还公开了利用这些多肽鉴定所述多肽的配体，拮抗剂和激动剂的方法。最后，公开了包含上述组合物的方法用于肿瘤性疾病的治疗，诊断和/或预后。

9. 发明申请

US20050214313A1 Soluble CTLA4 mutant molecules and uses thereof 有权
标题翻译：可溶性CTLA4突变体分子及其用途
公开(公告)号：US20050214313A1
公开(公告)日：2005-09-29
申请号：US10980742
申请日：2004-11-03
申请人： Robert Peach , Joseph Naemura , Peter Linsley , Jurgen Bajorath
发明人： Robert Peach , Joseph Naemura , Peter Linsley , Jurgen Bajorath
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , C07H21/04 , C07K14/705 , C07K14/74 , C12N5/0783 , C12N15/09
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/1774 , A61K39/39 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/70521 , C07K2319/30 , C12N5/0636 , C12N2501/51
摘要： The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.
摘要翻译：本发明提供与野生型CTLA4或非突变型CTLA4Ig相比，其结合比CD80和/或CD86抗原更高亲合力的可溶性CTLA4突变体分子。可溶性CTLA4分子具有包含CTLA4细胞外结构域的第一个氨基酸序列，其中S25-R33区域和M97-G107区域内的某些氨基酸残基被突变。本发明的突变分子还可以包括增加突变分子的溶解度的第二个氨基酸序列。

10. 发明授权

US06300775B1 Scattering parameter calibration system and method 有权
标题翻译：散射参数校准系统及方法
公开(公告)号：US06300775B1
公开(公告)日：2001-10-09
申请号：US09241704
申请日：1999-02-02
申请人： Robert Peach , Nicholas Svensson , Thai Vo
发明人： Robert Peach , Nicholas Svensson , Thai Vo
IPC分类号： G01R2728
CPC分类号： G01R27/28 , G01R35/00
摘要： A system and method of calibrating an S parameter measurement instrument (such as a vector network analyzer) in which the number of calibrations required to fully characterize the error model of an n-port system is n/2 calibrations for an even number of ports and (n+1)/2 calibrations for an odd number of ports. Each test port in the system is involved in at least one full calibration, thus n/2 test paths are fully calibrated. For each measured test path, the error terms of the applicable error model are calculated. These error terms are then decoupled from the associated test path into error parameters that are localized to the individual test ports of the test path. Having localized the error parameters, the error model for each test port can then be treated independently from the other test ports. The error terms for the test paths that are not calibrated are then constructed using the localized error parameters for the individual test ports.
摘要翻译：校准S参数测量仪器（如矢量网络分析仪）的系统和方法，其中完全表征n端口系统的误差模型所需的校准次数为偶数个端口的n / 2校准，（n + 1）/ 2个校准。系统中的每个测试端口都参与至少一次完全校准，因此n / 2个测试路径被完全校准。对于每个测量的测试路径，计算适用误差模型的误差项。然后将这些误差项从相关联的测试路径解耦到被定位到测试路径的各个测试端口的错误参数。本地化了错误参数后，可以独立于其他测试端口对每个测试端口的错误模型进行处理。然后使用各个测试端口的本地化错误参数构建未校准的测试路径的误差项。

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